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This research plan proposes developing a device to help people with Leber Congenital Amaurosis (LCA), a genetic disorder that causes blindness or severe visual impairment. The researchers aim to 3D print a pair of glasses with slots for small mirrors to assist those with LCA. They identify potential risks like broken glass and electrical hazards. The procedure involves designing the glasses using CAD software, 3D printing them, testing a prototype on oneself, and making refinements. The goal is to create a device that is comfortable, efficient, and does not cause social issues for LCA patients.
This research plan proposes developing a device to help people with Leber Congenital Amaurosis (LCA), a genetic disorder that causes blindness or severe visual impairment. The researchers aim to 3D print a pair of glasses with slots for small mirrors to assist those with LCA. They identify potential risks like broken glass and electrical hazards. The procedure involves designing the glasses using CAD software, 3D printing them, testing a prototype on oneself, and making refinements. The goal is to create a device that is comfortable, efficient, and does not cause social issues for LCA patients.
This research plan proposes developing a device to help people with Leber Congenital Amaurosis (LCA), a genetic disorder that causes blindness or severe visual impairment. The researchers aim to 3D print a pair of glasses with slots for small mirrors to assist those with LCA. They identify potential risks like broken glass and electrical hazards. The procedure involves designing the glasses using CAD software, 3D printing them, testing a prototype on oneself, and making refinements. The goal is to create a device that is comfortable, efficient, and does not cause social issues for LCA patients.
Research Plan (to Accompany Form 1A) A) Rationale Include a brief synopsis of the background that supports your research problem and explain why this research is important and if applicable, explain any societal impact of your research. Leber Congenital Amaurosis (LCA) affects about 2-3 babies for every 100,000 births, and about 130 million babies are born each year (“Leber Congenital Amaurosis (LCA).” UCSF Medical Center, www.ucsfhealth.org/conditions/leber_congenital_amaurosis/.). That is roughly 3,900 people that are diagnosed as babies or will be diagnosed in their early age. LCA can cause blindness and or severe visual impairment. It is very important that my partner and I make a type of glasses/headgear that will assist these people with their vision. B) Research Question(s), Hypothesis(es), Engineering Goal(s), Expected Outcomes. How is this based on the rationale described above? Research Question(s): Can a device be made that will help people with LCA see more efficiently? Hypothesis(es): If people with LCA can’t’ see normally, then a device that assists them is necessary. Engineering Goal(s): Engineer a prototype of an efficient device that assists people with LCA and their visual handicaps. Expected Outcomes: A well-made device that is comfortable, works efficiently, and does not create any social problems (not too big or awkward). Procedure(s) Detail all procedures and experimental design including methods for data collection. Describe only your project. Do not include work done by mentor or others. Part 1: State the process of constructing a pair of glasses that assists people with LCA Materials
Two 1in by 1in mirrors
3D printer Plastic for 3D printer Computer with software already installed Tinker Cad software Procedure 1. Turn on the computer with a 3D printer software. 2. Open TinkerCad software once the computer is on. 3. Turn on the 3D printer. 4. Make sure there is plastic ready. 5. Design the glasses being sure that there are slots for the individual mirrors. 6. Once finished, make sure everything works and the design comes out well. 7. Test if needed. Research Plan Template
Name(s): Alex Olmore and Wesley Anderson
Sketch of basic project design idea
Risk and Safety
Identify any potential risks and safety precautions needed. 1. Working with glass: My partner and I will be working with mirrors and they could break. 2. Potential shock hazard: A computer(s) and the 3D printer could both cause a shock hazard. Data Analysis Describe the procedures you will use to analyze the data/results. Data Analysis-
1. Test the device on yourself after completing the constructing stage
2. Make any necessary changes 3. If any changes made, repeat steps 1 and 2, and step 3 if necessary. IF Applicable Below are subject-specific guidelines for additional items to be included in your research plan/project summary as applicable. Human participants research: a. Participants: Describe age range, gender, racial/ethnic composition of participants. Identify vulnerable populations (minors, pregnant women, prisoners, mentally disabled or economically disadvantaged). b. Recruitment: Where will you find your participants? How will they be invited to participate? c. Methods: What will participants be asked to do? Will you use any surveys, questionnaires or tests? What is the frequency and length of time involved for each subject? d. Risk Assessment: What are the risks or potential discomforts (physical, psychological, time involved, social, legal, etc.) to participants? How will you minimize risks? List any benefits to society or participants. e. Protection of Privacy: Will identifiable information (e.g., names, telephone numbers, birth dates, email addresses) be collected? Will data be confidential/anonymous? If anonymous, describe how the data will be collected. If not anonymous, what procedures are in place for safeguarding confidentiality? Where will data be stored? Who will have access to the data? What will you do with the data after the study? f. Informed Consent Process: Describe how you will inform participants about the purpose of the study, what they will be asked to do, that their participation is voluntary and they have the right to stop at any time.
Vertebrate animal research:
Research Plan Template
Name(s): Alex Olmore and Wesley Anderson
a. Discuss potential ALTERNATIVES to vertebrate animal use and present justification for use of vertebrates. b. Explain potential impact or contribution of this research. c. Detail all procedures to be used, including methods used to minimize potential discomfort, distress, pain and injury to the animals and detailed chemical concentrations and drug dosages. d. Detail animal numbers, species, strain, sex, age, source, etc., include justification of the numbers planned. e. Describe housing and oversight of daily care f. Discuss disposition of the animals at the termination of the study. Potentially hazardous biological agents research: a. Give source of the organism and describe BSL assessment process and BSL determination. b. Detail safety precautions and discuss methods of disposal.
Hazardous chemicals, activities & devices:
• Describe Risk Assessment process, supervision, safety precautions and methods of disposal.