COLLEGE OF PHARMACY AND CHEMISTRY Page 1 of 3

University of the Immaculate Conception

Father Selga St., Davao City Test Date: 20 January 2020
Document: QUIZ 1: Learning Act. 6 – Assay of Sodium Chloride: The Volhard Method Semester: 2nd AY: 2019 - 2020
Subject: PCH301 (Lab) – PHARMACEUTICAL ANALYSIS 1 Period: MIDTERM

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Directions:
1. READ EVERY QUESTION WITH PROPER UNDERSTANDING.
2. USE THE ALLOTED TIME WISELY.
3. MAKE SURE THAT THE ITEM YOU’RE ANSWERING CORRESPONDS TO THE ITEM YOU’RE GOING TO SHADE IN YOUR
ZipGrade® OMR answer sheet.

**START OF QUIZ**

For item #s 1 - 15, refer to the titration set-up provided:

1 - 2) Refer to apparatus A. Identify the substance that it contained.

A) 0.1 N Silver Nitrate VS D) 1.0 N Ammonium Thiocyanate VS
B) 1.0 N Silver Nitrate VS E) NOTA
C) 0.1 N Ammonium Thiocyanate VS

3 - 4) Refer to apparatus A. Identify the industrial application of the substance inside.

A) Cleaning solution for glassware D) Weak oxidizing agent
B) API in herbicides E) NOTA
C) Complexing agent

5 - 6) Refer to apparatus B. In the choices given, identify the titrand inside.

A) Salitre (in Philippine Market) D) Rochelle’s Salt
B) Photographer’s Hypo E) Glauber’s Salt
C) Dendritic salt

7 - 8) Refer to apparatus B. In the choices given, identify the substance that will form a “film” to prevent the precipitate formed to react
further during the analysis.
A) Ferric alum D) Nitrobenzene
B) Conc. nitric acid E) Distilled water
C) 0.1 N Silver Nitrate VS
 PCH301 (Lab) – Q1_Midterm_AY 2019-2020 | 2

9 - 10) Refer to apparatus B. In the choices given, identify the substance that has the capacity to change its color during the reaction
which implies that the titrimetric analysis performed has been successful.
A) Ferric alum D) Nitrobenzene
B) Conc. nitric acid E) Distilled water
C) 0.1 N Silver Nitrate VS

11 - 12) Refer to apparatus B. In the choices given, identify the substance that will alter the pH level of the set-up in order to achieve the
ideal environment of performing Volhard method.
A) Ferric alum D) Nitrobenzene
B) Conc. nitric acid E) Distilled water
C) 0.1 N Silver Nitrate VS

13 - 14) Refer to apparatus B. In the choices given, identify the substance that primarily served as the solvent of the titrand prior to the
addition of other siginifcant reagents
A) Ferric alum D) Nitrobenzene
B) Conc. nitric acid E) Distilled water
C) 0.1 N Silver Nitrate VS

15) Refer to apparatus B. In the choices given, identify the substance that was said to be added in excess prior to its interaction with the
substance in apparatus A.
A) Ferric alum D) Nitrobenzene
B) Conc. nitric acid E) Distilled water
C) 0.1 N Silver Nitrate VS

16) What is the expected endpoint for this particular titrimetric analysis, and what is the name of the complex substance formed?
A) Blood Red-colored complex, Fe(SCN)3 D) Choice A or Choice B
B) Carmine red-colored complex, AgSCN E) Choice A or Choice C
C) Strong Wine Red-colored complex, Fe(SCN)3

For item #s 17 - 26, shade C if the statement is TRUE. Otherwise, shade E if the statement is FALSE.

17) Volhard method of precipitimetric analysis must be carried out in acidic environment or condition.

18) This titrimetric procedure may or may not utilize nitrobenzene since the precipitate has the ability to prevent itself from being involved
further in the reaction.

19) The indicator used is technically known as ferrous ammonium sulfate.

20) Volhard method of precipitimetric analysis is considered to be a residual type of titration because there are two volumetric solutions
involved – 0.1 N Silver nitrate VS and 0.1 Ammonium thiocyanate VS. Between the two volumetric solutions, 0.1 Ammonium thiocyanate
VS was the one added in excess.

21) The USP-NF acceptance criteria for this particular analysis is as follows: “Sodium chloride should contain nlt 99.0% and nmt 100.5%
of NaCl calculated on a dried basis”.

22) The warning that is most prominent with the use of sliver nitrate VS is that it can cause permanent staining in fabrics and in the skin.

23) The volume of nitrobenzene that was added in the titrand set-up was 0.0025 L.

24) The volume of distilled water added in the titrand set-up was 25 mL.

25) The volume of FAS added in the titrand set-up was 1000 μL.

26) The volume of concentrated nitric acid added in the titrand set-up was 1.50 L.
 PCH301 (Lab) – Q1_Midterm_AY 2019-2020 | 3

For item #s 27 – 28, refer to the data given:

TRIAL 1 TRIAL 2
Weight of NaCl (g) 0.1300 0.1300
Final reading – 0.09494 N NH4SCN (mL) 19.80 27.90
Initial reading – 0.09494 N NH4SCN (mL) 12.15 19.80
Volume of NH4SCN used (mL) (27) 8.10
Volume of 0.09898 N AgNO3 used (mL) 30.00 30.00
%NaCl (per trial) 100.9400% 99.0151%
Average %NaCl (28)

27) Determine the volume of 0.09494 N NH4SCN VS used in the 1st trial.
A) 7.56 mL D) 6.57 mL
B) 7.65 mL E) 5.76 mL
C) 6.75 mL

28) Determine the average %NaCl based on the data obtained from the two trials performed.
A) 99.9776% D) 99.7796%
B) 99.9677% E) 99.7769%
C) 99.9767%

For item #s 29 – 30, refer to the scenario given:

Rhys was given an unidentified salt sample to be subjected for Volhard precipitimetric analysis. An orientation was given to him
by the laboratory head Erika regarding such sample. The following were the information he obtained from the orientation:

- MW of Unidentified Salt Sample: 65.45 g/mol

- Total valence: 3

29 - 30) In order for Rhys to conduct the Volhard precipitimetric analysis on the said sample, help him by calculating the milliequivalent
(mEq) weight. The value must be reported to four (4) significant figures.
A) 0.02181 g/mEq D) 0.02812 g/mEq
B) 0.02182 /mEq
g E) 0.02118 g/mEq
C) 0.02811 g/mEq

**END OF QUIZ**

“My advice is, never do tomorrow what you can do today. Procrastination is the thief of time.”
(Charles Dickens)

God bless, future RPhs! 

-Sir Noy

©19 JANUARY 2020