Vous êtes sur la page 1sur 9

Technology in Cancer Research & Treatment

ISSN 1533-0346
Volume 3, Number 3, June (2004)
©Adenine Press (2004)

HDR Brachytherapy with Surface Applicators: Albert M. Sabbas, Ph.D.*


Technical Considerations and Dosimetry Fridon G. Kulidzhanov, Ph.D.
Joseph Presser, M.Sc.
www.tcrt.org
Mary K. Hayes, M.D.
HDR surface molds offer an alternative radiotherapy modality to electrons for the treatment Dattatreyudu Nori, M.D.
of skin lesions. Treatment planning and dosimetry are discussed for two types of surface
molds used in our clinic. Standard rectangular applicators are used on a variety of sites
Department of Radiation Oncology
where surface curvature is minimal. In these cases an idealized planar geometry is used
for treatment planning dose calculations. The calculations yield treatment dose uniformity New York Presbyterian Hospital
at the prescription depth in tissue as well as skin dose, as a percentage of the treatment Weill Cornell Medical College
dose, and its dose uniformity. The availability of optimization techniques results in superior
525 East 68th Street
dose uniformity at depth but the dose at the skin has to be carefully evaluated. We have
studied the dependence of these dosimetric parameters on the size of the surface mold and New York, NY 10021
the type of optimization procedure used in the dosimetry calculations. The second type of
surface applicator involves the use of a customized silicone rubber mold attached to a ther-
moplastic mask of the patient. We have used them to treat lesions of the face where sur-
face curvatures are appreciable and reproducibility of setup is more critical. In these cases
a CT data set is used for reconstruction of the catheters, activation of relevant dwell posi-
tions and dosimetry, including optimization. Towards establishing effective methods for
quality assurance of the optimized HDR surface mold planning calculations, we have com-
pared their dosimetry to both a classical brachytherapy system and to one based on an ana-
lytical model of the applicator. The classical system yields an independent verification of the
integrated activity used in the planning calculations, whereas the analytical model is used
to evaluate depth dose dependence on mold size and optimization.

Key words: High dose rate brachytherapy; Surface molds; Skin lesions; Dose optimization.

Introduction

Surface mold therapy was introduced in the beginning of the 20th century to treat
skin lesions following the discovery of radium (1). Radioactive molds became
one of the established radiation modalities to treat skin cancer along with super-
ficial and orthovoltage X-rays. The surface mold applicators were typically
loaded with gamma emitters such as Ra-226, Rn-222, Au-198, Co-60 or Cs-137
and they were widely used for the treatment of skin lesions of the extremities.
This technique was described in a report by Ashby et al. in 1989 (2) where they
used radon sources in wax and paraffin molds.

With the introduction of linear accelerators and the availability of high-energy


electron beams, brachytherapy mold therapy became less popular. Lovett et al.
(3) reported on the treatment of skin carcinomas with external beam radiothera-
py. Electrons in particular, became the preferred way of treating superficial skin * Corresponding Author:
lesions due to the wider availability of linacs and the radiation hazards associat- Albert M. Sabbas, Ph.D.
ed with the construction and use of the brachytherapy surface molds. Email: asabbas@nyp.org

259
260 Sabbas et al.

The development of afterloading techniques and in particu- Materials and Methods


lar the HDR remote afterloader overcame the issues associ-
ated with personnel radiation protection. HDR surface mold Standard Rectangular Applicators
therapy was first introduced by Joslin (4, 5). As HDR
brachytherapy units became more widely used there has We have been using commercially available (Mick Radio-
been a revived interest in surface molds. Radiation safety Nuclear Instruments, Inc.) flexible applicators made out of
hazards associated with LDR molds were no longer present a flexible silicone rubber material for treatment sites
and the treatment could be delivered safely over a short time where curvature is minimal such as skin lesions of the
as an outpatient procedure. Various authors have reported on extremities. The thickness of the applicator is 8 mm and
the use of HDR brachytherapy for the treatment of superfi- the distance between the catheter plane and patient skin is
cial tumors as an alternative to electron beam therapy (6-12). 5 mm. They come with predrilled holes every 1 cm for
embedding the HDR catheters These applicators were ini-
Svoboda et al. (13) used soft silicone rubber applicators that tially developed for intra-operative work and are known as
allow treatment of any flat areas by a single mold up to a 24 the HAM applicators (Harrison-Anderson-Mick) (16).
cm square. Cuix et al. (14) demonstrated the clinical effica- Figure 1 shows the two types of HAM applicators used in
cy of custom-made surface molds to treat irregular or curved our clinic. The 6 catheter applicator is used to treat small
surfaces with the HDR afterloader. They placed the molds on areas up to 6 cm × 6 cm2. The 12 catheter applicator can
top of individually-constructed patients’ masks made out of be used to treat larger areas, such as skin lesions at the
plaster. HDR surface molds have also been used to treat torso and legs, up to an area of 21 cm × 11 cm2.
tumors of sites other than skin. Jolly and Nag (15) reported
on the use of dental molds for the treatment of head & neck By activating certain combinations of catheters and dwell
cancers. Harrison (16) used specially-made flexible applica- positions a variety of areas of different sizes and shapes can
tors for intraoperative radiation therapy (IORT). be treated. With an overall thickness of less than 1 cm,
they conform well and easily to the treatment surfaces. A
In this paper we describe our experience in using two types spacing of 5 mm between the skin and the source plane is a
of surface molds for the treatment of skin lesions with par- good compromise between maintaining an acceptable dose
ticular emphasis being given on treatment planning and uniformity at the skin while at the same time maximizing
dosimetry aspects. We have treated close to 80 cases since the dose fall-off with depth.
1995, when we first introduced this technique in our depart-
ment as an alternative to electron beam therapy, including We place a solder wire over the marked outline of the lesion
lesions of the septum of the nose and the oral cavity. The plus margin on the skin prior to acquiring a single en-face
types of cutaneous lesions that we have treated are primary film. The applicator is positioned so that its distal edge is
and secondary skin cancers, Kaposis’s sarcoma, mycosis aligned to the distal edge of the lesion. By adjusting the ori-
fungoides and cutaneous lymphomas. Depending on the his- entation of the applicator the curvature of the treatment sur-
tology, patients were treated with a dose 300-500 cGy per face, if any, is set in a direction perpendicular to direction of
fraction twice a week, for a total dose ranging from 1600- the catheters and exposure to the surrounding patient’s
5000 cGy (4-13 fractions). A more detailed list of the types anatomy while the source is in transit from the afterloader
of cases we have treated along with clinical results will be to the applicator is kept at a minimum. We do not use the
presented in a separate manuscript. en face film for reconstructing the source dwell positions in
space. Rather we use it for documentation of the treatment
We have used standard commercially available applicators area and deciding which catheters and dwell positions to
when treating surfaces with minimal curvature. In these activate (Fig. 2). We also mark two corners of the applica-
cases we base the dosimetry on an idealized flat planar tor on the patient’s skin for reproducible placement of the
geometry. For these applicators we present the dependence mold prior to each radiation fraction (Fig. 3).
of the treatment dose and skin dose uniformity on method of
optimization and size of treatment area. We have also used For treatment planning purposes we assume an idealized
customized surface molds rigidly attached to the patient’s flat planar geometry of the surface mold. Figure 4
thermoplastic mask for facial sites where surface curvature is shows the coordinate system we use to input source
more pronounced. In these cases catheter reconstruction and dwell positions into the dose planning system. An atlas
dosimetry are all CT-based and image driven. Finally, the of plans corresponding to various combinations of
dosimetry of the HDR stepping source configuration is com- catheters and dwell positions can be thus calculated in
pared to a classical table-based dosimetry system as well as advance and the appropriate one chosen based on the
an analytical model of the surface mold, the latter two serv- desired number of catheters and dwell positions needed
ing as QA tools of the HDR computerized dose calculations. to cover the treatment area.

Technology in Cancer Research & Treatment, Volume 3, Number 3, June 2004


HDR Brachytherapy with Surface Applicators 261

We use optimization techniques for the calculation of dwell Results


times in order to meet certain prescription and dose unifor-
mity criteria. The optimization process can be thought of as CT-based Planning
a computerized application of the Paterson-Parker rules (17)
to achieve dose uniformity and homogeneity within the Figure 6 depicts the dosimetry of a CT-based plan using a 4
implant, albeit quite more flexible. The dose prescription/ mm silicone rubber mold securely attached to the patient’s
optimization points are arranged at a depth of 5 mm (some- thermoplastic mask. The setup is customized to the particu-
times 3 mm) within the skin or 1 cm from the source plane. lar patient for ease of placement, which also results in a repro-
We have used two types of optimization methods for these ducible treatment geometry. For the particular case described
planar molds. An optimization on dose points uses the sin- here, four catheters were embedded within the silicone mold
gular value decomposition algorithm (18) to minimize the with the catheter plane being at a distance of 5 mm from the
sum of the squares of the differences between calculated and skin. The treatment site was the right nasal side wall with the
desired dose to the points. This results in uneven dwell times lesion (squamous cell carcinoma of the skin) measuring
with larger dwell times at the periphery of the implant. A approximately 3 × 3 cm2. To provide adequate coverage the
geometric optimization (19) method calculates the dwell dwell positions enabled per catheter varied with the most
times according to the relative positioning of the dwell posi- medial having 7 positions enabled, the two central catheters
tions to achieve the desired dose homogeneity within the each with 8 active positions and the most lateral having 3
implant. The merits of each of these two optimization meth- active positions. The spacing between successive dwell posi-
ods, as they relate to the dosimetry of these planar surface tions was 5 mm. The dwell positions for the most lateral
molds, will be presented in the next section. catheter were activated with an offset of about 2.5 cm from
the tip of the catheter to avoid proximity to the right orbit.
Customized Surface Molds
This particular patient had undergone Moh’s surgery prior to
To provide even better conformality and reproducibility radiation treatment and the pathology results were positive
when treating curved surfaces, particularly with lesions of up to the bone. Therefore, the facial bone, also shown in the
the face near the nose, we have customized the construc- 3D view, served as the landmark for prescribing the dose at
tion of the surface mold to the particular patient. A mask depth. The optimization of the dwell times was done by
made out of thermoplastic material, 3 mm in thickness, is directly shaping the isodoses to conform to the CT anatomy.
made to conform to the patient’s face. If the lesion is close Image-based brachytherapy is fast becoming the standard
to the eyes the mask has provisions for attaching securely and as this example illustrates, a single CT data set can be
two 6 mm thick eye Pb shields (2 HVL’s) for all the treat- used for catheter reconstruction, deciding on which dwell
ment fractions. A highly flexible 4 mm thick Silicone positions to activate, displaying of the isodoses in 2D or 3D
Rubber applicator is then attached over the mask to cover as well as dwell time optimization. In the case described
the area to be treated. The catheters are embedded within above, TLD’s were placed by the right inner canthus and
the applicator at midplane thus providing a total distance under the right eye within the treatment field. These meas-
of 5 mm between the source plane and the skin. These sur- ured doses agreed to within a few percent with the calculat-
face molds can be cut to various rectangular sizes accord- ed doses by the treatment plan. The measured doses at the
ing to the area to be treated. They have two sets of holes two eye lids under the lead shields also agreed well with the
spaced every 1 cm, one set of holes for inserting the HDR calculated doses after the latter were multiplied by 0.25 to
catheters and the other set on the front plane for attaching account for the two HVL’s of Pb present during treatment.
them to the thermoplastic mask with plastic screws.
Figure 5 shows the customized face mask with the appli- Dosimetry of Flat Planar Applicators
cator attached over it.
Figure 7 shows the isodose distributions from a 6 × 6 cm2
Treatment planning and dosimetry are based on a volumet- surface mold on planes perpendicular and parallel to the
ric CT data set acquired with the mask and applicator in brachytherapy catheters. The parallel plane is at a distance
place. The slice thickness of the CT axial cuts is 3 mm or of 10 mm from the catheters which corresponds to a depth of
less. The reconstruction of the catheters in space is done by 5 mm in tissue. The effects on the shape of the isodoses with
tracking them on various consecutive CT images and the no optimization, dose point optimization and geometric opti-
activation of relevant dwell positions and choice of pre- mization are shown in Figures 7a, b and c respectively.
scription depth are entirely image-based. Isodose shaping Plans with no optimization or equal dwell times for all dwell
optimization software are used to conform the dose to the positions yield the widest variation of dose across the treat-
individual anatomy and target volumes without the use of ment plane. The maximum doses occur at the center of the
explicit optimization dose points. implant, while the periphery of the implant is underdosed.

Technology in Cancer Research & Treatment, Volume 3, Number 3, June 2004


262 Sabbas et al.

Figure 4: Schematic of the surface applicator and the coordinate system


used for treatment planning. Most of the times a flat planar geometry is
used for the dose calculations.
Figure 1: Two types of commercially available HAM applicators made out
of a silicone rubber material. These applicators are used to treat different
types of lesions through the activation of the appropriate number of
catheters and dwell positions. A. 12 channel mold. B. 6 channel mold.

Figure 5: A flexible silicone rubber applicator with 4 HDR catheters


embedded is shown attached to the patient’s thermoplastic face mask. The
extent of the lesion is outlined in blue ink. The Pb shields for the two eyes
are attached to the underside of the mask.

Variations of the prescription dose among the optimization


Figure 2: En face simulation film with the lesion delineated with solder
wire. The decision of which dwell positions to enable is based on this film.
points, placed opposite the source positions at 10 mm, can be
as high as 25 to 35% of the prescription dose.

Dose point optimization yields the most uniform dose across


the treatment plane with dose variations of only 2 to 4% among
the optimization points. Optimization results in unequal dwell
times with the highest dwell times occurring at the periphery of
the implant. As a result, dose homogeneity at distances from
the catheters closer than 10 mm worsens. The plan based on
geometric optimization is a compromise between dose unifor-
mity across the treatment plane and dose homogeneity at short-
er distances and is in-between the no optimization and dose
point optimization plans. The dose variations among the opti-

Figure 3: Applicator placed on the patient’s skin is attached to the HDR


afterloader prior to treatment delivery.

Technology in Cancer Research & Treatment, Volume 3, Number 3, June 2004


HDR Brachytherapy with Surface Applicators 263

mization points are within the 15-20% range relative to the pre- We then compare ∫Adt to the one derived based on the activ-
scription dose with a standard deviation of about 10%. ity of the HDR source multiplied by the sum of all the dwell
times of the HDR plan.
Of significant clinical importance when treating surface
lesions is the dose to the skin. In Figure 8 we plot the skin In Figure 9 we plot the ratio of the ∫Adt as derived from the
dose as a function of treatment area for a number of rectan- HDR brachytherapy calculations and that based on the inde-
gular planar surface molds. The skin dose is expressed as a pendent dosimetry verification, as outlined above, for various
percentage of the prescription dose and both the average and sizes of planar surface molds. Each surface mold is desig-
maximum dose to the selected skin points are shown. The nated by its size in terms of number of catheters times num-
skin points are positioned opposite to the source dwell posi- ber of positions (C × P) with 1 cm spacing between dwell
tions at a distance of 5 mm. Most of the calculations are positions. The prescription distance for all the molds was set
based on the geometric optimization, which is what is used to 1 cm (5 mm depth in tissue) except for the 11 × 9 mold
mostly in the clinic. For the 5 × 5 and 9 × 9 molds we also where the distance was set at 0.8 cm (3 mm depth in tissue).
show the calculated skin doses based on the dose point opti- For plans based on the dose point optimization algorithm the
mization which results in larger dose inhomogeneities and agreement is within 3%. For plans based on the geometric
maximum doses compared to the geometric optimization, optimization algorithm the agreement is acceptable, mostly
240% versus 175%, at the skin for the 5 × 5 mold. within 8%, though not as good as the dose point optimization
plans that seem to replicate the Paterson Parker rules better.
In general, the skin dose decreases with size of the surface
area treated since the dose fall-off is less with larger surface Comparison with Analytical Model
molds. This decrease is more pronounced when no opti-
mization is used and is least noticeable when the dose point We studied the exact dependence of the depth dose from an
optimization is used, since the optimization compensates for HDR surface mold on the treatment area by considering an
the finite surface area by increasing the peripheral dwell analytical model of the surface mold. For 192Ir the radial
times. For no optimization the maximum skin dose occurs dose function g(d) exhibits less than 1% variation over the
near the center of the treatment area. The dose variation at first 5 cm distance from the source (21). The variation of
the skin for dose-point optimized plans is the largest. The dose with distance d along the central axis of the mold is
center dose is close to the minimum and the maximum therefore mainly due to the geometry factor G(d).
occurs at the edge of the treatment area where the optimized Considering a circular mold of radius R, total activity A and
dwell times are the largest. We have observed skin reactions uniform activity density α, the geometry factor can be cal-
at the treatment edges for patients treated with plans opti- culated by integrating over the area of the applicator.
mized on dose points and this is a clinical confirmation of

[ ( )]
the substantial surface hot spot at the periphery. The least 2π R ρdρdθ 2
α∫ α∫ 2 2
0 ρ + d 1 R
variation in the skin dose and the smallest hot spots are G (d ) = 0
= ln 1 + . [1]
A R2 d
exhibited by plans calculated using geometric optimization.

Comparison with a Classical Brachytherapy System For treatment distances much greater than the lateral extent of
the applicator, R<<d, G(d)=1/d2 which is the familiar inverse
The optimization methods achieve a dose uniformity at the pre- square dependence of the depth dose from a point source. In
scription dose plane by yielding a set of unequal dwell times. Figure 10 we plot the dose fall-off, as predicted from Eq. [1] for
This is in close analogy to the Paterson Parker rules of the surface molds of uniform activity of radii 2, 3, 4, and 5 cm. For
Manchester LDR brachytherapy system (17), which is a set of comparison the 1/d2 curve of a point source and 1/d curve from
rules for arranging Radium or other types of low activity an infinitely long linear source are also plotted. The curves are
sources in order to achieve uniform dose to a plane or volume. normalized to a distance of 1 cm from the source plane or to a
The total activity multiplied by the duration of the implant ∫Adt, depth of 0.5 cm in tissue. As seen from Figure 10 the surface
is a good indicator of the dose delivered by such an implant. dose varies from 176% for the smallest 4 cm diameter applica-
tor to142% for the largest 10 cm diameter applicator. The depth
The Manchester tables (20) for planar implants list the dose is also steeper for the smaller size applicators.
mg·hr to deliver 10 Gy to tissue for different surface areas
and treatment distances from the source plane (RA). We In Figure 11 we compare the depth dose of the analytical
have used these tables to independently verify ∫Adt for com- model and the computerized HDR brachytherapy calcula-
puterized HDR plans. Specifically, we calculate ∫Adt using tions for a 6x6 cm2 mold (R=3.4 cm). Both the unoptimized
RA, the prescription dose D and a conversion factor of (equal dwell times) and the dose-point optimized calculations
6.3734 (Ci·s/mg·hr). The RA is based on a surface area are plotted. All three curves are normalized to a depth of 0.5

Technology in Cancer Research & Treatment, Volume 3, Number 3, June 2004


264 Sabbas et al.

Figure 6: CT-based dosimetry for the applicator


shown in Figure 5. A. Axial cut. B. Reconstructed
coronal view. C. Reconstructed sagittal view. D.
3D view with the 400 cGy/Fx dose cloud shown
together with the outlined anatomy.

Figure 7: Dosimetry of a flat 6 × 6 applicator on a


plane perpendicular to the catheters and a plane par-
allel to the catheters at a distance of 1 cm form the
plane of the catheters. A. No optimization. B. Dose
point optimization. C. Geometric optimization.

Technology in Cancer Research & Treatment, Volume 3, Number 3, June 2004


HDR Brachytherapy with Surface Applicators 265

Figure 11: Depth doses from a 6 × 6 surface applicator based on the ana-
Figure 8: Skin dose expressed as a percentage of the treatment dose as a lytical model (continuous curve) and the HDR stepping source non-opti-
function of the applicator size (# of catheters x # of dwell positions). There mized and optimized dose calculations.
is a 0.5 cm bolus between the plane of the catheters and the skin and the
dose is prescribed to a depth of 0.5 cm in tissue. Both the average and max-
imum skin doses are plotted for the geometric optimization (all sizes) and
for the dose point optimization (two sizes).

Figure 12: Comparison of the depth doses for different modalities: Co-60
80 SSD, 6 MeV electrons 100 SSD, 100kVp superficial X-rays 15 SSD and
a 6 × 6 surface mold with a 0.5 cm bolus between the skin and the plane of
the catheters. The HDR calculations are optimized. The dose is normalized
Figure 9: Agreement between the HDR contact therapy calculation and to 100% at the skin for the superficial and HDR modalities and dmax for the
the Paterson Parker tables of the integrated activity for various surface Co-60 and the electrons.
applicator sizes.

Figure 10: Depth dose calculations for various radii of surface applicators
based on the analytical model of the applicator. For comparison the inverse
square dose fall-off from a point source and the inverse distance dose fall- Figure 13: Comparison of the dosimetry on a curved surface from A. 6 ×
off from an infinitely long linear source are also shown. The dose is nor- 6 HDR surface applicator with 0.5 cm bolus and B. 6MeV electron beam
malized to a depth of 0.5 cm in tissue. with a 6 × 6 cone and 1 cm bolus.

Technology in Cancer Research & Treatment, Volume 3, Number 3, June 2004


266 Sabbas et al.

cm in tissue. The analytical model predicts well, to within a In conclusion, some of the key features of HDR contact ther-
few percent, the depth dose from the stepping source unopti- apy are summarized below:
mized plan. Upon optimization the depth dose becomes less
rapid by as much as 7% compared to the unoptimized plan (I) Surface molds can conform easily to the curva-
since peripheral dwell positions are weighted heavier. ture of the treatment surface. On the other hand,
there are uneven air gaps between the tip of the
Discussion electron cone and the patient’s surface, especial-
ly when treating curved surfaces, which con-
In Figure 12 we plot the percent depth dose for three external tribute to the dose inhomogeneity at depth with
beam modalities along with that from an optimized 6 × 6 cm2 electron beam therapy.
HDR surface mold used clinically. The high dose region for 6
MeV electrons ( > 80% of the maximum dose) extends over (II) Optimization algorithms are routinely incorporated
1.8 cm from the surface and is then followed by a precipitous in the HDR brachytherapy calculations and con-
drop in the radiation dose. In contrast the depth doses of the tribute further to the dose homogeneity at depth.
HDR 192Ir and superficial X-rays do not exhibit any skin spar-
ing and fall off exponentially with depth. For the HDR mold (III) Through adjustment of dwell positions and dwell
the dose is already down to 67% and 52% of the skin dose at times manually or as part of the optimization
depths of 5 mm and 1 cm respectively. HDR contact therapy process the radiation field can be customized in
treats more superficially than electrons. HDR contact therapy terms of its shape and intensity profile. No custom
also exhibits faster dose fall-off than the superficial beam. cutouts are needed to shape the radiation field.

The HDR mold, due to its flexibility, is able to conform well (IV) The dose fall-off is faster than Superficial
to the skin area and the dose can be delivered uniformly at Therapy and is thus better suited for the treatment
depth when treating curved surfaces as well. The electron of more superficial lesions.
cones on the other hand are rigid and as a result there can be
appreciable variations in the treatment SSD across the treat- (V) It is easy to shield selected areas of the treatment
ment area. Obliquity effects for electrons (22) when incident field using Pb sheets. The HVL for Ir-192 is 3
on curved surfaces can further contribute to the dose inho- mm of lead.
mogeneity at depth. We plot in Figure 13 the isodose distri-
butions on a curved surface (5 cm radius of curvature) from (VI) HDR contact therapy can be used to treat struc-
a standard 6cm × 6cm HDR surface applicator and from a 6 tures with excessive curvature like the septum of
MeV electron beam, 6 × 6 cone, 100 SSD and 1 cm bolus. the nose. It can be also used to treat cavities not
The thickness of the bolus used with electrons was chosen so easily accessible by electron applicators like the
that the prescription level of 100% occurs at approximately buccal mucosa.
7 mm from the surface at the center of the treatment area for
both modalities. For the HDR mold, the prescription dose is (VII) Radiation safety issues are minimal for the HDR
delivered uniformly at depth across the whole width of the remote afterloader since there is no radiation
treatment area. For electrons, on the other hand, the extent exposure to personnel.
of the prescription dose falls short of the intended treatment
width by as much as 2 cm. (VIII) The treatment times are of the order of a few min-
utes. Hence the dose is delivered quickly and
As mentioned earlier, a flat planar geometry is almost always effectively as an out-patient procedure.
assumed during dosimetry calculations when we use stan-
dard rectangular applicators to treat skin lesions of the (IX) Scheduling of HDR contact treatments does not
extremities and the torso. The dwell times for the 6cm × 6 impact on the busy schedule of the linac. In addi-
cm mold used to treat the curved surface shown in Figure tion, the HDR dose fractionation calls for fewer
13a were calculated based on a flat surface geometry to fractions or patient visits.
deliver 400 cGy at a treatment depth of 0.5 cm in the skin.
As seen from this figure, the curvature of the treatment area
causes the prescription isodose to appear deeper than 5 mm
by 1.7 mm on the concave side. Therefore, assuming a flat
geometry results in isodoses being shifted no deeper than 2
mm as long as the treatment surface curvature is not exces-
sive (more than 5 cm in radius).

Technology in Cancer Research & Treatment, Volume 3, Number 3, June 2004


HDR Brachytherapy with Surface Applicators 267

References 12. Evans, M. D. C., Yassa, M., Podgorsak, E., et al. Surface Applicators
1. Meredith, W., Massey, J. Fundamental Physics of Radiology. Bristol, for High Dose Rate Brachytherapy in Aids-related Sarcoma. Int. J.
Wright (1977). Radiat. Oncol. Biol. Phys. 39, 769-774 (1997).
2. Ashby, M. A., Pacella, J.A., De Groot, R., et al. Use of Radon Mould 13. Svoboda, V. H. J., Kovarik, J., Morris, F. High Dose Rate Micro-
Technique for Skin Cancer: Results from the Peter MacCallum selectron Molds in the Treatment of Skin Tumors. Int. J. Radiat.
Cancer Institute. Br. J. Radiol. 62, 608-612 (1989). Oncol. Biol. Phys. 31, 967-972 (1995).
3. Lovett, R. D., Perez C. A., Shapiro, S. J., et al. External Irradiation 14. Guix, B., Finestres, F., Tello, J. I., Palma, C., Martinez, A., Guix, J.
of Epithelial Skin Cancer. Int. J. Radiat. Oncol. Biol. Phys. 19, 235- R., Guix, R. Treatment of Skin Carcinomas of the Face by High-
242 (1990). dose-rate Brachytherapy and Custom-made Surface Molds. Int. J.
4. Joslin, C. A. F., Liversage, W. E., Ramsey, N. W. High Dose Rate Radiat. Oncol. Biol. Phys. 47, 95-102 (2000).
Treatment Mould by Afterloading Technique. Brit. J. Radiology 42, 15. Jolly, D. E., Nag, S. Technique for Construction of Dental Molds for
108-112 (1969). High-dose Rate Remote Brachytherapy. Spec. Care Dentist. 12, 219-
5. Joslin, C. A., Flynn, A. High Dose-rate Brachytherapy in the 224 (1992).
Treatment of Skin Tumors, in Principles and Practice of Brachy- 16. Harrison, L. B. HDR Intraoperative Brachytherapy, in International
therapy using Afterloading Systems, pp 393-399. Eds. C. A. Joslin, Brachytherapy: 8th International Brachytherapy Conference, pp 13-
A. Flynn, E. J.Hall. Oxford University Press, London (2001). 17. Nucletron-Oldelft, Veenendaal, The Netherlands (1995).
6. Sharma, S. C., Negi, P. S., Gupta, B. D. Selectron HDR Surface 17. Meredith, W. J. Radium Dosage, in The Manchester System. Ed., E.
Mould Therapy, in Brachytherapy 2, pp 572-575. Ed., R. F. Mould. S. Livingstone. Edinburgh and London (1967).
Nucletron International, Leersum, The Netherlands (1989). 18. Van der Laarse, R., De Boer, R. W. Computerized High Dose Rate
7. Porrazzo, M., Stabile, L., Ross, R., Moorthy, C., Tchelebi, A., Brachytherapy Treatment Planning, in Brachytherapy HDR and
Hilaris, B. S. HDR Remote Afterloading as an Alternative to LDR, pp 169-183. Eds., A. A. Martinez, C. G. Orton, R. F. Mould.
Electrons for Therapy of Superficial Tumours. Selectron Activity Nucletron International Publisher, Leersum, The Netherlands (1990).
Journal, Vol. 6, 11-13 (1992). 19. Edmundson, G. K. Geometry Based Optimization for Stepping
8. Kitchen, G., Dalton, A. E., Pope, B. P., Smith, P. D., Powner, M. Source Implants, in Brachytherapy HDR and LDR, pp 184-192.
Surface Applicator for Basal Cell Carcinoma of the Right Pinna: A Eds., A. A. Martinez, C. G. Orton, R. F. Mould. Nucletron
Case Report. Selectron Activity Journal, Vol. 5, 140 (1991). International Publisher, Leersum, The Netherlands (1990).
9. Kitchen, G., Dalton, A. E., Evans, M., Pope, B., Smith, P. D., 20. Johns, H., Cunningham, J. The Physics of Radiology. Springfield, C.
Selectron LDR Mould for Large Area Basal Cell Carcinoma. C. Thomas (1983).
Selectron Activity Journal, Vol. 4, 72-73 (1990). 21. Nath, R., Anderson, L. L., Luxton, G., Weaver, K. A., Williamson, J.
10. Brock, A., Prager, W., Pohlmann, S. Methodik der Kontakttherapie F., Meigooni, A. S. Dosimetry of Interstitial Brachytherapy Sources:
mit Hilfe des Afterloading-Verfahrens im Kopf-Hals-Bereich. Recommendations of the AAPM Radiation Therapy Committee Task
Radiobiol. Radiother. 29, 609-615 (1988). Group No. 43. Med. Phys. 22, 209-234 (1995).
11. Brock, A., Pohlmann, S., Prager, W. Surface Applicators for HDR 22. Biggs, P. J. The Effect of Beam Angulation on Central Axis Percent
Brachytherapy in the Head and Neck Region. Selectron Brachyther- Depth Dose for 4-29 MeV Electrons. Phys. Med. Biol. 29, 1089-
apy J. Suppl. 3, 22-25 (1992). 1096 (1984).

Date Received: March 9, 2004

Technology in Cancer Research & Treatment, Volume 3, Number 3, June 2004

Vous aimerez peut-être aussi