Académique Documents
Professionnel Documents
Culture Documents
Date of submission
January 2018
This guideline has been registered with the trust. However, clinical guidelines are guidelines only.
The interpretation and application of clinical guidelines will remain the responsibility of the individual
clinician. If in doubt contact a senior colleague or expert. Caution is advised when using guidelines
after the review date.
Maria Moran
Clinical Guideline Lead
2 May 2018
After the patient has been seen and assessed by the paediatric Nephrologist on-call
and peritoneal dialysis has been prescribed, these guidelines should be adhered to
unless instructed otherwise by the Nephrologist on-call.
The weight and fill volume of the child will determine whether a manual PD set or
Homechoice machine will be used to perform the dialysis. However, for insertion of
the catheter and the first 12 – 24 hours of therapy, it is recommended that a
manual set be used for all patients to make assessment and troubleshooting
easier.
Fill volumes 100mls - 500mls will require Homechoice Pro (low fill mode).
Fill volumes above 500mls will require Homechoice Pro (standard mode).
(all peritoneal dialysis equipment and consumables are available from Ward E17)
Contents
Acute patients have a ‘long term’ PD catheter inserted surgically under GA. The
current catheter of choice is a double cuff, coiled swan-neck catheter.
After the catheter has been inserted, it will need to be dressed and immobilised
appropriately. Dry, non-occlusive dressings are recommended. If possible the initial
dressing should remain undisturbed for 5 – 7 days. If oozing and/or bleeding occur,
the exit site should be cleaned with Normasol and a new dry dressing applied.
Silicone catheters are flexible and will exit the abdomen flush with the skin. They can
therefore have a dry Mepore dressing applied and a tube holder or tape used to
anchor it.
A wide range of commercially made peritoneal dialysis fluids are available with
varying compositions. To avoid confusion in this area only two are stocked but others
are available at short notice if required.
Dianeal PD4 is at present the routine solution of choice for both hospital and home
peritoneal dialysis in patients over 5 years of age. The buffer solution in Dianeal is
lactate, which in normal circumstances would be well tolerated but can become a
problem with certain patients. Lactate is converted into bicarbonate mmol for mmol as
long as the Liver is functioning normally. Neonates may be particularly intolerant of
lactate because of the severity of illness and immature livers. For patients who have
immature livers or are already suffering from a lactic acidosis, bicarbonate based
fluids may be required. Pure bicarbonate based fluids can be hand made on the unit
or in pharmacy if required and can be tailor made to suit the patients’ needs. It is
recommended that the fluid should be made in a sterile production area. Unit
prepared solutions are however, time consuming and require more frequent
The composition of P.D. solutions currently recommended for the use in acute
patients are;
Dianeal PD4
Available in 1.36%, 2.27% & 3.86% glucose concentrations.
Sodium 132 mmol/l
Calcium 1.25 mmol/l
Magnesium 0.25 mmol/l
Chloride 95 mmol/l
Lactate 40 mmol/l
Osmolarity 344, 395 & 483 mOsmol/l.
PH 5.3
Physioneal 40
Available in 1.36%, 2.27% & 3.86% glucose concentrations.
Sodium 132 mmol/l
Calcium 1.25 mmol/l
Magnesium 0.25 mmol/l
Chloride 95 mmol/l
Bicarbonate 25 mmol/l
Lactate 15 mmol/l
Osmolarity 344, 395 & 483 mOsmol/l.
PH 7.4
Bags can be changed using a strict aseptic non-touch technique at any time without
having to change the whole manual set.
Bags should be changed routinely every 24 hours
The whole PD set changed every 48 hours. (24 hours if infected)
Fill.
This is when the prescribed amount of dialysate fluid is infused into the patients
peritoneum.
Dwell
This is the length of time the dialysate fluid stays in the peritoneum.
Drain
This is when the dialysate and any extra fluid removed from the patient are taken out
of the peritoneum.
Fill volumes
Fill volumes in acute patients are calculated as ml/kg. As an initial therapy, it is
advisable to commence on 10 – 20 ml/kg. This can be increased slowly dependent on
patient tolerance. A fill volume of around 30 – 50 ml/kg is usually well tolerated and
should provide adequate dialysis.
Dwell times
Dwell times can vary throughout a patient’s treatment and it is advisable to check
blood chemistry levels at least twice a day in order to adjust the dialysis to meet the
patient’s requirements. As a starting point, hourly cycles are usually prescribed.
When using a manual PD set this will give a 5-minute fill, 45-minute dwell and
a 10-minute drain. When making adjustments to dwell times it is not necessary
to alter fill and drain times unless needed.
When using the Homechoice machine, the dwell time is automatically worked
out using a calculation of the fill volume, total therapy volume and the therapy
time. The formula below can be used to calculate the total therapy volume
based on hourly dwells and continuous therapy.
Nb: see ‘Setting up the Homechoice’ for how to program and examples of therapies.
Heparin, antibiotics and electrolytes can be added to new bags at any time. All
additives are prescribed in a concentration per litre to avoid errors when different sized
bags are used. Adding drugs to PD bags requires 2 staff members (one of whom is IV
drug competent) and should be done as a non-touch procedure.
A wide range of additives can be added to PD fluid including various electrolytes and
drugs. Discussion with your pharmacist is advisable to avoid precipitation.
Before adding to dialysis fluid bags, the expiry date, type of fluid and fluid strength
should be double checked.
Heparin should be added to the PD bags for the first 24 hours of therapy to avoid any
problems with blood clots from surgery. It can also be added to the bags if
experiencing any problems on drainage or fibrin is visible in the drainage bag.
Potassium can be added to fresh bags at any time and the bag changed without
having to change the whole set. It is common to add potassium after dialysis has
been running for a while as PD is a very effective way of removing potassium even in
an anuric patient.
The dose of Potassium is patient and condition dependant. The usual accepted dose
for maintenance is 4 mmol/litre. This can vary between 3 – 5 mmols/litre.
Remove same volume from PD fluid bag before addition (i.e. for target 150mmol/L
remove 18mls from Physioneal/Dianeal, then add 18mls sodium chloride (5mmol/ml)
Most antibiotics are compatible in PD fluid but if using one that has not been tried
before – advice should be sought from pharmacy in case of precipitation.
The main reason for antibiotics to be added to PD fluid is to treat peritonitis (see
Peritonitis section 12 and Peritonitis in Paediatric Peritoneal Dialysis Patients. Other
uses include; Prophylaxis for condition or leakage, Precautionary use due to
suspected contamination.
Section 9: Setting up PD
The flushing of an acute PD catheter is done to combat poor filling and drainage
caused by a potential blockage and should be done using a strict aseptic non-touch
technique. The flushing of a PD catheter should be undertaken after discussion with
the paediatric Nephrologist or renal nurse on-call. It should only be performed by
central line competent nurses.
Troubleshooting and alarms for the Homechoice are covered in the Homechoice
manual. The problems listed below relate mainly to manual set use.
Flow problems:
Cause Solution
Clamped or kinked lines or catheter. Unclamp or un-kink lines.
Fibrin blockage. Flush catheter with heparin & NaCl
- Fibrin is a form of protein that looks like strands And add heparin to bags.
of cotton wool.
Position of catheter obstructing drain. Reposition patient.
Fluid may have fully drained out Clamp drain clamp. Fill and drain
straight into drain bag because drain patient (no dwell) observing closely for
clamp not clamped. signs of over filling.
Cause Solution
Clamped or kinked lines or catheter. Unclamp or un-kink lines.
Fibrin blockage Flush catheter with heparin & NaCl
And add heparin to bags.
Position of patient obstructing fill. Reposition patient.
Suggestion Action
Increase strength of dialysis fluid. Add more glucose to bag if using unit
prepared solution.
Use higher strength bag if using pre-made.
Nb: try using a mix of two strengths as
opposed to going straight to next one up.
Decrease dwell times. Shorten the length of time the dialysate
stays in the patient.
This can increase the fluid removal but
can also have an effect on solute removal.
Increase fill volumes. Increasing the amount of fluid going into
the patient can sometimes increase fluid
removal but should be done cautiously.
This will also increase the solute removal.
Suggestion. Action
Decrease the glucose concentration. Add less glucose to the bag if using
unit prepared solution.
Use a weaker strength bag if using
pre-made.
Nb: try using a mix of two strengths.
Lengthen the dwell time. Leaving the dialysate in the patient for
longer will remove less fluid.
Urea One hour dwell times are usually sufficient to remove urea at
an acceptable rate. Dwell times can however be lowered to
remove more urea
Potassium Shorter dwell times are required to remove more potassium.
Half hourly rapid cycling can be used if required.
Continuous dialysis can reduce potassium levels too far and
may require adding it to bags.
Sodium High plasma sodium should be lowered slowly to avoid any
adverse effects. 1mmol per hour is a safe reference to use.
Very hypernatraemic patients (eg: >150mmols) should have
sodium chloride added to the dialysate to avoid lowering
levels too quickly.
Calcium Calcium contents of the unit prepared solutions can be
adjusted according to patient’s status. Pre-made solutions are
available with different calcium concentrations ranging from 0
– 1.75mmols/litre.
Pain on infusion:
Cause Solution
Internal position of catheter. Tidal dialysis can be tried in order to
keep a pool of fluid in the peritoneum
and hopefully float the catheter.
Analgesia
Pain on outflow:
Cause Solution
Internal position of catheter. Tidal dialysis can be tried in order to
keep a pool of fluid in the peritoneum
and hopefully float the catheter.
Breathlessness:
Cause Solution
Intra-abdominal pressure Reduce fill volume
Cross flow dialysis
P.D fluid passing into chest Change to extracorporeal therapy.
Leakage is a common problem with acute peritoneal dialysis. The main cause for this
is the early use of PD catheters without the recommended resting period enable
adequate healing or the use of acute PD catheters, which are inserted directly into the
peritoneum without tunnelling. If the entry site of the catheter becomes enlarged due
to movement, fluid can easily escape along the tract. The patient then becomes an
even higher risk for infection.
To avoid leakage the catheter should be well anchored to restrict any movement in
the entry site.
If leakage occurs a slight pressure dressing should be applied around the site in order
to stem the flow of fluid.
Nb: the dressing should be weighed prior to application in neonates so it can be re-
weighed if fluid continues to leak and fluid loss is inaccurate.
Suturing around the entry site may be attempted by the medical staff.
If leakage continues and becomes a problem then a new catheter should be
considered.
Patients are at a high risk of infection when receiving acute peritoneal dialysis. This is
due to the position and placement of the PD catheter and the flow of a glucose based
solution in and out of the peritoneum. Potential sites of infection are the peritoneum
(Peritonitis) and the catheter exit site. Observations of these two areas are simple to
carry out and can aid quick recovery.
Exit site.
The catheter exit site should be carefully examined when changing the
dressing. Signs of infection such as redness, oozing, pain and swelling should
be looked for and the site should be swabbed if infection is suspected.
Oral or intravenous antibiotics should be prescribed if infection is proved or
strongly suspected.
Topical agents such as Mupirocin ointment (Bactroban) can also be used, but
long term usage has been shown to cause some resistance.
Peritonitis
Peritonitis is an inflammation of the peritoneum caused by infection. This infection is
can be introduced to the peritoneum in various ways such as:
Contamination
Poor set-up technique
Exit/tunnel infection
Through gut wall.
Guidelines for children starting or receiving peritoneal dialysis for chronic renal
failure. Roy Connell. 2018. (Revised edition)
.
Schaefer et al. (2007). Worldwide variation of dialysis associated peritonitis in
children. Kidney International. 72, pp. 1374-1379.
Take a 1000ml bag of sterile water for irrigation, remove 90mls and discard, then add:
It does not contain phosphate. This can be added in the form of Potassium acid
phosphate.
Initial.
2. Bloods taken for Virology (Hep B/C, HIV)? (CVL insertion only)Date:____________
Haemo machine isolated (if required or result unknown) Yes / No. Machine No:_________
Results checked Date:____________
Replace line lock with prescribed amount and strength when returned to ward.