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  • Pathophysiology Dka

    Transféré par

    John Alano
    68 vues1 page
    This document outlines the pathophysiology of diabetes mellitus. It lists predisposing and precipitating factors such as heredity, age, obesity, and stress. The key pathophysiological processes involve insulin deficiency leading to hyperglycemia, glucosuria, polyuria, and ketone production from the breakdown of fat and protein. This can result in dehydration, electrolyte imbalances, metabolic acidosis, and potentially shock, coma and death if left untreated.

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    PATHOPHYSIOLOGY DKA

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    This document outlines the pathophysiology of diabetes mellitus. It lists predisposing and precipitating factors such as heredity, age, obesity, and stress. The key pathophysiological processes involve insulin deficiency leading to hyperglycemia, glucosuria, polyuria, and ketone production from the breakdown of fat and protein. This can result in dehydration, electrolyte imbalances, metabolic acidosis, and potentially shock, coma and death if left untreated.

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    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    68 vues1 page

    Pathophysiology Dka

    Transféré par

    John Alano
    This document outlines the pathophysiology of diabetes mellitus. It lists predisposing and precipitating factors such as heredity, age, obesity, and stress. The key pathophysiological processes involve insulin deficiency leading to hyperglycemia, glucosuria, polyuria, and ketone production from the breakdown of fat and protein. This can result in dehydration, electrolyte imbalances, metabolic acidosis, and potentially shock, coma and death if left untreated.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 1

    PATHOPHYSIOLOGY

    Predisposing Factor: Precipitating Factor:


    -Hereditary -surgery
    -Age (19 below) -diabetes 1 and 2
    -Type A personality -stress
    -Obesity -alcohol/drug abuse
    -Genetics -infection

    Glucose
    Fat Electrolytes Protein
    Water

    Insulin deficiency

    ↑ Glucagon ↓Glucose uptake by cells ↓Glucagon


    Gluconeogenesis Hyperglycemia Gluconeogenesis
    ↑Lipolysis Glucosuria ↑Protein catabolism
    Polyuria
    ↑Free fatty acids Hyperosmolality
    ↓Protein synthesis
    Ketogenesis ↑Amino acids
    Ketonaemia

    Ketonuria Osmotic dieresis ↑Blood urea


    Sodium Polyuria
    Nausea Electrolyte imbalance ↑Urinary nitrogen
    Vomiting Negative nitrogen
    ↓Sodium balance
    ↓Potassium
    ↓Phosporus
    ↓Bicarbonate

    Dehydration
    Hyperosmolality
    Haemoconcentration

    ↑Serum pH
    Acidosis Hypotension
    ↓Renal blood flow
    Underperfusion of tissue
    Tissue hypoxia
    Kussmaul breathing ↑Lactic acid
    Excretion of Acetone Metabolic Acidosis

    Metabolic acidosis, Shock, Coma, Death

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