Académique Documents
Professionnel Documents
Culture Documents
Table of Contents
Aging
Berrendero F. Romero J. Garcia-Gil L. Suarez I. De la Cruz P. Ramos JA. Fernandez-Ruiz JJ. Changes
in cannabinoid receptor binding and mRNA levels in several brain regions of aged rats. Biochimica et
Biophysica Acta. 1407(3):205-14, 1998 Sep 30.
Elwan O. Hassan AA. Abdel Naseer M. Elwan F. Deif R. El Serafy O. El Banhawy E. El Fatatry M.
Brain aging in a sample of normal Egyptians cognition, education, addiction and smoking. Journal of the
Neurological Sciences. 148(1):79-86, 1997 May 1.
Lyketsos CG. Garrett E. Liang KY. Anthony JC. Cannabis use and cognitive decline in persons under 65
years of age. American Journal of Epidemiology. 149(9):794-800, 1999 May 1.
Sidney S. Beck JE. Tekawa IS. Quesenberry CP. Friedman GD. Marijuana use and mortality.
American Journal of Public Health. 87(4):585-90, 1997 Apr.
Andreas Zimmer*,, Anne M. Zimmer*, Andrea G. Hohmann, Miles Herkenham, and Tom I. Bonner*
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice PNAS,
Vol. 96, Issue 10, 5780-5785, May 11, 1999
Maurizio Bifulco, Chiara Laezza, Giuseppe Portella, Mario Vitale, Pierangelo Orlando, Luciano De
Petrocellis, and Vincenzo Di Marzo ! Control by the endogenous cannabinoid system of ras oncogene-
dependent tumor growth. The FASEB Journal express article 10.1096/fj.01-0320fje. Published online
October 29, 2001.
Luciano De Petrocellis, Dominique Melck, Tiziana Bisogno, Vincenzo Di Marzo. Endocannabinoids and
fatty acid amides in cancer, inflammation and related disorders. Chemistry and Physics of Lipids 108
(2000) 191-209
Vincenzo Di Marzo, Tiziana Bisogno, Luciano De Petrocellis, Dominique Melck, Pierangelo Orlando,
Jens A. Wagner, and George Kunos. Biosynthesis and inactivation of the endocannabinoid 2-
arachidonoylglycerol in circulating and tumoral macrophages. Eur J Biochem 1999 264: 258-267
Ismael Galve-Roperh1, 3, Cristina Sánchez1, 3, María Luisa Cortés2, Teresa Gómez del Pulgar1, Marta
Izquierdo2 & Manuel Guzmán1 Anti-tumoral action of cannabinoids: Involvement of sustained ceramide
accumulation and extracellular signal-regulated kinase activation. Nature Medicine, March 2000
Volume 6 Number 3 pp 313 - 319
Labit-Le Bouteiller C. Jamme MF. David M. Silve S. Lanau C. Dhers C. Picard C. Rahier A. Taton M.
Loison G. Caput D. Ferrara P. Lupker J. Antiproliferative effects of SR31747A in animal cell lines are
mediated by inhibition of cholesterol biosynthesis at the sterol isomerase step. European Journal of
Biochemistry. 256(2):342-9, 1998 Sep 1.
Maccarrone, M; et.al.; Anandamide induces Apoptosis in Human Cells via Vanilloid Receptors:
evidence for a protective role of cannabinoid receptors. J Biol Chem, vol 275:41 Oct 13, 2000, 31938-
31945
Mackie, K & Hille, B; Cannabinoids Inhibit N-Type Calcium Channels in Neuroblastoma-Glioma Cells.
PNAS, vol 89:9 (May 1, 1992), 3825-3829
Mao, L & Oh, Y; Does Marijuana or Crack Cocaine Cause Cancer? JNCI, Vol. 90, no. 16, Aug. 19,
1998, 1182-1184
Munson AE. Harris LS. Friedman MA. Dewey WL. Carchman RA. Antineoplastic activity of
cannabinoids. Journal of the National Cancer Institute. 55(3):597-602, 1975 Sep.
Murison, G; et.al.; Cannabinoids Induce Incomplete Maturation of Cultured Human Leukemia Cells.
PNAS, Vol 84:15 (Aug. 1, 1987), 5414-5418
Piomelli D. Pot of Gold for Glioma Therapy. Nature Medicine, March 2000 Volume 6 Number 3 pp
255-256.
DANIEL RUEDA, ISMAEL GALVE-ROPERH, AMADOR HARO, and MANUEL GUZM ´ AN. The
CB1 Cannabinoid Receptor Is Coupled to the Activation of c-Jun N-Terminal Kinase. MOLECULAR
PHARMACOLOGY Vol. 58, No. 4 :814-820,
Cristina Sánchez, Ismael Galve-Roperh, Cecile Canova, Philippe Brachet, Manuel Guzmán Delta 9-
Tetrahydrocannabinol induces apoptosis in C6 glioma cells. Febs Letters Vol. 436 (1) pp. 6-10.
Theodore A. Sarafian, Donald P. Tashkin, and Michael D. Roth. Marijuana Smoke and D9-
Tetrahydrocannabinol Promote Necrotic Cell Death but Inhibit Fas-Mediated Apoptosis. Toxicology and
Applied Pharmacology 174, 264-272 (2001)
Weigang Zhu, Herman Friedman and Thomas W. Klein. delta 9-Tetrahydrocannabinol Induces
Apoptosis in Macrophages and Lymphocytes: Involvement of Bcl-2 and Caspase-11. Journal of
Pharmacology & Experimental Therapeutics, Vol. 286, Issue 2, 1103-1109, August 1998.
Li X. Zhu, Sherven Sharma, Marina Stolina, Brian Gardner, Michael D. Roth, Donald P. Tashkin and
Steven M. Dubinett. Delta-9-Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-
Mediated, Cytokine-Dependent Pathway. Journal of Immunology Volume 165 Issue 1 p 373 - 380. July
2000
Aceto MD. Scates SM. Razdan RK. Martin BR. Anandamide, an endogenous cannabinoid, has a very
low physical dependence potential. Journal of Pharmacology & Experimental Therapeutics. 287(2):598-
605, 1998 Nov.
Annette L. Beautrais; Peter R. Joyce; Roger T. Mulder. Cannabis abuse and serious suicide attempts.
Addiction 1999 Volume: 94 Number: 8 Pages: 1155-1164
Patrick M. Beardsley * , Mario E. Dance, Robert L. Balster, Patrik Munzar. Evaluation of the reinforcing
effects of the cannabinoid CB1 receptor antagonist, SR141716, in rhesus monkeys. European Journal of
Pharmacology 435 (2002) 209- 216
Margery C. Beinfeld * , Kelly Connolly. Activation of CB1 cannabinoid receptors in rat hippocampal
slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial
memory defects produced by cannabinoids. Neuroscience Letters 301 (2001) 69±71
Boyle, MH et.al. Familial Influences on Substance Use by Adolescents and Young Adults. Revue
Canadienne De Sante Publique Volume 92. No.3 2001
Brodkin J. Moerschbaecher JM. SR141716A antagonizes the disruptive effects of cannabinoid ligands
on learning in rats. Journal of Pharmacology & Experimental Therapeutics. 282(3):1526-32, 1997 Sep.
Brook JS et.al. Risk Factors for Adolescent Marijuana Use Across Cultures and Across Time. The
Journal of Gentic Psychology, 2001, 162(3). 357-374
Alan J. Budney; Warren K. Bickel; Leslie Amass. Marijuana use and treatment outcome among opioid-
dependent patients. Addiction 1998 Volume: 93 Number: 4 Pages: 493-503
Alan J. Budney; Pamela L. Novy; John R. Hughes. Marijuana withdrawal among adults seeking
treatment for marijuana dependence. Addiction 1999 Volume: 94 Number: 9 Pages: 1311-1322
Casswell, S; Marks, DF; Cannabis and temporal Disintegration in Experienced and naive Subjects,
Science Vol 179, 23 Feb 1973, 803-805
Chaperon F. Soubrie P. Puech AJ. Thiebot MH. Involvement of central cannabinoid (CB1) receptors in
the establishment of place conditioning in rats. Psychopharmacology. 135(4):324-32, 1998 Feb.
* Arthur Christopoulos , Kathryn Wilson. Interaction of anandamide with the M1 and M4 muscarinic
acetylcholine receptors. Brain Research 915 (2001) 70-78
Colombo G. Agabio R. Diaz G. Lobina C. Reali R. Gessa GL. Appetite suppression and weight loss after
the cannabinoid antagonist SR 141716. Life Sciences. 63(8):PL113-7, 1998.
Stacie A. Cook, John A. Lowe and Billy R. Martin. CB1 Receptor Antagonist Precipitates Withdrawal in
Mice Exposed to 9-Tetrahydrocannabinol1. Psychopharmacology, Vol. 285, Issue 3, 1150-1156, June
1998
Marco Diana*,, Miriam Melis, Anna Lisa Muntoni, and Gian Luigi Gessa. Mesolimbic dopaminergic
decline after cannabinoid withdrawal. Pharmacology, Vol. 95, Issue 17, 10269-10273, August 18, 1998.
Hannelore Ehrenreich, Thomas Rinn, Hanns J. Kunert, Manfred R. Moeller (3), Wolfgang Poser, Lothar
Schilling, Gerd Gigerenzer, Margret R. Hoehe original investigation: Specific attentional dysfunction in
adults following early start of cannabis use. Psychopharmacology, Volume 142 Issue 3 (1999) pp 295-
301
Ethan Russo, et al, Chronic Cannabis Users in the Compassionate Investigational New Drug Program,
Journal of Cannabis Theraputics., Vol. 2(1) 2002.
Fendrich, M & Vaughn, CM; Diminished Lifetime Substance Use Over Time: An Inquiry Into
Differential Underreporting. Pub Op Quart, Vol 58:1 (spring 1994) 96-123
Ferguson, DM & Horwood, J; Does cannabis use encourage other forms of illicit drug use?
Addiction(2000) 95(4), 505-520
F. Ferrari*, A. Ottani, D. Giuliani. Inhibitory effects of the cannabinoid agonist HU 210 on rat sexual
behaviour. Physiology & Behavior 69 (2000) 547-554
Fowler, FJ and Stringfellow, VL. Learning from experience: estimating teen use of alcohol, cigarettes,
and marijuana from three survey protocols. J Drug Issues 31(3), 643-664, 2001
French ED. Dillon K. Wu X. Cannabinoids excite dopamine neurons in the ventral tegmentum and
substantia nigra. Neuroreport. 8(3):649-52, 1997 Feb 10
Peter Fried, Barbara Watkinson, Deborah James, Robert Gray. Current and former marijuana use:
preliminary findings of a longitudinal study of effects on IQ in young adults. CMAJ APR. 2, 2002;
16 (7)
Gardner EL. Vorel SR. Cannabinoid transmission and reward-related events. [Review] [314 refs]
Neurobiology of Disease. 5(6 Pt B):502-33, 1998 Dec.
Sandy Ghozland,1 Hans W. D. Matthes,2 Frederic Simonin,2 Dominique Filliol,2 Brigitte L. Kieffer,2
and
Rafael Maldonado. Motivational Effects of Cannabinoids Are Mediated by _-Opioid and _-Opioid
Receptors. The Journal of Neuroscience, February 1, 2002, 22(3):1146-1154
Ginsberg, IJ & Greenly, JR; Competing Theories of Marijuana Use: A Longitudinal Study. J Health Soc
Beh, vol 19:1 (Mar 1978), 22-34
Giuliani, D. et.al. the cannabinoid receptor agonist HU 210 modifies rat behavioral responses to novelty
and stress. Pharmacological Research, vol 41, no 1, 2000, 47-53
Golub, A; et.al.; Response Reliablity and the Study of Adolescent Substance Use Progression. J Drug
Iss, 30(1), 103-118, 2000
Golub, AL; Johnson, BD; Alcohol is not the Gateway to Hard Drug Abuse. J Drug Iss, 28(4), 971-984,
1998
Mark K. Greenwald & Maxine L. Stitzer. Antinociceptive, subjective and behavioral effects of smoked
marijuana in humans. Drug and Alcohol Dependence, 2000, 59:3:261 - 275
Hampson RE. Deadwyler SA. Role of cannabinoid receptors in memory storage. Neurobiology of
Disease. 5(6 Pt B):474-82, 1998 Dec.
Hampson, RE; Deadwyler, SA; Cannabinoids Reveal the Necessity of Hippocampal Neural Encoding for
Short-Term Memory in Rats. J Neurosci, Dec 1, 2000, 20(23) 8932-8942
M. Haney, Amie S. Ward, Sandra D. Comer, Richard W. Foltin, Marian W. Fischman. original
investigation: Abstinence symptoms following smoked marijuana in humans
Psychopharmacology, Volume 141 Issue 4 (1999) pp 395-404.
Shuzhen Hao, Yosefa Avraham, Raphael Mechoulam & Elliot M. Berry. Low dose anandamide affects
food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice.
European Journal of Pharmacology, 2000, 392:3:147-156
Salvador Huitron-Resendiz, Lhys Gombart, Benjamin F. Cravatt, and Steven J. Henriksen. Effect of
Oleamide on Sleep and Its Relationship to Blood Pressure, Body Temperature, and Locomotor Activity
in Rats. Experimental Neurology 172, 235-243 (2001)
Hutcheson DM. Tzavara ET. Smadja C. Valjent E. Roques BP. Hanoune J. Maldonado R. Behavioural
and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-
tetrahydrocannabinol. British Journal of Pharmacology. 125(7):1567-77, 1998 Dec.
Jentsch JD. Wise A. Katz Z. Roth RH. Alpha-noradrenergic receptor modulation of the phencyclidine-
and delta9-tetrahydrocannabinol-induced increases in dopamine utilization in rat prefrontal cortex.
Synapse. 28(1):21-6, 1998 Jan.
Jones RT. Benowitz NL. Herning RI. Clinical relevance of cannabis tolerance and dependence. Journal
of Clinical Pharmacology. 21(8-9 Suppl):143S-152S, 1981 Aug-Sep.
Klonoff, H; Marijuana and Driving in Real-Life Situations. Science, vol 186:4161 (Oct 25, 1974), 317-
324
Elena M. Kouri, Harrison G. Pope Jr, Scott E. Lukas. original investigation: Changes in aggressive
behavior during withdrawal from long-term marijuana use. Psychopharmacology, Volume 143 Issue 3
(1999) pp 302-308.
Jodie Lawston, Alice Borella, John K. Robinson, Patricia M. Whitaker-Azmitia. Changes in
hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55,212-2.
Brain Research 877 (2000) 407-410
Ledent C. Valverde O. Cossu G. Petitet F. Aubert JF. Beslot F. Bohme GA. Imperato A. Pedrazzini T.
Roques BP. Vassart G. Fratta W. Parmentier M. Unresponsiveness to cannabinoids and reduced
addictive effects of opiates in CB1 receptor knockout mice. Science. 283(5400):401-4, 1999 Jan 15.
Lynsky, M & Hall, W; The Effects of adolescent cannabis use on educational attainment: a review.
Addiction (2000) 95(11), 1621-1630
Rafael Maldonado 1 and Fernando Rodri´guez de Fonseca. Cannabinoid Addiction: Behavioral Models
and Neural Correlates. The Journal of Neuroscience, May 1, 2002, 22(9):3326-3331
Mallet PE. Beninger RJ. The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory
impairment produced by delta9-tetrahydrocannabinol or anandamide. Psychopharmacology. 140(1):11-9,
1998 Nov.
Martellotta MC. Cossu G. Fattore L. Gessa GL. Fratta W. Self-administration of the cannabinoid
receptor agonist WIN 55,212-2 in drug-naive mice. Neuroscience. 85(2):327-30, 1998 Jul.
Martin, P & Consroe, P; Cannabinoid Induced Behavioral Convulsions in Rabbits. Science, vol.
194:4268 (Nov. 26, 1976), 965-967
Jan K Melichar, Mark RC Daglish and David J Nutt*. Addiction and withdrawal - current views.
Current Opinion in Pharmacology 2001, 1:84-90
Eric Murillo-Rodri$guez, Magda Giordano, Rafael Cabeza, Steve J. Henriksen, Mo´ nica Me´ ndez Di
´az, Luz Navarro, Oscar Prospe´ ro-Garci´a. Oleamide modulates memor in rats. Neuroscience Letters
313 (2001) 61_64.
Douglas K. Novins; Christina M. Mitchell. Factors associated with marijuana use among American
Indian adolescents. Addiction 1998 Volume: 93 Number: 11 Pages: 1693-1702
Axel Perkonigg; Roselind Lieb; Michael Hofler; Peter Schuster; Holger Sonntag; Hans-Ulrich Wittchen.
Patterns of cannabis use, abuse and dependence over time: incidence, progression and stability in a
sample of 1228 adolescents. Addiction 1999 Volume: 94 Number: 11 Pages: 1663-1678
Poncelet M. Barnouin MC. Breliere JC. Le Fur G. Soubrie P. Blockade of cannabinoid (CB1) receptors
by 141716 selectively antagonizes drug-induced reinstatement of exploratory behaviour in gerbils.
Psychopharmacology. 144(2):144-50, 1999 May.
Rafaelsen, OJ; et.al.; Cannabis and Alcohol: Effects on Simulated Car Driving. Science, Vol 179:4076
(Mar 2, 1973), 920-923
David Reilly; Peter Didcott; Wendy Swift; Wayne Hall. Long-term cannabis use: characteristics of users
in an Australian rural area. Addiction 1998 Volume: 93 Number: 6 Pages: 837-846
Sadovsky, R; driving impact from marijuana and alcohol. Am Fam Phys, 62:7, 1652 Oct 1, 2000
Sanudo-Pena MC. Walker JM. Effects of intrapallidal cannabinoids on rotational behavior in rats:
interactions with the dopaminergic system. Synapse. 28(1):27-32, 1998 Jan.
Sanudo-Pena MC. Force M. Tsou K. Miller AS. Walker JM. Effects of intrastriatal cannabinoids on
rotational behavior in rats: interactions with the dopaminergic system. Synapse. 30(2):221-6, 1998 Oct.
ZOLT ' AN SARNYAI,1 YAVIN SHAHAM, AND STEPHEN C. HEINRICHS. The Role of
Corticotropin-Releasing Factor in Drug Addiction. Pharmacol Rev 53:209-243, 2001
Schaeffer, J; et.al.; Cognition and Long-Term Use of Ganja (Cannabis). Science, Vol 213:4506 (Jul 24,
1981), 465-466
Marc A. Schuckit, M.D., Jean-Bernard Daeppen, M.D., George P. Danko, Ph.D., Megan L. Tripp, B.A.,
Tom L. Smith, Ph.D., Ti.-K. Li, M.D., Victor M. Hesselbrock, Ph.D. and Kathleen K. Bucholz, Ph.D.
Clinical Implications for Four Drugs of the DSM-IV Distinction Between Substance Dependence With
and Without a Physiological Component. Am J Psychiatry 156:41-49, January 1999
Sheldon, T; Cannabis Use Falls Among Dutch Youth. BMJ vol 321, 16 Sep 2000
Ken Soderstrom, Frank Johnson. CB1 cannabinoid receptor expression in brain regions associated with
zebra finch song control. Brain Research 857 2000 151-157
L.P. Spear. The adolescent brain and age-related behavioral manifestations. Neuroscience and
Biobehavioral Reviews, 2000, 24:4:417-463
Swaim RC. Bates SC. Chavez EL. Structural equation socialization model of substance use among
Mexican-American and white non-Hispanic school dropouts. Journal of Adolescent Health. 23(3):128-
38, 1998 Sep.
Wendy Swift; Wayne Hall; Peter Didcott; David Reilly. Patterns and correlates of cannabis dependence
among long-term users in an Australian rural area. Addiction 1998 Volume: 93 Number: 8 Pages: 1149-
1160
Wendy Swift; Jan Copeland; Wayne Hall. Choosing a diagnostic cut-off for cannabis dependence.
Addiction 1998 Volume: 93 Number: 11 Pages: 1681-1692
Wendy Swift *, Wayne Hall, Maree Teesson. Characteristics of DSM-IV and ICD-10 cannabis
dependence among Australian adults: results from the National Survey of Mental Health and Wellbeing.
Drug and Alcohol Dependence 63 (2001) 147-153
Gianluigi Tanda, Francesco E. Pontieri, * Gaetano Di Chiara. Cannabinoid and Heroin Activation of
Mesolimbic Dopamine Transmission by a Common µ1 Opioid Receptor Mechanism. Science, Vol
276,27 June 1997, 2048-2050.
Lars Terenius. Rational treatment of addiction. Current Opinion in Chemical Biology 1998, 2:541-547.
S. A. VARVEL and A. H. LICHTMAN. Evaluation of CB1 Receptor Knockout Mice in the Morris
Water Maze. JPET 301:915û924, 2002
Kirsten von Sydow, Roselind Lieb, Hildegard Pfister, Michael Ho¨ fler, Holger Sonntag, Hans-Ulrich
Wittchen. The natural course of cannabis use, abuse and dependence over four years: a longitudinal
community study of adolescents and young adults. Drug and Alcohol Dependence 64 (2001) 347-361
Walsh, GW & Mann, RE; On the High Road: Driving Under the Influence of Cannabis in Ontario.
Canadian J Pub Health, Jul-Aug 1999, Vol 90, No 4, 260-263
Gerhard A. Wiesbeck; Marc A. Schuckit; Jelger A. Kalmijn; Jayson E. Tipp; Kathleen K. Bucholz; Tom
L. Smith. An evaluation of the history of a marijuana withdrawal syndrome in a large population.
Addiction 1996 Volume: 91 Number: 10 Pages: 1469-1478
Zablocki, B; et.al.; Marijuana Use, Introspectiveness, and Mental Health. J Health Soc Beh, vol 32:1
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Agonists/Antagonists
Elio Acquas a , Augusta Pisanu a , Paola Marrocu a , Steven R. Goldberg b , Gaetano Di
Chiara. D 9 -tetrahydrocannabinol enhances cortical and hippocampal acetylcholine
release in vivo: a microdialysis study. Z . European Journal of Pharmacology 419 2001
155_161
Jonathon C. Arnold , Ann N. Topple , Paul E. Mallet , Glenn E. Hunt , Iain S. McGregor. The
distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and
Wistar strain. Brain Research 921 (2001) 240-255
D. W. Bonhaus, L. K. Chang, J. Kwan and G. R. Martin. Dual Activation and Inhibition of Adenylyl
Cyclase by Cannabinoid Receptor Agonists: Evidence for Agonist-Specific Trafficking of Intracellular
Responses. Journal of Pharmacology & Experimental Therapeutics Vol. 287, Issue 3, 884-888, December
1998
Barbara Costa & Mariapia Colleoni. Changes in rat brain energetic metabolism after exposure to
anandamide or 9-tetrahydrocannabinol. European Journal of Pharmacology, 2000, 395:1:1-7
Devane WA. Hanus L. Breuer A. Pertwee RG. Stevenson LA. Griffin G. Gibson D. Mandelbaum A.
Etinger A. Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid
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Felder CC et.al. Cannabinoid agonists stimulate both receptor- and non- receptor - mediated signal
transduction pathways in cells transfected with and expressing cannabinoid receptor clones. Molecular
Pharmacology, 42:838-845, 1992
Felder CC. Joyce KE. Briley EM. Glass M. Mackie KP. Fahey KJ. Cullinan GJ. Hunden DC. Johnson
DW. Chaney MO. Koppel GA. Brownstein M. LY320135, a novel cannabinoid CB1 receptor
antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. Journal of
Pharmacology & Experimental Therapeutics. 284(1):291-7, 1998 Jan.
Fellermeier, M; et.al.; Biosynthesis of Cannabinoids: Incorporation experiments with 13 C-labeled
glucoses. Eur J Biochem, 268, 1596-1604 (2001)
John Gatley, Ruoxi Lan, Beatrice Pyatt, Andrew N Gifford, Nora D Volkow, Alexandros Makriyannis.
BINDING OF THE NON-CLASSICAL CANNABINOID CP 55,940, AND THE DIARYLPYRAZOLE
AM251 TO RODENT BRAIN CANNABINOID RECEPTORS. Life Sciences, Vol. 61, No. 14, pp. PL
191-197, 1997 285, Issue 2, 553-560, May 1998
Paul Gouldson, Bernard Calandra, Pascale Legoux, Aimee Kerneis, Murielle Rinaldi-Carmona, Francis
Barth, Gerard Le Fur, Pascual Ferrara, David Shire, Mutational analysis and molecular modelling of the
antagonist SR 144528 binding site on the human cannabinoid CB receptor 2. European Journal of
Pharmacology 401 2000 17-25
Griffin G. et.al., Evaluation of Cannabinoid Receptor Agonists and Antagonists Using the Guanosine-5-
0-(3-{35S}thio)-trihosphate Binding Assay in Rat Cerebellar Membranes. JPET 285:553-560, 1998.
Graeme Griffin*,1, Emma J. Wray1, Billy R. Martin1 and Mary E. Abood. Cannabinoid agonists and
antagonists discriminated by receptor binding in rat cerebellum British Journal of Pharmacology 128:684-
688 (1999)
Haagen-Smit, AJ; et.al.; A Physiologically Active Principle from Cannabis Sativa (Marijuana). Science,
vol 91:2373 (Jan 21, 1940), 602-603
Hawkins, BL & Roberts, JD; Nuclear Magnetic Resonance Spectroscopy: fourier Transform Spectra of
Delta-8 and Delta-9 tetrahydrocannabinol. PNAS Vol 70:4 (Apr 1973), 1027-1029
Cecilia J. Hillard, Sukumar Manna, Marcie J. Greenberg, Ralph DiCamelli, Ruth A. Ross, Lesley A.
Stevenson, Vicki Murphy, Roger G. Pertwee and William B. Campbell. Synthesis and Characterization
of Potent and Selective Agonists of the Neuronal Cannabinoid Receptor (CB1)1. Journal of
Pharmacology & Experimental Therapeutics, Vol. 289, Issue 3, 1427-1433, June 1999
Allyn C. Howlett, Gerald H. Wilken, J. Jill Pigg, Devin B. Houston, Ruoxi Lan, Qian Liu, and
Alexandros Makriyannis. Azido- and Isothiocyanato-Substituted Aryl Pyrazoles Bind Covalently to the
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Marcel A.K. Jansen, Victor Gaba and Bruce M. Greenberg. Higher plants and UV-B radiation:
balancing damage, repair and acclimation [Review article] Trends in Plant Science, 1998, 3:4:131-135
J. M. Kirk a and Harriet De Wit aA. Responses to Oral 9-Tetrahydrocannabinol in Frequent and
Infrequent Marijuana Users. Pharmacology Biochemistry & Behavior, Vol. 63, No. 1, pp 137-142, 1999
Robert S. Landsman, Alexandros Makriyannis*, Hongfeng Deng*, Paul Consroe, William R. Roeske and
Henry I. Yamamura. AM630 IS AN INVERSE AGONIST AT THE HUMAN CANNABINOID CB1
RECEPTOR. Life Sciences, Vol. 62, No. 9, pp. PL 109-113, 1998
MacLennan SJ. Reynen PH. Kwan J. Bonhaus DW. Evidence for inverse agonism of SR141716A at
human recombinant cannabinoid CB1 and CB2 receptors. British Journal of Pharmacology. 124(4):619-
22, 1998 Jun.
Billy R. Martin, Renee G. Jefferson, Ramona Winckler, Jenny L. Wiley, Brian F. Thomas, Peter J.
Crocker, William Williams, Raj K. Razdan. Assessment of structural commonality between
tetrahydrocannabinol and anandamide. European Journal of Pharmacology 435 (2002) 35- 42
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612
FELICE NAVA, GIOVANNA CARTA AND GIAN LUIGI GESSA. Permissive Role of Dopamine D2
Receptors in the Hypothermia Induced by D 9 -Tetrahydrocannabinol in Rats. Pharmacology
Biochemistry and Behavior, Vol. 66, No. 1, pp. 183-187, 2000
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168:3936 (Jun 5, 1970), 1228-1229
François PetitetA, Bernadette Jeantaud, Philippe Bertrand and Assunta Imperato. Cannabinoid
penetration into mouse brain as determined by ex vivo binding. European Journal of Pharmacology,
Volume 374, Issue 3 June 1999, Pages 417-421
Francois Petitet*, Bernadette Jeantaud, Michel Reibaud, Assunta Imperato and Marie-Christine
Dubroeucq. COMPLEX PHARMACOLOGY OF NATURAL CANNABINOIDS : EVIDENCE FOR
PARTIAL AGONIST ACTIVITY OF 9 TETRAHYDROCANNABINOL AND ANTAGONIST
ACTIVITY OF CANNABIDIOL ON RAT BRAIN CANNABINOID RECEPTORS. Life Sciences, Vol.
63, No. 1, pp. PL 1-6, 1998
Pop E and Brewster ME. Dimerization of dexabinol by hydrogen bonding accounts for its hydrophobic
character. Int J Quant Chem 65: 1057-1064, 1997
Emil Pop. Cannabinoids, endogenous ligands and synthetic analogs [Review article] Current Opinion in
Chemical Biology 1999, 3:418-425.
Marielle Portier, Murielle Rinaldi-Carmona, Florence Pecceu, Thérèse Combes, Caroline Poinot-Chazel,
Bernard Calandra, Francis Barth, Gérard Le Fur and Pierre Casellas. SR 144528, an Antagonist for the
Peripheral Cannabinoid Receptor that Behaves as an Inverse Agonist. JPET, Vol. 288, Issue 2, 582-589,
February 1999
Vera Ralevic a, ) , David A. Kendall a , Jeffrey C. Jerman b , Derek N. Middlemiss b , Darren Smart.
Cannabinoid activation of recombinant and endogenous vanilloid receptors. Z . European Journal of
Pharmacology 424 2001 211_219
Ruth A. Ross, T. Michael Gibson, Lesley A. Stevenson, Bijali Saha, Peter Crocker, Raj K. Razdan and
Roger G. Pertwee. Structural determinants of the partial agonist-inverse agonist properties of
6'-azidohex-2'-yne-8-tetrahydrocannabinol at cannabinoid receptors. British Journal of Pharmacology
128:735-743 (1999)
Tiziana Rubino, Daniela Vigano’, Paola Massi, Maurizio Spinello, Elisabetta Zagato, Gabriella Giagnoni,
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