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ELSEVIER
PEPTIDES
Studies of endogenous opiates in sex and development
remained high, including the ontogeny of opiate systems
during development. The effects of prenatal exposure to
opiates on development continued to be addressed, and had
obvious clinical implications for opiate use and abuse dur-
ing pregnancy. There was more interest this year than in
previous ones regarding the role of endogenous opiates in
some mental illnesses, in particular anxiety and depression.
However, attempts to link opiate systems to other mental
illnesses were for the most part inconclusive. The role of
opiates in mediating seizure activity was examined, and it
was generally the case that opiate agonists were proconvul-
sive and antagonists anticonvulsive. The involvement of
opiates in ischemic brain damage were elucidated and re-
search indicated that -agonists may have neuroprotective
effects. Animal models also were used to examine opiate
modulation of other neurologic disorders, including the Par-
kinson’s and Alzheimer’s disease. Interest in opiate in-
volvement in electrical-related activity remained high in
1999, and used various in vitro preparations to examine
opiate modulation of neural events in both the spinal cord
and supraspinal structures. As in previous years, locomotor
activity was influenced by opiate agonists, but the results
were generally inconsistent and depended on the paradigm
that was used.
Research continued to focus on the inhibition of gastro-
intestinal functions by opiate agonists and on the potential
therapeutic benefits of the use of opiate antagonists to treat-
ment gut motility and transit. However, the involvement of
endogenous opiates in renal and hepatic functions is still not
entirely clear. The role of endogenous opiates in mediating
cardiovascular function continued to be studied, including
the potential benefits of using -opiate receptor agonists to
treat hypertension. Research also examined the possible role
opiate receptors located in the heart to protect against infarct
after ischemia, and arrhythmia. Research continued to ad-
dress opiate modulation of respiratory functions, but interest
in opiate involvement in thermoregulation was once again
low. Research on the relationship between opiate and im-
mune function remained high, revealing that opiates can
both suppress and enhance immune functions, determined
in part by whether they were tested in vitro or in vivo.
Furthermore, because of the high incidence of human im-
munodeficiency virus (HIV) among intravenous drug users,
the role of opiates in the progression of this disease received
much attention. Besides having obvious clinical implica-
tions, the results also highlight the importance of specifying
whether or not opiate analgesic are used in studies that
examine immunologic processes.
2. Stress
Many stressors interact with endogenous opiate systems.
In 1999, the physiological and behavioral effects of a vari-
ety of stressors were further elucidated, including forced