Académique Documents
Professionnel Documents
Culture Documents
Djumhana Atmakusuma
Dharmais Cancer Hospital
Evidence base medicine:
Guidelines - level of evidence
- grade of recommendation
Standard
operating
Must be done (mandatory)
procedures
(SOP)
Protocols
Guidelines
Consensus
Clinical Pathway
Standard
operating
procedures
(SOP)
Protocols
Guidelines
• A medical guideline (also called a clinical
guideline, clinical protocol or clinical practice
guideline) is a document with the aim of guiding
decisions and criteria regarding diagnosis,
management, and treatment in specific areas of
healthcare. Such documents have been in use
for thousands of years during the entire history
of medicine. However, in contrast to previous
approaches, which were often based on tradition
or authority, modern medical guidelines are
based on an examination of current evidence
within the paradigm of evidence-based
medicine. They usually include summarized
consensus statements, but unlike the latter, they
also address practical issues.
• Modern clinical guidelines briefly identify,
summarize and evaluate the best evidence and
most current data about prevention, diagnosis,
prognosis, therapy including dosage of
medications, risk/benefit and cost-effectiveness.
Then they define the most important questions
related to clinical practice and identify all
possible decision options and their outcomes.
Some guidelines contain decision or
computation algorithms to be followed. Thus,
they integrate the identified decision points and
respective courses of action to the clinical
judgment and experience of practitioners. Many
• Additional objectives of clinical guidelines
are to standardize medical care, to raise
quality of care, to reduce several kinds of
risk (to the patient, to the healthcare
provider, to medical insurers and health
plans) and to achieve the best balance
between cost and medical parameters
such as effectiveness, specificity,
sensitivity, resolutiveness, etc. It has been
demonstrated repeatedly that the use of
guidelines by healthcare providers such as
hospitals is an effective way of achieving
the objectives listed above, although they
are not the only ones.
GRADE OF CLARITY OF
METHODOLOGIC IMPLICATIONS
RECOMMENDATION RISK/BENEFIT
STRENGTH OF
SUPPORTING EVIDENCE
1 1 2 3 4 5
STAGES
Intake Diagnosis Pre Therapy Therapy Follow up
(> 1 month)
How to develop Consensus & Clinical
Pathway in Dharmais Cancer Hospital
Cancer Working Groups
13 cancer working groups (from 28 medical staff group)
• Gynelogical cancer (cervix, ovarium, korpus uteri)
• Breast cancer
• Nasopharyngeal cancer
• Blood cancers
• Lung cancer
• GIT & hepatic cancer
• Urogenital cancer
• Head & neck cancer
• Musculosceletal cancer
• Skin cancer
• Brain cancer
• Pediatric cance
• Ophthalmologic cancer
Guidelines Consensus
• Revision/Development: August 2005-August 2007
(2 yrs) : - 13 Tim Cancer Working Groups
- 54 cancers 82 consensus
• Format: - NCCN algorithm & manuscript
- Algorithm NCCN = clinical pathway
diagnosis, treatment, follow-up,
complication, co-morbidities
• Problems: difficulties in achieving consensus
among member of the team in terms of D/, Th/
and follow up ( many references: NCCN, ICN,
ASCO, ECCO, ESMO, cancer working groups)
Management of Acute Leukemia
Guideline of the Management of Acute Leukemia:
NCCN, NCI (USA)–Working Group (Europe, others)
evidence base medicine (EBM):
grade of recommendation - level of evidence
National Consensus
on the Management of Acute Leukemia
Self Experience
Hospital Consensus
Best Clinical Practice Revision of Essential
+ Nursing SOP + Care Package = PPE
Nutrition SOP, others
Care
Diagnostic / - Bone marrow
aspiration/ biopsy
procedures - Peripheral blood
aspiration (Rp ?)
- Cytology,Cytoche - Results of Lab tests: Result of Lab tests: - Results of Lab tests: - Results of Lab tests:
Laboratory mistry, flowcytome cytology, Flow cytometry Histology of BMB Cytogenetics & DNA
tests try, Cytogenetics,
DNA analysis
cytochemistry, CBC,
blood smear,
plus imprint cytology analysis
Varians
Persons in charge: Doctor I: Doctor II: Nurse:
CP 3 (Best Clinical Practice): Acute Myeloblastic Leukemia: - ICD 10: C 95.0
Pre – induction tests: - ICD 9-CM:
Varians
Persons in charge: Doctor I: Doctor II: Nurse:
CP 4.a. (Best Clinical Practice): Acute Myeloblastic Leukemia: ICD 10:C 95.0
Induction chemotherapy “D3C7 regimen”: - ICD 9-CM: 39.35
Varians
-CBC CBC, LFT, KF,BS, CBC CBC, LFT,KF,BS CBC , bone marrow
Laboratory cultures cytology-chemistry,
tests flow cytometry,DNA
-Oral & parentheral -Pre medications - Antiemetics drugs - Antiemetics drugs - Antiemetics drugs
Medications / -Pre medications -Day 7 Chemotherapy - Supportive drugs - Supportive drugs - Supportive drugs
Nutrition -D6 Chemotherapy - Blood transfusions - Blood transfusions - Blood transfusions
- See protocols
- Information (oral - Daily information: - Daily information: - Daily information: - Daily information:
Information / / written) a today program a today program a today program a today program
Education - Informed consent response & adverse
reactions
response & adverse
reactions
response & adverse
reactions
response & adverse
reactions
- A patient is ready No adverse events of No adverse evets of No adverse evets of - Daily information:
Outcome and suitable for the chemotherapy chemotherapy chemotherapy a today program
induction response & adverse
cheotherapy reactions
Varians
Standard
operating
Must be done (mandatory)
procedures
(SOP)
Protocols
Guidelines
Consensus
Clinical Pathway
Standard
operating
procedures
(SOP)
Protocols
• Indonesia ?? Guidelines ???