Académique Documents
Professionnel Documents
Culture Documents
Subcommittee:
William Martin (Kentucky) (Chairman)
Richard Eisenberg (Minnesota, Duluth)
Thomas Westfall (St. Louis Univ.)
Ezio Giacobini (Southern Illinois)
Harbans Lal (Texas Coll. Osteopathy)
Seymour Ehrenpreis (Chicago Med. School)
Warren Chernick (Hahnemann Med. School)
Joseph Goldfard (Mt. Sinai Med. School)
Louis S. Harris (Med. Coll. of Virginia)
Israel Hanin (Loyola University)
Claudio Cuello (McGill University)
Introduction to Neuropharmacology
A. Concepts
1) Anatomic pathway
2) Function
3) Cotransmitter
B. Classes
1) Acetylcholine (Ach)
2) Indoles (5HT)
3) Catechols (E, NE, DA)
4) Amino acids
a. Excitatory (glutamate and aspartate)
b. Inhibitory (GABA and glycerine)
5) Histamine
6) Peptides (Substance P, endorphins, enkephalins
Drugs to be considered:
ATROPINE
DANTROLENE
DIAZEPAN
EUFLURANE
PENTOBARBITAL
FENTANYL
HALOTHANE
ISOFLURANE
KETAMINE
MORPHINE
NITROUS OXIDE (N20)
PENTOBARBITAL
SUCCINYLCHOLINE
SUFENTANIL
THIOPENTAL
Drugs to be considered:
BENZOCAINE
COCAINE
LIDOCAINE
BUPIVACAINE
PROCAINE
Drugs to be considered:
CODEINE
D-PROPOXYPHENE
FENTANYL
DIPHENOXYLATE
HEROIN
MEPERIDINE
METHADONE
MORPHINE
Drugs to be considered:
Agonists/Antagonists
BUTORPHANOL
NALBUPHINE
BUPRENORPHINE
Specific Antagonists
NALOXONE
NALTREXONE
PENTAZOCINE
C. Antitussives, Expectorants and Mucolytics (0.5)
Drugs to be considered:
acetylcysteine
AMMONIUM CHLORIDE
Codeine
DEXTROMETHORPHAN
HYDROCODONE (dihydrocodeine)
GUAIFENESIN
POTASSIUM IODIDE
Drugs to be considered:
AMANTADINE
BENZTROPINE
BROMOCRIPTINE
CARBIDOPA
DEPRENYL
DOPAMINE
LEVODOPA (1 DOPA)
TRIHEXYPHENIDYL
6. Antiepileptics (1 hr.)
Drugs to be considered:
acetazolamide
CARBAMAZEPINE
clonazepam
DIAZEPAM
ETHOSUXIMIDE
PHENOBARBITAL
PHENYTIN
PRIMIDONE
VALPROIC ACID
7. Hallucinogens (1 hr.)
Drugs to be considered:
Drugs to be considered:
AMITRIPTYLINE
DOXEPIN
IMIPRAMINE
PHENELZINE
TRANYLCYPROMINE
FLUOXETINE
LITHIUM CARBONATE
NORTRIPTYLINE
CHLORPROMAZINE
HALOPERIDOL
PIMOZIDE
THIORIDAZINE
clozapine
A. Barbiturates
3) Discuss the relationship between the chemical
structure of barbiturates and their
pharmacokinetics (absorption, distribution,
biotransformation, elimination).
4) Describe the actions of the barbiturates on the
CNS, (including tolerance), respiration,
cardiovascular system, kidney, and liver.
5) Discuss the consequences of barbiturate induction
of enzymes, specifically on aminolevulinic acid
synthetase (porphyria).
6) Give the clinical indications for the use of
barbiturates; discuss adverse reactions of
elderly persons to barbiturates (confusion,
restlessness, etc.)
7) Describe the interactions of barbiturates with
other CNS agents and their effects on the
metabolism of other drugs.
8) Describe the effects of ionization and lipid
solubility on tissue distribution and duration of
action of barbiturates.
9) Classify the clinically useful barbiturates
according to duration of action.
10) Describe the effects of altering urinary pH on
the rate of phenobarbital elimination.
11) Describe the effects of barbiturates on REM
sleep.
12) Describe acute barbiturate intoxication and its
treatment.
13) Indicate the effects of combining barbiturates
with alcohol and other CNS depressants on CNS
function.
14) Discuss the therapeutic ratio of barbiturates.
15) Describe the symptoms of barbiturate withdrawal
in a barbiturate dependent subject.
Drugs to be considered:
PHENOBARBITAL
PENTOBARBITAL
THIOPENTAL (if not previously discussed)
Drugs to be considered:
chlorzoxazone
cyclobenzaprine
FLURAZEPAM
orphenadrine
TEMAZEPAM
CHLORAL HYDRATE
TRIAZOLAM
baclofen
Drugs to be considered:
AMPHETAMINE
CAFFEINE
COCAINE
fenfluramine
EPHEDRINE
METHYLPHENIDATE
picrotoxin-emphasizes role of glycinergic transmission
strychnine
12. Benzodiazepines (anxiolytics, hypnotics and muscle relaxants
(2 hrs).
Drugs to be considered:
ALPRAZOLAM
chlorazepate
CHLORDIAZEPROXIDE
buspirone
DIAZEPAM
FLURAZEPAM
LORAZEPAM
TRIAZOLAM
TEMAZEPAM
Drugs to be considered:
DISULFIRAM (ANTABUSE)
ETHANOL
METHANOL
ethylene glycol
Drugs to be considered:
ETHANOL
COCAINE
MARIHUANA
HEROIN
PENTOBARBITAL
AMPHETAMINES
DIAZEPAM
LSD
Drugs to be considered:
CAFFEINE
CLONIDINE
ERGOTAMINE
5-hydroxytryptamine (5-HT)
METHYSERGIDE
NOREPINEPHRINE (NE)
PROPRANOLOL
PROSTAGLANDINS (carboprost, tromethamine, dinoprost,
dinoprostone)
acetazolamide
acetylcysteine
ACETYLCHOLINE (ACH)
acetylcysteine
ADENOSINE
ADENOSINE TRIPHOSPHATE
+ALPRAZOLAM
AMATIDINE
+AMITRIPTYLINE
ammonium chloride
AMPHETAMINE
ASPARTATE
+ATROPINE
baclofen
BELLAADONNA ALKALOIDS
(ATROPINE, scopolamine)
BENZOCAINE
BENZTROPINE
BROMOCRIPTINE
+buspirone
BUPIVACAINE
BUPRENORPHINE
BUTORPHANOL
+CAFFEINE
+CARBAMAZEPINE
+CARABIDOPA
chloral hydrate
CHLORDIAZEPOXIDE
CHLORPROMAZINE (CPZ)
chloroxazone
CLONAZEPAM
CLONIDINE
+clorazepate
clozapine
COCAINE
+CODEINE
+cyclobenzaprine
DANTROLENE
DEPRENYL
+DEXTROMETHORPHAN
+DIAZEPAM
dihydrocodeine
DISULFIRAM (antabuse)
DIPHENOXYLATE
DOPAMINE
doxepin
+D-PROPOXYPHENE
dynorphins
endorphin
ENFLURANE
enkephaline
EPHEDRINE and pseudoephedrine
ERGOTAMINE
ETHANOL
ETHOSUXIMIDE
ethylene glycol
fenfluramine
FENTANYL
+FLUOXETINE
+FLURAZAPAM
GABA
glutamate
glycine
+GUAIFENESIN
HALOPERIDOL
HALOTHANE
HEROIN
HISTAMINE (5
hydroxytryptamine)
+HYDROCODONE
(dihydrocodeinone)
IMIPRAMINE
ISOFLURANE
KETAMINE
+LORAZEPAM
+LEVODOPA (1-DOPA)
LIDOCAINE
LITHIUM CARBONATE
LSD
MARIHUANA
MEPERIDINE
MESCALINE
METHADONE
METHANOL
METHYLPHENIDATE
METHYSERGIDE
MORPHINE
NALBUPHINE
NALOXONE
NALTREXONE
NITROUS OXIDE (N2O)
NOREPHINEPHRINE
+NORTRIPTYLINE
orphenadrine
PENTAZOCINE
PENTOBARBITAL
PHENCYCLIDINE
PHENEZINE
+PHENOBARBITAL
+PHENYTOIN
picrotoxin
PIMOZIDE
POTASSIUM IODIDE
PRIMIDONE
PROCAINE
+propranolol
+propoxyphene
prostaglandins (caraboprost,
tromethamine, dinoprost,
dinoprostone)
strychnine
substance P
SUCCINYLCHOLINE
SUFENTANIL
+TEMAZEPAM
THIOPENTAL
THIORIDAZINE
TRANYLCYPROMINE
+TRIAZOLAM
TRIHEXYPHENIDYL
VALPROIC ACID