SUPERIORITY OF SOLUTION FORM INTERFERON OVER

LYOPHILIZED POWDERD.
Liquid Lyophilized/ Freeze dried Powder

1. No chances of contamination as there is Chances of contamination due to due to

no reconstitution. reconstitution

2. No re-mixing required thus no refolding Reconstitution products are avoided in formularies of

of protein chains. Europe and USA because they have to pass through
tedious process of re-mixing. During mixing if
proper care is not taken the protein chains of
Interferon may remain without refolding due to
which the results may vary in the patients. It is
because the refolding of chains is essential to bring
the desired therapeutic effects.

3. Simple and easy to administration Difficult administration, these are even mentioned on
the leaf insert as well i.e. “The mixing of the
suspension should be made with gentle rotation, the
vial containing the suspension should not be shaken
vigorously”. But it is not done in reality. If you donot
believe just give a surprise check to the staff that is
injecting the product.

4. No chances of mistakes, Three big mistakes are done while injecting

5. No inconsistent results, lyophilized forms
6. Less undesirable side effects 1) The water / solvent is directly sprayed on the
powder which is against preparation
instructions
2) The vial is not left idle so that the contents get
mixed slowly
3) Vigorous shaking is done to mix the contents;
this results in breaking of many protein
chains, which leads to inconsistent cure rates
and more side effects.

7. Surity of Quality is present as all the
manufacturing process is completed
under one roof and quality control,
which is essential for biogeneric
product.
Actually two separate products are used in
lyophilized forms
1) Interferon
2) Water/solvent for injection
Both are separate pharmaceutical preparations and
are not manufactured by the same Co. This is usually
purchased from other companies; the quality control
may differ and thus is the quality of the mixed
product.
8. Do you want to leave aside these Do you want to buy for your patients:
benefits
• Simplicity in administration • Complicated administration
• Convenience • Difficulty
• More Safety • More side effects
• Better Results • Inconsistent/bad results
.
9. Liquid form is the modern in which all Admix able products i.e. products containing two
the original brands are available. separate formulations
• Intron-A 1) Lyophilized powder
• Roferon 2) Water/solvent for reconstitution
• Pegasys etc Is a primitive/discarded product form for interferon?
The Original BRANDS are now available only in
liquid forms. All have stopped manufacturing of the
powder and water combination Interferon.
No bio similar product can claim superiority over the
original brand
10 • Not approved by FDA
. Original Brand is always superior
• FDA Approved • Clinical data is not updated
• Clinical data is regularly update
Marked difference in formulation, marked difference
in results
.

Thus the only way is to keep as close in

formulation to original brand as
possible. The closer you are to
formulation, the closer you are to the When you want to treat patients in 2010 modern and
results of the original brand. easy to administer forms are required which are easy
INTEFEN is similar to the original to administer and patient compliance is at its best.
brand in all aspects.