Nipro Europe Headquarters

Weihoek 3H
1930 Zaventem
Belgium
T +32-(0)2-7255533
F +32-(0)2-7257041
www.nipro-europe.com

Nipro Europe - France Nipro Europe - Poland

Biôpole Clermont-Limagne Ul. Aleja Jana Paw ł a II, 23
63360 Gerzat 00-854 Warsaw
France Poland
T +33 (0)473 33 41 00 T +48 (0)22 653 85 98
F +33 (0)473 33 41 09 T +48 (0)22 653 85 06

Nipro Europe - Netherlands Nipro Europe - Italy

Regus Business Center Centro Direnzionale Milanafiori
Verlengde Poolseweg 34-36 Strada 1 - Palazza F/1
NL-4818 CL Breda I-20090 Assago
Netherlands Italy
T: +31-(0)76-524 50 99 T: +39-02-575 000 57
F: +31-(0)76-524 46 66 F: +39-02-575 181 11

Nipro Europe - Turkey Nipro Europe - Spain

Akasyali Sok. Mine Palas Apt.No.10/4 Avda. Castilla 2
Bostanci San Fernando Henares
34744 Istanbul SP-28830 Madrid
Turkey Spain
T +90 (0)216 445 16 88 T: +34-91-672 1834
F +90 (0)216 445 41 27 F: +34-91-672 1917

Nipro Europe - UK Nipro Europe - Russia

Ground Floor - Unit 7 12 Krasnopresnenskaya
The Forum - Minerva Business Park Nab. Office nr. 1017
Lynchwood 10th Floor - entrance nr. 6
Peterborough PE2 6FT World Trade Center
United Kingdom RF-123610 Moscow
T: +44-(0)173-322 4300 Russia
F: +44-(0)173-323 4310 T: +7-495 258 1364
F: +7-495 258 1367
 Specifications
Back To Basics ELISIO™
90H 110H 130H 150H 170H 190H 210H 250H

When we designed this dialyser, we once again Effective Surface Area (m2) 1,1 1,3 1,5 1,7 1,9 2,1

reviewed the human kidney function. The Priming Volume (ml) 70 85 95 105 115 130
human kidney is an assembly of nephron ele- Effective Length (mm) 228 245 259 271 281 290
ments. Therefore, as a starting point, we Inner Diameter (µm) 200 200 200 200 200 200
looked at a single nephron before designing a Membrane Thickness (µm) 40 40 40 40 40 40
single hollow fibre. From there, we focused on Maximum TMP (mmHg) 500 500 500 500 500 500
the overall human kidney functions by Membrane PolynephronTM
redesigning the dialyser housing and its inside

Materials
Housing Polycarbonate
structure. Header Polycarbonate
Potting Compound Polyurethane
Sterilization Method Dry Gamma
Package 24 pcs/box
 Dialyser Design
TM
Polynephron inside
The redesigned housing and its inside structure improves
removal of small molecules as well as low molecular weight
proteins, while conserving such essential proteins as albumin.
The ELISIO™ dialyser might look similar to competing pro-
ducts. Our exclusive POLYNEPHRON™ membrane and the
other dialyser elements have been finely tuned based on
years of experience and expertise, and this distinguishes our
product. The ultra-smooth PU cut surface and the finely-
finished inner lumen of hollow fibres will not damage blood
cells. The inner design of the fibre ensures smooth blood flow.
Consequently, the return of blood is easier and there will be
minimum residual blood in the dialyser.

The ELISIO™ dialyser with its POLYNEPHRON™ membrane

is state of the art and unique dialyser ready for the current dia-
lysis demands.
 Optimized use of m
Optimized dialysa
Perfect d
This dialyser uses less priming solution
than other dialysers currently
on the market.

Treatment
for all patients
The ELISIOTM dialysers are available
from 0,9 -2,5 m2.

Weight reduction
During the development of the ELISIOTM dialyser
we also looked at the environmental impact.
This resulted in a significant weight reduction.
membrane quantity
ate flow dynamics
degassing
Improved
header
shape
The caps have been redesigned
to reduce channeling
at the blood side.

Ultra-smooth ELISIOTM Competitor

PU-cut surface
During the production of the dialyser
the cutting of the potting is done
in such away that the surface is mirror-like,
making it smoother and less damaging for blood cells.

ELISIOTM Competitor
 Improved fibres with
TM
POLYNEPHRON membrane
The new rippled structure of the membrane fibres
makes spacer yarns unnecessary, resulting in a more
homogeneous dialysate flow and a slimmer dialyser design.

3D-structure of the membrane

The well-balanced mix of hydrophobic (reddish) and
hydrophilic (bluish) domains reduces membrane fouling.
 Optimised asymmetric structure
and wall thickness

Improved mechanical strength

of the fibres
Reduces the risk of fibre leakage

Better contact between dialysate

and blood compartment
and higher package density
Resulting in higher performances .

Uniform distribution of pore sizes

Pore sizes are optimized to have the highest possible clearances
for low molecular weight proteins, like ß2m, whilst avoiding albumin
loss.
In-vitro
Clearances
Urea

Phosphate ELISIO H
Polyflux H
Fx-series
HI-PS
 In-vivo
Clearances
Best ß2m Clearances in HD and HDF
Independently of the treatment mode, the Nipro ELISIO™ 190H dialyser demonstrated
much better performances than the reference filters, with regard to ß2 microglobulin
Remarks : Qb400/Qd700 /Qs 80 mL/min

Excellent biocompatibility
The POLYNEPHRONTM membrane showed an excellent biocompatibility (WBC, C5a) and
thrombogenicity (Platelet count, TAT) as could be expected from a synthetic membrane.
White Blood Cell count C5a generation

Clinical data obtained in Germany, 8 patients, Jan 2008

 SERIES

Performance Qf=0
ELISIO™
Clearances (mL/min)1 Qb/Qd(mL/min) 90H 110H 130H 150H 170H 190H 210H 250H
Urea 200/500 189 192 195 197 198 199 200 200
300/500 243 253 263 270 275 280 284 293
400/500 274 291 311 323 332 343 346 361
400/800 300 325 344 357 362 370 377 385
500/800 332 363 388 406 417 427 432 457
Creatinine 200/500 175 183 191 194 196 197 198 200
300/500 213 228 240 252 259 268 269 282
400/500 237 252 273 288 299 309 319 337
400/800 265 294 316 331 342 349 355 375
500/800 282 320 346 363 383 404 410 426
Phosphate 200/500 160 164 170 176 179 183 188 193
300/500 195 209 224 233 245 251 256 274
400/500 220 240 255 271 288 296 304 322
400/800 235 254 280 298 313 325 330 346
500/800 254 282 315 333 352 368 373 400
Vitamin B12 200/500 114 125 137 148 156 162 165 177
300/500 128 145 161 173 185 195 198 219
400/500 132 153 174 188 202 215 219 242
400/800 141 171 193 209 227 240 250 270
500/800 151 178 204 223 242 259 264 291
Inulin 200/500 77 82 90 97 105 115 120 149
300/500 84 86 97 109 117 127 138 166
400/500 86 90 100 116 126 137 145 176
400/800 91 92 106 120 128 140 150 185
500/800 94 97 112 122 135 148 158 203
Myoglobin 200/500 55 61 70 78 88 94 98 112
300/500 58 64 78 89 96 101 103 123
400/500 61 70 82 92 104 110 113 132
400/800 64 71 84 95 106 111 116 137
500/800 65 81 90 104 110 117 124 141
KUF (mL/hr/mmHg)2 53 59 64 67 74 76 82 93
Sieving Coefficient3 Vitamin B12 0,989
Inulin 0,926 1 In Vitro Test Condition(EN1283) : Qf 0mL/min
2 KUF (EN1283) : Bovine Blood (Hct 32±2%, Protein 60g/L, 37°C), Qb 300mL/min
Myoglobin 0,223 3 SC(EN1283) : Qb 300mL/min, Qf 60mL/min
Albumin 0,002
 Specifications
Back To Basics ELISIO™
90H 110H 130H 150H 170H 190H 210H 250H

When we designed this dialyser, we once again Effective Surface Area (m2) 0,9 1,1 1,3 1,5 1,7 1,9 2,1 2,5

reviewed the human kidney function. The Priming Volume (ml) 62 70 85 95 105 115 130 149
human kidney is an assembly of nephron ele- Effective Length (mm) 210 228 245 259 271 281 290 302
ments. Therefore, as a starting point, we Inner Diameter (µm) 200 200 200 200 200 200 200 200
looked at a single nephron before designing a Membrane Thickness (µm) 40 40 40 40 40 40 40 40
single hollow fibre. From there, we focused on Maximum TMP (mmHg) 500 500 500 500 500 500 500 500
the overall human kidney functions by Membrane PolynephronTM
redesigning the dialyser housing and its inside

Materials
Housing Polycarbonate
structure. Header Polycarbonate
Potting Compound Polyurethane
Sterilization Method Dry Gamma
Package 24 pcs/box
 Nipro Europe Headquarters
Weihoek 3H
1930 Zaventem
Belgium
T +32-(0)2-7255533
F +32-(0)2-7257041
www.nipro-europe.com

Nipro Europe - France Nipro Europe - Poland

Biôpole Clermont-Limagne Ul. Aleja Jana Paw ł a II, 23
63360 Gerzat 00-854 Warsaw
France Poland
T +33 (0)473 33 41 00 T +48 (0)22 653 85 98
F +33 (0)473 33 41 09 T +48 (0)22 653 85 06

Nipro Europe - Netherlands Nipro Europe - Italy

Regus Business Center Centro Direnzionale Milanafiori
Verlengde Poolseweg 34-36 Strada 1 - Palazza F/1
NL-4818 CL Breda I-20090 Assago
Netherlands Italy
T: +31-(0)76-524 50 99 T: +39-02-575 000 57
F: +31-(0)76-524 46 66 F: +39-02-575 181 11

Nipro Europe - Turkey Nipro Europe - Spain

Akasyali Sok. Mine Palas Apt.No.10/4 Avda. Castilla 2
Bostanci San Fernando Henares
34744 Istanbul SP-28830 Madrid
Turkey Spain
T +90 (0)216 445 16 88 T: +34-91-672 1834
F +90 (0)216 445 41 27 F: +34-91-672 1917

Nipro Europe - UK Nipro Europe - Russia

Ground Floor - Unit 7 12 Krasnopresnenskaya
The Forum - Minerva Business Park Nab. Office nr. 1017
Lynchwood 10th Floor - entrance nr. 6
Peterborough PE2 6FT World Trade Center
United Kingdom RF-123610 Moscow
T: +44-(0)173-322 4300 Russia
F: +44-(0)173-323 4310 T: +7-495 258 1364
F: +7-495 258 1367