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  • Pathophysiology of Hypertension: RAAS Activation and Organ Damage

    Transféré par

    Alvin Ramirez
    724 vues2 pages
    Family history of hypertension, diabetes, heart failure Stress High salt, high fat intake Age Stiffness of large arteries (such as aorta) as Part of aging process Hypoperfusion of blood to organs (such as kidneys) and tissues RAAS Activation Sensed by the Juxtaglomerular Cells of the kidneys Triggers the release of renin It will go to the liver ANGIOSTENSINOGEN Converted to Angiotensin 1 It

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    final patho-HCVD

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    Family history of hypertension, diabetes, heart failure Stress High salt, high fat intake Age Stiffness of large arteries (such as aorta) as Part of aging process Hypoperfusion of blood to organs (such as kidneys) and tissues RAAS Activation Sensed by the Juxtaglomerular Cells of the kidneys Triggers the release of renin It will go to the liver ANGIOSTENSINOGEN Converted to Angiotensin 1 It

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    724 vues2 pages

    Pathophysiology of Hypertension: RAAS Activation and Organ Damage

    Transféré par

    Alvin Ramirez
    Family history of hypertension, diabetes, heart failure Stress High salt, high fat intake Age Stiffness of large arteries (such as aorta) as Part of aging process Hypoperfusion of blood to organs (such as kidneys) and tissues RAAS Activation Sensed by the Juxtaglomerular Cells of the kidneys Triggers the release of renin It will go to the liver ANGIOSTENSINOGEN Converted to Angiotensin 1 It

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOCX, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 2

    V.

    Pathophysiology

    ETIOLOGIC RISK FACTORS


    AGENT Family history of hypertension ,
    Idiopathic/ unknown diabetes, heart failure
    Stress
    High salt, high fat intake
    Age

    Stiffness of large arteries (such as Aorta) as


    Part of aging process

    Hypoperfusion of blood to organs


    (such as kidneys) and tissues

    RAAS Activation

    Sensed by the Juxtaglomerular


    Cells of the kidneys

    Triggers the release of renin

    It will go to the liver

    ANGIOSTENSINOGEN
    Converted to Angiotensin 1

    It will go to the lungs


    Angiotensin Converting Enzyme
    Converts Angiotensin 1 to
    Angiotensin 2

    Stimulates the Adrenal cortex Vasoconstriction

    Release of aldosterone

    Na retention (increase circulatory decrease Preload increase Afterload


    Blood volume)
    Increase BP increase RR increase Peripheral Resistance

    Increase BP increase chloride Left Ventricle wall stress

    Oxygen consumption insufficient Left ventricle Hypertrophy Concentric LVH


    Oxygen as shown in Xray
    Anaerobic respiration
    Pale decreased blood pumped coronary flow reserve Diastolic
    By the heart Pressure
    Lactic acid, pyruvic acid ATP produced Fibrosis
    Production blood supply (vital organs) Diastolic filling
    Weakness/ Systolic Heart
    Irritation of nerve endings easy fatigability myocardial ischemia failure LVEDP

    Chest pain myocardial infarction Pulmonary Atrial Fibrilation Diastolic


    congestion Heart
    Failure
    Shortness of breath/ DOB

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