The Ohio State Universit y 2007-2008 Annual Report

Depa rtment of Ophth a lmology

Contents
1 CHAIRMAN’S LETTER

2 DEPARTMENT HISTORY

4 GIVING

10 FACULTY

14 DIVISION REPORTS

20 RESEARCH & GRANTS

24 PUBLICATIONS

28 OUTREACH

Chairman:
Thomas Mauger, M.D.
Administrator:
Robert LaFollette, M.B.A.
Outreach Director:
Laura Sladoje, B.S.
Program Coordinator:
Christina Stetson, B.A.
For more information contact Ophthalmology Outreach at
(614) 293-8760 or eye@osu.edu.
Dear Friends and Colleagues,
The mission of The Ohio State University Medical Center is “To improve people’s lives through innovation in
research, education and patient care”. In Ophthalmology we have a unique opportunity to improve the lives
of others through the preservation of vision through research, education, clinical treatment, and surgery.
The Department of Ophthalmology continued its growth during the 2007–2008 academic year. Exciting
developments have occurred in all three of our mission areas of clinical care, research, and education. As
the medical center embarks on a one billion dollar expansion the Havener Eye Institute is also making plans
for new physical facilities that should provide opportunities for additional growth. Plans include a new Eye
Institute site to encompass our main clinical, research, and educational activities as well as an outpatient sur-
gical facility. We are also planning to create additional outreach clinical space. We have made strategic
additions to our faculty during the past year in the areas of comprehensive ophthalmology, vitreoretinal
disease, and cornea and external disease. We are very fortunate to have a dedicated and caring team of
administrative and clinical staff that support each element of our mission.
Thanks to Dr. Paul Weber, the medical student lecture series remains one of the highest ranked in the
curriculum. Dr. Alan Letson has revised and improved the ophthalmology clerkship. Over five percent
of the medical school class have selected ophthalmology as their career choice. The ophthalmology
residency program remains the key element of our educational program. Applications to the residency
program are at an all time high in terms of quantity and quality. Thanks to the efforts of Residency
Program Director, Alan Letson, and Program Coordinator, Trish Rebish, along with all of the involved
faculty and residents, the program was successfully recertified last year. The resident experience in
surgical volume and patient encounters remains in the top 10% of programs. The faculty and residents
will have new operating room facilities at Nationwide Children’s Hospital, Chalmers P. Wylie Veterans
Clinic (V.A.), as well as our main surgical facilities. The fellowship program remains active with fellows
currently in cornea, glaucoma, and retina.
Research efforts continue to expand in the areas of ocular tumor, ocular biomechanics, and cerebrospinal
fluid physiology. The Department has been very active in clinical trials involving age-related macular
degeneration, diabetic retinopathy, glaucoma, ocular infections, and cataract surgery. The resident’s an-
nual research program continues to improve in the quality of the research and presentations.
Healthcare is at a critical point in the United States and globally. It is our goal to contribute to
the solution by training excellent physician leaders and by restoring sight and preventing blindness
through state of the art patient care, education, and research.
Sincerely,
Thomas F. Mauger, M.D.
Director and Chairman
The Carl M. and Grace C. Baldwin Chair in Ophthalmology
Havener Eye Institute, Department of Ophthalmology, The Ohio State University
Establishing the Tradition
In 1914, Starling Ohio Medical College joined OSU and
became The Ohio State University Medical College. At
that time, Ophthalmology and Otolaryngology were a com-
bined division. Recognizing the need for specialization,
the Department of Ophthalmology was officially formed
in 1929 under the leadership of Albert Frost, M.D. Patient
care clinics were located on State Street and at Children’s
Hospital. Surgery remained at University Hospitals.
Medical students attended the outpatient clinic on State
Street. In 1938, the State Street clinic was moved to the
University Hospitals. In 1949, the eye clinic occupied a
small space adjacent to the old emergency room. In 1959,
when Dr. Havener became the first full-time ophthalmolo-
gist at Ohio State, the eye clinic consisted of a large central
room for interviewing and refracting patients, a treatment
room, a small classroom, and a visual field room. Between
1949 and 1962, the number of patients grew from 1900 to
16,000. Because of this increasing demand, the Depart-
ment took up residence in the newly constructed Outpa-
tient Clinic Building in 1975. To meet the needs of Co-
lumbus’ increasing suburban population, the Department
established a satellite clinic in 1996 for refractive surgery,
anterior segment, neuro-ophthalmology, and comprehen-
sive eye care. This clinic as located at Stoneridge Medical
Plaza near the northeastern suburb of Dublin, but moved
to its current location in Dublin in 2006. That same year,
an additional clinic for retinal and glaucoma patients was
established across the street.

2
Havener Eye Institute in 2009
In the summer of 2009, the Department of Ophthalmology will move from the OSU Medical Center campus to a new
location across the Olentangy River. With over 28,000 square feet, patient exam facilities equipped with innovative
technology, and a state-of-the-art surgery center we will be able to meet the growing demand for quality eye care. In its
80th year, the Havener Eye Institute will continue establishing a tradition of excellence in ophthalmology.

3
Ohio Stadium
GIVING Annual Honor Roll
January-December 2007
The Annual Honor Roll and
Havener Society acknowledge $100,000 and above $1,000 to $2,499 (Cont)
Warner & Patti Blow
those who support the educa-
$50,000 to $99,999
tional and research mission of Dr. Henry & Suzanne Croci
the department. Our vision is Dr. Holton C. Letson
to expand research to increase $10,000 to $49,999 Dr. Howard & Pamela Bell
options for treatment and Jerry Colp
Harry Esbenshade
prevention of eye diseases, to
$5,000 to $9,999
share the latest advances and Drs. Jack & Bernard & Doris Mudrock
innovations in eye care with our Candace Hendershot
Dr. D. M. Nisbet
patients, and to train the next Dr. Dale & Bonnie Solze
generation of ophthalmologists
$2,500 to $4,999
to carry on the tradition of Dr. Dave & Cheryl Adam
Dr. Patrick Carroll
excellence. This includes funds Dr. Alan & Susan Letson
donated for resident and fel- Dr. Robert McKinlay
Dr. Garret Mouser
low salary support, equipment Dr. Jeff & Dr. Mary Oehler
used by residents and students Dr. Karl & Michelle Pappa
in clinic, student and resident $1,000 to $2,499
Mary & Howard Burnett
educational programming,
Dr. Ivan & Marcie Gilbert
books for the resident lecture Carolyn Greshemer
Phyllis Havener
series, named lectureships, and Drs. L. Carol Laxson &
support of chairs and faculty Thomas Mauger
Dr. Carl & Joan Minning
positions. John Marakas
5
$100 to $499 (Cont)
Hilde Hartline
Benjamin Haynes
Audrey Henry
Irma Huber
Dr. James Moses Thomas Jenkins
Dr. Baird Pfahl Ben & Anne Kauffman
Dr. Carl Shin Dr. Ali Keyhani
Dr. John J. Wilding Dr. James King
Bob LaFollette
$500 to $999 Barbara Landolfi
Dr. Max J. Lerner
Robert Hamm Bill Martin
Dr. Lawrence Karns Dr. Jeff & Sue McAdoo
Dr. Charles Leone Jr. Kathy McKinney
Dr. Larry Lohman Dr. Randy McLaughlin
Tim McNemar
Richard Poffenbaugh Martha Morris
Paul Ritter Jr. Frank New
Dr. David Stager Dr. Alfred Nicely
Dr. C. Michael & Fred & Cheryl Nicely
Sandra Thorne Dr. Phillip O’Donnell
David Ullman Pam Potter
Floyd & Patricia Redd
$100 to $499 Lee Rudibaugh
Alan Alford Michael Sauer
Dr. N. Douglas Baker Charles Sauers
Scott Bellinger T. Dwain Sayre
Thomas Baxter Nasser Sharifrazi
Judy Burke Dr. Jerry Shell
Dr. John Burns B. Lee Skilken
Dr. John Christoforidis Laura Sladoje
Albert Covelli Dr. John Stechshulte
Dr. Jonathan Davidorf Michael Steyer
Dr. Jack Dingle Dr. Michael Stone
Margery K. Forry Dr. Paul Treger
Justa Garrett Dr. Paul Weber
Tally M. Grossman Lisa Williamson
Steve Grub Dr. Jeffrey Wincko
Havener Societ y Havener Circle
The Havener Society was established in 1989 $1,000,000 and above
by the students of William Havener to perpetuate
the principles and high standards that he set for Carl M. Baldwin*
himself and for the students and benefactors of his Grace C. Baldwin*
talents. Warner & Patti Blow
William H. Havener, MD was the first full-time Irene D. Hirsch*
ophthalmologist at The Ohio State University Col-
lege of Medicine and Public Health and Chairman
of the Department of Ophthalmology from 1959-
1961 and 1972-1988. A distinguished teacher and
internationally known author, Dr. Havener was an
Chairman Circle
$500,000 - $999,999
innovative and skillful surgeon, thoughtful citizen, an
avid gardener, and most of all, a considerate and Martha Staub*
caring physician. Dr. Havener believed in planting
things and watching them grow. He loved to plant
seeds, whether in his garden or by nurturing medical
students, residents, and faculty.
For four decades, he had a single mission:
Ophthalmology. With his keen powers of observa-
Faculty Circle
$100,000 - $499,999
tion and unique ability to transmit knowledge to
others, as an educator, he had no peer. He was Phyllis Havener
directly responsible for the training of over 200 Dr. William H. Havener*
ophthalmologists and thousands of medical students. Dr. Milton C. Oakes*
The great planter of seeds is gone, but his harvest
will continue to be bountiful.

* Indicates deceased

6
 Fellow Circle
$50,000 - $99,999
Resident Circle
$25,000 - $49,999
Dr. N.
D N Douglas
D l BakerB k D Richard
Dr. Ri h d H.H Keates
K D Robert
Dr. R b Chambers
Ch b Dr. Robert & Helen McKinlay
Dr. John Burns Mary K. Laughlin* Helen Clabaugh* Lois Ann Moor
Dr. Kenneth Cahill Dr. Alan Letson Helen Coast* Dr. Alfred Nicely
Jerry R. Colp Dr. Holton Letson Helen Crane* Dr. Dick Nisbet
Dr. Henry & Suzanne Croci Dr. Torrence Makley* Drs. Jack & Dr. Karl Pappa
Dr. Frederick Davidorf Dr. Thomas Mauger & Candace Hendershot Dr. John Stechschulte
Leo & Grace Faust* Dr. L. Carol Laxson Dr. Marilyn J. Huheey Dr. Dale & Bonnie Solze
Margery Henderson* Ruby Nowak*
Katherine Kessler* Elmer Tankersley*
Dr. Roger C. Henderson* Ruth Tankersley*
Dr. Robert Magnuson* Dr. Paul Weber
Gayle Huffman* Eldon J. Tobias*
Eleanor Kilgore*

D David
Dr. D id Adam
Ad
Dr. Donald Anderson
Dr. James Andrew*
Student
St d tC Circlel
$10,000 - $24,999
Dr.
D Paul
P l Richards
Ri h d
Mrs. Ermal Roberts
Mary Ellen Sharshal
Dr. Paul Armstrong Dr. Carl Shin
Dr. William Banks III Dr. Elson Craig Dr. Fred & Dr. Randy McLaughlin Dr. Richard Simmons
Dr. Morris Battles* Dr. Robert Derick Audrey Kapetansky Timothy McNemar Dr. James Stewart
Dr. Susan Benes Dr. Jack Dingle Dr. John D. Kay Ann E. Meiling* Dr. Ted Suie, Jr.*
Dr. James Bennett* Gladys Dunlap* Dr. Curtin Kelley Dr. Carl Minning, Jr. Dr. Lloyd Taustine
Joseph L. Bitonte* Gilbert Eggleston Dr. Charles Kunesh* Dr. James Moses Patti Tewell
Dr. Wilbur Blount* Harry Esbenshade, Jr. Dr. Richard Lembach Marlene O’Dair Dr. Peter Utrata
Dr. Hans Bredemeyer Dr. Sanders Farber Dr. Jerrold Levin Dr. Robert O’Dair* Dr. Albert Van Fossenn
Dr. Robert Bruce* Dr. John Charles Garvin Dr. Donald Lewis Dr. E. Mitchel Opremcak Dr. Joel Wachtel*
Dr. Robert Bruce, Jr. Edward Gerhold, Sr.* Dr. John Mader Dr. Richard Orlando Dr. Charles Zepp
Howard Burnett Dr. Gregory Gibb John L. Marakas Dorothy Osborne Harold F. Zieg*
Dr. Patrick Carroll Florence Johnson* Dr. W. Thomas Martin Maude Osborne*

7
 Henr y & Suzanne Croci
Resident Education Endowment Founded

According to Dr. Henry Croci, “the educational experience as an ophthalmology resident shaped our lives
in such a positive way, we wanted to be able to help future residents experience the same thing.” That moti-
vated Dr. Croci and wife Suzanne to create the The Henry G. Croci and Suzanne D. Croci Resident Educa-
tion Fund in Ophthalmology, established in December 2007. He continued, “The example by Dr. Havener
and other faculty and staff influenced the way we interact with patients and people in general throughout our
lives. We want to continue to encourage young ophthalm
ophthalmology residents to foster the same
ame spirit of kind,
distribution of this fund shall be used to support
compassionate help to others.” The annual distributio upport the education
residents in the Department of Ophthalmology.
and training of resid hthalmology. “Resi-
dent education is one of the strengths at OSU and continues to im-
prove thanks to the generosity of donors like
ke the Crocis,” stated
Chief Resident,
Resid Matthew Ohr, M.D.
After Dr. Croci
C completed his residency internship
rnship and two years
in the Air Force as a Flight Surgeon, the Crocis
ocis settled in Athens,
Ohio in 1971,
19 where he practiced for more than 31 years. Dr. Croci
and Suzanne
Suzan relocated to Savannah, Georgiaa five years ago after
his retireme
retirement. They enjoy the warmer winters
rs and nautral
Coastal Georgia. Dr. Croci continuess to vol-l
beauty of Coa
unteer
untee in ophthalmology, helping with the Li-i
ons Lighthouse Foundation at St. Mary
o
Community Center. As a licensed
ed
volunteer in medicine in Georgiaa
he examines and treats uninsured
ed
and under served patients two full
ull
Henry & Suzanne Croci days a month.

8
Holton Letson, M.D.
Retina and Ophthalmology Endowment Established to honor Alan & Susan Letson
The Alan and Susan Letson Retina and Ophthalmology Fund was established in 2007 by an endowment gift from
Dr. Holton Charles Letson of Hilton Head, South Carolina. Dr. Letson created the fund to recognize the profes-
sional contributions of his son, Dr. Alan, and daughter-in-law Susan Letson. “I staffed the OSU Ophthalmology
resident clinic for many years,” said Dr. Letson. “Even when no longer staffing clinic, I maintained a close re-
lationship with the Department and staff, particularly Dr. William Havener. It was a pleasure and a privilege to
provide in a positive manner to the field of Ophthalmology. Now that I can no longer physically take part, I can
take pleasure through the establishment of this fund which I hope h will continue my efforts,
and also the efforts of others.” The annual distribution from ththis fund will be used to support
the education of ophthalmology residents, acquisition of equipment
eq for research, clinical
and patient care, projects in retina disease, and emerging p priorities or initiatives related
to retina disease in the Department of Ophthalmology. Ac According to Dr. Tom Mauger,
Department Chairman, “Private support for our de-
partment and programs are critical to our continued
growth and expansion
expansion. The generosity of Dr. Letson
and all our donors is greatly appreciated and truly
makes a difference iin what we do.”
After completing h his residency in Ophthalmol-
ogy in Detroit, Dr. Letson moved his family to
Zanesville, Ohio whwhere he practiced Ophthalmol-
ogy from 1954 until his retirement in 1986. He spent
more than 15 years staffing
staf the OSU Resident Clinic
and made many valua valuable contributions to the pro-
fession, the depar
department and many grateful resi-
dent trainees
trainees.

Betty & Holton Letson

9
The Oval
 Faculty (July 2007 - June 2008)

Thomas Mauger, M.D. David Castellano, M.D. Susie Chang, M.D. John Christoforidis M.D. Elson Craig, M.D. Matthew Dangel, M.D.
Department Chair Assistant Professor - Clinical Assistant Professor Assistant Professor Associate Professor Emeritus Associate Professor
Anterior Segment Refractive Surgery Retina Retina Pathology Anterior Segment

Frederick Davidorf, M.D. Gloria Fleming, M.D. Deborah Grzybowski, Ph.D. Reynell Harder Smith, M.D. David Hirsh, M.D. Steven Katz, M.D.
Professor Emeritus Assistant Professor-Clinical Assistant Professor Clinical Assistant Professor Assistant Professor-Clinical Associate Professor
Retina Glaucoma Research Anterior Segment Neuro-Ophthalmology Neuro-Ophthalmology

Richard Keates, M.D. Carol Laxson, M.D., Ph.D. Richard Lembach, M.D. Alan Letson, M.D. Jennifer Lewis, Ph.D. Jun Liu, Ph.D.
Professor Emeritus Assistant Professor-Clinical Professor Professor-Clinical Adjunct Assistant Professor Assistant Professor
Anterior Segment Retina Anterior Segment Retina Research Research

W. Randall McLaughlin, O.D. Cynthia Roberts, Ph.D. Amit Tandon, M.D. Annette Terebuh, M.D. Paul Weber, M.D. Katie Wulff, O.D.
Assistant Professor-Clinical Professor Clinical Assistant Professor Clinical Assistant Professor Professor Clinical Assistant Professor
Optometry Research Comprehensive Glaucoma Glaucoma Optometry

11
Faculty Awards 2008 New Faculty
America’s Best Doctors 2008
America’s Best Doctors Inc.
N. Douglas Baker, M.D.
Robin Beran, M.D.
Don Bremer, M.D.
Robert Bruce, M.D.
John Burns, M.D. Rebecca Kuennen, M.D. Paul Kurz, M.D. Hall McGee, M.D. Julie Meier, M.D.
Kenneth Cahill, M.D. Clinical Assistant Professor Assistant Professor Assistant Professor Clinical Assistant Professor
Robert Chambers, D.O. Anterior Segment Retina Anterior Segment Anterior Segment
Louis Chorich, M.D.
John Christoforidis, M.D.
Matthew Dangel, M.D.
Clinical Faculty
Faculty Emeritus N. Douglas Baker, M.D. Charles Letson, M.D.
Frederick Davidorf, M.D. Hans Bredemeyer, M.D. Kenneth Beckman, M.D. Richard Liston, M.D.
Robert Derrick, M.D. Martin Lubow, M.D. Robert P. Bennett, M.D. Mark Lomeo, M.D.
Jack Dingle, M.D. Harry Sage Jr., M.D. Michael Besson, M.D. John L. Marquardt, M.D.
Kenneth A. Boyle, Jr., M.D. A. Marie Martinek, M.D.
Alice Epitropoulos, M.D. Clinical Professors Bruce Buerk, M.D. Mary Lou McGregor, M.D.
Avrom Epstein, M.D. Susan C. Benes, M.D. C. Patrick Carroll, M.D. James McHale, M.D.
John A. Burns, M.D. Cybil Bean Cassady, M.D. Carl A. Minning Jr., M.D.
Kelly Everman, M.D. Kenneth V. Cahill, M.D.
Jill Foster, M.D. Frederick Kapetansky, M.D. George M. Chioran, M.D. Jennifer A. Morrison, M.D.
Gary L. Rogers, M.D. Louis Chorich III, M.D. James L. Moses, M.D.
Steven Katz, M.D. Elmer C. Collins, M.D. Paul Moyer, M.D.
Curtin Kelley, M.D. Clinical Associate Professors Elliott Davidoff, M.D. Jeffrey C. Oehler, M.D.
L. Carol Laxson, M.D. Don L. Bremer, M.D. David E. Denlinger, M.D. Richard G. Orlando, M.D.
Robert A. Bruce, M.D. Alice T. Epitropoulos, M.D. John T. Pajka, M.D.
Richard Lembach, M.D. Robert Chambers, D.O. Avrom D. Epstein, M.D. Karl S. Pappa, M.D.
Alan Letson, M.D. Robert J. Derick, M.D. Kelly Everman, M.D. Sugat Patel, M.D.
Mark Lomeo, M.D. Jack Dingle, M.D. Sanders M. Farber, M.D. Abhik Ray-Chaudhury, M.D.
Jill A. Foster, M.D. J. Charles Garvin, M.D. Archana V. Reddy, M.D.
Thomas Mauger, M.D. John W. Higbee, M.D. Richard Golden, M.D. Alan J. Rehmar, M.D.
Mary Lou McGregor, M.D. Curtin G. Kelley, M.D. Walter C. Hartel, M.D. Chester D. Ridenour, D.O
E. Mitchel Opremcak, M.D. Lawrence E. Leguire, Ph.D. Fareed Hasan, M.D. David Rogers, M.D.
Gary Rogers, M.D. Robert E. Lembach, M.D. Charles J. Hickey, M.D. Nicholas Rogers, M.D.
Robert T. McKinlay, M.D. Marilyn J. Huheey, M.D. Stephen C. Schumann, M.D.
John Stechschulte, M.D. E. Mitchel Opremcak, M.D. Marsha Kavanagh, M.D. Gregory Searcy, M.D.
Peter Utrata, M.D. Roger H. Sherman, M.D. Kevin G. Kegler, M.D. Shahin Shahinfar, M.D.
Paul Weber, M.D. Richard E. Simmons, M.D. Steven M. Kirkham M.D. James E. Silone, D.O.
George Stine, M.D. Dino Klisovic, M.D. Warren M. Sobol, M.D.
Who’s Who in Black Columbus, 2008 Peter J. Utrata, M.D. Heather C. Koelling, M.D. Brian R. Stahl, M.D.
Assistant Professors Susmitha P. Kolli, M.D. John R. Stechschulte, M.D.
Who’s Who Publishing Amy M. Kopp, M.D. Deanna J. Stevens, M.D.
Gloria Fleming, M.D. Ronald X. Xu, Ph.D. Marilyn K. Kosier, M.D. Steven H. Suh, M.D.
Clinical Assistant Professors John Kunesh, M.D. Annette Terebuh, M.D.
Makley-Battles Teaching Award, 2008 David R. Adam, M.D. Michael T. Kunesh, M.D. Phyllis Visocan, M.D.
Havener Eye Institute, OSU Charlotte M. Agnone, M.D. Mark S. Law, M.D. Todd E. Whitaker, M.D.
J. Geoffrey Allen, M.D. David M. Lehmann, M.D.
David Hirsh, M.D.

12
 Education
Residency Program
Residency Director
Alan Letson, M.D.
Third Year Residents Program Coordinator
Trish Rebish
Anne Elbiaadi, M.D., Matthew P. Ohr, M.D., Thomas J. Dingle, M.D.,
Julie Lange, M.D., and Kathryn R. Baker, M.D. Grand Rounds
10 Specialty Grand Rounds
26 Case Presentation Grand Rounds

Annual Ophthalmology
Research Symposium
June 13, 2007

Ophthalmology Award Recipients:

Residents:
Second Year Residents First Place: Rick Whitehead, M.D.
Second Place: Kathy Baker, M.D.
Andrea Knellinger, M.D., Ted Loizos, M.D., Andy Hendershot, M.D., Third Place: Landon Colling, M.D.
Carla Ford, M.D., and Anupama Horne, M.D.
Graduate Students:
First Place: Craig Morin, B.S.

Makley-Battles Teaching Award* Recipient:

Daivd Hirsh, M.D.

Fellows
Ryan F. Deasy, M.D.
Rebecca Kuennen, M.D.
First Year Residents Carrie Lembach, D.O.
Wendy Smith, M.D., Cedric Pratt, D.O., Rick Whitehead, M.D.,
*The Makley-Battles Teaching Award is given annually in recog-
Landon Colling, M.D., and Katie Baston, M.D. nition of outstanding faculty contributions to resident education.

13
Desk of OSU President E. Gordon Gee
Division Reports
Anterior Segment
Thomas F. Mauger, M.D.
The Anterior Segment Division includes the areas of Cornea and External Disease, Comprehen-
sive Ophthalmology, Optometry, and Refractive Surgery. The division is actively involved in
teaching, research, and clinical care.
Drs. Amit Tandon and David Castellano provided comprehensive ophthalmic care to the univer-
sity community and at our outreach clinics. They are integral to our resident clinical and surgi-
cal education on campus and through the Columbus VA clinic. They also provide outstanding
role models of comprehensive ophthalmology to our residents and medical students. Dr. Katie
Wulff joined the department to provide optometric care, including comprehensive examination,
contact lens services, and low vision rehabilitation services to patients at the Dublin office. Dr.
Randy McLaughlin continues to provide comprehensive examination and contact lens services at
the OSU office. Drs. Wulff and McLaughlin are both involved in education.
The Cornea Service remains active performing 171 keratoplasty procedures during the past year.
These procedures include a wide range of procedures including penetrating keratoplasty, endo-
thelial keratoplasty, deep anterior lamellar keratoplasty, and keratoprosthesis. The service cur-
rently includes Drs. Richard Lembach, Richard Keates, Matthew Dangel, and Thomas Mauger.
The newest addition to the service is Dr. Rebecca Kuennen who completed her cornea fellowship
with Dr. Mauger in June 2008. Dr. Carrie Lembach also completed a cornea fellowship under
the guidance of Dr. Richard Lembach in June 2008 and is in private practice in Columbus. Dr.
Matthew Ohr was the Chief Resident in Ophthalmology and is the current cornea fellow for
2008-2009.
The division is completing clinical research projects on acute conjunctivitis, fungal and acan-
thamoeba keratitis, capsular staining in cataract surgery, and intra-operative corneal topography.
Dr. Richard Keates is conducting a cornea cross-linking trial using riboflavin and UV light in
eyes with keratoconus and corneal ectasia post-refractive surgery.
The Division has been involved in two international missions. Drs. Ohr and Mauger performed
fifty cataract and pterygium surgeries in the village of Akima Akosa, Ghana in December 2007.
Drs. Kuennen and Mauger traveled to Managua, Nicaragua in June of 2008 and performed four-
teen successful keratoplasty procedures. The surgeries were made possible through a generous
donation of corneal tissue from Tissue Banks International and Vision Share.

15
Glaucoma
G Neuro-Ophthalmology
Paul A. Weber, M.D.
P Steven Katz, M.D.
Th Glaucoma Division has moved forward in a very positive way
The
in all three mission areas: patient care, research, and education.
Thanks to the generous continued support from grateful patient
Th
Jerry Colp, we have added state-of-the-art diagnostic equipment,
the Optovue Optical Coherence Tomographer. This advanced
technology allows us to diagnose glaucoma at the very earliest
stages of the disease and can detect progression earlier than other
methods, allowing us to provide optimum care of this potentially
blinding disease for our patients. We have also expanded patient
care options with Dr. Gloria Fleming now seeing patients at our
Dublin location.
We continue to be involved in the National Eye Institute funded
Ocular Hypertension Treatment Study (OHTS), a ground break-
ing study that has already altered how physicians here and
around the world manage glaucoma. Many cases of glaucoma
will be prevented, because of this clinical trial. This will result
in fewer patients losing vision from one of the leading causes of
blindness both nationally and internationally. The OHTS study
has also resulted in new unexpected results that have stimulated
new areas of research that will further advance the care and
management of glaucoma. Collaboration between the Glaucoma
Division and the Biomedical Engineering faculty has resulted in
very robust research efforts in many of these areas. We have in-
volved medical students, graduate students, residents and under-
graduate students in these research projects. Our research efforts
resulted in multiple presentations at this years ARVO meeting,
the most influential ophthalmology research meeting.
We have expanded our education efforts
effor for residents by adding
glaucoma faculty at both the Columbus
Columbu and Dayton VA facilities.
These additions are resulting in more glaucoma
g clinical and surgical
experience for our residents. The addition
addit of a glaucoma fellow, Dr.
Iyad Azrak, this year also enhances
en our educational efforts.
Altogether, this has been a year of innovations and
growth in the field of Glaucoma.
16
The Neuro-ophthalmology service continues to contribute to the
departmental mission in the core areas of clinical care, teaching
and research. Departmental faculty including David Hirsh, Susan
Benes and Steven Katz are responsible for the resident lecture
series as well as medical student teaching in neuro-ophthalmology.
Dr. Hirsh hosted the 51st Annual Postgraduate Symposium in
Ophthalmology, The Eye and Systemic Disease, from February 29
through March 1, 2008. At the conference, Dr. Hirsh also spoke
on Initiating Treatment for Giant Cell Arteritis and Dr. Katz gave
the Paul A. Weber Lecture on Systemic Inflammatory Diseases of
the Orbit. At the 28th Annual Ophthalmology Research Sympo-
sium on June 13, 2008, Dr. Hirsh was honored by the Residents
with the Makley-Battles teaching award. Chief Resident Andy
Hendershot cited Dr. Hirsh’s dedication to the Resident teaching
program and his clinical teaching in the Resident Clinic at Ohio
State and the Columbus VA.
Dr. Katz co-hosted a symposium on Headache Management on
February 2, 2008 at Ohio State where he also gave an update on
Idiopathic Intracranial Hypertension. He also co-directed the In-
tracranial Hypertension Research Foundation Patient Conference
at the University of Texas in Houston on June 21-22, 2008. Dr.
Katz gave lectures on diagnosis, medical management and optic
nerve sheath fenestration at the conference. Dr. Katz serves as a
scientific advisor for the foundation and regularly sees problem
patients nationally who are referred through the foundation.
He had three publications in peer reviewed journals in the past
year and was a manuscript reviewer for the journals Ophthalmic
Plastic & Reconstructive Surgery and Eye. Dr. Katz was a grant
reviewer for eye and vision research for the American Institute of
Biological Sciences and United States Army Medical Research
and Material Command (as part of the Congressionally Directed
Medical Research Program). He also reviewed grants for the Ann
Ellis Fund at the Columbus Foundation. In 2008, Dr. Katz was
again selected for Best Doctors in America by his peers.
Ophthalmic Pathology Central Ohio
Elson L. Craig, M.D.
All Ophthalmic Pathology specimens
from our department are processed in
The Division of Neuropathology under
the supervision of Abhik Ray Chaudhury,
M.D. Weekly review sessions were con-
ducted which included faculty, residents,
and students from both departments. A
joint report for each case was generated
and filed. For the Fiscal Year July 1, 2007
to June 30, 2008 a total of 548 cases were
examined, reported, and filed in the Divi-
sion Archives of Ophthalmic Pathology.
This total included the following cases:
19 Enucleations
(11 malignant melanomas)
7 Eviscerations
1 Exenteration specimen
34 Orbital tissues
(6 lacrimal gland biopsies)
51 Temporal artery biopsies
151 Eye lid lesions
88 Conjunctival lesions
150 Cornea tissues
(41 Descemet’s membrane
/endothelium specimens)
9 Iris tissues
(2 malignant melanomas)
4 Intraocular lens removed
13 Miscellaneous specimens
(6 foreign bodies, 1 optic nerve
sheath specimen, 1 glaucoma
tube, 4 nasal lacrimal tissues,
and 1 intraocular device)
21 Outside slides for consultation
Lions Eye Bank
This year the Central Ohio Lions Eye
Bank continued to successfully build its
program of providing pre-cut corneas for
DSAEK. Over 200 corneas have been
pre-cut for transplants since the service
was initiated. During 2007-08, the Eye
Bank provided a total of 395 corneas, and
sclera for nine surgeries. Donor eyes for
research and training continue to be pro-
vided with approved applications. Also
this year, the Eye Bank passed inspec-
tion by the FDA, and was inspected and
recertified by the Eye Bank Association
of America, receiving the EBAA’s highest
accreditation rating. The Eye Bank pre-
sented over 100 public and professional
educational programs during the year,
including a certification course for new
remote enucleators. More than 200 Lions
volunteers continue to support the organi-
zation. Ophthalmologists on the Central
Ohio Lions Eye Bank’s Board of Trustees
are Thomas Mauger, M.D., Chairman
of OSU Department of Ophthalmology;
Richard Lembach, M.D., who has served
as the Eye Bank’s Medical Director since
1989; and John Stechschulte, M.D.,
who serves as Associate Medical Direc-
tor. More than 20 ophthalmologists now
routinely use the Eye Bank’s services. In-
dustry support for the Eye Bank this year
included a sustaining gift of $10,000 from
Allergan, and an operating microscope
donated by Carl Zeiss Meditec.
17
Oculoplastics
Kenneth Cahill, M.D.
The Oculoplastic Service is
committed to excellence in clinical
care, research and teaching.
Active participation in medical
school teaching occurs in core cur-
riculum instruction, physical diag-
nosis instruction, clinical rotations,
elective rotations, and research
projects. Resident teaching is orga-
nized with didactic lectures, weekly
staffing of an Oculoplastics Clinic att
the OSU campus, weekly surgery and nd
clinic for ophthalmic plastic surgeryy
during the second year pediatric rota- a-
tion, and third year resident Oculoplas-
las-
tic Surgery rotations. The American
Society of Ophthalmic Plastic and
Reconstructive Surgery (ASOPRS)
Fellowship program compliments
the residency teaching program, andd
provides additional educational and
research resources to the residents.
Members of the Oculoplastic servicee are
John Burns, M.D., Kenneth Cahill, M.D., Kelly
Everman, M.D., Jill Foster, M.D., Steventeven Katz,
M.D., Kevin Michaels, M.D., and James ames Moses,
M.D. Local and national instructional nal courses are
presented in oculofacial surgery, pediatric
diatric oculo-
plastics, cosmetic facial surgery, blepharospasm,
pharospasm,
thyroid eye disease and ptosis. Researcharch presenta-
tions and publications during this pastast year included
topics of ptosis, the lacrimal outflow w system, mini-
mally invasive surgery, the use of tissue
ssue glue in place
of sutures and cosmetic facial surgery.ry.
Refractive Surgery
David Castellano, M.D.
The Refractive Surgery Division continues to see success
from utilizing the combination of both the IntraLase fem-
tosecond (FS) laser and the Custom Cornea/LADARVision
platform from Alcon.
The IntraLase FS laser
creates a much thin-
ner, bladeless corneal
flap which has proved
useful in LASIK treat-
ments by preserving
more corneal tissue.
Custom Cornea tech-
nology enables us to
improve the quality
of visual outcomes
by taking into account higher-order aberrations of the eye
which can cause problems in low-light conditions.
Using these lasers, our patients are able to get a truly
individualized treatment which provides excellent visual
acuity and quality results. Fairly high degrees of myopia,
hyperopia and astigmatism are currently treatable as well as
monovision/blended vision correction for patients over 40
with presbyopia.
Another new addition to the Refractive Surgery Division
are toric and multifocal intraocular lenses. The toric intra-
ocular lenses allow patients to obtain astigmatism correc-
tion during cataract surgery and the multifocal lenses are
used to correct both distance and near vision. We are look-
ing forward to adding intraocular contact lenses for patients
with very high degrees of myopia.
18
Pediatrics
Gary L. Rogers, M.D.
Outpatient clinic visits increased again this year to 8630
patient visits. The clinic continues to be staffed by three
residents from The Ohio State University.
Surgically, the Department of Ophthalmology also continues
to be extremely active. In the year 2007-2008, 3022 ophthal-
mologic surgical procedures were performed at Nationwide
Children’s Hospital. Ophthalmology performed the greatest
number of cases in the Children’s Surgery Center.
The department participates in both funded and unfunded
research. The Early Treatment for Retinopathy of Prematu-
rity (ETROP) investigators have completed the 6 year exams
with 100% follow-up. Several amblyopia protocols and a
randomized nasolacrimal duct study are being conducted
in association with the Pediatric Eye Disease Investigator
Group (PEDIG). Dr. Don Bremer is the Principal Investiga-
tor for these PEDIG trials. Larry Leguire, Ph. D., continues
to work with the OSU Department of Ophthalmology in
functional MRI research with an interest in congenital ocular
motor nystagmus. An eye tracker in the MRI scanner has
been acquired for these studies. Dr. David Rogers has been
active in clinical research with a special interest in corneal
topography in children under anesthesia.
We are working with the hospital to increase the amount of
space for both the laboratory and the clinic. It is our goal to
be a leader in the research of fMRI and changes to the visual
cortex in patients with amblyopia and nystagmus. PEDIG
has recognized our previous research with sinemet and
amblyopia and has started a multi-center study in amblyopia
involving the treatment of older children with amblyopia us-
ing a similar levodopa-carbidopa combination.
Research
Cynthia Roberts, Ph.D.
The Research Division spans all subspecialties of Ophthalmology,
and includes not only the faculty, but also programs that involve
residents, graduate students, and medical students in the scientific
process. For the academic year 2008, the Department of Ophthal-
mology received 13 new research awards and continued work on
24 multiple year grants. These awards focused on: age related
macular degeneration, corneal biomechanics in normal and
pathologic eyes, diabetic macular edema, retinal vein occlu-
sion, glaucoma, idiopathic intracranial hypertension, bacterial
conjunctivitis, fungal keratitis, managing ocular hyperten-
sion, and others. Funding sources included the National
Institutes of Health/National Eye Institute, the Columbus
Foundation, and the Ohio Lions Eye Research Founda-
tion, as well as numerous industry awards. The research
findings produced several peer reviewed publications,
and were reported in multiple presentations at a variety
of Ophthalmology related conferences around the world,
including the American Academy of Ophthalmology and
ARVO, which is the major international scientific meet-
ing for vision research and is held annually in Florida.
The resident research program exposes the residents to
the scientific research process by involving them with
a faculty mentor in either basic science or clinical stud-
ies. Many residents choose a project that spans all three
years of their residency to allow adequate time for a fully
developed project. All residents, fellows, and medical
students are encouraged to attend ARVO and present their
research.
Graduate students in either an M.S. or Ph.D. program
are advised by either Cynthia Roberts, Ph.D., or Deborah
Grzybowski, Ph.D. in their vision-related research. In addi-
tion, one of our affiliated faculty, Jun Liu, Ph.D., also advises
graduate students in vision research.
Many small research projects are supported by the Ohio Lions
Eye Research Foundation, from which the department receives
an annual endowment. The past year has witnessed many ac-
complishments in the Research Division, accomplishments that
reveal new questions to be asked and answered.
19
Retina
Alan D. Letson, M.D.
The Retina Division faculty for the 2007-2008 academic year included John
Christoforidis, MD, Susie Chang, MD, Fred Davidorf, MD and Alan Letson,
MD. Dr. Chang joined the faculty in October of 2007. Dr. Chang is a gradu-
ate of The Ohio State University College of Medicine, completed her Oph-
thalmology Residency at the Cole Eye Institute and her Retina Fellowship
at Massachusetts Eye and Ear. Patient care activity included over 13,600
patient visits, over 12,000 diagnostic imaging procedures for the division
and the department, including OCT, Fluorescein Angiography, Diagnos-
tic Ultrasound and Fundus Auto Fluorescence. The physicians performed
over 1,200 vitreo-retinal procedures, not including intravitreal injections.
Our PDT equipment was updated at our Dublin facility. New Fundus Auto
Fluorescence equipment was purchased. Fred Davidorf managed the ocular
oncology portion of the service with a steady inflow of ocular melanoma
patients.
Research efforts increased significantly during the year. Led by research
manager, Laura Sladoje and clinical coordinators Jill Salerno, Jill Milliron
and Joy Elliot, the division was actively involved in studies sponsored
by National Eye Institute/National Institutes of Health, Genentech and
EyeTech. AREDS 2 recruitment was completed in June 2008, and recruit-
ment for 6 other clinical trials was carried out through this fiscal year. Scott
Savage and his team of photographers of Steven Shelley and Amanda
Barnett contributed to imaging for these retinal trials as well as other trials
performed by other departmental divisions. In addition to the sponsored
clinical trials listed below, Fred Davidorf continued his research in ocular
melanoma and John Christoforidis has been developing high resolution MRI
for ocular diseases in conjunction with the radiology department.
The division maintained its teaching activity by supporting two retinal fel-
lows, Ryan Deasy, MD and Mark Barsamian, DO and working with resi-
dents in their first and second year retina rotations. Dr. Laxson, Dr. Chang
and Dr. Craig are also participating at the Columbus VA Clinic. We have
medical students rotate on the service. Retina faculty deliver weekly retina
lectures to residents and hold imaging conferences with residents and fel-
lows. The faculty also serves as preceptors for resident research projects and
is active in the curriculum of the College of Medicine.
Research
Detecting Cancer Cells in the Bloodstream of Patients with Ocular Melanoma
Frederick Davidorf, M.D. and Mohammed Abdel-Rahman, M.D., Ph.D.
Ocular melanoma can be fatal to patients by spreading to the liver, a process called metastasis. In order to
spread from the eye to the liver, the cancer cells break free from the eye tumor, travel in the bloodstream,
and take up residence in the liver. Approximately half of the patients with ocular melanoma develop liver
metastases. This project centered on detecting cancer cells in the bloodstream of patients with ocular
melanoma. We hypothesized that if a patient has cancer cells in the bloodstream, it is likely that they are
at high risk for developing metastases later. First, we developed a test to detect cancer cells in the blood-
stream. We used a test that could detect molecules that are only found in melanoma cells. If the test de-
tected one of those molecules in the blood sample, we knew it was from a melanoma cell. Next, we used
that test to detect melanoma cells in blood samples of 46 ocular melanoma patients and 30 normal patients.
All of the normal patients had negative tests, showing that our test is accurate. Three of the ocular mela-
noma patients had melanoma cells in their blood samples. Of the two melanoma patients who developed
metastases after their blood was drawn, one of them (50%) had cancer cells in their bloodstream. Of the 39
melanoma patients who have not developed metastases, one of them (3%) had cancer cells in their blood-
stream. In future experiments, we will have to take larger and/or more frequent blood samples in order to
reliably detect cancer cells. However, these results are a promising demonstration that we can detect can-
cer cells in the blood and that their presence likely indicates a high risk status for developing metastases.

Determining the Optical Quality and Impact Resistance of Nike and Oakley
Football Helmet Face Shields – Steven E. Katz, M.D., Randy McLaughlin, O.D., Aaron Zim-
merman, O.D. and Gregory Good, O.D., Ph.D.
A collaborative study between the Department of Ophthalmology and the College of Optometry has
found that the two most commonly used football face shields are durable and have excellent optical qual-
ity that meets industry standards. The study on brand new face shields was published in Optometry,
the official journal of the American Optometric Association in August, 2008. Mounted face shields were
subjected to direct impact from baseballs shot out of an air cannon at speeds up to 218 feet per second.
These findings are significant given that a 1993 study reported on more than 2,000 football-related eye
injuries in subjects under the age of 25. Ongoing work (unpublished data) testing face shields that have
been used for one year has shown that both the optical quality and the durability are significantly dimin-
ished. Game worn shields are very likely to crack or shatter with multiple projectile fragments at impact
that may be encountered on the football field. The goal of this ongoing research is to establish criteria for
equipment managers on when to replace worn face shields in order minimize the risk of ocular damage.

21
Grants
JA Burns (PI), KV Cahill, JA Foster. Evaluation of botulinum A toxins
antigenistic characteristics, Merz Pharmaceuticals, 2006-08.
RB Chambers (PI), FH Davidorf, LJ Chorich, AD Letson. A phase
IIIb, single masked, multicenter, randomized study to evaluate the
safety and tolerability of ranibizumab in naïve and previously treated
subjects with choroidal neovascularization (CNV) secondary to age-
related macular degeneration (AMD) (SAILOR). Genentech Pharma-
ceuticals, 2005–07.
RB Chambers (PI), LJ Chorich, FH Davidorf, AD Letson. Safety as-
sessment of intravitreal Lucentis for AMD: a phase IIIb multicenter
study to evaluate the safety and tolerability of ranibizumab (0.3 mg and
0.5 mg) in naïve and previously treated subjects with CNV secondary
to AMD (SAILOR II), Genentech Pharmaceuticals, 2006-07.
RB Chambers (PI), FH Davidorf. Phase IIIb randomized, double-
masked, sham controlled, multi-center study comparing photodynamic
therapy with Verteporfin (Visudyne) plus two different dose regimens
of intravitreal pegaptanib (Macugen) in patients with subfoveal cho-
roidal neovascularization secondary to AMD (VERITAS) Novartis
Pharmaceuticals, 2005–08.
K Osei,(PI), E Craig, FH Davidorf, AD Letson. Actions to control
cardiovascular risk factors in diabetes eye study (ACCORD), National
Institute of Health (NEI) 2004-09.
JB Christoforidis (PI), FH Davidorf, S Chang. Laser-ranibizumab-tri-
amcinolone for proliferative diabetic retinopathy (DRCR protocol J).
NEI/NIH, 2008-09.
JB Christoforidis (PI), AD Letson, FH Davidorf, S Chang. Ranibizum-
ab for Macular Edema secondary to Branch Retinal Vein Occlusions
(BRAVO). Genentech, 2008.
JB Christoforidis (PI), AD Letson, FH Davidorf, S Chang. Ranibizum-
ab for Maculaer Edema Secondary to Central Retinal Vein Occlusions
(CRUISE). Genentech, 2008.
22
FH Davidorf (PI), RB Chambers, LJ Chorich, J Christoforidis. Obser-
vational study of diabetic macular edema after PRP, Diabetic Retinopa-
thy Clinical Research Network, National Eye Institute (NEI), 2006-07.
FH Davidorf (PI), RB Chambers, LJ Chorich, J Christoforidis. Sub-
clinical diabetic macular edema with OCT, Diabetic Retinopathy Clini-
cal Research Network, National Eye Institute (NEI), 2006-2007.
FH Davidorf (PI), RB Chambers, LJ Chorich. Peribulbar triamcinolone
for diabetic macular edema, Diabetic Retinopathy Clinical Research
Network, National Eye Institute (NEI), 2004-07.
FH Davidorf (PI), RB Chambers, LJ Chorich. Laser photocoagulation
for diabetic macular edema, Diabetic Retinopathy Clinical Research
Network, National Eye Institute (NEI), 2004-07.
FH Davidorf (PI), RB Chambers, LJ Chorich. Phase III, multi-center,
randomized, double-masked controlled study of squalamine lactate
(MSI-1256F) for injection for the treatment of subfoveal choroidal
neovascularization associated with age-related macular degeneration,
Genaera Pharmaceuticals, 2005–07.
FH Davidorf (PI), MH Abdel-Rahman. MET oncogene as a thera-
peutic target for uveal melanoma, Selective Investment Grant, OSU
College of Medicine, 2006–08.
FH Davidorf (PI), RB Chambers, R Deasy. An open-label, multi-center
extension study to evaluate the safety and tolerability of ranibizumab in
subjects with subfoveal choroidal neovascularization (CNV) secondary
to age-related macular degeneration (AMD) who have completed the
treatment phase of a genentech-sponsored ranibizumab study (HORI-
ZON), Genentech Pharmaceuticals, 2006-08.
FH Davidorf (PI), JB Christoforidis. Diabetic retinopathy clinical
research network: a randomized trial comparing intravitreal triamcino-
lone acetonide and laser photocoagulation for diabetic macular edema
(DRCR protocol B). NEI/NIH, 2004-08.
FH Davidorf (PI), AD Letson, JB Christoforidis. Comparison of Anti-
angiogenesis Treatments Trial: a multi center Comparison of AMD
Treatment Trial (Avastin vs Lucentis) in the treatment of wet AMD
(CATT). NIH/Univ. Pennsylvania, 2008-10.
FH Davidorf (PI). Modulation of angiogenesis in ocular disease. OSU
Patti Blow Research Fund in Ophthalmology, 2000-07.
DM Grzybowski (PI). An in vitro model of CSF outflow through the
arachnoid membrane for IIH. North American Neuro-Ophthalmology
Society Pilot Research Grant, 2007–08
DM Grzybowski (PI), SE Katz. Clinical Investigation of CSF and blood
biological mediators of Idiopathic Intracranial Hypertension – A Pilot
Study. Health Services Strategic Initiative Research Grant, 2007–09
DM Grzybowski (PI). Identification of Vitamin A Metabolic Pathway
Receptors in Human Arachnoid Membrane. Intracranial Hypertension
Research Foundation, 2007-08.
DM Grzybowski (PI), M Lubow, PA Weber. Comparison of Novel
Antiproliferatives to Improve the Long Term Success of Glaucoma
Filtration Surgery. The Columbus Foundation, 2006-08.
RG Lembach (PI), CJ Roberts. Evaluation of the utility of intra-opera-
tive topography to optimize corneal shape during penetrating Kerato-
plasty. BIOMEC, 2004-07.
AD Letson (PI), FH Davidorf, JB Christoforidis, S Chang. A Phase IV,
open label, multi-center, trial of maintenance intravitreous injections of
Macugen® (pegaptanib sodium) given every 6 weeks for 48 weeks in
subjects with subfoveal neovascular Age-Related Macular Degenera-
tion initially treated with a modality resulting in maculopathy improve-
ment (LEVEL). OSI/EyeTech, 2006-08.
AD Letson (PI), JB Christoforidis, FH Davidorf. Age-related eye dis-
ease study 2: a multi-center, randomized trial of lutein, zeaxanthin, and
omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid
[dha] and eicosapentaenoic acid [epa]) in age-related macular degenera-
tion (AREDS2). NEI/EMMES, 2006-12.
AD Letson (PI), FH Davidorf, JB Christoforidis, R Deasy. Ranibizum-
ab injections for Diabetic Macular Edema: a phase III, double-masked,
multicenter, randomized, sham-controlled study of the efficacy and
safety of ranibizumab injection in subjects with clinically significant
macular edema with center involvement secondary to diabetes mellitus
(RIDE). Genetech, 2007-11.
J Liu (PI), CJ Roberts. The Impact of Corneal Elasticity on IOP and CCT
Measurement in Glaucoma Management. Columbus Foundation, 2008-09.
TF Mauger (PI), RG Lembach, ME Dangel, R Harder Smith. Rates
and risk factors for fungal keratitis among contact lens wearers. John
Hopkins University, 2006-08.
TF Mauger (PI), RG Lembach, D Castellano, R Harder Smith. A
double-masked randomized study of the safety and effectiveness of
DYME as an agent for selective staining of the anterior capsule during
cataract surgery. Aqumen Biopharmaceuticals, N.A., Inc., 2007-08.
TF Mauger (PI), R Harder Smith, A Horne, J Lewis, W Lawhorn.
Corneal Oxygen Uptake Measurements in Diseased Corneas. Internal
Funding by the Department of Ophthalmology 2007-08.
CJ Roberts (PI). A Study of MicroPulsed and low Fluence Diode
Laser-Tissue Interaction with Cultured Human Trabecular Meshwork
Cell Monolayers. Iridex, 2005-2008.
CJ Roberts (PI). Measurement and Evaluation of the Elastic and Viscous
Properties of the Cornea in Glaucoma. Columbus Foundation, 2006-2008.
CJ Roberts (PI), AS Litsky, RG Lembach, PA Weber. Biomechanical
Characterization of the Cornea in Pathologic Eyes. OSU Health Ser-
vices Strategic Initiative Grant, 2007-08.
PA Weber (PI), ND Baker, F Kapetansky, RJ Derick. Ocular hyperten-
sion treatment study (OHTS), National Eye Institute (NEI), 1994-2008.
R Xu (PI), CJ Roberts, L Leguire. Functional image of visual cortex
& retina tissue for vision pathophysiology.” Children’s Hospital/OSU
Collaborative Research Award, 2006-08.
23
Oxley Library
Publications & Presentations
Publications
Diabetic Retinopathy Clinical Research Network
(OSU Site: Christoforidis JB, Davidorf FH).
“Reproducibility of macular thickness and volume
using Zeiss optical coherence tomography in patients
with diabetic macular edema”. Ophthalmology,
114:1520-1525, Aug 2007.
Diabetic Retinopathy Clinical Research Network (OSU
Site: Christoforidis JB, Davidorf FH). “The risk of
endophthalmitis following intravitreal triamcinolone
injection in the DRCRnet and SCORE Clinical Trials”.
Am J Ophthalmol, 144:454-456, Sep 2007.
Diabetic Retinopathy Clinical Research Network (OSU
Site: OSU Site: Christoforidis JB, Davidorf FH). “Retinal
thickness on Stratus™ optical coherence tomography
in people with diabetes and minimal or no diabetic
retinopathy”. Am J Ophthalmol, 145:894-901, Feb 2008.
Diabetic Retinopathy Clinical Research Network
(OSU Site: OSU Site: Christoforidis JB, Davidorf
FH). “Comparison of Time-Domain OCT and Fundus
Photographic Assessments of Retinal Thickening
in eyes with Diabetic Macular Edema”. Invest
Ophthalmol Vis Sci, 49:1745-1752, May 2008.
Christoforidis JB, Warden SM, Farrell G, Baker M,
Mukai S. “Histology of retina overlying bacterial
subretinal abscess and implications for treatment”. Retinal
Cases and Brief Reports. 1(4) 257-260, Fall 2007.
Action to Control Cardiovascular Risk in Diabetes Study
Group (OSU Site: Davidorf FH, Craig E, Letson
AD). “Effects of intensive glucose lowering in type 2
diabetes”. N Engl J Med, 358:2545-2559, June 2008.
Lubow M, Grzybowski DM, Awad H. “Denileukin Diftitox
Vision Loss is Not PION.” Leukemia and Lymphoma, Leuk
Lymphoma. (author reply 372) 49(2) 370-1, Feb 2008.
25
Rennebohm RM, Lubow M, Rusin J, Martin L,
Grzybowski DM, Susac JO. “Aggressive immuno-
suppressive treatment of Susac’s syndrome in an
adolescent: using treatment of dermatomyositis as a
model”. Pediatr Rheumatol Online J. 6(1) 3, Jan 2008.
Grzybowski DM, Herderick EE, Kapoor K, Holman DW,
Katz SE. “Human Arachnoid Granulation Topographic
Distribution Part I: Implications for Cerebrospinal Fluid
Outflow”. CSF Research. 4:1-7, 2007.
Baker KR, Zimmerman A, Grzybowski DM,
McLaughlin WR, Katz SE, Pfriem DB, Good GW.
“Optical Quality and Impact Resistance Comparisons of
Two Football Helmet Faceshields”. Journal of American
Optometric Association. 79(8) 455-463, 2008.
Roberts CJ, Rivera BK, Grzybowski DM, Mahmoud
AM, and Weber PA. “Effect of low fluence diode laser
irradiation on the hydraulic conductivity of perfused
trabecular meshwork endothelial cell monolayers”.
Current Eye Research. 32(7) 625-638, 2007.
Hoyle JC, Katz SE, Newton HB. “Prognosis of
Refractory Neurosarcoidosis Altered by Thalidomide:
Case Report”. Journal of Medical Case Reports.
2(27) 1-5, 2008.
Maddox RA, Belay ED, Curns AT, Zou WQ, Nowicki S,
Lembach RG, et al. “Creutzfeldt-Jakob disease in recipients
of corneal transplants”. Cornea. 27:851-864, 2008.
Mahmoud AM, Roberts CJ, Lembach RG, Twa MD,
Herderick EE, McMahon TT, and the CLEK Study Group.
“CLMI: The Cone Location and Magnitude Index”.
Cornea. 27:480-487, 2007.
Liu J, He X, Pan X, Roberts CJ. “Ultrasonic Model
and System for Measurement of Corneal Biomechanical
Properties and Validation on Phantomes”. Journal of
Biomechanics. 40(5) 1177-1182, 2007.
Mauger TM (Editor). “Ophthalmology Clinical Case Studies”.
Oral Board Exam Review. Anadem Publishing, 2007.
Qazi MA, Cua IY, Roberts CJ, Pepose JS. “Determining corneal
power using Orbscan II videokeratography for intraocular lens
calculation after excimer laser surgery for myopia”. J Cataract
Refract Surg. 33(1) 21-30, 2007.
Touboul D, Roberts CJ, Kérautret J, Garra C, Maurice-Tison S,
Saubusse E, Colin J. “Correlations between Corneal Hysteresis,
Intraocular Pressure and Corneal Central Pachymetry”. Journal
of Cataract and Refractive Surgery. 34(4) 616-622, 2008.
Kerautret J, Colin J, Touboul D, Roberts CJ. “Ocular response analyzer
after LASIK: Comparison between ectatic and non ectatic eye”. Journal
of Cataract and Refractive Surgery. 34(3) 510-513, 2008.
Glass DH, Roberts CJ, Litsky AS, Weber PA. “A viscoelastic
biomechanical model of the cornea describing the effect of
viscosity and elasticity on hysteresis”. Invest Ophthalmol Vis Sci.
49(9) 3919-3926, 2008.
Roberts CJ. “Corneal Topography” In Dimitri T. Azar (ed), Damien
Gatinel, Thanh Hoang-Xuan (assoc. eds), and Ramon C. Ghanem (DVD
ed). Refractive Surgery. 2nd edition. Elsevier; 2007:103-116.
Roberts CJ. “Biomechanics of INTACS in Keratoconus.”
Chapter 10 In: Ertan A and Colin J (eds). Intracorneal Ring
Segments and Alternative Treatments for Corneal Ectatic
Diseases. Ankara Turkey: Kudret Eye Hospital; 2007:157-166.
Tandon A. “Five quick ways to take care of your eyes”. Health
Magazine. pg 110, April 2008.
Gordon MO, Beiser JA, Kass MA for the Ocular Hypertension
Treatment Study Group (OSU Site: Weber PA, Baker ND,
Kapetansky FM, Derick RJ). “Is a history of diabetes mellitus
protective against developing primary open-angle glaucoma?”
Arch Ophthalmol. 126:280-282, 2008.
Brandt JD, Gordon MO, Beiser JA, Lin SC, Alexander MY, Kass
MA and the Ocular Hypertension Treatment Study Group (OSU Site:
Weber PA, Baker ND, Kapetansky FM, Derick RJ). “Changes in central
corneal thickness over time: the Ocular Hypertension Treatment Study”.
Ophthalmology. 115:1550-1556, 2008.
26
Presentations
Fleming GP. “Gonioscopic Evaluation of the Anterior Chamber
Angle”. JCHAPO Annual Meeting. New Orleans, LA. November
12, 2007.
Hirsh DK. “Initiating Treatment in Giant Cell Arteritis”. 51st
Annual Postgraduate Symposium in Ophthalmology, Ohio State
University March 2, 2008.
Grzybowski DM. “Human Arachnoid Membrane: Active trans-
port of amyloid-beta”. Society for Research into Hydrocephalus
and Spina Bifida Annual Meeting. Providence, RI. June 13, 2008.
Grzybowski DM. “Amyloid-β and Glaucoma: The Retinal Gan-
glion Cell - Neurotoxic Connection”. North American Neuro-oph-
thalmology Society Annual Meeting. Orlando, Florida. March 11,
2008.
Grzybowski DM. “CSF Outflow Revisited: A New Paradigm”.
Society for Research into Hydrocephalus and Spina Bifida Annual
Meeting. Providence, RI. June 11, 2008.
Grzybowski DM. “The Effect of Vitamin A on Cultured Arach-
noid Granulation Cells: Implications for Idiopathic Intracranial
Hypertension”. North American Neuro-ophthalmology Society
Annual Meeting. Orlando, Fl. March 10, 2008.
Grzybowski DM. “Cytopathology of Hydrocephalus”. The Brain
Child Steering Committee. Salt Lake City, UT. October 29, 2007.
Katz SE “Thyroid Orbitopathy Update”. The Paul A. Weber In-
vited Lectureship, 51st Annual Postgraduate Symposium in Oph-
thalmology, The Ohio State University. Columbus, OH. February
29, 2008.
Katz SE “Idiopathic Intracranial Hypertension: Presenting Symp-
toms and Observed Signs”. Intracranial Hypertension Research
Foundation Patient Conference, University of Texas. Houston,
TX. June 21, 2008.
Katz SE “Medical Management of Idiopathic Intracranial Hyper-
tension”. Intracranial Hypertension Research Foundation Patient
Conference, University of Texas. Houston, TX. June 21, 2008.
Katz SE “Optic Nerve Sheath Fenestration in Idiopathic Intracra-
nial Hypertension”. Intracranial Hypertension Research Founda-
tion Patient Conference, University of Texas. Houston, TX. June
21, 2008.
Keates RH. “Corneal Crosslinking”. Northwest Ohio Ophthalmo-
logical Society. Toledo, OH. April 22, 2008.
Glass DH, Roberts CJ, Litsky AS, Weber PA, Lembach RG.
“The Response of the Keratoconic and Normal In Vivo Human
Cornea to an Air Pulse Using the Ocular Response Analyzer”.
Twenty-Eighth Annual Research Symposium in Ophthalmology,
The Ohio State University. Columbus, OH. June 13, 2008.
Letson AD. “Retinal Angiography and vascular Abnormalities
in Susac’s Syndrome and Other Endotheliopathies”. 4th Annual
Susac’s Syndrome Symposium, The Ohio State University. Co-
lumbus, OH. May 15, 2008.
Barsamian MD, Chang S, Mouser JG, Deasy R, Christoforidis
JB, Davidorf FH, Letson AD. “Intravitreal Bevacizumab for the
Treatment of Choroidal Neovascular Membranes associated with
Presumed Ocular Histoplasmosis Syndrome”. Association for
Research in Vision and Ophthalmology (ARVO). Fort Lauderdale,
FL. April 27, 2008.
Roberts CJ. “Practical Interpretation of Elevation and Curvature
Maps in Refractive Surgery: In Principles of Orbscan Topography
and Interpretation of Elevation and Curvature Maps for Early
Keratoconus Detection”. ASCRS Course. Chicago, IL. April 5,
2008.
Roberts CJ. “Integration of Corneal Biomechanics into the
Treatment of Irregular Astigmatism: In Customized Ablation in
Surgical Management of Irregular Astigmatism”. ASCRS Course.
Chicago,IL. April 7, 2008.
Roberts CJ. “Basics of the Ziemer Galilei: In Basic Course on
Galilei, New System Combining Dual Scheimpflug and Placido
Topography”. ASCRS Course. Chicago, IL. April 7, 2008.
Roberts CJ. “Clinical Applications of Corneal Biomechanical
Measurements with the ORA for Refractive Surgery and Glau-
coma: In Clinical Applications of Corneal Biomechanical Mea-
surements with the ORA for Refractive Surgery and Glaucoma”.
ASCRS Course. Chicago, IL. April 7, 2008.
Roberts CJ. “Topographies of Biomechanical Changes: In Ad-
vanced Corneal Topography for Refractive Surgeons”. ASCRS
Course. Chicago, IL. April 8, 2008.
Roberts CJ. “What’s New in Corneal and Ocular Biomechanics.”
College of Optometry Seminar Series, The Ohio State University.
Columbus, OH. February 19, 2008.
Roberts CJ. “Basics Principles of the Galilei” Galilei Users
Meeting, ASCRS. Chicago, IL. April 4, 2008.
Roberts CJ. “Biomechanical Basis of Keratoconus and Effects
of Photoablation on Stability: In JCRS Symposium on High Risk
Scenarios in Cataract and Refractive Surgery”. ASCRS. Chicago,
IL. April 7, 2008.
Roberts CJ. “LASIK Ectasia: What Every Refractive Surgeon
Needs to Know”. Symposium of the X International Congress of
Cataract and Refractive Surgery. Goiânia, Brazil. May 15, 2008.
Roberts CJ. “Corneal Biomechanics: What Have we Learned
from Refractive Surgery?” Symposium of the X International
Congress of Cataract and Refractive Surgery. Goiânia, Brazil.
May 16, 2008.
Roberts CJ. “Biomechanical Customization: The Next Genera-
tion of Refractive Surgery.” José Barrequer Medal and Inaugural
Lecture, X International Congress of Cataract and Refractive
Surgery. Goiânia, Brazil. May 16, 2008.
Roberts CJ. “Studies with the Pascal Dynamic Contour Tonome-
ter.” Symposium of the X International Congress of Cataract and
Refractive Surgery. Goiânia, Brazil. May 16, 2008.
Roberts CJ. “Pros and Cons of Pentacam in Anterior Seg-
ment Diagnosis: CON.” JCRS Symposium on Controversies in
Cataract and Refractive Surgery, XXV Congress of the ESCRS.
Stockholm, Sweden. September 10, 2007.
Tandon A. “Lecture Series and Wet Lab Instruction”. Kellogg
Cataract Conference, University of Michigan. Ann Arbor, MI.
September 2007
Tandon A. “Differential Diagnosis of Red Eye”. ATPO Monthly
Meeting. Columbus, OH. October 2007.
27
Royal Sonesta Hotel, New Orleans
 Outreach

Dr. & Mrs David Adam and Jonathan Davidorf, M.D., Mark Drabkin, M.D.,
Dr. & Mrs. Stephen Collins Paul Weber, M.D. and Jason Jones, M.D.

Havener Annual Alumni Reception at AAO

Every fall we celebrate the rich history of the Havener Eye Institute by bring-
ing together the many alumni that the Department has trained over the years
at a reception at the AAO annual meeting. Whether they are last year’s gradu-
ating residents or former residents under Dr. Havener, we welcome them to
an evening reception and honor the tradition that has spread far beyond our
campus borders.
The 2007 Alumni Reception was held in New Orleans at the Royal Sonesta on
Bourbon Street. This event once again provided a wonderful way to reconnect
with former colleagues and friends.

29
 2008 BuckEYE Golf Classic
BuckEYE
Benefactor
Bash
In recognition
o
of the generos-
iity shown by
sso many, the
Department
D
hosts an annual
hos
BuckEYE Benefac-
BuckE
tor Bash for alumni,
donors, aand friends of
Havener Eye Insti-
the Haven
tute. In O October of 2007,
it was held at the Ohio
Stadium in th the Presidential
Suite. Members of The Ohio State
University Alumni Band entertained
traditional Buckeye
the group with traditio
music. The Ohio State Buckeyes
were in Happy Valley p playing the
Penn State Nittany LioLions on their
home turf. It was a gr great evening
of fun watching Ohio State coach,
Jim Tressel, lead the Buckeyes to
a easy 28-6 victory o over the Lions. A beautiful, cloudless day greeted the 88 golfers that participated
in this year’s 2008 BuckEYE Golf Classic. The past two golf
outings had good weather, but this year was outstanding. With The
State Coach, Joe
In the end Penn Stat
Paterno, had to admadmit, “Their Ohio State University Buckeyes’ Football Coach Jim Tressel on hand
defense played w well. They can to support the charity outing, the day was a tremendous success.
well coached, and
run, they are wel The golfers showed up early to stand in line to buy an autographed
scheme.”
run a good sche football and take a photo with Coach Tressel. “With over a hundred

30
 first BuckEYE Golf Classic with Archie Griffin enabled the de-
partment to buy the expensive textbooks that are required for
resident lectures and education.
Last year, the 2007 BuckEYE Golf Classic had OSU Basketball
Coach Thad Matta as the special guest. With Coach Matta on
board, the department was able to raise enough money to complete-
ly update one of the examination rooms in the resident clinic. “The
resident clinic’s exam rooms are in critical need of new equipment,”
said Dr. Alan Letson, Havener Eye Institute Residency Director,
“Without the proceeds from the BuckEYE Golf Classic, it wouldn’t
have been possible.”
Ellen Tressel was also on handnd to lend her gen-
erous support by exhibiting her talent as an
rsome that shot
excellent golfer. She led a foursome
12 under par and tied for 3rd Place.
The 2008 BuckEYE Golf Classic ssic raised over
$65,000. “Along with the golfers, we had
so many wonderful sponsorss this year led by
major sponsor Fifth Third Bank,” said Sladoje,
munity was just
“the support from the community
amazing.”
“This year’s outing will bring us
hasing
closer to our goal of purchasing
updated equipment for the whole
resident clinic,” said Letson. son.
“Outfitting the patient rooms ms
with state-of-art examination on
and diagnostic equipment is
giving these young physi--
cians the tools to succeed.
footballs we thought for sure we’d have extra, but we sold out At the Havener Eye Insti-
without a single to spare,” said Laura Sladoje, Outreach Direc- tute, we believe that to-
tor for the Havener Eye Institute. “We were thrilled to have Jim gether we can improve the
Tressel as our special guest this year, and knew it would be a future of eye care by educat-
great opportunity to raise money for the residents”. ing tomorrow’s physicians. s.
The BuckEYE Golf Classic was started as a way to raise funds The BuckEYE Golf Classic is
for the OSU Department of Ophthalmology. Proceeds from the helping us reach that goal.”

31
The Eye & Systemic Disease
51st Annual Ophthalmology Postgraduate Symposium
On February 29 - March 1, 2008, the Havener Eye Insti-
tute sponsored the 51st Annual Ophthalmology Postgrad-
uate Symposium at the Hilton Easton in Columbus, Ohio.

This year’s conference focused on systemic diseases

related to the eye. The focus was an update for ophthal-
mologists on a wide variety of topics given by
physicians who are experts in their specialties.
These lectures provided practical review and
new knowledge to both the general and specialty ophthalmologist.

The course director was David K. Hirsh, M.D., Clinical Assistant

Professor at The Ohio State University. The meeting faculty included
Gregory Christoforidis, M.D., David Hirsh, M.D., Steven Katz, M.D.,
Eric Kraut, M.D., Boris Karanfilov, M.D., Herbert Newton, M.D.,
Kwame Osei, M.D., Enver Ozer, M.D., Jonathan Trobe, M.D., Judith
Westman, M.D., Ronald Whisler, M.D., and Matthew Zirwas, M.D.

The Annual Havener Society Dinner was held

Friday evening February 29, 2008. Along with Dr.
Don Lewis, a new inductee to the Havener Soci-
ety, Dr. Holton Letson and Dr. Henry & Suzanne
Croci were recognized for achieving new heights
of giving and advancing to the Havener Society’s
Fellow Circle.

32
Ophthalmology
International Missions
Akin-Akrosa, Ghana
Establishing a tradition in Ophthalmology

www.eye.osu.edu

Havener Eye Institute

456 West 10th Avenue, 5th Floor
Columbus, OH 43210
614-293-8116