«Approved»

Dean of the foreign students

Professor _______________Yu.G.Poostovyy
«____»________________2010

LECTURE TOPICS FOR IV STUDENTS

2010-2011 academic year
№ п/п Topic Content Lecture Day
1. Tuberculosis as scientific and Tuberculosis as scientific medical and humanitarian Ph.D For content
humanitarian challenge. challenge. Main eras of the tuberculosis investigation. M.G.Dolynska module 1,
Historical review. Epidemiology, Gippocarat, Avicenna, R.Koch, R.Laennec, W.Roentgen, Topic 1.
etiology and pathogenesis. A.Calmett, C.Geren, A.I.Abricosov, N.I.Pyrogov, First day of
Immunity. Z.Waksmann, K.Styblo. classes.
Incidence and prevalence of the disease in different
countries. Different approach of the tuberculosis
epidemiology. Descriptive epidemiology. Etiologic
epidemiology. Predictive epidemiology. Risk factors.
Pathomorghology of the tuberculosis.
Causative agent of the tuberculosis: morphology,
tinctorial properties, resistance in the environment.
Mycobacteria types. Variability (L-form, persisting,
reversion). Drug resistance (Multidrug resistance (MDR),
extensively drug resistance (XDR)).
Sources of the infection and ways of transmission,
interaction with the human being. Local and general reaction
onto innoculation. Native resistance and antituberculosis
immunity. Humoral and cell immunity.

2. Case detecting Ways and approaches of case detecting. Risk groups. Risk Ph.D For content
evaluation. High risk and populational strategy of case M.G. Dolynska module 2,
detecting. Topic 2.
Clinical examination of the TB patient peculiarities. The Second day of
most typical complaints, course, anamnestic data, risk factor classes.
revealing; social, family and personal history. Physical
 examination: palpation, percussion, auscultation significance.
Routine laboratory tests. Functional tests.
Etiological (microbiological) tests. Direct
microscopy and cultural tests as a “gold standard” of case
detecting. Accelerated cultural tests: Middlebrook,
BACTEC sets. Polymerase chain reaction (PCR) and
ELISA tests. Approach of resistance detecting.
Radiological examination place. Main methods of
radiological examination. Plain chest X-ray examination and
CT scanning significance. Main radiological syndromes
typical for tuberculosis: hilum widening, lung patterns
changing, dissemination, limited opacity, ring-like and round
shadow.
Screening X-ray examination: different national
strategies. WHO recommendation.
Diagnostic algorithms in TB suspicion.
Tuberculin test. Tuberculin preparations. Modern
tuberculin probes. Tuberculin test conversion. Differential
diagnosis between pos-vaccine immunity and latent
tuberculosis.
3. Primary and secondary tuberculosis Primary and secondary tuberculosis pathogenesis. Ph.D For content
Morphological peculiarities. Typical course of each type. M.G.Dolynska modules 3-4,
Early period of the tuberculosis infection. Pre-local Topics 3-6.
tuberculosis. Intrathoracic lymph nodes tuberculosis. Clinical Third day of
peculiarities, differential diagnosis, complication, residuals. The classes
significance of residuals in secondary tuberculosis
development. Chronic primary tuberculosis. Primary
tuberculosis peculiarities at different age. Primary
tuberculosis in adults.
Miliary tuberculosis pathomorphology. Frequency
among immunocompromised and non-immunocompromised
patients. Clinical variants. Differential diagnosis. Prognosis.
Tubercle meningitis as generalized type of primary and
secondary tuberculosis. Clinical peculiarities, differential
diagnosis, complication, outcomes, residuals.
Disseminated tuberculosis. Frequency and
pathomorphology. Clinical variants (sub-acute and chronic).

4. Tuberculosis treatment:
general principles and approach
Clinical peculiarities, differential diagnosis, complication,
residuals.
Focal and infiltrative tuberculosis. Pathomorphology,
clinical peculiarities. Foci activeness appreciation. Causes of
progressing and advanced cases appearance. Clinico-
radiological infiltrates types. Residuals.
Caseous pneumonia. Clinico-radiological variants.
Differential diagnosis, outcomes, prognosis, residuals.
Tuberculoma, morphological variants. Classification.
Clinical course peculiarities. Ways of revealing. Differential
diagnosis, management peculiarities. Outcomes, prognosis.
Pleural tuberculosis. Diagnostic peculiarities. Differential
diagnosis, outcomes, prognosis, residuals.
Chronic tuberculosis (fibrous-cavernous, cirrhotic).
Causes of development. Pathomorphological peculiarities.
Variants and clinical course peculiarities. Differential
diagnosis, outcomes, prognosis.
Secondary tuberculosis complication. Pulmonary
haemorrhage, spontaneous pneumathorax, heart insufficiency,
amyloidosis, pleurisy, haematogenic dissemination.
Management and prevention. Residual classification.
Secondary tuberculosis case demonstration.
General principles of antimycobactrial treatment. Ph.D. For content
Historical background. M.G.Dolynska modules 5,
Antituberculosis drugs: classification, dosage Topics 7.
mechanisms of activity. Side effects: treatment and Forth day of
prevention. classes
Organizational principles of DOTS (Directly observed
treatment short course). The five elements of the expanded
DOTS framework. Basical treatment regimens. Multidrug
resistance (MDR), extensively drug resistance (XDR)
management. Second-line drugs. Expanded treatment
conception: appropriate antibacterial treatment, hygienic and
dietary regimen, pathogenetic measures (desintoxication,
hepatotropic therapy, tissue stimulation, collapsotherapy).
Surgical treatment.
Recovery criteria.
 5. Tuberculosis: Chain of Transmission. Social, medical, sanitary approach. Professor For content
preventive interventions BCG vaccination. National recommendations concern with Yu.G.Poostovyy modules 5,
indication and contraindication. Immunity properties. Topics 7.
Vaccination procedure. Post-vaccination period. Fifth day of
Complications and safety. classes.
Drug preventive courses. Indication, regimen.
Sanitary preventive interventions. Hotbed of the tuberculosis
infection. Priority of hotbeds. Interventions in hotbeds.
Sanitary education methods and significance.

Approved on chair meeting August, 31 2010 Protocol №1_______

Head of the Phtisiology chair,

Professor _______________Yu.G.Poostovyy

Mehodic board head ,

Professor _______________Yu.N.Kolchin