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  • Pathopysiology of Colorectal CA

    Transféré par

    RicherAguilarYSanchez
    89 vues2 pages
    This document summarizes the pathophysiology of colorectal cancer. It involves predisposing factors like increasing age and diet that can lead to alterations in gut bacteria and the concentration of potential carcinogens in the colon. These carcinogens can then undergo metabolic activation and electrophilic reactions to cause permanent DNA damage and mutations, especially in the p53 and ras genes. This promotes the growth of mutated cells and the development of preneoplastic polyps that can enlarge into malignant neoplasms and colon cancer.

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    This document summarizes the pathophysiology of colorectal cancer. It involves predisposing factors like increasing age and diet that can lead to alterations in gut bacteria and the concentration of potential carcinogens in the colon. These carcinogens can then undergo metabolic activation and electrophilic reactions to cause permanent DNA damage and mutations, especially in the p53 and ras genes. This promotes the growth of mutated cells and the development of preneoplastic polyps that can enlarge into malignant neoplasms and colon cancer.

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    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOC, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    89 vues2 pages

    Pathopysiology of Colorectal CA

    Transféré par

    RicherAguilarYSanchez
    This document summarizes the pathophysiology of colorectal cancer. It involves predisposing factors like increasing age and diet that can lead to alterations in gut bacteria and the concentration of potential carcinogens in the colon. These carcinogens can then undergo metabolic activation and electrophilic reactions to cause permanent DNA damage and mutations, especially in the p53 and ras genes. This promotes the growth of mutated cells and the development of preneoplastic polyps that can enlarge into malignant neoplasms and colon cancer.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme DOC, PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 2

    Pathophysiology of Colorectal CA

    Predisposing Fx Precipitating Fx
    • 90% in age >50 (pt-68) • Adenomatous polyps
    • Race: Asian
    • Alcohol Intake
    • Fat/Low fiber intake

    Alteration in fecal-floral

    Degradation of bile salt or


    Breakdown products
    Of protein and fats

    Maybe carcinogenic

    Concentration of potential
    Carcinogens into smaller Presence of Carcinogen in the
    volume descending colon

    Metabolism
    (metabolic actiation)

    Electrophilic reaction

    Carcinogen Normal Cells


    (Electron deficient) (Electron rich)

    ascites Attack to DNA, RNA p53 gene mutation


    Protein

    Permanent DNA damage Mutation of ras


    (Mutation)

    Altered differentiation Promote growth of mutated cells

    Preneoplastic clone

    Colorectal Polyps

    Enlargement of polyps

    Malignant neoplasm

    Colon cancer

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