DRUGS FOR GESTATIONAL TROPHOBLASTIC DISEASE

DRUG CLASSIFICATION ACTION INDICATION/CONTRAINDICATION NURSING

RESPONSIBILITY
Methotrexate Antineoplastic Inhibits dihydrofolic Indication: Treatment of Hydatidiform  Arrange for tests
acid reductase, leading mole. to evaluate CBC,
to inhibition of DNA Contraindication: Used cautiously with urinalysis, liver
synthesis and inhibition renal disease, infection, peptic ulcer, and renal function
of cellular replication. ulcerative colitis, debility. tests, and chest x-
rat before theapy,
and during
therapy and for
several weeks
after therapy,
severe toxicity
could occur.
 Reduce dosage or
discontinue if
renal failure
occurs.
 Arrange for
antiemetic if
nausea and
vomiting are
severe.
 Arrange adequate
hydration during
therapy to reduce
the risl of
hyperuricemia.
 Do not administer
any other
medication
containing
alcohol.
Dactinomycin Antibiotic Cytotoxic: inhibit Indication: gestational trophoblastic
Antineoplastic synthesis of messenger neoplasia, as monotherapy or Use strict handling
RNA, causing cell combination. procedures, drug is
death. Contraindication: allergy to extremely toxic to skin
Dactinomycin, pregnancy, lactation and and eyes.
chicken pox. Do not give IM or
subcutaneously, severe
local reaction and tissue
necrosis occur, IV use
only.
Monitor injection site for
extravasation, burning, or
stinging. Discontinue
infusion immediately,
apply cold compress to
the area, and restart in
another vein.
Oxytocin Hormone Stimulate the uterus Indication: To produce uterine
Oxytocic especially the gravid contraction during the third stage of Monitor maternal BP
uterus just before labor and to control post partum during oxytocin
parturition, and cause bleeding or hemorrhage. administration;
myoepithelium of the Contraindication: unfavorable position discontinue drug and
lacteal glands to or presentation, cephalopelvic notify physician with any
contract, which results disproportion, previous cesarean sign of hypertensive
in milk ejection in section, pregnancy. emergency.
women.

Jean arellano B.S Nursing A303

DRUG FOR INCOMPETENT CERVIX

DRUG CLASSIFICATION ACTION INDICATION/ NURSING

CONTRAINDICATION RESPONSIBILITY

Tocolytics Tocolytic drug Relax the pregnant uterus, Indication: prevent preterm
labor.
Terbutaline Sulfate
Contraindication: Use
cautiously with diabetes,
hypertension.
Use minimal doses for
minimal period of time,
drug tolerance can occur for
prolonged use.
Do not exceed
recommended dosage.