Product Information Novel Kinase Inhibitors

for cell signaling & oncology research

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Formula: C28H22F3N7O CF3
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Solubility: DMSO O
H
Purity: 99% N N
N N N Tech Support
H tech@selleckchem.com
N
Storage: at -20℃ 2 years N
(chemistry support)
CAS No.: 641571-10-0 Synonyms: Tasigna, AMN-107 techbio@selleckchem.com
(bio support)

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Biological Activity
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AMN107 was quantitatively via capture ELISA for its effect on cellular Bcr-Abl autophosphorylation
activity and on Bcr-Abl-dependent cell proliferation. AMN107,IC50 =20–60 nM.[1] The effects of
AMN107 were compared with those of imatinib on imatinib-sensitive (KBM5 and KBM7) and
imatinib-resistant CML cell lines (KBM5-STI571R1.0 and KBM7-STI571R1.0). Compared with the
antiproliferative activity of imatinib , AMN107 was 43times more potent in KBM5 (IC50 of 11.3
versus 480.5 nM) and 60 times more potent in KBM7(IC50 of 4.3versus 259.0 nM) cells. IC50 for
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AMN107 and imatinib were 2,418.3 and 6,361.4 nM, respectively, in KBM5- STI571R1.0, and 97.2
and 2,497.3nM, respectively, in KBM7-STI571R1.0 cells.[2]

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Please inspect packages immediately upon
[1] Ellen Weisberg et al. Cancer Cell. 2005 February;17(2):129-141 receipt and notify customer service within

[2] Mirna Golemovic et al. Clinical Cancer Research.2005 July; 11:4941 3 days of delivery of any damage or

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