IF IMMUNITY IS YOUR

TOP PRIORITY...
 INTRODUCTION
— Immune system plays pivotal role in fighting against
pathogenic microbes thereby helps in maintaining
overall health and well-being of bird.
— The primary role of the immune system is to recognize
foreign organisms that have managed to enter the
system and initiate appropriate physiological responses
to neutralize or eliminate them.
— The avian immune system have both non-specific and
specific defence mechanisms to fight against infectious
agents which includes :
1. Innate (nonspecific) immunity
2. Adaptive (specific) immunity
— Animals in a production environment can be exposed to
stressors and infectious diseases that impair innate and
adaptive immunity, erode general health and welfare,
and diminish genetic and nutritional potential for
efficient production.
— Innate immunity can be affected by stressful physiologic
events related to hatching and to environmental factors
during the first week of life. Exposure to environmental
ammonia, foodborne mycotoxins, and suboptimal
nutrition can diminish innate immunity.
— Similarly, the Infectious bursal disease (IBD), chicken
infectious anemia (CIA), and Marek's disease (MD) are
major infectious diseases that increase susceptibility to
viral, bacterial, and parasitic diseases and interfere with
adaptive vaccinal immunity.
— In general the control measures for tackling the avian
immunosuppression rely largely on minimizing stress,
reducing exposure to infectious agents through
biosecurity, and increasing host resistance to infectious
immunosuppressive diseases by immunomodulation.
— Thus a well-balanced immune system & improved
intestinal function is correlated with :
1. Production performance
2. Health & wellness
3. Food safety

Disease Condition (with Normal Body Cells)

(+) ˜ Presenting
(+) ˜ Surface
˜ Antigens
Immune Response

(-)
Innate linked Adaptive
IMMUNE PROCESS
immunity immunity Virus (Body Defense Mechanism)
Broad Specific
Controls spread clears infection
(+)
Lymphocyte-B
Directs adaptive response Elicits a memory response
Bacterium
(+)
(+)
Ag-Ab Specific Memory Cells
hours-days days-weeks
Reaction Antibodies
Production

ABOUT IMMUNOTECH
dase Nat
pti tok
pe in
— With the growing pressures on the livestock farming tio
as
r ra

industry, there is great need for innovative solutions that can

Se

help boost the animals' immune system, reduce stress and

inflammation leading to animal health and effective
production.
Immunotech
Immunotech ™
oids

— Immunotech is a unique systemic enzyme based

avon

immunomodulator which comprises a synergistic

combination of Serratiopeptidase, Nattokinase, Bromelain,
fl
B io

Papain & Bioflavonoid (Rutin).

 MODE OF ACTION
— Immunotech increases the serum levels of systemic — Immunotech hydrolyses bradykinin, histamine, and
enzymes, which activates α-2-macroglobulin - a serum serotonin responsible for inflammation due to infection.
protein that facilitates the binding and removal of — Immunotech reduces the impact of disease stress and its
foreign peptides, excessive inflammatory mediators and secondary complications by targeting the circulating
auto-toxic endogenous proteins and thereby support immune complexes from the blood, degrading the
balanced humoral and cell-mediated immune function toxins and facilitating their removal from the system via
and modulate systemic inflammation. phagocytes.
— Immunotech binds to α-2-macroglobulin in the blood in
the ratio of 1:1, which helps to mask it’s antigenicity but
retain its enzymatic activity. It is slowly transferred to site
of infection.

E α-2 macroglobulin Activation (Complex Formation)

E E

Binding of the Complex to Inflammatory Mediators

E E
E
Clearance of α-2M-Protease-MI Complexes from Circulation

E E

E E E E

E E E E
E
E

IMMUNOTECH TRIAL
Field based research trial was conducted to evaluate impact of
Parameter Control Immunotech
Immunotech supplementation on bird performance. For this
trial, a straight run flock of 400 Cobb 400Y broiler chickens were Body Weight Gain (Kg) 2.621 2.636
distributed into 2 treatment groups. Each treatment group had FCR 1.67 1.63
20 replicate pens and there were 10 birds in each pen (n = 200 Mortality (%) 11 1.5
per group).

Vaccine titre against ND at different ages

11
2.4
Mortality (%)

Antibody Titre (Log10)

2.35
1.5
2.3

Control Immunotech 2.25

2.2

2.15
2.636 12-d 28-d 40-d
Body Weight

2.621 Control Immunotech

Gain (Kg)

Vaccine titre against IBD at different ages

4
Control Immunotech
3.5
Antibody Titre (Log10)

3
2.5
1.67 2
1.63 1.5
FCR

1
0.5
0
12-d 28-d 40-d
Control Immunotech
Control Immunotech
IMMUNOTECH A VERSATILE SOLUTION PRODUCT SPECIFICATION
Recommended Inclusion Levels:

ion Infl An
u lat am ti- Continuous Application (Low-Risk Condition)
od ma
n om to
r Recommended as a preventive measure to stimulate the
mu y
Im Immunomodulation process and the overall Immune
function.
Dosage for continuous application: 250 ml/ 1000 birds
Drug Efficacy

in drinking water twice a day for first two days of

Oxidative
Improved

IImmunotech
mmunotech

Anti-
™
application, followed by 100ml/ 1000 birds twice a day
third day onwards.

Intermittent Application (High-Risk Condition)

It is flexible and recommended to identify stress periods
Liv
er tic with precision.
He oly
alt in
h
Fibr — Stress conditions (Disease outbreaks, heat shock)
— Newly hatched chicks from day 1 to day 3
— 24 h after post-antibiotic therapy for three days
Dosage for intermittent application: 250 ml/ 1000 birds
in drinking water twice a day.
BENEFITS

BROILER
PRESENTATION
— Body Weight Gain
— Processing Yields Immunotech Liquid : 1,5 Lit.
— Feed Efficiency Immunotech Powder : 1 Kg
— Higher Vaccine Titre

LAYER
— Egg Production
— Egg Quality
— Feed Efficiency
— Higher Vaccine Titre

BREEDER
— Egg Production
— Fertility & Hatchability
— Chick Quality & Performance
— Immunity

Advanced Bio-Agro Tech Limited (ABTL)

Corporate Office: Registered Office:
No. 201, 2nd Floor, S.N.6/1/1, 5th Floor Sun Magnetica,
Deron Hills, Baner Road, LIC Service Road, Louiswadi,
Pune 411045 (India) Thane (W) 400604 (India)

info@abtl.in +91 20 2729 1020 / 21 www.abtlenzymes.com

CIN: U24100MH2004PLC149464