Pathology assignment

Attempt all questions with clear and short answer

1. Wound may undergo repair by secondary intention, what is the reason?

2. A 10-year-old child presented with 12 hours history of acute appendicitis where

appendectomy was done. What type of gross morphologic change do you see on the
appendectomy specimen?

3. What is the pathophysiology of metaplasia?

4. Cytopathology is part of general pathology, what is the focus of study?

5. A 30-year-old body builder has bulky biceps and quadriceps, what type of adaptation
is this? Why does such form of adaptation occur?

6. Pulmonary tuberculosis is common in Ethiopia. Which type of inflammation is caused

by tuberculosis? What type of microscopic changes do you expect?

7. Where is the area of focus for forensic pathology?

8. Growth factors assist in the initiation and progress of tissue repair. Which is the
potent chemical mediator for connective tissue deposition? Where is the source of
such mediators?

9. Why do we find high number of neutrophils in time of acute inflammation?

10. How do we define irreversible cellular change? What do we mean necrosis and
apoptosis?
 Answer sheet

Name: Nathnael Gebeyehu ID Number: DDMO231/B6/11

Attempt all questions with short answers

1. Healing by secondary intention occurs when the wound is severe and the sides of
the wound are not opposed, therefore healing must occur from the bottom of the
wound upwards.
2. Grossly inflamed, swollen & red.

Prominent vessels visible on the surface.

3. Defined as change in structure of cell from normal to abnormal one, caused by

physical or chemical irritation, reversible if the environment returns to normal, can
be initial stage for tumor formation.
4. Cytopathology is a branch of pathology that studies and diagnoses diseases on the
cellular level.
5. It is hypertrophy to overcome physical stress the body has to deposit more protein
in the muscle.
6. Chronic Inflammation, manifested by Presence of lymphocytes and plasma cells in
tissues.
7. Forensic pathology is pathology that focuses on determining the cause of death by
examining a corpse.
8. TGF-β
Sources- Macrophages, lymphocytes and platelet.
9. To eliminate Pathogens and phagocytise microorganisms and foreign materials that
cause the inflammation.
10. Irreversible cell injury refers to one of the severe types of cell injury that leads to the
cell death and not recovery.
Apoptosis is programmed cell death.
Necrosis is a form of cell injury which results in the premature death of cells in living
tissue by autolysis.