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Comparison
Between Clinical and Radiological Classifications
of Infants with the Respiratory Distress Syndrome (RDS)
The respiratory distress syndrome (RDS) is still one of the main problems in
premature infants, although the mortality from this disease has decreased dra-
matically during the past few years [6]. The treatment in RDS consists of both
prevention and active therapy of the disease [2, 8, 16]. The results, however, vary
greatly from one hospital to another in spite of the same treatment regimes. One
reason for this is that different criteria for grading the syndrome are applied.
Comparing results is of no use if there is no standard method for assessing the
severity of the disease.
One of the most useful single diagnostic aids in RDS is the chest roentgeno-
gram [4, 5]. Radiological examination of the chest in an infant with respiratory
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272 P.O. Kero and E. O. Mgkinen
Table 1. Classification of the infants on the basis of their gestational age and birth weight
Total 55 55
Under 29 7 12.7 Under 1250 7 12.7
29--33 21 38.2 1250--2000 17 30.9
33--37 22 40.0 2000--2500 12 21.8
Over 37 5 9.1 Over 2500 19 34.6
Score Cyanosis Intercostal retraction Rate of breathing Pulmonary auscultation * PaO2, * PCO2, * FiO2
1 point Slight peripheral cyanosis Slight difficulties in 60--80/min G o o d air entry to the lungs PaO2 = 7--10 kPs
breathing and slight PCO2= 6--7 kPs
retraction FiO2 = 21--40%
g
2 points Stationary moderate Moderate difficulties in 81--100/rain Air entry poor with spontaneous PaO2 = 5--7 kPs t~
peripheral cyanosis breathing and retraction Infant in need of breathing. Much whirring and PCO2 = 7--10 kPs
therapy with CPAP fine rales heard FiO: = 4 1 - - 5 0 %
3 points Stationary grey-blue Severe difficulties in Over 100/rain or Air entry poor also with art. PaO2 < 5 kPs
cyanosis also on breathing and retractions, apnea. Respirator ventilation. Superficial PCO2 > 10 kPs ~J
respirator therapy paradoxal breathing therapy spontaneous breathing. Breath FiO2 > 51%
sounds weak
b.a
274 E O. Kero and E. O. Mgkinen
Within our material a birth weight of 1250 g corresponded on average to 29 week's gesta-
tion and 2000g to 33 weeks. The most important clinical data are listed in Table 2.
Class 1. Slight reticulo-granular infiltration due to slight peribronchial atelectasis, mostly in the
central part of the lung field. Air bronchogram present. The peripheral part of the lungs
still normal (Fig. 1)
Class 2. In addition a pattern of alveolar opacification in the air bronchogram confluent
opacification and a dense reticulo-granular pattern making the borders of the heart,
thymus and diaphragm unclear (Fig. 2)
Class 3. Lungs quite airless and an air bronchogram seen in the major parts of the bronchi and
the trachea, or only in the trachea. Impossible to distinguish the borders of the heart,
thymus and diaphragm (Fig. 3)
Results
Clinical Classification
A c c o r d i n g to t h e clinical c l a s s i f i c a t i o n , 17 o f the R D S i n f a n t s b e l o n g e d to the first
class ( m i l d R D S ) , 22 to t h e s e c o n d class ( m o d e r a t e R D S ) a n d 16 to the t h i r d a n d
w o r s t class ( s e v e r e R D S ) . T h e m e a n b i r t h w e i g h t was 2 2 0 0 g f o r all 55 R D S
i n f a n t s . I n t h e m i l d class it w a s 2076 g, in the m o d e r a t e class 2576 g a n d in the
s e v e r e class 1 8 1 5 g ( T a b l e 5).
Respiratory Distress Syndrome (RDS) 275
Fig. 1. R D S class 1. An air bronchogram is seen in the central part of the lung fields (q'). A very
slight reticulo-granular pattern is also seen due to alveolar atelectasis
Fig. 2. R D S class 2. Confluent opacification and dense reticulo-granular patterns make the
borders of the heart (thymus) and diaphragm (t) unclear, but in the X-ray they are still clearly
distinguished from the lung parenchyma
Fig. 3. R D S class 3. The borders of the diaphragm (I") are mostly undistinguishable. The lungs
are quite airless. An air bronchogram (?) is seen in the proximal parts of the bronchi
276 R O. Kero and E. O. M~ikinen
I 11 5 I 17
II 6 11 5 22
III 1 3 12 16
Total 18 19 18 55
Radiological Classification
On the basis of the radiological classification, 18 of the infants belonged to the
first class, 19 to the second class and 18 to the third class (Table 6). The
comparison between the clinical and the radiological classification is shown in
Table 6. Quite a number of infants belonged to different classes according to
these two classification systems, but there were only two infants who differed by
more than one class. One infant was clinically in a very serious condition (third
class), but the radiological findings were small. This infant, whose birth weight
was 3050 g, had severe asphyxia during delivery and perhaps this explains the
discrepancy between the classifications. The other infant was in quite a good
condition clinically (first class), but the X-ray findings were very severe. This
infant had a possible pulmonary infection and this made it difficult to classify the
infant radiologically. In 34 (62%) of the 55 RDS infants the clinical and the
radiological classifications agreed.
Discussion
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