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Brief Summary
by Abraham J. Nunes (abrahamjnunes.wordpress.com)
Introduction
The quality and quantity of health services, and indirectly, health itself,
improve roughly in parallel with a country’s gross domestic product (Figs.
1-3). However, alone, GDP cannot account for the seeming improvement in
these health indicators. For instance, Portuguese and Japanese gross
domestic products are significantly less than that of the United States, but
life expectancies in these nations are not appreciably different. Moreover,
little to no correlation can be found between disability adjusted life years
(DALY; years of life lost due to either early mortality or disability; fig. 4)
and national GDP. DALY is widely recognized as a more robust measure of
population health, compared to life expectancy.
The explanatory factor is likely due to the socioeconomic gradient of health.
For example, when analyzing the WHO mortality regions, Reidpath and
Allotey (2007; Fig 5) found that the poorest world regions suffered the
greatest DALY losses when compared to their wealthiest counterparts.
Figure 1: Higher life expectancies are associated with greater per capita income across
nations.
Figure 2. Increased per capita income is associated with a decreased all cause
newborn mortality rate across nations.
Figure 3: Lower values of all cause mortality in children are associated with increases in
per capita income, when measured across nations.
Figure 4: Disability Adjusted Life Years Against National GDP: Data courtesy of WHO
and Wolfram Alpha
Summary of The Socioeconomic Gradient in Population Health:
Explaining Health Inequalities
Throughout history, observers have noted that health status improves
incrementally with increases in socioeconomic status (SES), and that this
gradient is evident for a myriad of afflictions: from the perinatal period
until elderly life. Longitudinal evidence supports this theory. A prominent
UK study (aka “Whitehall”; Marmot et al., 1978), showed that, although
affluence levels of all subjects were high when compared to other nations,
the remaining SES gradient (based on occupational status, education, etc.)
continued to affect health outcomes in a roughly linear fashion, consistent
with the SES gradient of health theory. In short, the SES gradient exists
regardless of whether it is analyzed with respect to income, occupation, or
education (Fig. 6).
Figure 5: Disability Adjusted Life Years Across WHO Mortality Subregions (Reidpath
and Allotey, 2007)
Status differences may be observed at any stage of the life cycle:
Figure 7: School Readiness per Parental Income Bracket (Marmot, 2011; Washbrook
and Waldfogel, 2008)
As mentioned above, the SES gradient may be observed at any age:
■ Perinatally: gradient exists for infant mortality and low birth weight
■ Childhood: gradient exists for injurious death and socio-emotional
development (Fig. 8; Marmot et al. 2010; Power and Matthews,
1997).
■ Early adulthood: gradient exists for injury and mental health related
deaths.
■ Late adulthood (age 45-74): gradient exists for morbidity and
mortality related to “premature” chronic degenerative diseases (i.e.
stroke, heart attack, arthritis, cancer). This period represents the
most significant observable gradient in health outcomes related to
SES. Data from the 25 year Whitehall follow-up report demonstrate a
readily observable gradient for coronary heart disease, when
measured against occupational rank (Fig. 9; Marmot, 2000)
■ Elderly life (75 +): a gradient exists for dementia and other
degenerative conditions.
Figure 8: Childrens' Poor Social Adjustment Based on Parental Occupational Status
(Marmot et al. 2011; Power and Matthews, 1997)
Figure 9: The Mortality Gradient for Coronary Heart Disease Based on Occupational
Status (Whitehall 25 Year Follow-Up Report). Note that administrators were used as the
reference (RR=1.0).
Although late adulthood represents the most significant gradient in health
outcomes related to SES, the individuals comprising this demographic have
expressed multiple sources of heterogeneity throughout their life cycles.
These sources of heterogeneity are known as “pathways of disease
expression.” These pathways are encompassed in six explanatory theories
(Public Health Agency of Canada).
1. Health selection
2. Differential susceptibility
3. Individual lifestyle preferences
4. Physical environment differences
5. Differences in access to health services
6. Socioeconomic-psychosocial condition
Health selection refers to the potential trend for unhealthy individuals and
their families to move into lower income areas. This has been refuted based
on the fact that the SES gradient persists following statistical adjustment
for income (although income is the primary determinant of a
socioeconomic gradient).
The theory of differential access to health care is quite weak, for in nations
with universal access to health care, stark SES health gradients persist.
Furthermore, medically avoidable deaths account for a very small portion
of the SES health gradient.
1. The latency model: states that early experiences will affect well-being
and health outcomes in later life regardless of further intervention.
This supports the notion of a “critical period” in early development.
2. The pathway model: states that the cumulative effect of events and
experiences throughout one’s life is the prime determinant of end
well-being and health outcomes. This model intrinsically supports the
efficacy of interventions targeted at preventing or treating critical
negative events which may occur at important “transition points”
during human development.
Resolutions
The most likely reality is that both the latency and pathway models operate
to some extent, and that a disproportionately high investment in an
individual’s early life, followed by ongoing investment in his or her well
being are both required for achievement of optimal SES and health
outcomes. Implied in this statement are changes in individual needs
throughout the life cycle (see also Fig. 11):
■ During early age, infants require much attention, care, security, and
to a healthy degree, spoiling, dare I say it.
■ As they age, children receive progressively less influence from the
home, and begin to absorb (a) community characteristics, (b) labour
market forces, and most importantly, (c) the influence of peer
relationships. The authors of this full manuscript suggest that these
factors are likely to contribute the greatest cumulative effect on future
well-being and health outcomes.
Figure 11: Graphical representation of the life cycle and its associated developmental
facets, with performance suggestions (Marmot et al., 2011)
AN
References
Mainly The Socioeconomic Gradient in Population Health: Explaining
Health Inequalities, with further contributions from the following sources:
Hollstein RD, et al. Social inequalities and health. Socioeconomic level and
infant mortality in Chile in 1985–1995. Revista Medica de Chile
1998;126:333-40
Marmot, M. et al. Fair Society, Healthy Lives: The Marmot Review. 2010
(Download the Full Marmot Review Here)