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4. A 20 y/o male was brought to the ER due to muscle rigidity. He also manifest with
hallucination, pupil dilation and increased temperature with dry skin. The above
findings can be due to:
A. Amphetamine abuse C. Heat stroke
B. Extrapyramidal symptoms D. Tetany
7. Which of the following manifestation is not a major criterion for rheumatic fever?
A. Erythema multiforme C. Subcutaneous nodules
B. Migratory polyarthritis D. Sydenham’s chorea
10. What is the most common cause of secondary hypertension in the general
population?
A. Cushing’s syndrome C. Primary aldosteronism
B. Pheochromocytoma D. Renal diseases
13. Valvular abnormalities and chamber dilatation are best diagnosed by:
A. Electrocardiogram C. Echocardiography
B. Treadmill exercise testing D. Nuclear imaging techniques
(p. 1320)
14. The electrocardiogram of a patient who is hypertensive for almost 5 years would
show which of the following?
A. Tall left precordial R waves and deep right precordial S waves
B. Diminished voltages in the limb leads (aVL or aVR)
C. Right atrial abnormality absence of repolarization abnormalities (ST
depression and T-wave inversions)
(p. 1314)
16. A patient who shows on auscultation with an accentuated first heart sound,
opening snap and a mid-diastolic rumbling murmur at the apex is suffering from:
A. Mitral regurgitation C. Aortic regurgitation
B. Mitral stenosis D. Aortic stenosis
(p. 1390-1391)
18. Liebman-Sacks lesion which is a small verrucous vegetation usually found in the
ventricular surface of the mitral valve is associated with this disease:
A. Rheumatoid arthritis C. Rheumatic Heart Disease
B. SLE D. Rheumatomyositis
27. Cytoplasmic inclusion bodies found in certain neurons in the brain, and are
diagnostic of rabies:
A. Negri bodies C. Schuffner’s dots
B. Owl’s eye bodies D. James stipplings
(See p.1157 Pathogenesis of Rabies, 16th ed. Harrison’s)
28. Most vaccine for adults can be given also to pregnant women EXCEPT:
A. Tetanus, diphtheria C. MMR, Varicelia
B. Pneumococcal, influenza D. Rabies, Hepatitis B
(See p.720 Use of Vaccines in Special Circumstances, 16th ed. Harrison’s)
29. The single most important diagnostic test to request for a patient with clinical signs
and symptoms suggestive of PTB is:
A. CXR C. TB culture
B. PCR D. Direct microscopy
(Sep.960 AFB microscopy, 16th ed. Harrison’s)
31. Among the available test for Leptospirosis, the most sensitive and specific is:
A. Culture with EMJH
B. ELISA for antibodies
C. MAT using genus specific antigen for Leptospira patoc
D. Dipstick assay
(See p.990 Diagnosis of Leptospirosis, 16th ed. Harrison’s)
32. The following are true of malaria EXCEPT:
A. Hypoglycemia in falciparum malaria is associated with poor prognosis
B. Splenic enlargement in endemic areas reflects repeated infection
C. In severe malaria, one predicter of poor prognosis is the predominanceof
immature P. falciparum parasites
D. The thick malarial smear has the advantage over the thin smear of
concentrating parasites, thus increasing diagnostic sensitivity
(See Table 195-3 p.1222, 16th ed. Harrison’s)
42. The prothrombotic effect of coumarin (warfarin) during the early phases of its
administration is due to a rapid drop in the plasma concentration of:
A. Antithrombin C. Factor VII
B. Protein C D. Plasminogen
43. A 55-year old woman with Grave’s disease developed pallor and scleral jaundice.
Her peripheral blood showed pancytopenia, presence of macro-ovalocytes and
hypersegmented neutrophils. What is the most likely diagnosis?
A. Megaloblastic anemia C. Aplastic anemia
B. Myelodysplastic syndrome D. Paroxysmal nocturnal hemoglobinuria
44. A 55-year old man previously diagnosed to have stage 0 CLL developed anemia
and unconjugated hyperbilirubinemia. What is the single most important
laboratory test required to diagnose the cause of the anemia?
A. A repeat bone marrow examination C. Serum ferritin determination
B. Coomb’s test D. Serum folate and vitamin B12
determination
45. A 24-year old female suddenly developed jaundice, confusion, petechiae, and
fever. Peripheral blood examination showed anemia and thrombocytopenia.
Fragmented red cells were seen with nucleated red blood cells. Prothrombin and
partial thromboplastin time were normal. What is the treatment of choice for this
patient?
A. Plasmapharesis C. Pulse therapy with cyclophosphamide
B. High dose glucocorticoids D. Splenectomy
47. A 36-year old male was refereed to an internist after a routine blood examination
showed a low mean cell volume (MCV) but with no evidence of anemia. Stool is
negative for occult blood nor was there exposure to lead. Serum ferritin is normal.
What is the most likely diagnosis?
A. Early iron deficiency anemia C. Thalassemia minor
B. Anemia of chronic disease D. Sideroblastic anemia
48. A 32-year old male had excessive bleeding after a dental extraction. He has no
other medical problems and physical examination is unremarkable. His mother
has history of excessive bleeding. Bleeding time and PTT was prolong twice the
normal range but the prothrombin time is normal. What is the most likely
diagnosis?
A. Hemophilia A C. Factor XII deficiency
B. Hemophilia B D. von Willebrand’s disease
49. A 64-year old woman for preoperative evaluation was noted to have a markedly
prolong PTT. Her prothrombin time, platelet count, and bleeding time were
normal. She required blood transfusion blood transfusion after a dental extraction
2 years ago. Two siblings male and female has history of bleeding. The most
likely diagnosis is a deficiency of:
A. Factor VII C. Factor XI
B. Factor VIII D. Factor XII
50. An 18-year old male develops massive bleeding after removal of a large
sebaceous cysts. Prothrombin time, PTT, platelet count, and bleeding time were
normal. There is no family history of bleeding time. Which of the following tests
should be ordered?
A. Factor XI level C. Urea clot lysis test
B. Factor XII level D. Platelet aggregation study
51. A 59 year old, female, known hypertensive for 5 years, with poor compliance to
anti-hypertensive medications, now complains of pallor, easy fatigue, anorexia,
and itchiness. The kidneys on ultrasound appear contracted. Which casts will you
find in the urinalysis in this condition?
A. RBC casts C. Broad casts
B. WBC casts D. Hyaline casts
th
Harrison 16 ed. pp. 251
53. A 40 year old, male, known diabetic for 8 years is noted to have +1 proteinuria.
The best medication at this time is:
A. Glibenclamide C. Rosiglitazone
B. Insulin D. Captopril
th
Harrison 16 ed. pp. 1689
54. A 25 year old, female, developed anasarca over 2 months period. Her urinalysis
showed RBC and RBC casts. Kidney biopsy revealed membranous
glomerulonephritis. This condition is most likely to be associated with:
A. Hepatitis B infection C. Diabetes mellitus
B. Hypertension D. Periarteritis nodosa
th
Harrison 16 ed. pp. 1687
55. A 44 year old, male, operated twice for kidney stones has an estimated creatinine
clearance of 40 ml/min. At what stage of renal failure is he in now?
A. Stage 1 C. Stage 3
B. Stage 2 D. Stage 4
th
Harrison 16 ed. pp. 1653
57. A 25 year old, male, was admitted because of multiple gunshot wounds. On
admission, he was hypotensive and tachycardic. He was immediately scheduled
for exploratory laparotomy which lasted for about 4 hours. A total of 6 units of
blood were transfused. He was oliguric and acidotic, for the next 7 days. At what
phase of acute renal failure is he in?
A. Initiation phase C. Diuretic phase
B. Maintenance phase D. Recovery phase
th
Harrison 16 ed. pp. 1645
58. A 10 year old, boy, has puffy eyelids, tea-colored urine, and BP of 130 / 100,
noted after 2 weeks bout of sore throat and fever. The clinical diagnosis is
nephrotic syndrome. The condition that would initiate all the subsequent
components of the syndrome is:
A. Hypoproteinemia C. Lipiduria
B. Glomerular proteinuria D. Edema
Harrisson 16th ed. pp. 1684
59. A 44 year old, male, was admitted to Philippine Hear Center because of severe
chest pain. Initial findings indicate acute myocardial infarction. Within few minutes
after admission, he developed transient arrhythmia and drop in BP. The serum
creatinine went up from 0.9 mg% on admission to 1.3 mg% after 2 days. The urine
output was about 250-300 /day. These findings can be explained on the basis of:
A. Intratubular block by debris C. Back leak of glomerular filtrate
B. Renal hypoperfusion D. Nephrotoxicity from drugs
Harrison 16th ed. pp. 1645
60. A 33 year old, female, is suffering from SLE for the last 5 years. A year ago,
proteinuria and hematuria were noted in her urinalysis. And subsequently her
serum creatinine slowly deteriorated. The progression of her renal failure is due to:
A. Nephrotoxicity C. Renal hypoperfusion
B. Reduction in renal mass D. Interstitial nephritis
Harrison 16th ed. pp. 1653
61. One of the following is not a classification criteria in the diagnosis of Rheumatoid
arthritis:
A. Morning stiffness less than 1 hour
B. Radiographic change like erosion or decalcification of wrist bone
C. Serum rheumatoid factor positivity
D. Symmetric arthritis
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1885
62. One of the following statements is not true with regards to the epidemiology of
SLE:
A. Common in women of child bearing age
B. Males are spared
C. More common in blacks than in white
D. Prevalence is form 15 to 50/100,000 population
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1874
Aling Nena, 75-years old, female, 5’2 ft tall, 100 lbs. Consulted because of pain
in the (R) knee for a year; which is worst in the afternoon and after a long walk and
improves with rest. On P.E. as bony hypertrophy and worse crepitation.
63. The pain she is experiencing maybe due to any of the following EXCEPT:
A. Ligament insertion strain C. Muscle pain
B. Cartilage destruction D. Capsular stretching
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1936-1937
Carla, 18-years old student is being treated for pneumonia. On the 4th day of
hospitalization she noted swelling, redness and severe pain of the (L) knee. Aspiration
of the knee revealed whitish, purulent fluid consistent with septic arthritis.
66. The laboratory test you would request for the condition is:
A. Liver function test C. Culture and sensitivity of fluid
B. Urinalysis D. ANA
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1945
67. The probability of a CPPD disease will reveal crystals appearing as:
A. Highly birefringent, large flat
B. Negatively birefringent, needle shape
C. Positively birefringent, rod shaped
D. Spheroidal aggregation
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1942
68. The pain in osteoarthritis arise from the following structure EXCEPT:
A. Articular cartilage
B. Stretching of joint capsule
C. Stretching of periosteum covering osteophytes
D. Synovitis
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1937
69. One of the following is not a classification criteria in the diagnosis of Rheumatoid
arthritis:
A. Morning stiffness less than 1 hour
B. Radiographic change like erosion or decalcification of wrist bone
C. Serum rheumatoid factor positivity
D. Symmetric arthritis
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1885
70. One of the following statements is not true with regards to the epidemiology of
SLE:
A. Common in women of child bearing age
B. Males are spared
C. More common in blacks than in white
D. Prevalence is form 15 to 50/100,000 population
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1874
Aling Nena, 75-years old, female, 5’2 ft tall, 100 lbs. Consulted because of pain
in the (R) knee for a year; which is worst in the afternoon and after a long walk and
improves with rest. On P.E. as bony hypertrophy and worse crepitation.
71. The pain she is experiencing maybe due to any of the following EXCEPT:
A. Ligament insertion strain C. Muscle pain
B. Cartilage destruction D. Capsular stretching
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1936-1937
72. One of the following statement about TB arthritis is true:
A. Culture of M. tuberculosis from the synovial biopsy is positive in 90% of cases
B. Joint destruction is rapid
C. Polyarticular involvement is more common
D. Treatment includes administration of Nafcillin and gentamycin
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1947
73. A 23-years old female patient consulted because of on and off pains, malar rash,
oral ulcers and increasing hairloss. A probable diagnosis of SLE was made
confirmed by:
A. High ESR and (+) CRP
B. High titer dsDNA and hypocomplementemia
C. Leucopenia and anemia
D. Thrombocytosis
Reference: Harrison’s Principles of Internal Medicine 14th ed. pp. 1877
75. All of the following symptoms are consistent with hypothyroidism EXCEPT:
A. Constipation C. Heat intolerance
B. Menorrhagia D. Hoarse voice
Reference: Harrison’s Principles of Internal Medicine 16th ed. pp. 2109
77. All of the following chronic diabetic complications are microvascular in nature
EXCEPT:
A. Retinopathy C. Nephropathy
B. Neuropathy D. Peripheral vascular disease
Reference: Harrison’s Principles of Internal Medicine 16th ed. pp. 2161
78. The following statements are true regarding the pathophysiologic abnormalities of
type 2 DM EXCEPT:
A. It is characterized by autoimmune destruction of the beta cells
B. There is impaired insulin secretion
C. Peripheral insulin resistance may be present
D. There is excessive hepatic glucose production
Reference: Harrison’s Principles of Internal Medicine 16th ed. pp. 2157
79. The combination of insulin deficiency and hyperglycemia would result to the
following biochemical abnormalities EXCEPT:
A. Reduces the hepatic level of fructose 2-6 phosphate
B. Decreases the activity of pyruvate kinase
C. Promotes the process of glycogenolysis
D. Increases the levels of the GLUT4 glucose transporter
Reference: Harrison’s Principles of Internal Medicine 16th ed. pp. 2159
80. The major effects of cortisol on body water are as follows EXCEPT:
A. Retards the migration of water into cells
B. Promotes renal water excretion
82. The leading cause of cancer death in both men and women.
A. Lymphoma C. Lung CA
B. Nasopharyngeal CA D. Large cell CA
Harrison’s Internal of Medicine, 16th ed. 436, 506
83. The most common histologic subtype of lung cancer for the past 25 years.
A. Squamous or Epidermoid C. Small cell CA
B. Adenocarcinoma D. Large cell CA
th
Harrison’s Internal of Medicine, 16 ed. 506
84. Usually, these types of lung cancer have already spread at the time of
presentation and diagnosis, hence, surgery is unlikely to be curative. They are
managed primarily by chemotherapy with or without radiotherapy.
A. Squamous or Epidermoid C. Small cell CA
B. Adenocarcinoma D. Large cell CA
th
Harrison’s Internal of Medicine, 16 ed. 506
CASE: Leo Garcia, 68-year old male came in to your clinic because of urgency,
hesitancy and bloody urine: (Questions 167-169).
85. Prostate cancer is highly entertained, and the first screening modality that you will
perform is:
A. Digital rectal exam
B. Assay for serum PSA (prostate specific antigen)
C. Ultrasound of bladder/prostate
D. Transrectal ultrasound guided biopsy
Harrison’s Internal of Medicine, 16th ed. 446
86. Examinations revealed prostate cancer. The most common site for its metastasis:
A. Lungs C. Colon
B. Liver D. Bone
th
Harrison’s Internal of Medicine, 16 ed.
90. Tumor lysis syndrome is an oncologic emergency which may present as acute
renal failure. This is due to destruction of a large number of neoplastic cells
during chemotherapy. It is characterized by the following, EXCEPT:
A. Hyperuricemia C. Hypercalcemia
B. Hyperphosphatemia D. Hyperkalemia
Harrison’s Internal of Medicine, 16th ed. 581
CASE
A 55-year old male, farmer from Pampanga came to the ER because of difficulty of
breathing. Present condition started 2 weeks prior to consult as cough productive of
opious grayish yellow sputum accompanied by moderate grade fever body malaise and
lost of apetite. Condition progressed despite over the counter antitussive medication,
until 1 day PTC he started to have difficulty of breathing.
94. If arterial blood gas examination showed – ph7.33, pCO2-50 mmHg, pCO2 of 75
mmHg and HCO3 of 28 mEq/L. What would be your interpretation?
A. Respiratory acidosis with hypoxemia
B. Respiratory alkalosis with hypoxemia
C. Respirator and metabolic acidosis
D. Adequate Oxygenation
95. What further laboratory examination would you add aside from above
examinations?
A. PFT C. ECG
B. Sputum for fungus D. A and B
96 - 100. A 60-year old male, 30-pack year smoker came in due to chronic cough and
mild exertional dyspnea for 3 years. He self medicated with mucolytic but
afforded no relief. On PE occasional wheezes and rhonchi were noted.
101. A 40 year old male complains of chest pain, characterized by burning retrosternal
discomfort that radiates to the neck and angles of the jaw. It is aggravated by
bending forward, straining and lying recumbent and is worse after meals.This
classic symptom is called:
A. Heartburn C. Regurgitation
B. Angina D. Water Brash
p.1588
105. A 70 year old male with chronic constipation presented with sudden onset left
lower quadrant abdominal pain and high grade fever. Physical examination
showed direct and rebound tenderness at the left lower quadrant. Your clinical
diagnosis is:
A. Sigmoid Diverticulits C. Irritable Bowel Syndrome
B. Acute Appendicitis D. Colon Cancer
p. 1649
106. Mark, a 7 yr old boy was passing by McDonald’s and smelled the aroma of
hamburgers. At this instant, acid secretion took place in his stomach. Which phase
of acid secretion was responsible for the acid secretion?
A. Cephalic C. Intestinal
B. Gastric D. Interdigestive
107. While Mark was eating his hamburger, the food in his stomach stimulated further
acid secretion. Which of the following substances is responsible for the increased
acid secretion?
A. Histamine C. Somatostatin
B. Gastrin D. Acetylcholine
C.
108. Mark grew up to become an executive of a leading company. Because of the
stresses of his job, he developed Duodenal Ulcers. The ulcers of Mark will be
found:
A. 3cm from the pyloric opening C. 2nd portion of the duodenum
B. 10cm from the duodenal bulb D. 3rd potion of the duodenum
109. Mark consulted his physician at MCU because of his Duodenal ulcer. The
physician examined Mark and found that Mark had a succussion splash. This
finding indicates that Mark had this DU complication.
A. Perforation C. Gastric outlet obstruction
B. Penetration D. Hemorrhage
110. Which of the following items below is a function of the pre-epithelial level of
defense to prevent mucosal damage?
A. The mucus gel functions as a unstirred water layer impeding diffusion
of ions and molecules including pepsin.
B. The surface epithelial cells act as ionic transporters that maintain
intracellular pH and bicarbonate production
C. Gastric epithelial cells bordering an injury migrate to restore a damage
region
D. Epithelial cell renewal occurs and together with angiogenesis preserve
integrity of the gastric tissues