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Customers’Review

Fluorometric analysis data was Western Blot result offered from Western Blot analysis data
offered by Dr. David Dr. Saraswati Sukumar, Johns obtained from Prosl. Acad. Sci.
Schürmann,University of Basel... Hopkins University... USA 2009 106(48)...

New Products
Cat.No. Product Name / Activity

S1523 XL765(SAR245409)
XL-765(SAR245409) is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110a, ß,
and d,respectively

S1532 AZD7762

AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively.

S1524 AT7519
AT7519 is a novel small molecule multi-cyclin-dependent kinase inhibitor.

S1486 AEE788
AEE788 is a novel dual inhibitor of EGFR/ErbB2 and VEGFR tyrosine kinases (IC50s: EGFR=2 nM, ErbB2=6
nM,KDR=77 nM, and Flt-1=59 nM).

S1575 RO4929097
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of the low nanomolar
range.

file:///E|/wujing/news%20letter/newsletter1(1).html[2011/3/7 10:56:27]
 more>>

Papers with Our Products

P53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic ß-Cell Apoptosis Induced
by Proinflammatory Cytokines and Endoplasmic Reticulum Stress. Esteban N. G., Carla M. G., Daniel A. C., et al.
J. Bio. Chem. 2010(285):19910-19920.
doi:10.1074/jbc.M110.122374 Fulltext
ABT737 purchased from Selleck Chemicals.

Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell–lymphotoxin- dependent
pathway. Varsha K., Elke S., Renzo D., et al. Blood 2010 155(23):4725-4733.
doi:10.1182/blood-2009-10-250118. Fulltext
SUNITINIB purchased from Selleck Chemicals.

MEK1 mutations confer resistance to MEK and B-RAF inhibition. Caroline M. E., Krishna G. V., Marie C. Z., et al.
Proc. Natl. Acad. Sci. USA 2009 106(48):20411-20416.
doi:10.1073/pnas.0905833106 Fulltext
AZD6244 purchased from Selleck Chemicals.
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Customers' Feedback

"I would like to confirm you that everything is perfectly fine with ABT-737 and Obatoclax we got from your
company. We confirmed their activity in vitro.We notably observed their impact in an apoptotic model and results
are similar to those which have been published."
---- Arnaud AUTRET from Trinity College

"I am very satisfied with your product and costumer service.Bortezomib works very well in our assay, it is
comparably cheaper than other inhibitors that we tested is more reliable for our assays. We see a great effect by
using 10nM concentration."
------ Dr. Alexandra Segref, CECAD Cologne,Germay

"The GDC0449 compound worked very well. The results in my hands are equally good as what's been published.
Thanks for this great resource for our research."
------ Yu Wang, Harvard University

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Selleck Chemicals . Tel: +1-713-922-4115 +1-832-582-8158

Fax: +1-713-796-9816 +1-832-582-8590
2626 South Loop West, Suite 225,Houston,TX 77054 USA
Products are for research use only.

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