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lung diseases, and spinal injuries. These words are synonymous with pain and suffering but a
new hope on the horizon has the potential to change that. Imagine a single cell, not just any cell
but a cell that could develop into any other type of cell in the human body, a master cell. This
cell could replace damaged and diseased cells in order to heal the human body. A master cell
does exist. It is called a stem cell. Human stem cells have sparked a new revolution in medicine,
the rise of regenerative medicine. These cells are able to become any type of cell in the human
body ranging from muscle cells to nerve cells and anywhere in between. Stem cells have
limitless possibilities. “Cell-replacement therapies based on stem cell lines will render obsolete
many current drug and medical interventions” (Green 1: 2). The debate on stem cells is not
scientific but moral and ethical, especially when pertaining to embryonic stem cells, which either
come from In Vitro fertilization clinics or aborted embryos. The two main ethical problems that
oppose stem cell research are cloning and embryonic stem cells. “…Obstacles result from the
fact that, of the three sources of stem cells, human embryos are the most promising” (1: 2). With
an understanding of stem cells and treatments derived from that understanding, mankind will
improve the quality of life; however, with the new cures, treatments, and possibilities that
accompany stem cells there must also come great responsibility and care in order to maximize
Not all stem cells are created equally. Stem cells are generally cells with the ability to
become or produce specialized cells’ but there are many different types of stem cells. The
National Institutes of Health defines stem cells as “Cells with the ability to divide for indefinite
periods in culture and to give rise to specialized cells” (Natl. Inst. of Health 2). These master
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cells can give rise to other types of cells and are able to multiply for a long time. Two of these
Stem cells that are present in the human body since childhood are adult stem cells. An
adult stem cell is “An undifferentiated cell found in a differentiated tissue that can renew itself
and (with certain limitations) differentiate to yield all the specialized cell types of the tissue from
which it originated” (1). This means that adult stem cells are found in tissues that can regenerate
themselves but can only produce more of the same tissue, like the liver. While adult stem cells
can produce many other types of cells, they only produce the types of tissue associated with the
tissue they originate. “These cells are “multipotent”, meaning they are able to produce a range of
related tissues, such as the differing types of blood system cells” (Green 1: 2). Adult stem cells
can be gathered from the brain, bone marrow, blood vessels, skin, and the liver. In addition,
some of these adult stem cells can be collected from a living person. One example are ADAS
cells, stem cells that come from fat. “For the first time, stem cells purified from fat have been
used to heal an injury in a living animal… In mouse experiments that so-called Adipose-Derived
Adult Stromal (ADAS) cells purified from a rodent's belly fat could be coaxed to heal a skull
fracture too large to mend by itself” (Cohen 1). ADAS cells are fat stem cells, which are a form
of adult stem cells, and have been used in mice to heal bone fractures. “If the same technique
works in humans, these cells could be coaxed to mend broken bones and correct other defects in
tens of thousands of surgical procedures each year in which bone grafts and prosthetics are now
necessary” (1). A treatment developed from these cells could not only render current treatments
obsolete but also cut down the time it takes the bone to heal from a fracture. “ADAS cells grow
seven times faster than the bone marrow cells in the laboratory. And it is relatively easy to
harvest more than a litre of fat tissue, even from patients who are not obese. Bone marrow is
much less plentiful and must be removed in a painful surgical procedure” (1). Added benefits
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from this kind of treatment are that ADAS cells can be generated faster and obtained easier than
bone marrow, which is also a type of adult stem cell found at the core of bones.
The most versatile and less differentiated, less specialized, stem cells come from human
embryos. “…ES [Embryonic Stem] cells, derived from the inner cell mass of the blastocyst-stage
embryos [a fertilized egg about a week after conception]. These pluripontent [able to produce
every type of cell] cells are the most ubiquitous of all [stem cells]” (Green 1: 3). ES cells are the
mothers of all cells. They are completely blank and scientists think that they can be “nudged”
into becoming any type of cell in the human body (1: 3). By learning the secrets of the ES cell
scientist can produce all types of tissue for use in regenerative medicine and for testing of new
drugs. Issues regarding stem cell research rise from the fact that of the three sources of stem
cells, human embryos are the most promising (1: 2). Their potential lies in that they are the most
In Vitro fertilization clinics are a prime source of stem cells. “Until very recently the vast
majority of stem cells used in research came from discarded (or excess) embryos stored at In
Vitro fertilization clinics” (Reaves 2). In Vitro fertilization, or IVF, clinics create excess embryos
while they provide their service. “In IVF, several hundred eggs are fertilized in a petri dish. 5
days after fertilization (approximately the time at which an embryo fertilized in the womb would
implant in the uterus), a few of these ‘blastocyst’ embryos are transferred into the mother’s
womb. If the transfer is successful (i.e. the embryo implants into the uterus) then the rest of the
embryos are discarded” (Gilbert RA100). Those excess embryos are usually destroyed; however,
they can be used for Embryonic Stem, or ES, cell research. “British infertility clinics in the
course of performing their legally mandated duty of discarding 3300 unwanted or unclaimed
embryos, are reported to have thawed and administered a few drops of alcohol to each embryo
before incinerating them” (Green 2: 1). The unwanted embryos at IVF clinics will be destroyed
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regardless whether they are used for ES cell research. This source of ES cells has no ties to
abortion. In fact, it is the opposite because IVF clinics help people with fertility problems, which
stem cells could help cure also. “Presuming that at least initially such stem cells will likely come
from discarded embryos from IVF clinics, then research or no research the embryos will be
destroyed” (Green 2: 1). IVF clinics are a great potential source of stem cells that must be
Many oppose all stem cell research based on one source of ES cells, aborted fetuses. “In
the most controversial method, scientist can also pull stem cells from aborted fetuses, first asking
for signed consent from a patient who’d previously (and independently) decided to terminate
their pregnancy” (Reaves 2). This is done most like an organ donor program. It is not an open
door for scientists, or anyone, to encourage abortion. While this method of obtaining ES cells
can be performed, it is not usual. “One misconception is that ES cells are derived from aborted
fetuses. The practice of abortion has no relationship, direct or indirect, to ES cells. All (without
exception) ES cell lines are derived from 5-day embryos (blastocyst) that were voluntarily
donated by couples undergoing In Vitro Fertilization (IVF) and would otherwise be discarded.”
(Gilbert RA100) What is more, the stem cells that come from aborted fetuses have differentiated
somewhat, their stem cells have begun to specialize, and as a result are not as flexible as those
obtained from IVF clinics when the embryo is about a week old. “Embryonic stem cells are
pluripontent, able to give rise to all tissue type, although recent research suggest that their
usefulness in cell replacement therapies might be limited because they have already begun to
take on some specific characteristics of their reproductive function” (Green 1: 3). Contrary to
popular belief, the ideal stem cell does not come from a fetus that has already developed. In fact,
the ideal stem cell comes from the inner cell mass of about a week old embryo called a
blastocyst, which is a mass of cells not a developed baby. A developed fetus is not the ideal
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source of ES cells because beyond the first week the ES cell begins to differentiate inside the
womb further than the sought after cells. These differentiated cells are less flexible than the
younger cells and therefore less appealing for research involving ES cells.
A major issue concerning ES stem cells regards the classification of ES cells, “are
[embryonic stem cells] morally protectable entities [human beings] or are they more like other
disposable tissues gleaned from the human body?” (Green 1: 3). This ethical dilemma centers
mainly on abortion but effects ES cells because they are derived from human embryos. “No one
denies that early embryos lack sensory organs or tissues. They cannot suffer pain. Their moral
worth, if any, resides in their potential for further development” (Green 2: 1). Furthermore,
embryos stored in IV clinics lack the potential that a fetus inside a womb has. The left over
In 1999, DHHS [the U.S. Department of Health & Human Services] announced that it
intended to fund research on human ES cells derived from embryos remaining after
embryonic stem cells are not a human embryo within the statutory definition” because
“the cells do not have the capacity to develop into a human being even if transferred to
the uterus, thus their destruction in the course of research would not constitute the
The embryos that were left over from infertility treatments cannot develop beyond a mass of
Another controversy in stem cell research is cloning. “The term cloning is used by
scientists to describe many different processes that involve making duplicates of biological
material. In most cases, isolated genes or cells are duplicated for scientific study, and no new
animal results” (Natl. Human Genome Research Inst. 1). Usually, cloning is used to duplicate
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genes and cells for study, not to create whole, complex entities. There is a fear of cloning based
on the idea of “genetic determinism”, that genes alone will entirely determine the individual and
clones will be exact copies (Natl. Human Genome Research Inst. 2). This fear is false because
even a clone will not be an exact copy of an individual because genes unaided do not define a
person. For a clone to be exact, he would have to experience the same, physical and mental,
development as the original. “ES cells also could be derived from embryos created through
somatic cell nuclear transfer, or cloning. In fact, several scientist believed that deriving ES cells
in this manner is the most promising approach to developing treatments because the condition of
…[IVF] embryos over time is questionable and this type of cloning could overcome graft-host
responses if resulting therapies were developed from the recipient’s own DNA” (Natl. Human
Genome Research Inst. 4). Such cloning would never yield a human, but instead, customized
tissue for the regenerative treatment, which would eliminate the risk of rejection by the patient of
the treatment.
A third common misconception is that either derivation or the intended use of ES cells
implies that egg is able to develop to a blastocyst, which is then implanted into the womb
of a recipient mother who brings to term an individual genetically identical to the original
donor… ‘Therapeutic cloning’ refers to the process of deriving such cells from
blastocyst, which destroys the cloned human embryo before it develops beyond the
Therapeutic cloning of ES cells involves the cloning of ES cells, not a full human being. In the
process, the blastocyst is destroyed for its inner mass, which contains the needed ES cells. An ES
cell without the rest of the blastocyst can never become a human being.
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Stem cells are a major scientific break through. These new findings in science do not
offer false hope. They do not offer proven hope either, because it is, in fact, a new discovery.
Stem cells and their cure just offer hope. Hope with great potential and that is why it is crucial
that stem cells are thoroughly investigated. ES cell research holds many possibilities and much
potential. “There are essentially three categories of medical promise from ES cell research. First,
researching the requirements for ES cells to differentiate into various tissues will provide a
wealth of valuable information about early human development” (Gilbert RA100). With this new
information scientist can figure how and why early diseases in humans, such as genetic disorders
and birth defects, develop which can lead to more cures. “ES cells also provide potential to test
drugs in freshly differentiated cells of different tissue types to more closely resemble the human
condition” (Gilbert RA100). Tissues derived from ES cells can test drugs better for humans than
other animal models. The beauty of stem cells are their flexibility to become any cell in the
human body, even the highly specialized reproductive sperm and egg cells, which in turn can
create more stem cells. This is the foundation of regenerative medicine. Regenerative medicine
could repair cells within organs that drugs and surgery cannot fix by replacing cells that are
damaged beyond repair. “…Because stem cells are undifferentiated, they aren’t committed to
becoming a liver cell, say, or a blood cell, scientist may be able to prompt them to become
whatever type of cell is needed” (Reaves 2). Stem cells could cure diabetes by differentiating
them into beta-islet cells that produce insulin. They could also cure Parkinson’s disease by
differentiating them into dopamine-producing cells, the absence of which causes Parkinson’s
(Green 1: 2). “Also on the distant horizon lies the possibility of new cardiac tissue for heart
attack victims, replacement blood and marrow cells for those who have undergone…therapy for
cancer, new skin tissue for burn victims, bone for those suffering from severe fractures or
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osteoporosis, and so on” (1: 2). Stem cells have the potential to ease the suffering of many who
are in pain.
Future research on stem cells may reveal new sources of stem cells. It may also reveal
new techniques and treatments using stem cells. The necessity to destroy embryos for research
may even vanish with further research and development. The ability of stem cells to differentiate
into other types of tissue is undeniable. Now the mystery holding back stem cell cures is the
mechanism that makes them differentiate into other cells; more narrowly, the obscurity that
shrouds the mechanism that controls which type of cell the stem cell becomes.
“If there were no regeneration there would be no life. If everything regenerated there would be
no death” (Parson 13). Everything in nature has some sort of regeneration, whether it is the
human liver or an amphibian limb. Everything has regeneration but with varying degrees. With
an understanding of stem cells and treatments derived from that understanding, mankind will
improve the quality of life. Stem cell research does not equal abortion. It does not endorse the
cloning of humans. Stem cells will make drug testing more accurate and safe. It will reveal the
mysteries of genetic diseases and help the understanding of not only the human body but also
life. They will also give rise to new treatments and regenerative medicine. However, with the
new cures, treatments, and possibilities that accompany stem cells there must also come great
responsibility and care in order to maximize the gains from stem cells. “Moral reasoning must
always be in conversation with human experience” (Green 1: 4). This means that people should
use judgment and common sense in order to make informed decisions about stem cells. The
pending success of stem cell cures will change the world and how mankind perceives itself. The
only sure way to find out where stem cells will take humankind is to continue research, monitor
the results and act accordingly. For stem cells, the possibilities are endless. It is now a matter of
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how mankind will handle this new discovery and where it will lead. As more is learned about
stem cells and new technologies and treatments are developed it is undoubtedly certain that
humans will face new challenges, choices, and opportunities. Science and possibly the destiny of
mankind are at a crossroad. It is not the first or the last. People must learn the facts and make
Works Cited
Cohen, Philip. “Fat Stem Cells Heal Broken Skulls”. NewScientist.com. 13 April
<http://www.newscientist.com/news/news.jsp?id=ns99994873.
Gilbert, M. David. “The Future of Human Embryonic Stem Cell Research: Addressing
Ethical Conflict With Responsible Scientific Research”. Med Sci Monit. 10(5). 1
<http://www.MEDSCIMONIT.com/pub/vol_10/no_5/4448.pdf
Green, M. Ronald. “The Stem-Cell Debate”. Part 1. NOVA Online "Life's Greatest
<http://www.pbs.org/wgbh/nova/miracle/stemcells.html.
<http://www.pbs.org/wgbh/nova/miracle/stemcells2.html.
<http://www.genome.gov/10004765.
Parson, B. Ann. The Proteus Effect. Washington, D.C.: Joseph Henry Press. 2004
Reaves, Jessica. “The Great Debate Over Stem Cell Research”. Time. 17 April 2006.
<http://www.time.com/time/health/article/0,8599,167245,00.html.