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A Neuropsychological Profile
of Capgras Syndrome
SCOTT W. SAUTTER
Division of Behavioral Medicine
Western State Hospital
Staunton, Virginia
Department of Behavioral Medicine and Psychiatry
University of Virginia School of Medicine
LEONARD BRISCOE
KAY FARKAS
Department of Behavioral Medicine and Psychiatry
University of Virginia School of Medicine
The delusion of misidentification has fascinated clinicians since its original descrip-
tion in the psychiatric literature almost seven decades ago (Capgras & Reboul-
Lachaux, 1923). Psychodynamic interpretations of this phenomenon were richly
described in colorful terms; however, recent advances in the clinical behavioral
neurosciences have helped to elucidate a possible neuropathological etiology. In
this article, we present a neuropsychological profile of Capgras syndrome. Both
psychodynamic and neuropathological interpretations are described in the litera-
ture review, and the results of this particular case support evidence of anterior
right-hemisphere-mediated dysfunction. Further questions are raised about com-
peting explanations and use of the term syndrome.
Most of the literature we reviewed provided case presentations with psycho-
dynamic interpretations involving "ego splitting and projection in defense of
139
140 Scott W. Sauter el al.
Case History
Ms. C. is a 45-year-old, right-handed, divorced White woman with 11 years of
education and an episodic work history of unskilled jobs. She had a number of
psychiatric hospitalizations dating back to 1979 for psychotic symptomatology,
including paranoid delusions, depression, and noncompliance with medication
regimens. She had been diagnosed with schizophrenia and treated with Xanax and
Mellaril. When admitted to our facility on an involuntary, mentally ill status, she
exhibited marked paranoid delusions and reported that she felt someone had taken
the place of her real father and that this person was out to kill her. Three weeks
prior to this hospitalization, Ms. C. had been discharged from a psychiatric facility
in New Orleans with the diagnosis of undifferentiated schizophrenia. After dis-
charge, she traveled to Florida to meet her father for a return trip to Virginia,
during which they decided to take a vacation at a state park. Upon returning from
an evening walk in the park, the patient reportedly found a man in her room
claiming to be her father. She stated that this man was not her real father, but an
Capgras Syndrome 141
imposter, and became very angry and agitated. The park rangers were called to
subdue her and take her to a local emergency room, where she complained of
tactile hallucinations and thought broadcasting. She also reported that she felt she
may have done something to her real father and that this imposter wanted to kill
her.
Although Ms. C. has no history of neuropathology in her medical records, her
long history of alcohol abuse and numerous motor vehicle accidents suggested
otherwise. In one accident, she lost consciousness and was hospitalized for 5 days.
The duration of unconsciousness and probable posttraumatic amnesia was not
reported. Although she had been charged with driving while under the influence
earlier in that year, Ms. C. denied using alcohol or other drugs since that charge.
At admission, Ms. C.'s speech was quiet with decreased intonation and rate.
Her thought processes showed looseness of associations and tangentiality. She
denied any suicidal or homicidal ideation. Her judgment was poor, and insight was
absent. She was well dressed, groomed, and appeared slightly younger than her
chronological age of 45 years. At admission, she scored 20/30 on the Mini-Mental
State Examination (MMSE; Folstein, Folstein, & McHugh, 1975), the next day,
she scored 27/30. She remained reserved and suspicious and was quite guarded
when talking about her "father." She complained of decreased sleep and increased
feelings of guilt but not of anhedonia, change in energy, or decreased appetite. Ms.
C. was given the diagnosis of paranoid schizophrenia, chronic, with acute exacer-
bation, and was placed on a regimen of 100 mg of Thorazine twice a day for
attenuation of psychotic symptoms. After a brief hospital stay of 3 weeks and a
course of neuroleptics, her psychotic symptoms dissipated, and she was discharged
to her local community.
Neuropsychological Profile
Ms. C. was referred for neuropsychological evaluation for the purpose of providing
a differential diagnosis and documenting suspected brain-behavior dysfunction
resulting from multiple motor vehicle accidents and alcohol abuse. During the
evaluation, Ms. C. was initially suspicious about being tested. However, after the
type of procedures that would be given were explained to her, she relaxed. As a
result, she was pleasant and cooperative but remained guarded. She denied auditory
hallucinations but frequently smiled and laughed out loud at inappropriate times.
Ms. C. did not report that her father was an imposter during the testing, although
she appeared perplexed when confronted about this. An electroencephalograph
was within normal limits, and no further neuroradiological studies were pursued.
Neuropsychological impressions were consistent with greater anterior right-
hemisphere-mediated dysfunction of mild to moderate cognitive impairment,
particularly for tasks of memory and abstract reasoning. Right- and left-hemisphere-
mediated functions with respect to normative data are presented as z scores in
Figure 1. A breakdown of various neuropsychological functions (also z scores) are
presented in Figure 2. Relatively greater impairment can be seen in right-hemi-
sphere-mediated functions (Figure 1), as well as more anterior functions (Figure
2). Standard scores were computed by subtracting the mean of each test from the
raw score and dividing the result by the test's standard deviation as found in the
normative literature (Benton & Hamsher, 1976; Bornstein, 1984; Delis, Kramer,
Kaplan, & Ober, 1987; Fromm-Auch & Yeudall, 1983; Golden, 1978; Halstead &
text continues on p. 148
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Figure 2. Ms. C's individual test results, presented as z scores, grouped by neuropsycholog-
ical function (DH = dominant hand; NDH = nondominant hand; REC = recognition;
Hooper = Hooper Visual Organization Test; WAIS-R = Wechsler Adult Intelligence Scale-
Revised; PIQ = performance IQ; VIQ = verbal IQ; CVLT = California Verbal Learning
Test; WMS = Wechsler Memory Scale; W = word; C = color, C-W = color and word;
WCST = Wisconsin Card Sort Test; RESP = response).
Capgras Syndrome 147
a s s
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Figure 3. Ms. C's Minnesota Multiphasic Inventory (MMPI) profile (L = Lie scale; F =
Frequency scale; K = Correction scale; 1 = Hypochondriasis scale; 2 = Depression scale;
3 = Hysteria scale; 4 = Psychopathic Deviate scale; 5 = Masculinity-Femininity scale;
6 = Paranoia scale; 7 = Psychasthenia scale; 8 = Schizophrenia scale; 9 = Hypomania scale;
0 = Social Introversion scale).
148 Scott W. Sauter et al.
Wepman, 1978; Heaton, 1981; Hooper, 1985; Loring, Martin, Meador, & Lee,
1990; Wechsler, 1945, 1981; Yeudall, 1987).
Ms. C's language skills were seen as a relative strength, as were her attempts to
increase interpersonal contact. Interestingly, the personality assessment depicted a
profile uncharacteristic of paranoid schizophrenia; Ms. C.'s profile may best be
described as a resolving episodic psychotic depression (see Minnesota Multiphasic
Inventory profile in Figure 3). Ms. C.'s apparent need for nurturance and attempts
to increase interpersonal contact were viewed as a positive prognostic sign for
further gains in adaptive competency, as long as she complies with outpatient
follow-up (e.g., to the extent that she takes medication as prescribed, abstains from
alcohol, and receives supportive therapy). As her psychiatric symptomatology
clears, a return to work will become important for continued recovery.
Discussion
The results of this case presentation of Capgras syndrome support the literature in
describing the neuropathological aspects of this syndrome, as well as Berson's
(1983) criteria for Capgras syndrome. The use of the term syndrome may be
misleading because of the heterogeneity of possible etiologies. Symptoms of delu-
sional misidentification may be a more accurate description because it can occur
in varied presentations. Some clinicians have suggested that the use of multiple
and colorful descriptions of delusions of misidentification may not be as helpful as
a thorough and careful differential diagnosis based on neuropsychological and
personality testing, as well as neuroradiological evidence. Ms. C. was psychotic
with paranoid features, had a delusion of misidentification of a significant other,
and had neuropsychological impairment in the absence of prosopagnosia or an
acute confusional state.
Treatment typically follows a therapeutic regimen of antipsychotic medication
and supportive therapy in which areas of cognitive-behavioral strength are used to
overcome weaker areas of functioning. Ms. C.'s case was useful for documenting
the many competing explanations that clinicians are forced to rule out in a
hypothesis-testing model when making a differential diagnosis; her history included
alcohol abuse and withdrawal, along with neuropathological involvement, such as
head trauma, paranoid delusions, and psychodynamic issues. With regard to
assessment, differential diagnosis, and subsequent treatment, the context of the
referral and its specific question should dictate whether neuroradiological, neuro-
psychological, and psychodynamic perspectives ought to be considered. It may be
more appropriate to use the term symptoms of, rather than syndrome, when
describing delusions of misidentification because of the heterogeneity of etiologies
and varied clinical presentations.
References
Benton, A., & Hamsher, K. deS. (1976). Multilingual Aphasia Examination. Iowa City:
University of Iowa.
Berson, R. (1983). Capgras syndrome. American Journal of Psychiatry, 140, 969-978.
Bick, P. (1984). The syndrome of intermetamorphosis. A merican Journal of Psychiatry, 141,
588-589.
Bienenfield, D., & Brott, T. (1989). Drs. Bienenfield and Brott reply. Journal of Clinical
Capgras Syndrome 149