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Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs. Tumor-derived cytokines IL-6 and IL-8 acted as CTC attractants and the poor-prognosis markers MMP1 / collagenase-1 and the actin cytoskeleton component fascin-1 as mediators of CTC infiltration into mammary tumors.
Self-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs. Tumor-derived cytokines IL-6 and IL-8 acted as CTC attractants and the…