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NEONATAL
NEONATAL HERPES
HERPES SIMPLEX
SIMPLEX (1)(1)
~ babyusually infected primarily during passage thru birth canal
~ babyusually infected primarily during passage thru birth canal
~ premature membrane rupturing is risk factor
~ premature membrane rupturing is risk factor
~risk of perintl transmision high if florid primary infection in mom
~risk of perintl transmision high if florid primary infection in mom
~ smaller risk fr recurrent maternal lesion bcoz lower viral load and presence of specific Abs.
~ smaller risk fr recurrent maternal lesion bcoz lower viral load and presence of specific Abs.
~ baby can be infected fr other sources like oral lesion fr mother or hepatic whillow in nurse
~ baby can be infected fr other sources like oral lesion fr mother or hepatic whillow in nurse
~ spectrum of neonatal HSV varies fr mild disease localized to skin to fatal disseminated infection
~ spectrum of neonatal HSV varies fr mild disease localized to skin to fatal disseminated infection
~ when
~ whenbrain is involved, prognosis is poor. If survived, they have residual disabilities
brain is involved, prognosis is poor. If survived, they have residual disabilities
~ give acyclovir and prevent by caeserian section
~ give acyclovir and prevent by caeserian section