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1: Int J Dermatol. 2002 Sep;41(9):606-11. Links

Evidence supporting zinc as an important antioxidant for skin. Related Links

Rostan EF, DeBuys HV, Madey DL, Pinnell SR. [Enhancement of endogenous antioxidant defenses: a
[BullofAcad
promising strategy for prevention skin Natl Med. 2001]
cancers]
Duke University, Durham, NC 27710, USA.
Metals, toxicity and oxidative stress.
[Curr Med Chem. 2005]
Antioxidants play a critical role in keeping skin healthy. The antioxidant benefits of
vitamin C and E are well known, but the importance of the trace mineral, zinc, has Free radical tissue damage: protective role of
been overlooked. This article reviews the evidence supporting zinc's antioxidant antioxidant nutrients. [FASEB J. 1987]
role in protecting against free radical-induced oxidative damage. Zinc protects The antioxidant properties of zinc and metallothionein.
against UV radiation, enhances wound healing, contributes to immune and [NeurochemInt. 1996]
neuropsychiatric functions, and decreases the relative risk of cancer and
Zinc, antioxidant systems and metallothionein in metal
cardiovascular disease. All body tissues contain zinc; in skin, it is five to six times mediated-apoptosis: biochemical and
[Comp Biochem Physiol C Toxicolcytochemical
Pharmacol. 2007]
more concentrated in the epidermis than the dermis. Zinc is required for the
normal growth, development and function of mammals. It is an essential element » See all Related Articles...
of more than 200 metalloenzymes, including the antioxidant enzyme, superoxide
dismutase, and affects their conformity, stability, and activity. Zinc also is
important for the proper functioning of the immune system, and for glandular,
reproductive and cell health. Abundant evidence demonstrates the antioxidant role
of zinc. Topical zinc, in the form of divalent zinc ions, has been reported to provide
antioxidant photoprotection for skin. Two antioxidant mechanisms have been
proposed for zinc: zinc ions may replace redox active molecules, such as iron and
copper, at critical sites in cell membranes and proteins; alternatively, zinc ions may
induce the synthesis of metallothionein, sulfhydryl-rich proteins that protect
against free radicals. No matter how they work, topical zinc ions may provide an
important and helpful antioxidant defense for skin.
PMID: 12358835 [PubMed - indexed for MEDLINE]

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