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New antifungal flavonoid glycoside from Vitex negu...[Bioorg Med Ch... http://www.ncbi.nlm.nih.


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1: Bioorg Med Chem Lett. 2007 Jan 1;17(1):239-42. Epub 2006 Oct 5. Links

New antifungal flavonoid glycoside from Vitex negundo. Related Links

Sathiamoorthy B, Gupta P, Kumar M, Chaturvedi AK, Shukla PK, Maurya R. Antidermatophytic activity of extracts from Psoralea
corylifolia (Fabaceae) correlated Ethnopharm acol. 2004]
the presence of a
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, flavonoid compound.
Cytotoxic flavone analogues of vitexicarpin, a
[J Nat Prod. 2003]
constituent of the leaves of Vitex negundo.

Flavonoids are ubiquitous in photosynthesizing cells and are common part of Antifungal principles from Piper fulvescens.
human diet. For centuries, preparations containing these compounds as the [Planta Med. 2001]
principal physiologically active constituents have been used to treat human Antifungal activity of a new triterpenoid glycoside from
diseases. Increasingly, this class of natural products is becoming the subject of Pithecellobium racemosum (M.). [PharmRes. 1997]
anti-infective research. Our bioactivity guided fractionation of ethanolic extract of
Flavonoids, triterpenoids and a lignan from Vitex
leaves of Vitex negundo resulted in the isolation of new flavone glycoside (4) along
altissima. [Phytochemistry. 2005]
with five known compounds 1-3, 5 and 6. All the isolated compounds were
evaluated for their antimicrobial activities. The new flavone glycoside 4 and » See all Related Articles...
compound 5 were found to have significant antifungal activity against Trichophyton
mentagrophytes and Cryptococcus neoformans at MIC 6.25 microg/ml.
PMID: 17027268 [PubMed - indexed for MEDLINE]

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