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February 11, 2011
George B. Dantzig is also known as the father of Linear Programming and the creator of a mathematical
model of the general linear programming problem called the simplex method. He proposed that
interrelations between activities of a large organization can be viewed as a LP model and that the
optimal program (solution) can be obtained by minimizing a (single) linear objective function.
The simplex method is based on a fundamental theorem, also known as the ͞Extreme Point Theorem͟,
which follows:
͞Î
The simplex method provides an efficient systematic search guaranteed to converge in a finite number
of steps.
It is important to consider that this method only deals with equalities and it compares constraint
conversions with goal conversions using deviation variables.
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The modified simplex method (MSM) has been applied, to determine compounds by a luminescence
technique. The method was based on the optimization of chemical and instrumental variables affecting
phosphorescence using a geometric simplex in two and three dimensions of space, respectively. As
application, we have determined a novel antihypertensive drug, naftopidil, in urine and serum, by heavy
atom induced room temperature phosphorescence (HAI-RTP); this technique enables us to determine
analytes in complex matrices, biological fluids, without the need for a tedious prior separation process.
Aith the proposed method, the maximum signal of phosphorescence appears instantly once the sample
has been prepared and the intensity was measured at ex=287 nm and em=525 nm. Overall least-
squares regression was used to find the straight line that fitted the experimental data. The detection
limit, as well as the repeatability and the standard deviation (S.D.) for replicate sample, were also
determined.
Arreola, îesús S.
2003, México.
Andreas T. Ernst, Mohan Krishnamoorthy, Robert H. Storer. Heuristic and Exact Algorithms for
Scheduling Aircraft Landings. 1998, Australia.
î. A. Murillo Pulgarín, A. Alañón Molina and M. T. Alañón Pardo. Department of Analytical ¦hemistry and
Foods Technology, University of ¦astilla-La Mancha, 13071, ¦iudad Real, Spain, 2002.