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EMPLOYMENT CHRONOLOGY:
RESEARCH ASSOCIATE II, COVANCE INC., GREENFIELD IN 10/08 - 04/10
Project: (1) Mined clinical cancer microarray gene expression and pathological d
ata from both external and Lilly internal databases. Developed and programmed pa
ir-wise gene algorithm to classify various phenotypes of DLBCL, lung cancers.
(2) Applied statistics methods and pathway analysis to identify g
enes associated with liver toxicity from Drug Matrix database. Searched gene seq
uence. Annotated genes and proteins in internal drug discovery database.
(3) Developed various 3D *CT imaging markers to quantify normaliz
ation of entire tumor vasculature and evaluate anti-VEGF treatment.
(4) Synthesized both albumin and lipid microbubble and conjugated
antibody to lipid microbubbles to detect related antigen expression in xenograp
h model.
(5) Investigated the optimized ultrasound settings for siRNA and
plasmid sonoporation both in vitro and in vivo.
Achievement:
In Bioinformatics, I searched the databases and programmed all of necessary code
s and applied different software to various Bioinformatics tasks in Lilly. We w
ere invited to Seoul of South Korea to present our novel gene-pair algorithm to
classify phenotypes of cancers in VLDB meeting. We published our Bioinformatics
work in two different journals and were invited to publish in a book chapter th
is year. In March of this year, the book chapter was accepted for publication.
I was awarded for Team Work in Bioinformatics lipoprotein projects in 2005.
In support to Imaging group in Lilly, we successfully developed ultrasound micro
bubble synthesis and researched microbubble applications in both non-invasive im
aging and drug delivery. We not only gained the experiences of sonoporation but
reduced the cost at least 50% compared to contract out to academic labs. We de
veloped our own imaging analysis algorithm to quantify the antigen/receptor expr
essions after acquiring targeted microbubble images. The work was awarded by Lil
ly LRL both in team work and scientific achievement.
BIOINFORMATICS/BIOMECHANICS
DEPARTMENT OF COMPUTER SCIENCE, PHYSICS, CHEMISTRY, DEPARTMENT OF CELL AND ANATO
MY OF IUSM, DEPARTMENT OF BIOLOGY OF IU BLOOMINGTON 08/00 - 06/04
Project: (1) Functional Genomics Yeast Cell Cycling cDNA Microarray Analysis An
d Modeling (Project of Computer Science and BME)
(2) Proteomics Ovarian Cancer Prognostic Biomarker Search And Pa
rathyroid Hormone Treatment Evaluation By Analyzing SELDI-TOF-MS data (Ciphergen
ProteinChip Technology) (Project of Computer Science and Cancer Center)
(3) NMR/AFM/NSOM investigation on lipid orientation and perfusio
n on artificial liposome (Project of Physics and Biology Department)
Achievement: We developed proteomics data analysis algorithm to search proteins
from SELDI-TOF-MS spectrum with methods in Physics and Statistics. We used thi
s algorithm to analyze the SELDI proteomics data for Cancer and Bone group. I t
ransformed the yeast gene expression values to phase space to characterize the m
echanism of yeast cell cycling. Six papers and conference reports at different
topics were published.