ROBERT W. GOULET, Ph.D.

20 Northwood Dr.
Labadie, MO 63055
(636) 742-2699 (Home)
(636) 399-1632 (Cell)
rg6b4556@westpost.net

Summary
Insightful, deliberative Senior Principal Scientist with extensive knowledge in
developing scientific programs, cheminformatic and computational chemistry tools
used in the pharmaceutical industry. These tools have impacted both local and g
lobal teams. Background includes developing several web-based tools. Used commer
cial tools and integrated them within internal computational environment. Am kno
wn for my ability to carefully indentify and weigh all options before making dec
isions, able to easily adapt to new situations and ensure project completion ben
efiting the organization and customer. Work well within a team or individually,
continuously strive to learn, apply, teach and develop successful solutions usin
g ingenious methods.
Professional Experience
Pfizer, Inc., St Louis, MO 2007 to Present
Senior Principal Scientist
* Using experience from developing local patent analysis tools, significantly co
ntributed to the Global Patent Analysis Tools team goal of developing and delive
ring several tools by the end of 2009 enabling scientists to more easily and qui
ckly get a better understanding of the IP space.
* As member of the Structural and Computational Chemistry group in PGRD St Louis
, developed innovative computational tools and procedures that enabled researche
s to test and evaluate drug candidates ensuring only the most desirable ones wou
ld be synthesized. Developed docking protocols, QSAR models, independently and i
n collaboration with computational chemists for use in Pfizeras compute infrastr
ucture, as well as lead generation or scaffold hoping tools that became part of
a set of global Lead Generation tools.
Pfizer, Inc., Ann Arbor, MI 2004 to 2007
Senior Principal Scientist
* As a member of a global team developing application to allow computational che
mists to build and publish QSAR models, implemented many of the statistical comp
onents used, helped define and develop the standards of the application's compon
ents, as well as worked with end-users ensuring the application met their needs
and was easy to use. This tool has been very well received by computational chem
ists within Discovery, PDM, and other groups becoming the preferred tool to deve
lop and deploys QSAR models.
* Served as leader of a global team that set the best practices and educating us
ers in the publication of computational models within Pfizer's internal computin
g environment. Responsibilities included organizing team, setting goals, objecti
ves, and holding monthly meetings. We successfully increased productivity of new
model publications and their use via Pfizeras various global desktop applicatio
ns.
* Key developer on a local Java application that bridged the computational biolo
gy and chemistry fields for use in evaluating targets drugability. Although we s
topped development of this application, the requirements, work-flows, and use ca
ses developed were incorporated into various global efforts.
Pfizer, Inc., Ann Arbor, MI 2001 to 2004
Research Associate
* As a member of global team developing a molecular visualization application, s
et the specifications for accessing and running computational models published o
n Pfizer's computational servers, defined and wrote the User Help documentation
used within the application, as well as involved in developing and giving traini
ng classes on using the application. Also employed Contextual Inquiry and Use Te
sting expertise to the application design which has allowed users to work more e
fficiently with the application.
* Using my knowledge and expertise in developing computational models/tools, wor
ked on a global team to define standards for Pfizer's global computational serve
rs. Because of this, it allowed a smooth transfer of all models from the local A
nn Arbor environment to the global computational environment enabling the retire
ment of several applications, free up local resources and eliminate duplication
of effort saving the company money.
* As a team member to streamline in vitro measurements of ADME/Tox properties, l
ead the development and implementation of a web-based application to calculate i
n silico ADME/Tox and other properties. The application was well received and us
ed not only by team members, but by all scientists at the Ann Arbor laboratories
and several other Pfizer research sites. Many of the best practices established
in this application were incorporated into newer Pfizer tools.
* Key member of the team that formed the BioImaging Center at Pfizer, Inc.. Base
d on my experience in using micro-CT to study the structural-mechanical properti
es of bone and strong computer background, defined the specifications for micro-
CT usage and computer-network requirements of the Center.
Warner Lambert, Ann Arbor, MI 1997 to 2001
Senior Scientist
* Lead developer of web based tools which allowed computational chemists to post
alignment, pharmacophore, or docking models to a computational application serv
er. Medical chemists on numerous projects used these tools and models to save ti
me by testing hypotheses and/or assessing how well their ideas for ligands might
bind to a target before actually synthesizing them. Several compounds were nomi
nated for further development as a direct result of ligands modeled utilizing th
ese tools.
* Coordinated efforts with Tripos, Inc. to conduct Contextual Inquiry/Use Testin
g studies to improve our local web-tools as well as their molecular visualizatio
n program used by the tools. This effort resulted in much easier and well receiv
ed web-tools by Ann Arbor colleagues; and enabled the vendor to produce a much m
ore marketable visualization tool.
Warner Lambert, Ann Arbor, MI 1996 to 1997
Senior Systems Programmer
* Collaborated with the Informatics group to develop, setup, and implement autom
atic procedures to calculate several in silico PK/physiochemical properties whic
h were loaded into the global corporate database; and to automatically update lo
cal copies of the corporate chemical structure database (in 2D and 3D formats) f
or use by Ann Arbor computational chemists in their analyses. These procedures
were later adopted by Pfizer in newer database systems.
Warner Lambert, Ann Arbor, MI 1995 to 1996
Systems Programmer
* Maintained and directed system administration for CADD computing environment,
developed proposals/budgets for maintenance and future enhancements of CADD comp
uting environment, installation of scientific software, coordinated licensing an
d software installation with vendors, and evaluated and recommended new software
for the group.
* Acted as liaison between CADD group and Ann Arbor Data Center (AADC) for compu
ter or networking issues.
* Setup, maintained and served as webmaster for Ann Arbor CADD intranet website.
University of Michigan, Ann Arbor, MI 1993-1995
Postdoctoral Fellow at the Orthopaedic Research Laboratories, Dept. of Orthopaed
ic Surgery
* Developed software upgrades for specific segments controlling the micro-comput
ed tomography (cone beam scanner developed by Dr. Lee Feldkamp) system in the La
boratory, and improved elements of the associated image reconstruction and analy
ses algorithms. Taught members of the Orthopaedic Research Labs how to operate
the micro-CT scanner, and worked with them to develop protocols for scanning and
analyzing specimens for their projects.
* Research included the evaluation of a canine osteoarthritis model, the determi
nation of structural and mechanical properties of cortical bone in a transgeneti
c mouse model, failure characterization of vertebral trabecular bone, and the as
sessment of structural and mechanical properties differences due to donor age in
human vertebral trabecular tissue.
Relevant Skills:
Programming: Perl, HTML, Python, Java, R(statistical)-scripting, MOE SVL, Daylig
ht Toolkit, FORTRAN, C, JavaScript, CGI/Bin, CShell
Software Development: Pipeline Pilot protocols, Perl and Python scripts, Web app
lications, Java applications, Java/Swing, GA and other scientific applications f
or use in the drug design process, 2D & 3D Image analysis and visualization prog
rams
Software Packages: Computational Chemistry software (MOE, Tripos, Daylight, Open
Eye, GOLD, Schrodinger), Pipeline Pilot, Spotfire, Image analysis programs, NetB
eans, Eclipse, Dreamweaver, Microsoft Word, Microsoft Excel, Microsoft PowerPoin
t, Microsoft Visio, Statistical analysis programs
Operating Systems: UNIX, IRIX, Windows 2000/XP-Professional, Linux and Macintosh
Education:
Ph.D. in Bioengineering December, 1993
The University of Michigan, Ann Arbor, MI
M.S.E. in Bioengineering December, 1986
The University of Michigan, Ann Arbor, MI
M.S.E. in Mechanical Engineering December, 1986
The University of Michigan, Ann Arbor, MI
B.S.E. in Engineering Science May, 1984
The University of Michigan, Ann Arbor, MI
Ongoing professional development courses
Professional Societies / Activities:
Member, The American Chemistry Society

Professional References:
Available upon request
Publications / Presentations:
Author on Peer Reviewed Journal Articles
* Kibbey, C., Goulet, R.W., Hughes, J., Kuhn, M., Li, D., Luty, B., Samuelson, S
., Schefzick, S. and Sng, S-T: In silico Model Generator (isMG): A QSPR Modeling
Environment built on a Distributed Computing Framework, submitted in preparatio
n, 2009.
* McCreadie, BR, Goulet, RW, Feldkamp, LA, Goldstein, SA: Hierarchical structure
of bone and micro-computed tomography. Advances in Experimental Medicine and B
iology, 469: 67-83, 2001.
* Sherick, DG, Buchman, SR, Goulet, RW, Goldstein, SA: A new technique for the q
uantitative analysis of cranial suture biology. The Cleft Palate Craniofacial Jo
urnal, 37(1): 5-11, 2000.
* Buchman, SR, Sherick, DG, Goulet, RW, Goldstein, SA: Use of microcomputed tomo
graphy scanning as a new technique for the evaluation of membranous bone. The Jo
urnal of Craniofacial Surgery, 9(1): 48-54, 1998.
* Zysset, P.K., Goulet, R.W., Hollister, S.J.: A global relationship between tr
abecular bone morphology and homogenized elastic properties. Journal of Biomech
anical Engineering, 120(5):640-646, 1998.
* Guldberg, RE, Caldwell, NJ, Guo, XE, Goulet, RW, Hollister, SJ, Goldstein, SA:
Mechanical stimulation of tissue repair in the hydraulic bone chamber. Journal
of Bone and Mineral Research, 12(8): 1295-302, 1997.
* Jepsen, KJ, Schaffler, MB, Kuhn, JL, Goulet, RW, Bonadio, J, Goldstein, SA: Ty
pe I collagen mutation alters the strength and fatigue behavior of Mov13 cortica
l tissue. Journal of Biomechanics, 30(11-12): 1141-7, 1997.
* Dedrick, DK, Goulet, RW, O'Connor, BL, Brandt, KD: Preliminary report: increa
sed porosity of the subchondral plate in an accelerated canine model of osteoart
hritis. Osteoarthritis and Cartilage, 5(1): 71-4, 1997.
* Goulet, R.W., Goldstein, S.A., Ciarelli, M.J., Kuhn, J.L, Brown, M.B., Feldkam
p, L.A.: The relationship between the structural and orthogonal mechanical prop
erties of trabecular bone. Journal of Biomechanics, 27(4):375-389, 1994.
* Dedrick, D.K., Goldstein, S.A., Brandt, K.D., O'Connor, B.L., Goulet, R.W., Al
brecht, M.: A longitudinal study of subchondral plate and trabecular bone in cr
uciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis
& Rheumatism, 36(10): 1460-1467, 1993.
* Goldstein, S.A., Goulet, R.W., and McCubbrey, D.A.: Measurement and significa
nce of three dimensional architecture to the mechanical integrity of trabecular
bone. Calcif. Tissue Int., 53(Supp 1): S127-S133, 1993.
* Fyhrie, D.P., Fazzalari, N.L., Goulet, R.W., Goldstein, S.A.: Direct calculat
ion of the surface-to-volume ratio for human cancellous bone. Journal of Biomec
hanics, 26(8):955-967, 1992.
* Dedrick, D.K., Goulet, R., Huston, L., Goldstein, S.A., Bole, G.G.: Early bon
e changes in experimental osteoarthritis using microscopic computed tomography.
Journal of Rheumatology, 27(18):44-45, 1991.
* Kuhn, J.L., Goldstein, S.A., Feldkamp, L.A., Goulet, R.W., Jesion, G.: Evalua
tion of a microcomputed tomography system to study trabecular bone structure. J
ournal of Orthopaedic Research, 8(6):833-842, 1990.
* Kuhn, J.L., Goulet, R.W, Pappas, M., Goldstein, S.A.: Morphometric and anisotr
opic symmetries of the canine distal femur. Journal of Orthopaedic Research, 8
(5):776-780, 1990.
* Layton, M.W., Goldstein, S.A, Goulet, R.W., Feldkamp, L.A., Bole, G.G.: Exami
nation of subchondral bone architecture in experimental osteoarthritis by micros
copic computerized axial tomography. Journal of Arthritis and Rheumatism. 31(1
1):1400-1405, 1988.
Author on Published Abstracts
* Ortwine, D.F., Dunbar, B.W., Goulet, R.W., Humblet, C.; Lunney, E.A.; Narasimh
an, L.; O'Donnell, T.J.; Rojnuckaran, D.: Modeling on the web: Intranet-based d
rug design software. 224th ACS National Meeting, Boston, MA, United States, Augu
st 18-22, 2002.
* Blankley, C.J., Gifford, E., Goulet, R.W., Humblet, C., OaDonnel, TJ: WebPK.
5th Annual Drug Discovery Symposium, PGRD Ann Arbor Laboratories, 2000.
* Goulet, R.W., Hollister, S.J.: Determination of minimum microstructural analy
sis volumes for trabecular bone using 3-D stereology and FFT analysis. Trans. o
f Ortho. Res. Soc., 21:715, 1996.
* Smith, E.A., Guo, X.E., Goulet, R.W., Hollister, S.J., Goldstein, S.A.: Predi
ction of local strains in human vertebral bone specimens using CT-based finite e
lement models. Trans. of Ortho. Res. Soc., 21:604, 1996.
* Guo, X.E., Weissman, D.E., Goulet, R.W., Hollister, S.J., Derwin, K.A., Goldst
ein, S.A.: Characterization of local failure in vertebral trabecular bone. Tra
ns. Orthop. Res. Soc., 20, 1995.
* Dedrick, D.K., Goulet, R.W., O'Connor, B.L., Brandt, K.D.: Changes in subchon
dral plate and cancellous bone in an accelerated canine model of osteoarthritis.
Trans. Orthop. Res. Soc., 20, 1995.
* McCubbrey, D.A., Mascha, E.J., Goulet, R.W., Goldstein, S.A.: Relationships b
etween trabecular architecture and failure properties of whole vertebrae in the
beagle. Trans. Orthop. Res. Soc., 19(1):55, 1994.
* McCubbrey, D.A., Yian, E.H., Goulet, R.W., Shih, M-S., Parfitt, A.M., Goldstei
n, S.A.: The effects of calcitonin on trabecular bone properties in the ovariec
tomized beagle. Trans. Orthop. Res. Soc., 18(1):53, 1993.
* McCubbrey, D.A., Cody, D.D., Gross, G.J., Goulet, R.W., Goldstein, S.A.: Rela
tionships between cancellous density, architecture, and material properties of t
he human proximal femur. Trans. 9th International Workshop on Bone Densitometry
, 1992.
* Goulet, R.W., Feldkamp, L.A., Goldstein, S.A.: Quantification of the architec
ture of cancellous bone by surface and volume orientation methods. Trans. of Or
tho. Res. Soc., 17:159, 1992.
* McCubbrey, D.A., Goldstein, S.A., Cody, D.D., Goulet, R.W., and Kuhn, J.L.: T
he regional density, architectural, and tissue properties of vertebral trabecula
r bone and their relation to whole bone failure properties. Trans. ASME Winter
Annual Mtg., 20:575-578, 1991.
* Dedrick, D.K., Goulet, R.W., Widmer, W.R., O'Connor, B.L., Brandt, K.D., Golds
tein, S.A.: Evaluation of trabecular bone in experimentally induced canine oste
oarthritis. Trans. Ortho. Res. Soc., 16:332, 1991.
* McCubbrey, D.A., Goulet, R.W., Goldstein, S.A., Shulick, A.M.: Vertebral body
architecture and mechanical properties alterations due to ovariectomy in the be
agle. Trans. Ortho. Res. Soc., 16:284, 1991.
* Dedrick, D.K., Brandt, K., Goulet, R.W., Goldstein, S.A., O'Connor, B.: Subch
ondral plate (SP) and trabecular (T) bone in experimental osteoarthritis (OA).
Arthritis and Rheumatism, 33(9):S91, 1990.
* Goldstein, S.A., Kuhn, J.L., Goulet, R.W., Choi, K., Hollister, S.J., Ciarelli
, M.J., Matthews, L.S.: Properties and remodeling of trabecular bone. First Wo
rld Congress of Biomech., 2:210, 1990.
* Goldstein, S.A., Goulet, R.W., Kuhn, J.L., Feldkamp, L.A.: Experimental data
on cancellous bone architecture. First World Congress of Biomech., 2:45, 1990.
* Hollister, S.J., Goulet, R.W., Goldstein, S.A.: Predicting trabecular bone st
iffness using two methods of microstructural analysis. First World Congress of
Biomech., 1:210, 1990.
* Hollister, S.J., Goldstein, S.A., Jepsen, K.J., Goulet, R.W.: Continuum and m
icrostructural stress morphology relationships for trabecular bone subject to co
ntrolled implant loads. Trans. Ortho. Res. Soc., 15:74, 1990.
* Dedrick, D.K., Goldstein, S.A., Goulet, R.W., Bole, G.G.: Early bone changes
in experimental osteoarthritis. Arthritis and Rheumatism, 23(4):1095, 1989.
* Goulet, R.W., Feldkamp, L.A., Kubinski, D.J., Kuhn, J.L., Goldstein, S.A.: Pr
edicting the architectural orientation of trabecular bone. Trans. Ortho. Res. S
oc., 14:263, 1989.
* Kuhn, J.L., Goulet, R.W., Goldstein, S.A., Feldkamp L.A.: A study of the varia
tion of trabecular architectures in small volumes of bone using a micro-computed
tomography system. J. Biomech., 21(10):853, 1988.
* Layton, M.W., Goldstein, S.A., Goulet, R.W., Feldkamp, L.A., Bole, G.G.: Evalu
ation of subchondral bone architecture in experimental osteoarthritis by microsc
opic computerized axial tomography. Trans. Ortho. Res. Soc., 13:489, 1988.
* Goldstein, S.A., Kuhn, J.L., Hollister, S.J., Goulet, R.W., Loubert, P.V., Swe
et, K., Matthews, L.S.: The relationship between experimentally controlled load
s and trabecular bone remodeling. Trans. Ortho. Res. Soc., 13:102, 1988.
* Goulet, R.W., Ciarelli, M.J., Goldstein, S.A., Kuhn, J.L., Feldkamp, L.A., Kru
ger, D., Viviano, D., Champlain, F., Matthews, L.S.: The effects of architectur
e and morphology on the mechanical properties of trabecular bone. Trans. Ortho.
Res. Soc., 13:73, 1988.
* Goldstein, S.A., Ku, J.L., Hollister, S.J., Goulet, R.W., Champlain, F.W., Mat
thews, L.S.: Experimentally controlled trabecular bone remodeling: effects of a
pplied stress. Trans. Ortho. Res.Soc., 12:461, 1987.
* Goldstein, S.A., Ku, J.L., Goulet, R., Feldkamp, L.A., Ciarelli, M., Kruger, D
., Jesion, G., Matthews, L.S.: The relationship between three-dimensional archi
tecture of trabecular bone and its mechanical properties. 1987 Biomechanics Sym
posium, Amer. Soc. Mech. Engin., 84:287-89, June 1987.
Presentations at National Conferences
* aAn Integrated Desktop Computing Environment for Chemistsa, presented at the B
ridging Pharma and IT conference, Boston, MA, September, 2007.
* aComputational Chemistry Desktop Applications For Chemistsa, presented at the
CHI Intelligent Drug Discovery & Development Conference, Philadelphia, PA, May,
2003.
* aMaking WebTools work for Chemistsa, presented at the 6th International Confer
ence on Chemical Structures, in The Netherlands, June, 2002.
* "Quantification of the Architecture of Cancellous Bone by Surface and Volume O
rientation Methods", presented at the 38th meeting of the Orthopaedic Research S
ociety, Washington, DC, February, 1992.
* "Predicting the Architectural Orientation of Trabecular Bone," presented at th
e 35th meeting of the Orthopaedic Research Society, Las Vegas, NV, February, 198
9.
* "The Effects of Architecture and Morphology on the Mechanical Properties of Tr
abecular Bone," presented at the 34th meeting of the Orthopaedic Research Societ
y, Atlanta, GA, February, 1988.