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EPIBEZA TAB.

Composition
Each tablet contains:
Bezafibrate 200 mg

Properties and Mode of Action

EPIBEZA is a fibric acid derivative which promotes the catabolism of triglyceride-rich lipoproteins, in particular VLDL,
mediated by enhanced activity of lipoprotein lipase.
EPIBEZA may interfere with the synthesis of VLDL, possibly by inhibiting hepatic acetyl coenzyme A carboxylase.
EPIBIZA slightly decreases LDL-cholesterol level and increases HDL-cholesterol concentration in both
normotriglyceridaemic and hypertriglyceridaemic patients.

Indications
Treatment of Type II a,Type II b,Type III, Type IV, and Type V Hyperlipoproteinaemia.

Dosage and Administration

The usual dose is 200 mg three times daily taken after food.
200 mg twice daily may be an adequate dose for maintenance.

Precautions
If necessary to be given to impaired renal function or hypoalbuminaemia patients, the dose must be reduced as follows:
If Creatinine clearance is 40 - 60 ml/min., give 400 mg daily.
If Creatinine clearance is 15 - 40 ml/min., give 200 mg daily or on alternate days.
If Creatinine clearance is < 15 ml/min., and dialysis patients, give 200 mg every third day.

Drug Interactions
EPIBEZA may enhance the effects of oral anticoagulants by displacing them from their binding sites on albumin,so, the
dose of the anticoagulant must be reduced.
The dosage of anti-diabetics may need adjusting during concomitant EPIBEZA therapy.
Coadministration with statins may increase the risk of myositis-like syndrome,so,CPK must be checked at regular intervals
during this combination therapy.

Contra_indications
Severe liver or kidney impairment.
Primary biliary cirrhosis.
Gallstones or gallbladder disorders.
Pregnancy and lactation.
Children.

Side effects
The most common side effects are gastrointestinal upsets including nausea and gastric discomfort.
Less frequently, headache, dizziness, vertigo, fatigue, skin rash, pruritus, alopecia, impotence and anaemia.
Rarely, muscular pain or muscular weakness.

1 of 2 3/2/2011 7:36 PM
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Presentation
Box of 3 blisters of 10 tablets each.

2 of 2 3/2/2011 7:36 PM