BT - 2004 Syllabus

SCHEME OF EXAMINATION & SYLLABI
BIOTECHNOLOGY ENGINEERING
B. Tech. Degree Course of C A L IC U T U N IV E R S IT Y
2004 A D M IS S IO N O N W A R D S
COMBINED FIRST AND SECOND SEMESTER

Code
EN04 101
Subject
Hours/Week
L T P/D
Session Uni./Exam Marks Hrs Marks .
Engineering Mathematics I EN04 102 Engineering Mathematics 11 EN04 103 A(P) Engineering Physics(A) EN04 103 A Physics Lab(A) 103A(P) EN04 104A Engineering Chemistry(A)
EN04104A(P) EN04 105 EN04 106A EN04 107A EC04 108 EC04 109
3 3 2 2 2 1 2 2 2 19
1 1
1 1 3 3 2 10
50 50 50 25 50 25 50 50 50 50 50 50 50 600
3 3 3 3 3 3 3 3 3 -
100 100 100 100 100 100 100 100 100 900
Chemistry Lab(A) Humanities Engineering Graphics(A) Engineering Mechanics(A) Basic Electronics
Basic Electrical Engineering EC04 110(P) Mechanical Workshop EC04 111P) Electrical and Electronics Workshop
TOTAL
Note : Details of Common Course

SL SUBJECT NO. CODE 1 EN04-10I 2 ENO4-102 3 NAME OF SUBJECT
MATHEMATICS-1 MATHEMATICS-II ENGINEERING PHYSICS(A) PHYSICS LAB(A) ENGINEERING PHYSICS(B) PHYSICS LAB(B) ENGINEERING CHEMISTRY(A) CHEMISTRY LAB(A) ENGINEERING CHEMISTRY(B) CHEMISTRY LAB(B) ENGINEERING CHEM1STRY(C) CHEMISTRY LAB(C) HUMANITIES ENGINEERING GRAPHICS(A) ENGINEERING GRAPHICS(B) ENGINEERING MECHANICS(A) ENGINEERING MECHANICS(B) BASIC ELECTRONICS COMPUTER PROGRAMMING IN C BASIC ELECTRICAL ENGINEERING BASIC ELECTRICAL ENGINEERING CIVIL AND MECHANICAL WORKSHOP MECHANICAL WORKSHOP ELECTRICAL AND ELECTRONICS WORKSHOP
COMMON FOR
COMMON FOR ALL. COMMON FOR ALL. AI,EE,EC,1C,BM,BT CH,CE,ME,PE CH,CE.ME,PE AI,CS,EE,EC,IT,IC,BM,BT,PT AI,EE,BC,IC,BM,BT CE,ME,PE CE,ME,PE CH CH COMMON FOR ALL AI,CS,EE,IT,IC,PT,BM,BT CE,CH,ME,PE AI,CH,CS,EE,EC,IT,IC,BM,BT,PT CE,ME,PE EC,BM,BT,AI,IC CS, IT, PT AI,EE,EC,IC,BM,BT, CS,IT.PT EE,CS,IT,PT EC,A1,BT,BM,IC EE,EC,AI,BT,BM,CS, IT,IC,PT
Al, S,EE,EC, IT,IC,BM,BT, PT
ENO4-103A ENO4-103A(P) ENO4-103B EN04-103B(P) EN04-104A EN04-104A(P) EN04-104B EN04-104B(P} ENO4-104C EN04-104C(P) EN04-105 EN04-106A EN04-106B EN04-107A EN04-107B EC04-108 CS04-108 EE04-I09 CS04-109 EE04-110(P) EC04-110(P) EEO4-111(P)
5 6 7 8 9 10 11
THIRD SEMESTER
Code
EN04 301A BT04 302 BT04 303 BT04 304 BT04 305 BT04 306 BT04 307(P) BT04 308(P)
Subject
ENGINEERING MATHEMATICS-III COMPUTER PROGRAMMING IN C CELL BIOLOGY CHEMICAL ENGINEERING I MICROBIOLOGY BIOCHEMISTRY I MICROBIOLOGY LAB BIOCHEMISTRY LAB
Hours/Week Session University Marks Exam L T P/D Hrs Marks
3 2 3 3 3 3 -
1 1 1 1 1 -
2 3 3
50 50 50 50 50 50 50 50
3 3 3 3 3 3 3 3
100 100 100 100 100 100 100 100
TOTAL
17 5
400
800
FOURTH SEMESTER
Code
EN04 401A EN04 402 BT04 403 BT04 404 BT04 405 BT04 406 BT04 407(P) BT04 408(P)
Subject
ENGINEERING MATHEMATICS - IV ENVIRONMENTAL STUDIES BIOCHEMISTRY II CHEMICAL ENGINEERING II BIOPROCESS PRINCIPLES ANALYTICAL TECHNIQUES IN BIOTECHNOLOGY CHEMICAL ENGINEERING LAB I BIO-ANALYTICAL TECHNIQUES LAB
Hours/Week Session
L T P/D Marks
University Exam Hrs Marks
3 3 3 3 3 3 -
1 1 1 1 1 1 -
3 3
50 50 50 50 50 50 50 50
3 3 3 3 3 3 3 3
100 100 100 100 100 100 100 100
TOTAL
18
400
800
FIFTH SEMESTER
Code
Subject
Hours/Week Session
L T P/D Marks
BT04 501 BT04 502 BT04 503 BT04 504 BT04 505 BT04 506
Industrial Biotechnology Mass Transfer and Separation Process Molecular Biology Enzyme Engineering & Technology Chemical Reaction Engineering Applied Electronics
3 3 3 3 3 3 -
1 1 1 1 1 1 -
3 3
50 50 50 50 50 50 50 50
3 3 3 3 3 3 3 3
100 100 100 100 100 100 100 100
BT04 507(P) Chemical Engineering Lab II BT04 508(P) Molecular Biology Lab TOTAL
18
400
800
SIXTH SEMESTER
Code
BT04 601 BT04 602 BT04 603 BT04 604 BT04 605 BT04 606 BT04 607(P) BT04 608(P)
Subject Engineering Economics & Principles of Management Instrumentation and Process Control Bio-Process Engineering Genetic Engineering Protein Engineering Bioinformatics
Hours/Week Session University Marks Exam

L T P/D Hrs Marks
3 3 3 3 3 3 -
1 1 1 1 1 1 -
3 3
50 50 50 50 50 50 50 50
3 3 3 3 3 3 3 -
100 100 100 100 100 100 100 -
Bio Process Technology Lab I Mini Project

TOTAL
18
400
700
SEVENTH SEMESTER
Code
BT04 701 BT04 702 BT04 703 BT04 704
Subject Downstream Processing Bioprocess Plant Design Recombinant DNA Technology
Hours/Week Session University Marks Exam

L T P/D Hrs Marks
3 3 3 3 3 -
1 1 1 1 1 -
3 4 3
50 50 50 50 50 50 50 50
3 3 3 3 3 3 -
100 100 100 100 100 100 -
Environmental Biotechnology BT04 705 Elective I BT04 706(P) Bio Process Technology Lab II
BM04 707(P) BM04 708(P)
Seminar Project Work

TOTAL
15
10
400
600
ELECTIVE 1 A Software Engineering B Chemical Engineering Thermodynamics C Food Biotechnology D Operation Research E Plant Biotechnology and Tissue Culture.
EIGHTH SEMESTER
Code
Subject
Hours/Week
P/D
Session Marks
BT04 801 BT04 802 BT04 803 BT04 804 BT04 805 BT04 806 BT04 808(P) BT04 808(P)
Immunology & Immuno Technology Bioethics and Intellectual Property Rights Metabolic Engineering
Elective-II Elective-III
Immunology & Genetic Engineering Lab
Project Work Viva Voce

TOTAL
3 3 3 3 3 -
1 1 1 1 1 -
3 7 -
50 50 50 50 50 50 50 -
3 3 3 3 3 3 3 -
100 100 100 100 100 100 100 100
15
400
700
AGGREGATE FOR EIGHT SEMESTERS : 5300 ELECTIVE II

A B C D E Genomics & Proteomics Molecular Modelling & Drug Design Design of Process Equipments Safety in Process Plants Hazardous Waste management.
8300
3000
ELECTIVE II
A B C D E Bio Pharmaceutical Technology Animal Biotechnology Project Management Transport Phenomena Material Science and Technology.
EN04- 101: MATHEMATICS I

(Common for all B. Tech. programmes) 3 hours lecture per week Module I: Differential Calculus (15 hours) Indeterminate forms - L' hospital's rule - radius of curvature - centre of curvature -evolute unctions of more than one variable - idea of partial differentiation - Euler's theorem for homogeneous functions - chain rule of partial differentiation - applications in errors and approximations - change of variables - Jacobians - maxima and minima of functions of two method of Lagrange multipliers. Module II: Infinite Series (15 hours) Notion of convergence and divergence of infinite series - ratio test - comparison test - Raabe's test - root test - series of positive and negative terms - absolute convergence - test for alternating series - power series - interval of convergence Taylors and Maclaurins series expansion of functions - Leibnitz formula for the nth derivative of the product of two functions - use of Leibnitz formula in the Taylor and Maclaurin expansions Module III: Matrices (21 hours) Rank of a matrix - reduction of a matrix to echelon and normal forms - system of linear equations - consistency of linear equations - Gauss' elimination -homogeneous linear equations fundamental system of solutions - solution of a system of equations using matrix inversion Eigen values and eigen vectors - Cayley-Hamilton theorem - Eigen values of Hermitian, skewHermitian and unitary matrices- Diagonalisation of a matrix using Eigen values and Eigen vectors- quadratic forms- matrix associated with a quadratic form- definite, semidefmite and indefinite forms. Module IV: Fourier series and harmonic analysis (15 hours) Periodic functions - trigonometric series - Fourier series - Euler formulae - even and odd functions - functions having arbitrary period - half range expansions -approximation by trigonometric polynomials - minimum square error - numerical method for determining Fourier coefficients - harmonic analysis. Reference books 1. Michael D. Greenberg, Advanced Engineeing Mathematics(second edition), - Pearson Education Asia. 2. Wylie C.R. and L.C. Barrent, Advanced Engineering Mathematics, McGraw Hill 3. Kreyszig E., Advanced Engineering Mathematics, Wiley Eastern 4. PiskunovN., Differential and Integral calculus, MIR Publishers 5. Ayres F., Matrices, Schaum's Outline Series, McGraw Hill 6. Sastry, S.S., Engineering Mathematics-Vol. 1 and2., Prentice Hal! of India. Internal work assessment 60 % - Test papers ( minimum 2) 30 % - Assignments/Term project/any other mode decided by the teacher. 10 % - Other measures like Regularity and Participation in Class. Total marks = 50 University examination pattern QI - 8 short type questions of 5 marks, 2 from each module QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII- 2 questions A and B of 15 marks from module II with choice to answer any one QIV- 2 questions A and B of 15 marks from module III with choice to answer any one QV - 2 questions A and B of I5 marks from module IV with choice to answer anyone.
EN04 -102: MATHEMATICS II

(Common for all B. Tech. programmes) 3 hours lecture per week
Module I: Ordinary differential equations (21 hours) Equations of first order - separable, homogeneous and linear types - exact equations - orthogonal trajectories - linear second order equations -homogeneous linear equation of the second order with constant coefficients -fundamental system of solutions -Solutions of the general linear equations of second order with constant coefficients- method of variation of parameters -Cauchy's equation - simple applications of differential equations in engineering problems, including problems in mechanical vibrations, electric circuits and bending of beams. Module II: Laplace transforms (15 hours) Gamma and Beta functions - definitions and simple properties - Laplace transform -inverse transform - Laplace transform -shifting theorems-Transforms of derivatives and integrals differentiation and integration of transforms - transforms of unit step function and impulse function - transform of periodic functions - solution of ordinary differential equations using Laplace transforms. Module III: Vector differential calculus (15 hours) Vector function of single variable - differentiation of vector functions scalar and vector fields gradient of a scalar field - divergence and curl of vector fields - their physical meanings relations between the vector differential operators. Module IV: Vector integral calculus (15 hours) Double and triple integrals and their evaluation - line, surface and volume integrals - Green's theorem - Gauss' divergence theorem - Stokes' theorem (proofs of these theorems not expected) line integrals independent of the path. Reference books 1. Michael D. Greenberg, Advanced Engineering Mathematics(second edition), Pearson Education Asia. 2. Wylie C.R. and L.C. Barrent, Advanced Engineering Mathematics, McGraw Hill 3. Kreyszig E., Advanced Engineering Mathematics, Wiley Eastern 4. Piskunov N., Differential and Integral calculus, MIR Publishers 5. Ayres F., Matrices, Schaum's Outline Series, McGraw Hill 6. Sastry, S.S., Engineering Mathematics-Vol.1 and2., Prentice Hall of India Internal work assessment 60 % - Test papers (minimum 2) 30 % - Assignments/Term project/any other mode decided by the teacher. 10 % - Other measures like Regularity and Participation in Class. Total marks = 50. University examination pattern QI - 8 short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII- 2 questions A and B of 15 marks from module II with choice to answer any one QIV - 2 questions A and B of 15 marks from module III with choice to answer any one Q V - 2 questions A and B of 15 marks from module IV with choice to answer any one.
EN04- 103A: ENGINEERING PHYSICS(A)

(common for AI, CS, EE, EC, IT, IC, BM,BT, PT) 2 hours lecture per week Module I (11 hours) Semi conductor Physics- Formation of energy bands in solids- Classification of solids on the basis of energy band gap-Intrinsic and extrinsic semiconductors-Elemental and compound Semiconductors- Fermi level in intrinsic semiconductor- Electron and hole concentrations in intrinsic semi conductor in thermal equilibrium- Law of mass action-Electrical conductivity of intrinsic semiconductor- Fermi level in n-type and p-type semiconductors- Electrical conductivity of extrinsic semi conductor- Diffusion and total current. Application of semi conductors- Band model of p-n junction- Junction diode and its characteristics- characteristics of a transistor in common emitter configuration-Input, output resistance and current amplification factor- Light emitting diode, photo diode, solar cell, photo resistor (LDR),photo transistor, liquid crystal display(LCD) and zener diode- Avalanche and zener breakdown- Application of zener diode as a voltage regulator. Hall effect in semiconductors- Derivation of Hall coefficientDetermination of Hall coefficient by measuring Hall voltage-Applications of Hall effect Super conductivity-Properties of superconductors (critical magnetic field, Meisnner effect, critical current, flux quantisation)- Types of super conductors- BCS theory of super conductivity (qualitative) - Josephon's effect- Theory of d.c. Josephon's effect- SQUID - Applications of super conductivity. Module II (11 hours) Interference of light- Interference due to division of amplitude- Interference from plane parallel thin films- Colours of thin films in reflected and transmitted light- Newton's rings- Measurement of wavelength and refractive index- Thin wedge shaped film- Air wedge- Testing of optical planeness of surfaces. Interferometry- Michelson's interferometer-Types of fringes-Visibility of fringes-Application of Michelson's interferometer in determination of wavelength of monochromatic light, resolution of spectral lines and refractive index of gases. Diffration of light-Introduction of Fresnel and Fraunhoffer class of diffraction and their distinction- Fresnels diffraction and rectilinear propogation of light-Diffraction pattern due to straight edg and expression for intensity maximum and minimum- Fraunhoffer diffraction -Simple theory of diffraction grating, its construction and working- Rayleigh's criteria, for resolution of spectral lines- Resolving power and dispersive power of grating. Module III (11 hours). Poarisation of light- Double refraction- Huygen's explanation of double refraction in uniaxial crystals-Positive and negative crystals- Nicol prism, construction and working -Quarter and half wave plates- Theory of circularly and elliptically polarised light, their production and detectionRotatory polarisation- Laurent's half shade (brief explanation)- Laurent's half shade polarimeterApplications of polarised light. Laser physics- Basic concepts and properties of laserSpontaneous and stimulated emission- Expression for ratio of their coefficients-Absorption,population inversion and optical pumping-Construction and components of a laser-Ruby,Helium and Neon and semiconductor lasers-Applicattion of lasers. Basic principle of holography and its application.Fibre optics- Basic principle -fibre dimensions and construction- Step index single mode and multi mode- fibre- Graded index fibre-Numerical aperature and acceptance angleSignal distortion in optical fibres and transmission losses( brief ideas only)- optic fibre communication (block diagram) and it's advantages-Applications of optic fibres.
9
Module IV (11 hours). Planck's quantum theory- Absorbing power, reflecting power and transmitting power of a body or surface- Perfect black body- Distribution energy in the spectrum of a black body- Wein's displacement law- Planck's hypothesis-Derivation of Planck's law of radiation. Quantum mechanics- Distinction between Newtonian and quantum mechanics- Schroedinger wave equation for free particle -Potential in schrodinger equation -Time dependant and time independent schroedinger equations and their derivations- Expectation values-ApplicationsParticle in a box (motion in one dimension).Ultrasonics- Piezo - electric effect- Piezo electric crystal- Production of ultrasonics by piezo-electric oscillater- Detection of ultrasonics - General properties and applications of ulltrasonics - Ultrasonic diffractometer and determination of velocity of ultrasonics in a liquid. Text books 1. Sreenivasan M .R, Physics for Engineers, New Age International 2. Vasudeva A.S; Modern Engineering Physics, S. Chand 3. S.O. Pillai, Solid state physics, New Age International Reference books 1. Tyagi, M.S. Introduction to semi conductor materials and devices, John Wiley and Sons 2. Mayer, Intoduction to classical and modern optics, Arendt 3. John Senior, Fibre optic communiction 4. G Aruldhas Quantum mechanics Prentice Hall of India 5. Murukesan R. Modern Physics S.Chand and Co 6. Brijlal and Subrahmanyam N, Text book of Optics, S. Chand 7. Kale Gokhale;. Fundamentals of Solid State Electronics, Kitab Mahal 8. Gupta S.L. and Kumar, V; Solid State Physics, K.Nath. Internal work assessment 60 % - Test papers (minimum 2) 30 % - Assignments/Term project/any other mode decided by the teacher. 10 % - Other measures like Regularity and Participation in Class. Total marks = 50. University examination pattern QI - 8 short type questions of 5 marks, 2 from each module QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII- 2 questions A and B of l5 marks from module II with choice to answer any one QIV - 2 questions A and B of 15 marks from module III with choice to answer any one QV - 2 questions A and B of 15 marks from module IV with choice to answer any one
10
EN04-I03A(P): PHYSICS LAB(A)

(Common for AI,EE, EC. IC,BM) 1 hour lab per week or 2 hours lab per alternate weeks 1. Band gap energy in a semi conductor using a reverse biased p-n junction. 2. Static characteristcs of a transistor (p-n-p or n-p-n )in common emitter configuration 3. Characteristics of a Zener diode 4. Characterisitics of a LED.and wave length of emitted radiation 5. Characterisitc of a photo diode. 6. Characteristic of a photo resistor (LDR) 7. Voltage regulation using Zener diode
8. 9.
Wavelength of mercury spectral lines using diffraction grating and spectrometer. Refractive indices of ordinary and extra ordinary rays in calcite or m quarts prisms. Wave length of sodium light by Newton's rings method. Diameter of a thin wire or thickness of a thin paper by air wedge method. Specific rotatory power of cane sugar solution using polarimeter. Frequency of an electrically maintained tuning fork(transverse and longitudinal mode) Wave length and velocity of ultrasonic waves using ultrasonic difractometer. Divergence of laser beams using He-Ne laser or diode laser. Wave length of laser using transmission grating. Resolving and dispersive power of a grating . Wave length of a monochromatic light by straight edge using laser beam. Characterics of a solar cell. Planck's constant using photo-electric cell or solar cell Hall coefficient by measuring Hall voltage in a semi conductor. Measurement of numerical aperature , acceptance angle and attenuation in an optical Measurement of displacements using optic fibre.
10. 11. 12.

13.
14. 15. 16. 17. 18. 19. 20. 21.

22.
fibre. 23.
24.
Michelson's interferometer- determination of wavelength of a monochromatic source, resolution of spectral lines and refractive index of a gas. (Any 12 experiments should be done)
Reference Books:1. "Practical Physics with viva voice"- Dr. S.L.Guptha and Dr.V KumarPublishers- Pragati Prakashan. 2. " Experiments in Engineering Physics"- M.N. Avadhanulu, A.A.Dani, and R.M.Pokley- Publishers- S. Chand. Internal work assessment Lab practicals and record Test/s = 15 = 10
11
Total marks = 25
EN04-104A: ENGINEERING CHEMISTRY(A)

(Common for AI, CS, EE, EC, IT, IC, BM, BT, PT) hours lecture per week
SECTION-1
CHEMISTRY OF ENGINEERING MATERIALS: Module 1(13 Hours) Solids: Classification of solids with examples- (Crystalline - Polycrystalline -Amorphous Partially melted solids - (KCN) - Super cooled liquids - (Glass) - liquid crystals.) (1 Hour) Crystalline state: Steno's law - Internal structure - Space lattices -Crystallographic axes- Law of rational indices-Crystal systems - Elements of symmetry - X-ray study- Braggs equation (derivation) single crystal and powder method -(Debye-Scherrer Camera) Cubic systems structure elucidation -d100: d110: d111 ratio (problems to be worked out) - crystal imperfections(point-line-surface-volume -burgers vector- dislocations- edge and screw) Physical properties, bonding characteristics and Structure relation of- (Covalent solids - Ionic solids metals) - metallic bonding- Stacking of atoms- (ABCABC....),(ABAB) - tetrahedral and octahedral voids-Alloys - Hume Rothery rule-Conductivity - Resistivity -(Free electron theoryexplanation with Fermi - Diracstatistics)- Fermi level -Applications of conductors-(transmission lines-OFHC Copper, ACSR, Contact materials, Precision resistors- heating elements-Resistance thermometers)- Super Conductors (type I and II-examples) (5 Hours) Semi conductors - Band theory-(MOT) Valence band-Conduction band-intrinsic and extrinsic semiconductors-Fabrication of semiconductor materials-Crystal Growth-ultra pure Silicon production-zone refining-Fabrication of Integrated Circuits (IC) (2 Hours) Dielectric materials-Polarization - Ferro-electricity - Piezoelectricity examples- Introduction to Nano Science -Carbon nano tubes and nanowires Applications with (l Hour) Non-crystalline state - glass - properties - (applications- conducting glasses - solid supported liquids (stationary phases in reverse phase chromatography) - Optical fibre. (l Hour) Liquid crystals- Characterization- Nematic phases-Smectic Phases-Cholesteric PhasesColumnar Phases- Chemical Properties-thermotropic-lyotropic-epitaxial- growth-Freedericksz transition-applications -Liquid crystal thermometers- LCD displays (3 Hours) Reference books 1. J. D. Lee (1996) "Concise Inorganic Chemistry" Chapman and Hall Ltd. London, pp1032 2. S. Glasstone {1997) "Textbook of Physical Chemistry" Macmiilan, New Delhi, pp-1320 3. P. W. Atkins (1987) "Physical Chemistry" Oxford University Press, Oxford, pp-857. 4. P. W. Atkins and J. Depaula (2001)" Physical Chemistry" W.R Freeman and Co, pp1000.
12
V. Raghavan (2000) "Material Science and Engineering-A First Course" Fourth edition, Prentice-Hall of India Pvt. Ltd, New Delhi, pp-485. 6. L.H. Van Vlack (1998) "Elements of Materials Science and Engineering" Sixth edition, Addison-Wesley, London pp-598. 7. J. W.Goodby (1997) "Chemistry of liquid crystals" VCH Publishing, pp-400. 8. K. W. KoIasinski (2002) "Surface Science: Foundations of Catalysis and Nano science" John-Wiley and Sons, pp-326. 9. K. J.Klaubunde (2001) ''Nano scale Materials in Chemistry" Wiley-Interscience,pp-304. J.l.Gersten and F. W.Smith (2001)" The Physics and Chemistry of Materials" WileyInterscience, pp-856.
5.
10.
Module 2 (13 Hours) High Polymers and Lubricants- Classification of Polymers-(Natural and Synthetic, Organic and Inorganic, Thermoplasic and Thermosetting, Plastics, Elastomers, Fibres and liquid resins) Polymerization (Chain polymerization Polythene- PVC- Teflon -polystyrene -polymethylmethacrylate) Condensation1 polymerization(Polyamide and Polyesters) Copolymerization (Buna-S, Buna-N, PVC- Co-polyvinylacetate, PAN-Co-poly vinyl Chloride),Coordination polymerization (Ziegler- Natta Polymerization)-Electrochemical Polymerization-Metathetical Polymerization-Group transfer Polymerization (3 Hours) Mechanism of polymerization (Cationic, anionic, and free radical).Polymerization techniques( Bulk polymerization, Solution polymerization, Suspension polymerization, Emulsion polymerization, Melt polycondensation, Solution polycondensation, Interfacial condensation, Solid and Gas Phase Polymerization (2 Hours) Structure relation to properties(Chemical resistance, Strength, Plastic deformation, Extensibility, Crystallinity) -Mol.Wt of Polymers-Number average Molecular wt, Weight average Mol.wt- Gel Permeation Chromatography (1 Hour) Thermosetting resins (Bakelite, Urea-Formaldehyde, Silicones), Thermoplastic resins (Acrylonitrile, PVC, PVA ,PS, PMMA, PE).-Fibres (Nylon6, Nylon66, NyIon 6,10, Cellulose fibres, dacron, Kevlar) Application of polymers in electronic and electrical industry. ElastomersNatural rubber-Structure- Vulcanization-Synthetic rubbers (Neoprene, Buna-S, Buna-N, thiokol, Silicone rubber) (3 Hours) Compounding of Plastics (Fillers, Plasticizers, lubricants, pigments, antioxidants, Stabilizers) and Fabrication (Calendering, Die Casting, Film casting, Compression, injection, Extrusion and Blow moulding, Thermoforming, Foaming, Reinforcing) (1 Hour) Lubricants: Theory of friction - mechanisms of lubrication -Fluid film or hydrodynamic, thin film or boundary lubrication, extreme pressure lubrication- Classification of Lubricants(Liquid(animaI and vegetable oils, Petroleum oiIs),Semi-solid (Ca-soap grease, Li-soap grease, Al-soap grease, Axle grease) Solid lubricants (Graphite, Molybdenum di-sulphide- Structure relation to lubrication property) and synthetic lubricants (Di-basic acid esters, Poly glycol ethers, Organo phosphates, Organo silicones)). Properties of Lubricants (Viscosity index, Cloud point and pour point, flash point and fire point, Corrosion stability, Emulsification, Aniline point). Additives and their functions (Fatty acids, Sulphurised fats, Phenols, Calcium sulphonates, Organo-metallics, Hexanol, Amine phosphates, Tricresyl phosphates, Silicon polymers)
13
(3 Hours) Reference books 1. B.R.Gowarikeret.al (2002) "Polymer Science" New Age International pp-505 2. B.W.Gonser et.al (1964)" Modem Materials-advances in development and application" Vol 17, Academic Press, New York. Module - 3 (9 Hours) Electrochemistry: Single Electrode potential (theory - Nernst equation, derivation from thermodynamic principles) - types of electrodes (M|M+; M|MA|A-, M|A+, A+2, Pt|H21H+, Pt|CL| Cl-, Pt|02|OH" -glass electrode) Electrochemical cells-concentration cells-Salt bridge - Liquid junction potential- emf measurement - Poggendorf's compensation method- digital method electrochemical series - over voltage - theory - application in corrosion control - Polarographystorage cells - lead acid, Ni/Cd, - Fuel cells - H 2/O2 fuel cells(Bacon cell), Hydrocarbon/air fuel cell-Bio-chemical fuel Cell. (5 Hours) Acid- Bases - (Lowry-Bronsted and Lewis concepts - examples) - concept of pH - pH measurement- (instrumental details required) - Dissociation constants-Potentiometric titrations(Neutralization, Oxidation-reduction, and Precipitation) Buffer solutions - Henderson's equation for calculation of pH. (4 Hours) Reference books 1 S.Glasstone(1997) Text book of Physical Chemistry Macmillan, New Delhi, pp1320. 2 P.W Atkins(1987)"Physical Chemistry Oxford University Press, Oxford, pp-857. 3 C.A. Hampel(Ed)(1964)'Encyclopedia of Electrochemistry" Reinhold Publishing Corpcenration, New York, pp-1206. 4 A. Standen (Ed)(1964) "Kirk - Othmr Encyclopedia of Chemical Technology " Vol. 3 John Wiley and Sons. lnc, New York, pp-925.
SECTION 2
CHEMISTRY OF MATERIAL AND ENVIRONMENTAL DAMAGE Module - 4 (9 Hours) Material damages and prevention: Corrosion - theoretical aspects -(electrochemical theory) - Galvanic series -Pourbiax diagram assessment of corrosion potential of materials - Types of corrosion - Dry corrosion-direct chemical -Wet Corrosion-Electrochemical-differential aeration -Corrosion of Iron in acidic neutral, basic condition (Corrosion in boilers) - Galvanic corrosion-(corrosion at contact points in computers-Ag/Au)-Inter granular corrosion (18-8 Steel).Microbial corrosion-Factors influencing corrosion. Corrosion protection-Self protecting corrosion products-Pilling-Bedworth rule- CoatingsOrganic-(paints and polymers )-Inorganic Coatings-Galvanizing (dip coating, Sherardizing, Wire-gun method)-Tinning- ElectropIating-(Chromium, Nickel), Anodization of AluminiumPassivation of metals by chemical treatment- Protection by Sacrificial Anode- Impressed current. (4 Hours) Environmental damages and prevention: Pollution - Definitions - Classification of pollutants (Global, Regional, Local; Persistent and Non-persistent; Pollutants - Eg: CO2, CO, SOx, NOx, VOC, SPM, CFC, POP, Dissolved metals) - effects on environments -Air pollution Fossil fuel burning - Automobile exhausts - Photochemical smog - PAN, PBN formation-chemical equations required) -
14
Stratospheric Ozone depletion- CFCs -Nomenclature CFCs -Chapman cycle of Ozone formation- CFC dissociation and its reaction with Ozone -Alternate refrigerants Monitoring of pollution - gases (CO, SO2,NOX )and paniculate (High volume sampler) -Pollution from thermal power plants - Coal composition- fly ash - Thermal pollution. Methods of control of Air pollution - Bag filters, cyclones, Scrubbing, ESP, Catalytic converters -composition and action with CO, NOs. Water pollution- Pollutant Classification-(Organic, Inorganic, Suspended and Dissolved- Toxic metal waste- BOD-COD-) monitoring (analytical methods-brief discussion) and control -Waste water treatment-Aerobic, Anaerobic-USAB process-Industrial waste water treatment.- Soil pollution-Solid waste-radio nuclides-Toxic metals- monitoring and. controlIncineration-Dioxins- hazardous waste - deep-well injection (5 Hours) Reference books 1. L L Shreir (Ed) ''Coirosion Control Vol 1 and II Newnes-Butterworths, London. 2. C. A. Harnpel (Ed) "Encyclopedia of Electrochemistry' Reinhold Publishing corporation, pp-1206. 3. V Raghavan (2000) 'Material Science and Engineering A First Course PrenticeHall of India Pvt. Ltd, New Delhi, pp-485. 4. A. K. De (I996), "Environmental Chemistry Newage International Pvt. Ltd., New Delhi pp-364. 5. 5 C.N. Sawyer and P. L. McCarty (1986) Chemistry for Environmental Engineering McGraw Hill Book Company, New Delhi pp-530. 6. H. S. Peavy, D. R. Rowe and G.T. Chobangoglus(1985) Environmental Engineering MaGraw Hill International, pp-720. 7. S P Mahajan (1985) Pollution Control in Process Industries " Tata McGraw Hill, New Delhi pp-273. 8. S. E. Manahan (1975) Environmental Chemistry Willard Grant Press Boston, pp-532. Internal work assessment 60 % - Test papers (minimum 2) 30 % - Assignments/Term project/any other mode decided by the teacher. 10 % - Other measures like Regularity and Participation in Class. Total marks = 50. University examination pattern QI - 8 short type questions of 5 marks, 2 from each module QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII- 2 questions A and B of l5 marks from module II with choice to answer any one QIV - 2 questions A and B of 15 marks from module III with choice to answer any one QV - 2 questions A and B of 15 marks from module IV with choice to answer any one
15
EN04-104A(P):
CHEMISTRY LAB(A)
(Common for AI, EE, EC, IC, BM, BT) 1 hour lab per week or 2 hours lab per alternate weeks List of Experiments
1.
Estimation of purity of Copper (Iodometric method) Estimation of purity of Alumiraum (EDTA method) Crystal growth (melt growth, Solution. Phenol formuldehyde-preparation and study of properties Urea formaldehyde-preparation and study of properties. Flash and fire point-Pensky--Martens apparatus. Measurement of Single Electrode potential-Poggendorf s method (M|M+, M|MA| A-, Salt bridge preparation, Calculation of Junction potential) . Corrosion potential measurement of certain metals and alloys in 3.5% salt solution (Steel) 18-8), Al, Cu, Brass, Bronze, Monel metal or any alloys of industrial use ) Potentiodynamic and Potentiostatic methods. pHmeter-Calibration and measurement of pH-Preparation of pH by Henderson's equation and verification Potentiometric titration of acid and base- plots of E/V, AFVAV; A2E/AV2plots. Electrodepostion-plating of Copper-detection of the thickness of the layer deposited. Anodizing of Aluminium--Characteristics of the coating. Estimation of SO2, NO2, H2, S2, Calculation of concentration in ppm and microgram per M3 and comparison ofdatawith permitted levels. Estimation of Pb, Cd in water-colourimetric method.
2.
3.
4.
5. 6. 7. 8.
9. 10. 11. 12. 13.
14. Estimation of fluoride (Alizarind method) NItrate in water-colourimetric method 15. Estimation of Dissolved oxygen (Winklers method)
16.
Identification tests for certain common plastics (PE, PVC, Nylon, PET, etc.). (Atleast 12 experiments should be done)
17. Preparation of some liquid crystals and study of their properties.
Internal work assessment Lab practicals and record = 10 + 5 ( Lab performance to be evaluated by the thoroughness of the procedure and practices, results of each experiment and punctuality in the submission of Rough and Fair Records) Test/s = 10 Total Marks = 25.
16
EN04 - 105:
HUMANITIES
(Common for all B. Tech. programmes) 2 hours lecture per week Module I (10 hours) Introduction to English usage and grammarReview of grammar affixes, prefixes, suffixes, participles and gerunds -transformation of sentences - commonly misspelt words - correction of mistakes - punctuation - idioms - style vocabulary building. Reading comprehension Exposure to a variety of reading materials, articles, essays, graphic representation, journalistic articles, etc.. Writing comprehensionSkills to express ideas in sentences, paragraphs and essays. Module II (10 hours) Technical communication and report writing Need, importance and characteristics of technical communication -correspondence on technical matters-aspects of technical description of machinery, equipment and processes - giving instructions in an industrial situation - note taking and note making - correspondence on technical topics -different types of technical reports Module III (14 hours) History of science and technology Science and technology in the primitive society - the development of human civilization from primitive to modern society- impact of sciences and technology on societies - Cultural and industrial revolutions - the rise and development of early Indian science - contribution of Indian scientist-JC Bose CV Raman Visweswaraya-Ramanujam and Bhabha- Gandhian conceptsrecent advances in Indian science. Module IV (10 hours) Humanities in a technological age Importance of humanities to technology, education and society - relation of career interests of engineers to humanities - relevance of a scientific temper -science, society and culture. Reference Books: 1. 2. 3.
4. 5. 6.
7. 8.
9. 10.
11.
12. 13. 14. 15.
Huddleston R., English Grammer - An outline, Cambridge University Press Pennyor, Grammar Practice Activities, Cambridge University Press Murphy, Intermediate English Grammar, Cambridge University Press Hasgemi, Intermediate English Grammar Supplementary Exercise with answer Cambridge University Press. Vesilind; Engineering Ethics and the Environment, Cambridge University Press. Larson E; History of Inventions, Thompson Press India Ltd.. Bemal J.D., Science in History, Penguin Books Ltd. Dampier W.C., History of Science", Cambridge University Press. Encyclopedia Britannica, History of Science, History of Technology. Subrayappa; History of Science in India, National Academy or Science, India. Brownoski J., Science and Human Values, Harper and Row. Schrodinger, Nature and Greeks and Science and Humanism, Cambndge University Press. Bossel, H, Earth at a Crossroads - paths to a sustainable Future, Cambridge University Press. McCarthy, English Vocabulary in Use, Cambridge University Press. Anna University, English for Engineers and "Technologists, Orient Longman.
17
16.
Meenakshi Raman etal, Technical Communication-Principles and practice. Oxford University Press.
Internal work assessment One essay on relevant topic One Technical Report 2 Tests Total marks
2x15
10 10 = 30 = 50.
University examination pattern QI - 8 short type questions of 5 marks, 2 from each module QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII- 2 questions A and B of l5 marks from module II with choice to answer any one QIV - 2 questions A and B of 15 marks from module III with choice to answer any one QV - 2 questions A and B of 15 marks from module IV with choice to answer any one
18
EN04 - 106A:
ENGINEERING GRAPHICS(A)
(Common for AI, CS, EE, EC, IT, IC, PT, BM,PT) 1 hour lecture and 3 hours drawing Module-0 ( 8 Hours -1 Drawing exercise) Drawing instruments and their use - different types of lines - lettering and dimensioning familiarization with current Indian Standard Code of practice for general engineering drawing. Construction of ellipse, parabola and hyperbola. Construction of cycloid, involute and helix. Introduction to Computer Aided Drafting. (For practice only, not for University Examination). Module - 1 (12 Hours - 3 drawing exercises) a) Introduction to orthographic projections - vertical, horizontal and profile planes - principles of first angle and third angle projections. Projections of points in different quadrants. Orthographic projections of straight lines parallel to one plane and inclined to the other plane straight lines inclined to both the planes and occupied in one quadrant- traces of lines. b) True length and inclination of a line with reference planes. Line occupied in more than one quadrant. Line inclined to the two reference planes but parallel to the profile plane. line dimensioned in surveyor's unit. Module - II (16 Hours - 3 drawing exercises) a) Projections of plane laminae of geometrical shapes parallel to one plane and inclined to the other plane - plane laminae inclined to both the planes. Auxiliary projections of plane laminae. Projections of laminae inclined to the two reference planes but perpenticular to the profile plane. b) Projections of polyhedra and solids of revolution - frustums - projections of solids with axis parallel to one plane and inclined to the other plane. Projections of solids with the axis inclined to both the planes.(Solids to be drawn : Cube, prisms, pyramids, tetrahedron, cone, and cylinder.) Projections of solids on auxiliary planes. Projections of combinations of solids. (Solids to be drawn : Prisms, pyramids, tetrahedron, cube, cone, and sphere). Module-III (12 Hours - 3 drawing exercises) a) Sections of solids - sections by planes parallel to the horizontal or vertical planes and by planes inclined to the horizontal or vertical planes. True shape of section by projecting on auxiliary plane, ( Solids to be drawn : Cube, prisms, pyramids, tetrahedron, cone, and cylinder.) b) Development of surfaces of solids - method of parallel line, radial line, I triangulation and approximate developments. Development of polyhedra, cylinder, cone, and sectioned solids. Development of solids having hole or cut. Module-IV (12 Hours - 3 drawing exercises) a) Introduction to isometric projection - isometric scale - isometric views - isometric projections of prisms, pyramids, cylinder, cone, spheres, sectioned solids and combinations of them. Principle of oblique projection - cavalier, cabinet and general oblique projections of solids and simple objects. b) Introduction to perspective projections - Classification of perspective views - parallel, angular and oblique perspectives - visual ray method and vanishing point method of drawing perspective projection- perspective views of prisms, pyramids and circles. Module-V (12 Hours - 6 drawing exercises) a) Introduction to multiview projection of objects - the principle of the six orthographic views -
19
convertion of pictorial views of simple engineering objects into orthographic views.
b) Conventional
representation of threaded fasteners. Drawing of nuts, bolts, washers and screws. Locking arrangements of nuts. Bolted and Screwed joints. Foundation bolts of eye end type, hook end type and split end type. NOTE: All drawing exercises mentioned above are for class work. Additional exercises where ever necessary may be given as home assignments. Text books 1. John K.C., Engineering Graphics, Jet Publications 2. P.I. Varghese, Engineerng (Graphics, VIP Publications' 3. Bharr N.D., Elementary Engineering Drawing, Charotar Publishing House. Reference books 4. LuzadderW. J., Fundamentals of Engineeiing Drawing, Prentice Hall of lndia. 5. Narayanana K. I. and Kannaiiah P, Engineering Graphis, Tata McGraw Hill. 6. Gill P. S., Geomatrical Drawing , Kataria and sons. Internal work assessment Drawing exercises (Best 10) 2 Tests Total marks 10x3 2x10 = 30 = 20 = 50
University examination pattern No questions from module 0 QI - 2 questions A and B of 20 marks from module I with choice to answer any one QII- 2 questions A and B of 20 marks from module II with choice to answer any one QIII- 2 questions A and B of 20 marks from module III with choice to answer any one QIV- 2 questions A and B of 20 marks from module IV with choice to answer any one QV - 2 questions A and B of 20 marks from module I with choice to answer any one
20
EN04 - 107A: ENGINEERING MECHANICS(A)

(Common for AI, CH, CS, EE, EC, IT, IC, BM, BT, PT) 2 hours lecture and 1 hour tutorial per week Objectives 1. To acquaint the student with general methods of analyzing engineering problems 2. To illustrate the application of the methods to solve practical engineering problems Module I (17 hours) Principles of statics - Free body diagrams - Coplanar forces and Force systems -Resultant and equilibrium conditions for concurrent, parallel and general system of forces - Solution of problems by scalar approach. Introduction to vector approach (Application to simple problems only) - Concurrent forces in space - Resultant - Equilibrium of a particle in space Non-concurrent forces in space - Resultant of force systems. Module II (17 hours) Friction - Laws of friction - Simple contact friction problems - Wedge - Screw jack and its efficiency. Properties of surfaces - First moment and centroid of curve and area - Centroid of composite plane figures - Theorems of Pappus-guldinus- Second moments of plane figures and composite sections - Transfer theorems - Polar moment of area - Product of area and Principal axes (conceptual level treatment only). Moment of inertia of a rigid body - M.I of a lamina - M.I of 3 dimensional bodies (cylinder, circular rod, sphere). Module III (17 hours) Introduction to structural mechanics - Different types of supports, loads and beams - Reactions at supports. Shear force and Bending moment in beams -Shear force and bending moment diagrams for cantilever and simply supported beams (only for concentrated and uniformly distributed load cases). Plane trusses - Types of trusses (Perfect, Deficient and Redundant trusses) -Analysis of trusses Method of joints - Method of sections. Module IV (15 hours) Kinetics of rectilinear motion - Newton's second law- D'Alembert's principle -Motion on horizontal and inclined surfaces - Analysis of lift motion - Motion of connected bodies. Curvilinear motion - Equation of motion - Tangential and normal acceleration - Centripetal and centrifugal forces - Motion of vehicles on circular path. Work, Power and Energy - Work done by a force - Work of the force of gravity and force of spring - Work-energy equation - Transformation and conservation of energy - Applications to problems. Kinematics of rotation - Rigid body rotation about a fixed axis - Rotation under the action of constant moment. Introduction to mechanical vibrations - Simple harmonic motion- free vibration - Oscillation of spring - Torsional vibration. Text Books 1. Timoshenko and Young, "Engineering Mechanics", McGraw Hill Publishers
21
2. Hibbeler, Engineering Mechanics, Vol.1 statics, Vol II Dynamics, Pearson 3. Shames, I.H., "Engineering Mechanics- Statics and Dynamics", Prentice Hall of India.
Reference Books 1. Beer,F.P. and Johnson, E.R., "Mechanics for Engineers- Statics and Dynamics", McGraw Hill Publishers. 2. Rajasekharan and Sankarasubramanian, "Engineering Mechanics", Vikas Publishing House. Internal work assessment 60%- Test papers (minimum) 30%- assignment should be computer based using spread sheet or suitable tools) Total marks = 50 University examination pattern QI - 8 short type questions of 5 marks, 2 from each module (in which atleast 5 questions to be Numerical) QII - 2 questions A and B of 15 marks from module! with choice to answer anyone QIII -2 questions A and B of 15 marks from module III with choice to answer any one QIV - 2 questions A and B of l5 marks from module III with choice to answer any one. Q V - 2 questions A and B of 15 marks from module IV with choice to answer any one (QII to V can have subdivisions and at least 80 % weightage for numerical problems)
22
BM04 -108 :
BASIC ELECTRONICS
(Common for EC, BM, BT, AI, IC) 2 hours lecture per week Module - l (Hours 10) Electron ballistics - Motion of electron in Electric field - Two dimensional motion of electrons in uniform electric field- motion of electron in transverse magnetic filed- Electron motion in parallel electric and magnetic fields- Electron motion in perpendicular electric and magnetic field. Electrostatic and magnetic deflection sensitivities. CRO- Principle, CRT, block diagram of CRO. Magnetic focusing-electrostatic focusing, applications of CRO. Multimeter-principle of measurement of voltage, current and resistance. Vacuum diode, triode and pentode- principles of operation only. Module 2 (Hours 12) Electronic components (Brief discussion only-construction aspects not required). Resistors-fixed and variable, different types, characteristics, colour coding and tolerance. Capacitors-fixed and variable, different types, characteristics. Inductors, Relays and trans formers-different types. The ideal diode- terminal characteristics of practical diodes- analysis of diode circuits-DC model of the diode- Zener diodes- clipping and clamping circuits Transistors- Physical structure and modes of operation- graphical representation of transistor characteristics- DC equivalent model and analysis- The three configuration- comparison and basic applications- Junction filed effect transistors- structural features, operation and VI characteristics. Module 3 (Hours 10) Graphical analysis of BJT operations- Biasing- load line, Q-point-effect of Q-point location on allowable signal swing- different resistor biasing circuits-various biasing technique- using two DC sources- potential divider biasing, collector feed back biasing- Bias stability- definition of stability factors-calculation of stability factor for potential divider biasing circuit. Module 4 (Hours 12) Rectifiers and power supplies - Half wave and full wave rectifiers. Definition and derivation of rectifier specifications such as PIV, DC output voltage, ripple factor, efficiency, rectification factor- rectifiers with filter: Inductive filter-analysis capacity filter- LC and pi filters. Simple Zener regulator - working - analysis and design - Series voltage regulator - analysis and design. Text Books 1. Milman, J. and Halloas, C. Electronic Devices and Circuits, Tata McGraw Hill. 2. Add S. Sedra and Kenneth C Smith, Microelectronic Reference books 1. Boylestad, R and Nashelsky, L Electronic Devices and Circuit Theory, PHI/Pearson 2. Boggart T.F. Electronic Devices and Circuits, UBS. 3. Horenstein, M. N. Micro Electronics Circuits, PHI. Internal work assessment 60% - Test papers (minimum 2 ) 30% - Assignments / Term project/any other mode decided by the teacher. 10% - Other measures like Regularity and Participation' in Class Total marks = 50 University Examination Pattern QI - 8 short questions of 5 marks, 2 from each module QII - 2 questions A and B of 15 marks from module I with choice to answer any one
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QIII- 2 questions A and B of I5 marks from module I with choice to answer any one QIV- 2 questions A and B of 15 marks from module I with choice to answer any one QV- 2 questions A and B of 15 marks from module I with choice to answer any one.
BM04 -109 : BASIC ELECTRICAL ENGINEERING

(Common for EE, EC, AI, IC, BM, BT, PT) 2 hours lecture per week. Module 1(10 hours) Elementary concept and definitions of current, voltage, power and energy -Introductory circuit analysis - Independent voltage and current sources-Dependent voltage and current sources Source transformation Ohms law-Kirchoff 's laws -Solutions of simple series, parallel and series-parallel circuits with DC excitation - Solutions of resistive circuits with dependent sources -Mesh analysis and Nodal analysis - Nodal conductance matrix and mesh resistance matrix. Basic network theorems - Linearity - Concept of a linear element - Concept of a linear circuit Passive vs. active elements - Bilateral & unilateral elements -Thevenin's theorem - Norton's theorem - Superposition theorem - Substitution theorem- Maximum power transfer theorem. Module II (12 hours) Magnetic circuits - MMF - Magnetic flux - Reluctance - Comparison of magnetic and electric circuits - Magnitisation curves of ferromagnetic materials - Solution of magnetic circuits. Faraday's laws of electromagnetic induction - Lenz's law - Dynamically and statically induced emfs - Self and mutual inductances - Inductances in series and parallel - Mutual flux and leakage flux - Coefficient of coupling - Dot convention- Cumulative and differential connection of coupled coils. Electostatics - Capacitance- Parallel plate capacitor - Capacitors in series and parallel - Charging and discharging of capacitor - Energy stored in electrostatic fields - potential gradient Dielectric strength. Two terminal element relationships - V-I relationship for inductance and capacitance. Time domain analysis of circuits - Linier differential equations for series RL and RC, parallel RL and RC, series RLC and parallel RLC circuits - Complete solution for step/dc, voltage/current inputs - Natural response - Transient response -Time constant - Rise and fall times - Determination of initial conditions. Module III (12 hours) Single phase AC circuits; Alternating quantities - Generation sinusoidal emf.-Mathematical equations - Definitions and explanations of the terms: wave form, cycle, time period, frequency, amplitude, phase, phase difference, rms value, average value, form factor and peak factor Calculations for square, triangle, trapezoidal and sinusoidal waveforms. Phasor representation of sinusoidal qualities - Phase difference - Addition and subtraction of sinusoids -Symbolic representation - Cartesian, polar and exponential forms. Analysis of ac circuits: R, L, C, RL, RC and RLC circuits using phasor concept -Concept of impedance, admittance, conductance and susceptance - Power in single phase circuits Instantaneous power - Average power - Active and reactive powers - Apparent power - Power factor - Complex power - Solutions of series, parallel and series-parallel AC circuits. - Series and parallel resonances - Q-factor - Frequency response curves - Half power frequencies Bandwidth -Application of Thevenin's and Norton's theorems for AC circuits. Module IV (10 hours) Analysis of polyphase circuits - 2 phase circuits - Three phase AC circuits -Generation of 3 phase AC voltages"- Balanced system - Phase sequence -Star-delta transformation - Balanced 3 phase AC source supplying balanced 3 phase star connected and delta connected loads - 3 wire and 4 wire systems -Neutral current - Active power, reactive power, apparent power, and power
24
factor - Power factor. improvement-Unbalanced systems - Neutral shift (explanation and concept only) - Three phase power measurement - Three wattmeter and Two wattmeter methods. Text Books 1. Hughes E. Electrical technology, Pearson Education. 2. D.P. Kothari & Nagarth - Theory and problems of Basic Electrical Engineering Prentice Hall (India) PVT LTD. Reference books 1. Edminister J A. Electric circuits, Schaum's series. McGraw Hill. 2. Van valkenberg, Electric circuits and network analysis, Prentice Hall (India) PVT LTPT 3. Smarjith Ghosh - Fundamentals of Electrical and Electronics Engineering Prentice Hall (India) PVT LTD. Internal work assessment 60 % -Test papers ( minimum 2) 30 % - Assignments/Term project/any other mode decided by the teacher. 10 % - Other measures like Regularity and Participation in Class. Total marks = 50. University examination pattern QI - 8 short type questions of 5 marks 2 from each module. QII- 2 questions A and B of 15 marks from module I with choice to answer any one QIII- 2 questions A and B of 15 marks from module II with choice to answer any one QIV- 2 questions A and B of l5 marks from module III with choice to answer any one Q V - 2 questions A and B of 15 marks from module IV with choice to answer any one
25
BM04 - 110(P) : MECHANICAL WORKSHOP

(Common for EC, IC, AI, BM, BT) 3 hours practical per week
1.
Machine Shop Practice Study of different machine tools-lathe-shaper-milling machine- drilling machine-grinding machine Exercises on lathe-models involving straight turning, taper turning, facing, knurling, boring, and thread machining-thread standards and specifications.
2. Fitting Practice Study of hand tools and measuring tools used in fitting work Fabrication exercises involving cutting, chiseling, filing, and drilling - use of thread dies and taps. 3. Welding Practice Study of welding equipment and tools-safety practices. Demonstration of electric arc welding, gas welding and cutting Exercises involving preparation of different types of welded jointslap and butt joints. Demonstration of special welding processes-welding defects and weldment inspection 4. Sheet metal work Study of tools and equipment for sheet metal work. Types of joints in sheet metal work-cutting, bending, forming, and joining operations-development & fabrication of simple sheet metal components like tray, funnel, cylindrical dish, rectangular duct, etc. Demonstration of brazing, soldering, shearing/cutting machine. Internal work assessment Workshop practicals and recor 2 tests Total marks
2x10
=30 =20 =50
26
BM04 - 111(P): ELECTRICAL AND ELECTRONICS WORKSHOP

(Common for EE,EC, AI, IC,BT, BM, CS, IT, PT) 2 hours practicals per week
Part A: Electrical Workshop (2 hours per alternate weeks)

1. 2.
3. 4.
5.
6. 7. 8. 9.
10.
Familiarisation of various types of Service mains - Wiring installations Accessories and house-hold electrical appliances Methods of earthing - Measurement of earth resistance - Testing of electrical installations - Precautions against and cure from electric shock Practice of making Britannia joints on copper / aluminium bare conductors. Practice of making Married joints on copper / aluminium conductors. Practice of making T joints on copper / aluminium conductors Wiring practice of a circuit to control 2 lamps by 2 SPST switches. Wiring practice of a circuit to control 1 lamp by 2 SPDT switches. Wiring practice of a circuit to control 1 fluorescent lamp and 1 three-pin plug socket. Wiring practice of a main switch board consisting of ICDP switch, DB, MCB's, and ELCB's. Familiarisation of various parts and assembling of electrical motors and Wiring practice of connecting a 3-phase / 1-phase motor with starter = = = 15 10 25
Internal work assessment Workshop practicals and record Test/s Total marks
Part B - Electronics Workshop (2 hours per alternate weeks)

1. 2. 3. 4. 5. 6.
7.
8.
9.
10.
Familiarisation of various electronics components such as resistors, AF&RF chokes, capacitors, transistors, diodes, IC's and transformers. Assembling and soldering practice of single phase full wave bridge rectifiers circuit with capacitor filter. Assembling and soldering practice of common emitter amplifier circuit. Assembling and soldering practice of common emitter amplifier circuit on PCB. Assembling and soldering practice of non inverter amplifier circuit using OPAMP on PCB. Assembling of a timer circuit IC555, phase shift oscillator circuit using OPAMP and JK flip-flop using NAND gates on a bread-board. Coil winding - Single layer and multi layer - Demonstration. Miniature transformer winding Demonstration. PCB layout using software like ORCARD, CIRCUITMAKER, EDWIN. PCB fabrication Demonstration.
Internal work assessment Workshop practicals and record = 15 = Test/s 10 Total marks = 25
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THIRD SEMESTER
EN04 - 301A ENGINEERING MATHEMATICS
(Common for all B. Tech. programme except CS and IT) 3 hours lecture and 1 hour tutorial per week Module I Linear Algebra: Vector spaces- linear dependence and impedance, and their computation- Bases and dimensionSubspaces- Inner product spaces- Gram-Schmidt orthogonalization process- Linear transformations- Elementary properties of linear trans formations- Matrix of a linear transformation. (Proofs of theorems omitted) Module II Fourier Transforms: Fourier integral theorem (proof not required)- Fourier sine and cosine integral representationsFourier transforms- Fourier sine and cosine transforms- Properties of Fourier transformsSingularity functions and their Fourier transforms. Module III Probability Distributions: Random variables- Mean and variance of probability distributions- Binominal and Poisson distributions- Poisson approximation to binominal distribution- Hypergeometric and geometric distributions- Probability densities- Normal, uniform and gamma distributions. Module IV Theory of lnference: Population and samples- Sampling distributions of mean and variance- Point and interval estimations- Confidence intervals for mean and variance- Tests of hypotheses- Hypotheses concerning one mean, two mean, one variance and two variances- Test of goodness of fit. Text Books For Module I K. B. Datta, Matrix and Linear Algebra for Engineers, Prentice-Hall of India, New Delhi, 2003 (Sections: 5.1, 5.2, 5.3, 5.4, 5.5, 5.8, 6.1, 6.2, 6.3) For Module II C R Wylie & L C Barrett, Advanced Engineering Mathematics (Sixth Edition), McGrawHill. (Sections: 9.1, 9.3, 9.5) For Module III Richard A Johnson, Miller & Freund's Probability and Statistics for Engineers, Pearson Education, 2000. (Sections: 4.1, 4.2, 4.3, 4.4, 4.6, 4.8, 5.1, 5.2, 5.5, 5.7) For Module IV Richard A Johnson, Miller & Freund's Probability and Statistics for Engineers, Pearson Education, 2000. (Sections: 6.1,6.2,6.3,7.1,7.2,7.4,7.5,7.8,8.1,8.2,8.3,9.5) Reference Book: 1. Bernard Kolman & David R Hill, Introductory Linear Algebra with Applications (Seventh Edition), Pearson Education, 2003. 2. Lipschutz S, Linear Algebra - Schaum's Outline Series, McGraw Hill 3. Erwin Kieyszig, Advanced Engineering Mathematics (Eighth Edition), John Wiley & Sons. 4. Larry C Andrews & Bhimsen K Shivamoggi, Integral Transforms for Engineers, PrenticeHall of India, 2003. 5. Ronald E Walpole, et al, Probability and Statistics for Engineers and Scientists (Seventh
28
Edition), Pearson Education, 2004. Robert V Hogg & Elliot A Tanis, Probability and Statistical Inference, Pearson Education, 2003. 7. Chatfield C, Statistics for Technology, Chapman & Hall.
6.
Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x15
= = = =
15 30 05 50
University examination pattern Q1 - 8 short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII- 2 questions A and B of l5 marks from module II with choice to answer any one QIV - 2 questions A and B of 15 marks from module III with choice to answer any one QV - 2 questions A and B of l5 marks from module IV with choice to answer any one
29
BT04 302 : COMPUTER PROGRAMMING IN C

(Common for all B. Tech. programmes except CS, IT& PT) 2 hours lecture and 2 hours practical per week Module I (12 Hours) Programming and problem solving- Basic computer organization- Developing algorithms- Flow charts- High level and low level languages- Compilers and interpreters- Steps involved in computer programming- Writing, compiling and executing a program- Debugging a programDescription of a programming language. Module II (18 Hours) Basics of C- Overview of C- Program structure- Lexical elements- Numerical constantsVariables- Arithmetic operators- Arithmetic Expressions- Arithmetic conversion- Increment and Decrement operators- Assignment expressions-Multiple assignments- Input and output- Format specifiers - Fundamental data types- Bit level operators and applications- Relational operatorsRelational expressions- Logical operators- Logical expressions- Conditional operator- Precedence and associativity of operators. Module III (16 Hours) Compound statements- Conditional statements- if statement- if else statement-nested if statement-switch statement- Loop control statements- While statement-do while statement- for statement-continue statement- break statement- go to statement- Functions- user defined functions- library functions- Recursion- Global, local and static variables. Module lV (20 Hours) Arrays- single dimensional- multi dimensional- Arrays in functions- Stacks-Strings- String processing- Bit-wise operators- Enumerated data types- Structures - Type def - Structures in Arrays- Arrays in structures- Unions- Pointers-Pointers and Arrays- Pointers and functionsLinear linked lists and list operations- Files- sequential files- unformatted files- text files. Text books V. Rajaraman, Computer Programming in C, Prentice Hall of India, New Delhi. Reference Books: 1. Kernighan B. W., & Ritchie, D.M., The C Programming Language, Prentice Hall of India. 2. Balaguruswamy, Programming in ANSI C, Tata McGraw Hill. 3. Venugopal K.R & Prasad S.R., Programming with C, Tata McGraw Hill. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks = = = = 15 30 05 50
2x15
University examination pattern QI - 8 short type questions of 5 marks, from each module QII - 2 questions A and B of I5 marks from module l with choice to answer any one QIII- 2 questions A and B of 15 marks from modules II with choice to answer any one Q IV- 2 questions A and B of 15 marks from module III with choice to answer any one. Q V - 2 questions A and B of 15 marks from module IV with choice to answer any one.
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BT04 303 : CELL BIOLOGY

3 hours lecture and 1 hour tutorial per week Module I Introduction to cell theory - prokaryotic cells - eukaryotic cells - cell number - plant and animal cells - cell as a polyphasic colloidal system - ultrastructure and chemical composition of plasma membrane -membrane asymmetry - fluidity in plasma membrane - pores - glycocalyx functions of plasma membrane - permeability and transport - structure of plant cell wall and bacterial cell wall. Module II Cytoplasmic vacuolar system - morphology, ultrastructure and functions of endoplasmic reticulum - microsomes - structure, chemical composition and functions of golgi complex. Microbodies - structure, enzymes, stability, polymorphism, biogenesis and functions of lysosomes. Ribosomes - shape and size -ultrastructure - mitochondrial and chloroplast ribosomes chemical composition - biogenesis functions. Mitochondria - ultrastructure - respiratory chain - redox potential - chemical composition biogenesis - functions. Module III Plastids - functions - chloroplasts - chemical composition - pigments - phycobilins photochemical reaction systems - mechanism of photosystem. Structure and functions of centriole - extra cellular structure - interphase nucleus - morphology of eukaryotic chromosomes - molecular organization of chromosomes Module IV Cell division - mitosis - karyokinesis cytokines is - cytoplasmic events - process and significance of meiosis - spermatogenesis and cogenesis Cell growth - cellular aging - regulation of cell size - theories of carcinogenesis. Techniques for the propagation of prokaryotic and eukaryotic cells - cell line - generation of cell lines maintenance of stock-cells - characterization of cells - immuno cytochemistry - morphological analysis techniques - cell culture -cell fractionation - tissue hornogenization - centrifugation elutriation. Text/Reference Books:
1. 2. 3.
Kimball T.W : Cell Biology, Wesley Publishers Smith and Wood : Cell Biology, Chapman and Hall. Darnell, Lodish and Baltimore : Molecular Cell Biology, W.H. Freeman = = = = 15 30 05 50
2x15
University examination pattern QI - 8 short type questions of 5 marks, from each module QII - 2 questions A and B of I5 marks from module l with choice to answer any one QIII- 2 questions A and B of 15 marks from modules II with choice to answer any one
31
Q IV- 2 questions A and B of 15 marks from module III with choice to answer any one. Q V - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 304 : CHEMICAL ENGINEERING I

3 hours lecture and 1 hour tutorial per week Module I Overview of process industry - unit operations and unit processes - conservation of mass and energy SI units and conversion factors . Stoichiometric and composition relations - gram atom and gram mol concepts - excess reactants - degree of completion of reaction. Overall and component material balances - material balance involving chemical reaction and not involving chemical reaction. Module II Concepts and calculation involving energy , heat and work and enthalpy of reversible and irreversible processes. Heats of formation, combustion, solution and dilution and the effect of pressure and temperature on them. Energy balance for systems with and without chemical reaction. Module III Properties of fluids and units - theological classification. Mechanism of non-compressible fluid flow - Reynold's number - Laminar and turbulent flow through pipes - Hagen Poiseuille equation - friction factor- distribution of velocities - Bernoulli equation. Friction losses in a pipeline and losses in various fittings - equivalent length - flow past immersed bodies and motion of particles through fluids. Principles of particulate and aggregative fluidization. Module IV Fluid moving machineries - general study of various pumps, blowers and compressors and detailed study of Centrifugal pumps - various types of centrifugal pumps- work done - minimum starting speed - specific speed - priming - cavitation - the concept of NPSH - pump characteristics. Measurement of fluid flow -orifice and venturimeter - pitot tube - rotarneter notches and weirs . Fundamentals of mixing and characteristics of mixing equipments - power consumption and efficiency. Reference 1. Reynolds and Cotburn, Momentum, Heat and Mass Transfer. 2. W.L.McCabe & J.C.Smith , Unit Operations in Chemical Engineering, McGraw Hill. 3. Ch. .Durgaprasad & DVS Murthy, Process Calculation for Chemical Engineers. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x15
= = = =
15 30 05 50
University examination pattern QI - 8 short type questions of 5 marks, from each module QII - 2 questions A and B of I5 marks from module l with choice to answer any one QIII- 2 questions A and B of 15 marks from modules II with choice to answer any one Q IV- 2 questions A and B of 15 marks from module III with choice to answer any one. Q V - 2 questions A and B of 15 marks from module IV with choice to answer any one
32
BT04 305 : MICROBIOLOGY

3 hours lecture and 1 hour tutorial per week Module I History and development of microbiology - microbial diversity - brief outline on the taxonomy, morphology and ultrastructure of bacteria, actinomycetes, luegreen algae, yeasts, fungi, algae and virus. Principles of microbial taxonomy - genetic methods in taxonomy - international rule for nomenclature, microbial phylogeny and current classification of bacteria. Principle- of microscopy - bright field microscopy - fluorescence microscopy - phase contrast microscopy - electron microscopy. Theory of staining microorganisms - gram staining - flagella staining. Principles of sterilization - types of sterilization - control of microorganisms by physical and chemical agents. Module II Nutritional requirements of microorganisms - nutritional groupings of microorganisms - growth medium and different types of media - enumeration of microorganisms - isolation, preservation and maintenance of cultures. Reproduction in bacteria , actinomycete, yeast, fungi and virus - physiology of reproduction and sporulation. Module III Growth - growth curve - generation time - continuous culture - restriction of growth and synchronous culture - mass culture - kinetics of growth - measurement of cell growth - induction of growth - growth factors - growth of bacteriophage-macromolecular synthesis and growth. Effect of environmental factors on growth, reproduction and survival of microorganisms. Module IV. Microbiology of water - Bacteriological evidence of pollution - the coliform groupbacteriological methods of examining water- microbiological characteristics of waste water. Microbial flora of soil - interactions among soil microorganisms. Microbial flora of fresh foods - microbial spoilage of foods - preservation of foods. Text/Reference Books: 1. Pelczar et al: Microbiology, Tata McGraw Hill, New Delhi 2. Tauro, Kapoor and Yadav : An Introduction to Microbiology, Wiley Eastern Ltd., 1986 3. Prescott et al : Microbiology, McGraw Hill, USA Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x15
= = = =
15 30 05 50
University Examination Pattern QI - 8 short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII- 2 questions A and B of 15 marks from module II with choice to answer any one QIV- 2 questions A and B of 15 marks from module III with choice to answer any one QV - 2 questions A and B of l5 marks from module IV with choice to answer any one.
33
BM04 306 : BIOCHEMISTRY I

3 hours lecture and 1 hour tutorial per week Module I Introduction to, biochemistry : a historical perspective. Carbohydrates structure and properties of monosaccharides, oligo saccharides and polysaccharides - ring structure and muta rotation homo and hetero polysaccharides - muco poiysaccharides - sialic acids -bacterial cell Wall polysaccharides - glycoproteins - membrane glycoproteins and their biological functions - blood group substances. Module II Amino acids and Proteins - structure and properties of amino acids - general reactions of amino acids - peptide bond - classification of proteins - primary, secondary, tertiary and quarternary structure of proteins -purification of proteins - denaturation and renaturation - fibrous and globular proteins. Nucleic acids - structure and properties of purine and pyramidine bases - nucleosides and nucleotides -structure of nucleic acids - base pairing rule - structure and functions of DNA and RNA - double helical model of DNA structure - A, B and Z DNA. Module III Lipids - classification and structure - essential fatty acids - glycerides - hydrolysis of fats structure and properties of phospho lipids and glycolipids - prostaglandines- structure, biological properties and uses of cholesterol. Module IV Enzymes - Nomenclature and classification of enzymes - activation energy and transition state enzyme activity -active sites - theories of enzyme specificity - role of cofactors in enzyme catalysis. Vitamins - chemistry and biological functions of fat soluble Vitamin A, Vitamin D, Vitamin K and Vitamin E - water soluble vitamin B complex - biological function of B complex Vitamins and Vitamin C Text / Reference Books: 1. A.L. Leninger: Principals of Biochemistry, CBS Publications. 2. E.L. Smith, R.L. Hill et al : Principles of Biochemistry, Vol.1 and II, McGraw Hill Book Company. 3. Lubert Stryer : Biochemistry, W.H. Freeman & Co. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks = = = = 15 30 05 50
2x15
34
BT04 307(P) : MICROBIOLOGY LAB

3 hours practical per week
1.
Sterilization techniques (lecture & demonstration)) wet heat, dry heat, Preparation of culture media .cotton plugging and sterilization.
filtration,
disinfection. 2.
3.
Culturing of microorganisms: broth, agar, pure culture technique, streak plate, pour plate, Isolation and preservation of bacterial culture Identification of microorganisms: staining techniques, spore, capsule, fungal staining, biochemical tests. Quantification of microorganisms: counting microscopy, nephalometry/ turbidometry or dry weight.
4. 5. ,total N 6. 7. 8. 9.
10.
Environmental sample analysis, bacteriological analysis of water, SPC, presumptive test, confirmed test, IMVic test. Food microbiology: milk, fermented food. Cultivation of moulds and yeast. Growth curve of bacteria. Clinical Microbiology
Internal work assessment Regular work and record Tests Regularity Total marks
= = = =
25 20 5 50
35
BT04 308(P): BIOCHEMISTERY LAB

1.
Units, Volume/Weight measurements, concentrations units, pH. measurements. Preparation of buffers, Sensitivity, Specificity, precision and Accuracy. Qualitative tests for Carbohydrates. Estimation of Reducing sugars by the Benedict's method. Qualitative tests for Amino Acids. Quantitative method for Amino Acids, Ninhydrin method . Protein estimation Biuret, Folin's, Spectrophotometry and Bradford Assay. Acid hydrolysis of Proteins and Estimation of Amino acids by Ninhydrin, oPA, PTH. Extraction of lipids. Saponification of Fats. Phospholipids: Ashing and estimation of phosphate. Estimation of cholesterol. Estimation of Nucleic Acids, Precipitation by sodium sulphate, Test for ribose and deoxyribose Enzyme assays: Phosphatase from potato, Amylase from sweet potato, Trypsin digestion of proteins.
2.
3. 4.
5. 6.
7. 8. 9.
10. 11.
12.
Internal work assessment Regular work and record = 25 Tests = 20 Regularity = 5 Total marks = 50
36
FOURTH
SEMESTER
EN04 401A : ENGINEERING MATHEMATICS - IV

(Common for all B. Tech. programmes except CS and IT) 3 hours lecture and 1 hour tutorial per/week Module I (13 hours) Functions of a Complex Variable I: Functions of a complex variable- Derivatives and analytic functions- Cauchy-Reimann equations- Laplace equation- Conformal mapping- Exponential functions- Trigonometric functions- Hyperbolic functions- Logarithm- Linear functional transformations. Module II (13 hours) Functions of a Complex Variable II: Line integral in the complex plane- Cauchy's integral theorem (Proof of existence of indefinite integral to be omitted)- Cauchy's integral formula- Derivatives of analytical functions ( proof to be omitted)- Taylor series- Laurent series-Singularities and zeros- Residues and residue theorem- evaluation of real integrals. Module III (13 hours) Series Solutions of Differential Equations: Power series method for solving ordinary differential equations- Legendre's equation and Legendre polynomials- Rodrigue's formula- Generating functions-Relations between Legendre polynomials- Orthogonality property of Legendre polynomials( proof omitted). Frobenius method for solving ordinary differential equations- Bessel's equation- Bessel functions-Generating functions- Relations between Bessel functions- Orthogonality properties of Bessel functions (proof omitted). Module IV (13 hours) Partial Differential Equations: Basic concepts- Classification of linear PDE's-Derivation of the one dimensional wave equation and the one dimensional heat equation- Solutions of these equations by the method of separation of vari-ables- Solutions satisfying initial and boundary conditions- D'Alembert's solution of the one dimensional wave equation- Steady state two dimensional heat flow. Text Book: Ervin Kreyszig, Advanced Engineering mathematics (8th Edition) John Wiley & Sons Module I Sections: 12.3, 12.4, 12.5, 12.6, 12.7, 12.8, 12.9 Module II Sections: 13.1, 13.2, 13.3,14.4,15.1,15.2,15.3,15.4 Module III Sections: 4.1, 4.3, 4.4, 4.5 Module IV Sections: 11.1, 11.2, 11.3, 11.4, 11.5 References 1. C R Wylie & L C Barrett, Advanced Engineering Mathematics (Sixth Edition),
37
2. 3. 4. 5.
McGraw Hill. Churchill R V, Brown J W & Verhey R F, Complex Variables and Applications, McGraw Hill. Pipes LA & Harvill L R, Applied Mathematics for Engineers & Physicists, McGraw Hill Michael D Greenberg, Advanced Engineering Mathematics (Second Edition) Pearson education Asia. Sastry S S, Engineering Mathematics - Volumes 1 & 2, Prentice Hall of India.
2x15
= = = =
15 30 05 50
38
EN04 402 : ENVIRONMENTAL STUDIES

(Common for all branches) 3 hours lecture and 1 hour tutorial per week Objective: The importance of environmental science and environmental studies cannot be disputed. Continuing problems of pollution, loss of forest, solid waste disposal, degradation of environment, loss of bio diversity etc. have made everyone aware of environmental issues. The objective of this course is to create general awareness among the students regarding these environmental issues Module 1 (12 Hours) The multidisciplinary nature of environmental studies Definition- Scope and importance- need for public awareness. Natural Resources Renewable and non renewable resources: Natural resources and associated problems- forest resources: use and over exploitation, deforestation, case studies. Timber extraction, mining, dams and their defects on forests and tribal people- water resources: Use and over utilization of ground and surface water, floods, drought, conflicts over water, dam benefits and problems- Mineral resources: Use and exploitation, environmental effects of extracting and using mineral resources, case studies Food resources: world food problems, changes caused by agriculture overgrazing, effects of modem agriculture, fertilizer-pesticide problems, water logging, salinity, case studies - Energy resources: Growing energy needs, renewable and non renew-able energy sources, use of alternate energy sources, case studies - Land resources: Land as a resource, Land degradation, man induced land slides, soil erosion and desertification- role of an individual in conservation of natural resources- Equitable use of resources for sustainable life style. Module II (12 Hours) Ecosystem: Concept of an ecosystem- Structure and function of an ecosystem-producers, consumers and decomposers- Energy flow in the ecosystem- ecological succession- Food Chains, food webs and ecological pyramids - Introduction, types, characteristic features, structure and function of the following ecosystems: Forest ecosystem- grassland ecosystem desert ecosystem -aquatic ecosystem (ponds, streams, lakes, rivers, oceans, estuaries). Bio diversity and its conservation Introduction-definition: genetic, species and ecosystem diversity- bio geographical classification of India- value of bio diver-sity: consumptive use, productive use, social, ethical, aesthetic, and option values - Bio diversity at global, national, and local levels - India as a mega diversity nation - hot spots of Bio diversity- threads to bio diversity: habitat loss, poaching of wild life man- wildlife conflicts- endangered and endemic species of India - conservation of bio diversity : in-situ and ex-situ conservation of bio diversity Module III (11 Hours) Environmental pollution Definition-causes, effects and control measures of :-air pollution- water pollution- soil pollutionmarine pollution- noise pollution-thermal pollution- nuclear hazards- solid waste management:
39
causes, effects and control measures of urban and industrial wastes-role of an individual in prevention of pollution- pollution case studies - Disaster management: Floods, earth quake, Cyclone and Land slides- environmental protection act- air (prevention and control of pollution) act - water (prevention and control of pollution) act - wild life protection act- forest conservation act -issues involved in enforcement of environmental legislation- public awareness.
Module IV (10 Hours) Social Issues and the environment From unsustainable to sustainable development- urban problems related to energy- water conservation, rain water harvesting, water shed management- resettlement and rehabilitation of people; its problems and concerns, case studies- Environmental ethics: Issues and possible solutions- climate change, global warming, acid rain, ozone layer depletion, nuclear accidents and holocaust, case studies- waste land reclamation- consumerism and waste products. Human population and the environment Population growth, variation among nations- population explosion- Family welfare programmeEnvironment and human health- pollution hazards, sanitation and health- Human rights for clean environment- Value education- HIV/AIDS-social concern- Women and child welfare- Role of information technology in environment and human health- case studies.
Field work (5 Hours) Visit to a local area to document environmental assets- river/forest/ grassland/hill/mountain. Visit to local polluted site- urban/rural/industrial/agriculture Study of common plants/insects/birds Study of simple eco systems- pond, river, hill slopes etc.. Text books 1. Clark, R.S. Marine Pollution. Clanderson Press Oxford 2. Mhaskar A.K, Matter Hazardous. Techno-science Publications 3, Miller, T.G Jr. Environmental Science. Wadsworth Publishing Co. 4, Townsend, C, Harper, J. and Michael Begon, Essential of Ecology. Blackwell Science. 5, Trivedi. R.K. and Goel. P.K. Introduction to air pollution. Techno - Science Publications. Reference Books 1. Agarval. K.C.2001 Environmental biology. Nidi Publ. Ltd. Bikaner. 2. Bharucha Erach, Biodiversity of India, Mapin Publishing Pvt. Ltd., Ahmedabad-380 013, India, Email: mapin@icenet.net 3. Brunner, R.C. 1989. Hazardous Waste Incineration. McGraw Hill Inc. 480p. 4. Cunningham, W.P., Cooper, T.H., Gorhani, E & Hepworth, M.T. 2001 Environmental encyclopedia Jaico publ. House Mumbai 1196p. 5. De, A.K. Environmental Chemistry. Wiley Eastern Ltd.. 6. Down to Earth, Centre for Science and Environment. 7. Gleick, H.P. 1993. Water in crisis. Pacific Institute for Studies in Dev., Environment and security, Stockholm Env. Institute. Oxford Univ. Press. 473p. 8. Hawkins, R.E. Encyclopedia of Indian Natural History, Bombay Natural History Society, Bombay. 9. Heywood, V.H. & Watson, R.T. 1995. Global Biodiversity Assessment Cambridge Univ. Press 1140p. 10. Jadhav, H. & Bhosale, V.M. 1995. Environmental Protection and Laws. Himalaya Pub. House, Delhi. 11. Mckinney, M.L. & School, R.M. 1996. Environmental Science system & Solutions, Web enhanced edition, 639p. 12. Odum, E.P. 1971. Fundamentals of Ecology. W.B.Saunders Co. USA, 574p. 13. Rao, M.N. & Datta, A.K 1987. Waste Water treatment. Oxford & IBH Publ. Co. Pvt. Ltd.,
40
345p. 14. Sharma, B.K. 2001. Environmental Chemistry. Goel Publ. House, Meerut. 15. Survey of the Environment, The Hindu (M). 16. Trivedi, R.K., Handbook of Environmental Laws, Rules, Guidelines, Compliances and Standards, Vol. I and II. Enviro Media. 17. Wagner. K. D. 1998. Environmental Management. W.B. Saunder Co. Philadelphia, USA 499p Magazine.
2x15
= = = =
15 30 05 50
University Examination Pattern: QI - 16 short answer questions(4 from each module) of 5 marks each with choice to answer any 12(12x5) QII - 2 questions A and B of 10 marks from module l with choice to answer anyone QIII- 2 questions A and B of 15 marks from module II with choice to answer any one QIV- 2 questions A and B of 15 marks from module III with choice to answer any one QV - 2 questions A and B of l5 marks from module IV with choice to answer any one.
41
BT04 403 :
BIOCHEMISTRY II
(Common with AI 04 403) 3 hours lecture and 1 hour tutorial per week Module I Metabolism of carbohydrates - reactions,, energetics and regulation of glycolysis - pentose phosphate pathway and its significance - gluconebgenesis pathway and its regulation biosynthesis of lactose, sucrose and starch - glycogenolysis and glycogenesis - control of glycogen metabolism - maintenance of blood glucose levels - TCA cycle - photosynthesis. Module II Metabolism of lipids - fatty acid oxidation - ketone bodies - ketosis - biosynthesis of fatty acids and triglycerides - metabolism of phospholipids - cholesterol metabolism. Metabolism of proteins - essential and non-essential amino acids - degradation and biosynthesis of amino acids - urea cycle : reactions, regulation and its linkage with the citric acid cycle metabolism of aromatic amino acids, cystein, histidine and serine. Module III Metabolism of nucleic acids - Denovo biosynthesis of purine and pyrimidine nucleotides regulation of purine and pyramidine nucleotide biosynthesis - salvage pathways of purines and pyrimidines - formation of deoxyribonucleotides - catabolism of purines and pyrimidines. Module IV Bioenergetics - redox potential - biological oxidation - mitochondria and components of electron transport system - respiratory control -oxidative phosphorylation - ATP production chemiosmotic theory - uncouplers and inhibition of oxidative phosphorylation. Text / Reference Books: 1. A.L. Leninger: Principles of Biochemistry, CBS Publications. 2. E.L. Smith, R.L. Hill et al: Principles of Biochemistry, Vol. I and II, McGraw Hill Book Company. 3. Lubert Stryer : Biochemistry, W.H. Freeman & Co. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks = = = = 15 30 05 50
2x15
University Examination Pattern QI - 8 short type questions of 5 marks, 2 from each module QII -2 questions A and B of 15 marks from module I with choice to answer any one QIII- 2 questions A and B of 15 marks from module II with choice to answer any one QIV - 2 questions A and B of 15 marks from module III with choice to answer anyone QV - 2 questions A and B of 15 marks from module IV with choice to answer any one
42
BT04 404 : CHEMICAL ENGINEERING II

3 hours lecture and 1 hour tutorial per week Module I Chemical Engineering Thermodynamics - quantitative development of the fundamental laws -thermodynamic functions - general equations of equilibrium - pressure, volume, temperature relations of fluids - concepts of chemical potential and fugacity-thermodynamics of fluid flow compression and expansion of fluids - equilibrium criteria for homogeneous chemical reactions evaluation of equilibrium constant. Module II Mechanical operations - properties of solids - types of equipments for size reduction -laws of crushing-power requirement - closed and open circuit grinding Screening - efficiency of screens. Sedimentation - free and hindered settling - thickening. Theories -of filtration and washing - constant pressure and constant rate filtration - optimum cycle. Centrifugal separation -Principles of conveying of solids Module III Mechanism of heat transfer - heat conduction - conduction through series resistances convection -extended surfaces -the- concept of two dimensional conduction - shape factors forced convection in pipe and other geometries - natural convection - boiling and condensation heat transfer to Non Newtonian fluids - basic laws of radiation. Module IV Individual and overall heat- transfer coefficients - types of heat exchangers - design principles of heat exchangers - factors affecting evaporation - calculations for single effect and multiple effect evaporation. Text/Reference Books: 1 2. 3. 4. Smith H.C and Van Ness: Introduction to Chemical Engineering Thermodynamics. Mc Cabe and Smith: Unit Operations in Chemical Engineering. Brown: Unit Operation. Badger and Banchero: Introduction to Chemical Engineering
2x15
= = = =
15 30 05 50
University Examination Pattern QI - 8 short type questions of 5 marks, 2 from each module.
43
QII - 2 questions A and B of 15 marks from module I with choice answer any one QIII- 2 questions A and B of 15 marks from module II with choice to answer any one QIV - 2 questions A and B of l5 marks from module III with choice to answer any one QV - 2 questions A and B of l5 marks from module IV with choice to answer any one.
BT04 405 : BIO PROCESS PRINCIPLES

3 hours lecture and 1 hour tutorial per week Module I Introduction to bioprocesses: Historical development of bioprocess technology, an overview of traditional and modern applications of biotechnological processes, role of bioprocess engineer in the biotechnology industry, outline of an integrated bioprocess and the various (upstream and downstream) unit operations involved in bioprocesses, generalized process flow sheets. Module II Fermentation processes: General requirements of fermentation processes, Basic design and construction of fermentor and ancillaries, Main parameters to be monitored and controlled in fermentation processes, An overview of aerobic and anaerobic fermentation processes and their application in the biotechnology industry, solid-substrate fermentation and its applications. Module III Metabolic stoichiometry and energetics: Stoichiometry of Cell growth and product formation, elemental balances, degrees of reduction of substrate and biomass. available, electron balances, yield coefficients of biomass and product formation, maintenance coefficient Energetic analysis of microbial growth and product formation, oxygen consumption and heat evolution in aerobic cultures, thermodynamic efficiency of growth. Enzymatic bioconversion processes: Kinetics and thermodynamics of enzyme-catalyzed reactions. Techniques of enzyme immobilization, basic design and configuration of immobilized enzyme reactors, applications of immobilized enzyme technology. Module IV Media design and sterilisation for fermentation processes: Medium requirements* for fermentation processes, carbon, nitrogen, minerals, vitamins and other complex nutrients, oxygen requirements, medium formulation for optimal growth and product formation, examples of simple and complex media, design and usage of various commercial media for industrial fermentations, thermal death kinetics of micro organisms,batch and continuous heat, sterilization of liquid media, filter sterilization of liquid media, Air, Design of sterilization equipment. References 1. Bailey and Ollis, Biochemical Engineering Fundamentals, McGraw Hill 2. Shule and Kargi, Bioprocess Engineering, Prentice Hall Internal work assessment Assignments (minimum 2) 2 tests = 15 = 30
2x15
44
Regularity Total marks = 05 = 50
University Examination Pattern QI - 8 short type questions of 5 marks, 2 from module QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII - 2 questions A and B of 15 marks from module III with choice to answer any one QIV - 2 questions A and B of 15 marks from module IV with choice to answer any one QV- 2 questions A and B of 15 marks from module V with choice to answer any one..
BT04 406 : ANALYTICAL TECHNIQUES BIOTECHNOLOGY

(Common with A104 406) 3 hours lecture and 1 hour tutorial per week Module I Photometry and spectrophotometry : The Beer-Lambert Law, percentage transmittance and absorbance ; photoelectric colorimeters; spectrophotometers - types, UV visible, IR, atomic absorption, NMR and mass spectrophoto meters. Module II Chromatography : Partition chromatography - mobile and stationary phases paper chromatography -solvent systems - development of Rf value- ascending and descending techniques - two dimensional chromatography - thin layer chromatography. Column chromatography - preparation of columns - gradient elution - analysis of fraction and elution profiles - ion exchange chromatography - preparation and activation of ion exchange materials - affinity chromatography - separation of macromolecules - gas chromatography and high performance liquid chromatograph (HPLC). Module III Electrophoresis - paper and gel electrophoresis - immuno electrophoresis - enzyme linked immuno absorbant assay(ELISA) - isoelectric focusing - two dimensional electrophoresis capillary electrophoresis. Dialysis - separating membranes - factors affecting dialysis gelfiltration - ultrafiltration- application of filtration techniques. ..; Differential centrifugation - preparation of cellular organelle and other materials ; disintegration of cells , density gradient centrifugation; analytical ultracentrifuge - determination of molecular weight. Module IV Radio isotope techniques - radioactive disintegration - radioactive isotopes used in biology detection of radioactivity - Geiger counters strip counters - labeling of biological material with radioactive isotope -scintillation counting - liquid scintillation counters - autoradiography. Text / Reference Books 1. T.G. Cooper : Tools of Biochemistry, Wiley Interscience 2. D. Holme and H. Peck : Analytical Biochemistry, Longman. 3. Willard Merrit and Deana Settle : Instrumental Methods of Analysis, CBS Publishers & Distributors. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x15
= = = =
15 30 05 50
45
University Examination Pattern QI - 8 short type questions of 5 marks, 2 from module QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII - 2 questions A and B of 15 marks from module III with choice to answer any one QIV - 2 questions A and B of 15 marks from module IV with choice to answer any one QV- 2 questions A and B of 15 marks from module V with choice to answer any one.
BT04 407(P) : CHEMICAL ENGINEERING LAB I

3 hours practical per week 1. 2.
3. 4.
Drag coefficient of a falling sphere in a fluid. Pressure drop of liquid passing through a packed bed. Characteristic curves of a centrifugal pump and determination of maximum efficiency. Determination of the coefficient of discharge of orifice meter and venturi meter. Pressure drop characteristics in a fluidized bed. Verification of the laws of crushing using a ball mill Sieve analysis Effectiveness of a screen batch leaf filter.
5. 6. 7. 8.
9. Determination of the mean specific cake resistance and the compressibility factor using a 10. Batch sedimentation of a slurry.
= = = =
25 20 05 50
46
BT04 408(P) : BIO-ANALYTICAL TECHNIQUES LAB

3 hours practical per week 1. 2. 3.
4.
Verification of Beer - Lambert law using calorimeter Estimation of inorganic phosphate. Absorption spectra of nucleotides and bases Separation of aminoacids by paper chromatography - determination of Rf value. Extraction of lipids from tissues and their separation using TLC. Column chromatography of proteins Determination of molecular weight of an enzyme by gel filtration. Separation of proteins by SDS-PAGE. Isotope techniques - labeling of cellular constituents of E. coli.
5. 6. 7. 8.
9.
= = = =
25 20 5 50
47
FIFTH
SEMESTER
BT04 501: INDUSTRIAL BIOTECHNOLOGY

3 hours lecture and 1 hour tutorial per week Module I Market Economics relating to modem Industrial Biotechnology in India. Various thrust areas and a study of some major biotech companies in India. Government initiatives. Outlook for the future. Isolation, Preservation, and Improvement of industrial microorganisms for overproduction of primary and secondary metaboloites - Regulation of enzyme activity and synthesis, Catabolite and phosphate regulation, Use of mutants in overproduction. Production of commercially important enzymes: Proteases, Amylases, Lipases, Celluloses, Pectinases, Isomerases ( Glucose Isomerase) and their uses. High-Fructose Corn Syrup Production. Module II Production of primary Metabolites: A brief outline of processes and conditions for the production of some commercially important metabolites, - Organic acids - Citric acid (surface and submerged processes), Acetic acid (Frings Trickling Generator, Submerged production), Lactic acid (batch production), Gluconic acid. - Amino acids - Glutamic acid (biotin and cell permeability effect on production), Lysine (production regulation using mutants), Aspartic acid. - Alcohols - Ethanol (Raw material selection/batch, Melle Boinot and Biostil processes, various recovery methods, by product recovery, biodiesel) Module III Production of secondary metabolites: Study of industrial production processes for various classes of low molecular weight secondary metabolites - Antibiotics - beta-lactams (Penicillins, Cephalcsporins etc.), Production of synthetic and semi synthetic penicillin - difference between natural and synthetic penicillins amino glycosides (streptomycin, ,kanamycin), Macrolides (erythromycin), Aromatic antibiotics (chlorcphenicol, griseofulvin), - Vitamins (B12, Riboflavin) and bioconversion of steroids. . . Module IV Production of Health care Products Proteins having therapeutic and diagnostic applications ( insulin, interferon, human growth hormone)- production of bacterial vaccines, Ergot alkaloids. Specialty bioproducts Bioproducts for agricultural food and -pharmacestical industries - Biopesticides, Biofertilizers Natural bio -preservatives (Nisin), Biopolymers (Xanthan gum and PHB) - Single cell proteins from various substrates (pruteer--, Symba, Bell process).
48
References 1. Moorray-Mu-Youtig.- Comprehensive Biotechnology, Pergamon Press. 2. Prestt and Dunn, Industrial Microbiology, C.B.S. .Publishers & Distributors. 3. Cascida, L. E., Industrial. Microbiology, New Age International. 4. Wulf Crueger and Anneliese Crueger, Biotechnology - A Text book of Industrial Microbiology, Panima Publishing. Corporation. 5. Michael Waites, Neil L .Morgan et al. Industrial Microbiology : An Introduction, Black Well Science, Replika Press, Delhi.
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern QI - 8 short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of l5 marks from module I with choice to answer any one. QIII- 2 questions A and B of l5 marks from module II with choice to answer any one QIV - 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer anyone.
49
BT04 502 : MASS TRASFER AND SEPARTION PROCESSES

3 hours lecture and 1 hour tutorial per week Module I Molecular diffusion in fluids - steady state modular diffusion in fluids at rest and in laminar flow momentum and heart transfer in laminar flow - mass transfer co-efficiencies - in laminar flow - in turbulent flow. Mass, heat, and momentum transfer analogies. Diffusion in solids ficks law - types of solid diffusion - inter phase mass transfer - equilibrium - diffusion between phases - material balances - stages. . Absorption - equilibrium solubility of gases in liquids - one component transferred; material balance - counter current multistage operation; one component transferred - continuous contact equipment - multi component systems. Module II Liquid extraction - liquid equilibria - equipment and flow sheets - stage wise contact - stage type, extractors differential continuous contact extractors. . . Leaching - unsteady state operation - steady state continuous operation - methods of calculation. Module III Drying - equilibrium - drying operations - batch crying - mechanism of batch drying continuous drying - types of driers. Module IV Distillation - vapour liquid equilibria - single stage operation - flash vaporization, differential or simple distillation continuous rectification binary system - multistage tray towers - Ponchonsavarit and McCabe -Thiele methods. Packed towers - mult: component system - low pressure distillation. Adsorption - equiibria - single gases and vapours - mixtures of liquids - adsorption operation stage wise operation continuous contact - ion exchange principles. Text Book 1. Treybal R. E, Mass Transfer operations, McGraw Hill. Reference 1. Geankoplis C J - Transport process and unit operations. Prentice Hall India Pvt. Ltd. 2. McCabe. W.L., SinithC.J. and Harriot P., Unit operations in Chemical Engineering, McGrow Hill. 3. Coulson J. M.& Richardson J.F., Chemical Engineering, Vol. II ELBS, Pergamon. Internal work assessment Assignments (minimum 2)
2x7.5
= 15
50
2 tests Regularity Total marks 2x15 = 30 = 05 = 50
University examination Pattern Q1 - 8 Short type questions of 5 marks, 2 from each module. QII-2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of l5 marks from module II with choice to answer any one. QIV- 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 503: MOLECULAR BIOLOGY

3 hours lecture and 1 hour tutorial per week Module I General features of chromosomes - chromosome theory of inheritance -genome size and evolutionary complexity the structure of bacterial and eukaryotic chromosomes - linkage and recombination of genes in a chromosome -histones chromatin structure. Structure of DNA - DNA as the genetic material - repetitive and nonrepetitive DNA - C value paradox.- super coiling and periodicity in DNA Module II Origin of DNA replication - mechanism of DNA replication and its regulation Excision repair and SOS response. Characteristics of gene mutation. Mutations in DNA. Module III Gene expression in prokaryotes - Transcription - tRNA as adapter - turn over of messenger RNA - RNA polymerase - role of sigma factor - promoter recognition, initiation ,elongation and termination of transcription. Gene expression in eukaryotes - Initiation of transcription - eukaryotic RNA polymerases -downstream and upstream promoters ~ factors of transcription - enhancers - transcription in mitochondria and chloroplast. Structure of t-RNA - role, of ribosomes in protein synthesis regulation of translation in prokaryotes and eukaryotes - pest transiational. modifications of proteins. Module IV The operon positive and negative control of transcription - represser/inducer complex catabolite repression attenuatiert Regulation of transcription - DNA binding domains - homeodomains demethylation. Nuclear splicing - Lariat formation - cis splicing and trans splicing reactions - processed pseudegenes catalytic RNA Transposons, retroviruses and retroposons life cycle of phages. Concept of the regulation of gene expression by hormones Text 1. 2 3. / Reference Books: Freibler D 'Molecular Biology, Jones and Bartletf Publishers Inc. Benjamin Lewin: Genes VI, Oxford University Press, Oxford ,New York Bruce Alberts and James D.Watson : Molecular Biology of the Cell, Garland Publishing.
Internal work assessment Assignments (minimum 2)
2x7.5
= 15
51
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer anyone. QIV- 2 questions A and B of 15 marks from module III with choice to answer any one, QV - 2 questions A and B of l5 marks from module IV with choice to answer any one.
BT04 504: ENZYME ENGINEERING & TECHNOLOGY

(Common with AI04 504) 3 hours lecture and 1 hour tutorial per week Module 1: Applications of enzymes: Classification of Enzymes; Commercial applications of enzymes in food, pharmaceutical and other industries; Enzymes for analytical and diagnostic applications. Purification and characterization of enzymes from natural sources: Production and Purification of Crude Enzyme extracts from plant, animal and microbial sourcessome case studies- methods of characterization of enzymes - development of enzymatic assays. Module II: Mechanisms and Kinetics of enzyme action: Machanisms of Enzyme action - Concept of active site and energetics of enzyme substrate complex formation Specificity of enzyme action - Kinetics of single substrate reactions turnover number - estimation of Michaelis-Menten parameters Multi-substrate reactions - mechanisms and kinetics - Types of Inhibition kinetic models Substrate and Product Inhibition Allosteric regulation of enzymes - Deactivation kinetics. Module III: Enzyme Immobilization: Physical and Chemical techniques for enzyme immobilization adsorption, matrix entrapment, encapsulation, cross-linking, covalent binding etc., examples - advantages and disadvantages of different immobilization techniques'- overview of applications of immobilized enzyme systems. Mass transfer effects in immobilized enzyme systems: Analysis of Film and Pore Diffusion Effects on Kinetics of Immobilized Enzyme Reactions - Formulation of dimensionless groups and calculation of Effectiveness Factors. Module IV: Design of enzyme reactors for bioconversion processes: Design of Immobilized Enzyme "Reactors-Packed-bed, Fluidized- bed and Membrane reactors Bioconversion. calculations in free enzyme CSTRs and immobilized enzyme reactors. Enzyme biosensors: Applications of enzymes in analysis; .Design of enzyme electrodes and their application as biosensors in industry, health care and environment. References: 1. Zubay G, Biochemistry, Maxwell Macmillan International Editions. 2. Gerharts. W, Enzymes in Industry-Production and Application. 3. Tailer, R. F, Protein Immooblisation-fundamentals and applications. Internal work assessment Assignments (minimum 2) 2x7.5 = 15
52
University examination Pattern Q1 - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module l with choice to answer any one. QIII - 2questions A and B of 15 marks from module II with choice to answer any one. QIV - 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer anyone.
BT04 505: CHEMICAL REACTION ENGINEERING

3 hours lecture and I hour tutorial per week Module I Basics of kinetics: Introduction, Kinetics of Homogeneous reactions - searching for mechanism - Arrhenius equation - Batch reactor analysis (integral and differential methods) for kinetics. Multiple reactions - parallel, series and series-parallel. Module II Reactor Design: Introduction to reactor design Ideal reactors - Single reactor and multiple reactor design - Design Principles. Module III: Non Isothermal reactors and pressure effects. Non-ideal flow - Non-ideal flow models and reactor performance. Module IV: Heterogeneous catalysis Nature of catalysis, catalytic specificity, physical properties of catalyst, classification and preparation of catalyst, catalyst poisoning. Kinetics of fluid-solid catalytic reactions: Adsorption phenomena, Langmuir equation, BET isotherm, Rate expressions for heterogeneous catalytic reactions. . References 1. Octave Levenspiel - Chemical Reaction Engineering, John Wiley. 2 H. Scott Fogler, Elements of Chemical Reaction Engineering, Prentice Kali India Pvt. Ltd. 3. J.M. Smith, Chemical Engineering Kinetics, Mc Graw Hill. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern QI - 8 short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module l with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV - 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer anyone.
53
BT04 506: APPLIED ELECTRONICS

3 hours lecture and I hour tutorial per week Module I Basic electronics - Energy band diagram - Work function - Description of simple CRO tubes Structure of semiconductor materials - P-type & N-type semiconductors - Junction diodes Transistors - Construction, operation and characteristics Special semiconductor devices - FETSCR-LED-LCD - VI characteristics- applications. Module II: Principle of rectification and amplification - Different types of amplifiers - RC & transformer coupled amplifiers - Class A, B, C, voltage and current feedback amplifiers - Oscillators - Basic principles, -Transistor oscillators. Module III: Multivibrators - Bistable, actable and monostable multivibrators using transistors -OP-Arrp - OrAmp as buffer, summer, integrator, differentiator & difference amplifier - Instrumentation amplifier: - Astable, monostable & schmitt trigger using OP-Amp. Module IV: Industrial electronics-Induction heating-Principle of induction Heating - Applications - Power sources for induction heating - Dielectric heating- Dielectric properties of materials - Electrodes used in dielectric heating - Application with emphasis on chemical process-Ultrasonics.Principles and operations Reference Books: 1 Ramabhadran S., Electronics Principles & Techniques, S. Chand 2 Mithal G. K., industrial Electronics, Khanna Pub. 3. Grob B., Basic Electronics, McGraw Hill 4. Cage J.M. & Bashe C.J., Theory & Application of Industrial Electronics, McGraw Hill. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern Q1 - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer anyone. QIII-2quesIiorisAandBofl5rnarksrrommodulelIwith choice to answer any one. QIV- 2 questions A and B of l5 marks from module III with choice to answer any one.
54
QV- 2 questions A and B of 15 marks from module IV with choice to answer any one
BT04 507(P): CHEMICAL ENGINEERING LAB II

1. Heater 2. Heat
- determination of heat transfer efficiency. Determination of overall heat transfer coefficient by radiation to water flowing Study of long tube evaporator. of material balance equation and Rayleigh's equation for simple
transfer from steam to air - Determination ox overall heat transfer coefficient.
3. 4.
through pipe.
5. Verification
Distillation. 6. 7. 8. 9. 10. 11. 12. 13. Vaporization efficiency in steam distillation Drying - rate of drying curve under constant drying condition . Leaching - Principles of leeching from leaching a mixture of salt and sand. Ternary liquid equilibrium Adsorption isotherms Kinetics of chemical reaction in batch reactors, tubular flow and stirred tank Open loop response of a two link liquid level system. Frequency response of first and second order
Reactors.
Internal work assessment Regular work and record Test Regularity Total marks
= 25 = 20 = 05 = 50
55
BT04 508(P): MOLECULAR

1. Isolation
BIOLOGY LAB
3 hours practical per week of genomic DNA from eukaryotic cells. Isolation of RNA from eukaryotic of proteins from eukaryctic cells. of genornic DNA from prokaryotic cells of plasmid DNA from prokaryotic cells. Restriction mapping of plasmid Gel electrophoretic separation of electroprioretic separation of RNA. electrophoretic separation of proteins Transblot analysis of DNA. Gel extraction of DNA. PCR amplification of DNA Conjugation and transformation in
2. cells.
3. Isolation 4. Isolation 5. Isolation
6. DNA. 7. DNA and molecular weight determination

8. Gel 9. Gel
10. 11.
12. 13.
E. coli
Internal work assessment Regular work and record Test
= 25 = 20
56
Regularity Total marks = 05 = 50
SIXTH
SEMESTER
BM04 601: ENGINEERING ECONOMICS & PRINCIPLES OF MANAGEMENT

3 hours lecture and 1 hour tutorial per week Objective: The first par of this paper provides the fundamental ideas on economics an engineer to have. The second part provides the basic principles of engineering management. Module I (13 hours): Definition of economics - nature and scope of economic science - nature and. scope of managerial economics - basic terms and, concepts - goods - utility - value - wealth - factors of production - land -' its peculiarities - labour - its peculiarities and division of labour- capital and capital formation - organisation or enterprise -economies of large and small scale - consumption wants - its characteristics and classification - law of diminishing marginal utility - relation between economic decision and technical decision - economic efficiency and technical efficiency. Module II (13 Hours) Demand - demand schedule - demand curve - law of demand - elasticity of demand - types of elasticity - factors determining elasticity - measurement -' its significance - supply - 'supply schedule - supply curve - law of supply elasticity of supply- time element to the determination of value - market price and normal price - perfect competition - monopoly - monopolistic competition. Module III (13 Hours) Principles of management - management functions - planning - organising - organisation structures - span of control - delegation - directing - leadership and motivation - controlling decision making - single stage decision making under risk multistage decision makingV decision tree - decision making under uncertainty - equally likely,- minimax and maximin criteria- Operation management - production systems and functions - product design and
57
selection concepts Network crashing - concept of total quality management and ISO. 9000 system of standards of supply chain management Project management - Project and management analysis critical path method (CPM) Network - finding critical path slacks (time cost trade off) - PERT network.
Module IV (13 Hours) Marketing management - concept of market and marketing - marketing function - marketing mix - market research advertising and sales promotion human resource management - manpower requirement analysis - recruitment and training -job analysis - job evaluation wages and Incentives. Financial management - objectives/functions - concept of time value of money basics of financial accounting - profit and loss account - balance -sheet - costing - elements of costs' - cost sheet - allocation of overheads - break-even analysis depreciation - significance and methods of depreciation Internal work assessment: 60% - Test Papers (Minimum 2) 30% - Assignments/Term Project/ any other mode decided by the teacher. 10% - Other measures like regularity and participation in class Total Marks = 50
University examination Pattern: Q I - 8 short type questions of 5 marks, 2 from each module QII - 2 questions A and B of 15 marks from module I with choice to answer any one Q III- 2 questions A and B of 15 marks from module II with choice to answer any one Q IV- 2 questions A and B of 15 marks from module HI with choice to answer any one Q V - 2 questions A and B of 15 marks from module IV with choice to answer any one.
58
BT04 602: INSTRUMENTATION AND PROCESS CONTROL

3 hours lecture and 1 hour tutorial per week Module I: Functions and elements of instruments - static and dynamic characteristics of instruments sensing elements - transducers- measuring and transmission methods - indicating and recording means - piping and instrumentation diagrams. Temperature Measurement: Working principle of thermocouple - resistance thermometers thermistors - optical and radiation pyrometers. Module II Pressure Measurement: Working principle of manometers - Bourdon gauge - bellows - type gauge and vacuum measuring instruments. Flow Measurement: Use of obstruction type meters - variable area meter - pressure probe and positive displacement type meters. Liquid level measurements in open and pressure vessels Measurement of viscosity, conductivity and pH. Module III General principles of process control: Basic control elements - degree of freedom and fixing of control parameters. Simple system analysis - Laplace transforms and transfer functions block diagrams linearization. First and higher order systems- interacting and non-interacting systems - distributed and lump parameter systems - dead time. Module IV Control systems: Different modes of control and their basic characteristics - controller characteristics - process characteristics Optimization of control system response - stability analysis. Introduction to advanced control techniques as feed forward feedback, cascade, ratio, adaptive and digital computer control. Instrumentation and control of bioreactors and fermentor Text / Reference 1. Eckman D F: Industrial Instrumentation, Wiley eastern Ltd. 2. Kerk F W et al: instrumentation, Wiley & sons
59
3. 4.
D R Ccughnowerand L B Koppel: Process system analysis and control, McGrraw Hill Kogakusha. A Pollard: Process Control for Chemical and Allied Industries, Heinemann Education Co.
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern Q1 - 8 Short type questions of 5 marks, 2 from each module. QII- 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one QIV - 2 questions A and B of 15 marks from module III with choice to answer any one QV - 2 questions A and B of 15 marks from m module IV with choice to answer any one
BT04 603:
BIOPROCESS ENGINEERING
3 hours lecture and 1 hour tutorial per week Module I Design and Analysis of Bioreactors: Modelling of Non-Ideal Behavior hi Bioreactors - Tanks-in-series and Dispersion models applications to-design of continuous sterilisers Design and operation of novel bioreactors Air-lift loop reactors - Fluiaized-bed bioreactors - Stability analysis of bioreactors. Module II. Bioreactor Scale-up: Regime analysis of bioreactor processes - Correlations for oxygen transfer.- Oxygen requirements of microbial cultures, Oxygen mass transfer fundamentals, Oxygen transfer and oxygen demand, Oxygen transfer by aeration and agitation, Determination of oxygen transfer coefficient by various methods like sulphite oxidation, dynamic gassing out and oxygen balance methecs. Factors affecting oxygen transfer coefficient. Scale-up criteria for bioreactors based on oxygen transfer and power consumption. Monitoring of Bioprocess: On-line data analysis for measurement of important physicochemical and biochemical parameters - Methods of on-line and off-line biomass estimation - microbial calorimetry - Flow injection analysis for measurement of starters, products and other metabolites - State and parameter estimation techniques for biochemical processes. Module III Modern biotechnological processes. Recombinant cell culture processes - guidelines for choosing host vector, systems -plasmid stability hi recombinant cell culture - limits to over expression - Modelling of recombinant bacterial cultures - Bioreactor strategies for maximising product formation -Bioprocess design considerations for plant and animal cell cultures. Module IV
60
Study of Structured Models for analysis of various bioprocess - Model simulation 'using MATLAB-SIMULINK. and ISIM software packages. Computer-based data acquisition, monitoring and control - Labview Software. References:
1.
Shule Baiely Stanbury
and and
Kargi, Ollis,
Bioprocess 'Engineering, Prentice Hall.

2.
Biochemical Engineering Fundamentals., McGraw Hill

3.
P.F. and
Whitaker A, Principles of Fermentation Technology. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern QI - 8 short type questions of 5 marks, 2 from each module. QII- 2 questions A and B of 15 marks from module l with choice to answer anyone. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV- 2 questions A and B of 15 marks from module III with choice to answer anyone. QV - 2 questions A and B of 15 marks from module IV with choice to answer anyone.
BT04 604 : GENETIC ENGINEERING

3 hours lecture and 1 hour tutorial per week Module I Role of genes within ells - elucidation of the genetic code - genetic elements that control gene expression - method of creating recombinant DN A molecules Module II Basic tools of genetic engineering: Restriction, endonucleases, ligases, modifying enzymes Restriction enzymes and mapping of DNA. Cloning vectors: salient features of vectors, plasmid and phage vectors - vector design Module III Construction of recombinant DNA by various methods - Generation of DNA fragments by restriction endonuclease digestion - joining of DNA molecules - homopolymer tailing -.ligation of cohesive and blunt ended terminal -linkers and adapters. Module IV c-DNA synthesis -Construction of genomic and cDNA libraries - methods of nucleic acid sequencing, expression of cloned genes. Application of recombinant DNA technology: Cloning, in plants, Ti plasmid of agrobacteria, transgenic animals. References: Old RW, Primrose SB, Principals of Gene manipulation; An Introduction to Genetic engineering, Black well Scientific Publications. 2. Sambrook, J., Fritsch, E. 3. F. and Maniatis, T. Molecular cloning -a Laboratory Manual. Cold Spring Harbor laboratory Press.
1.
61
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern QI - 8 short type questions of 5 marks, 2 from each module. QII- 2 questions A and B of 15 marks from module l with choice to answer anyone. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV- 2 questions A and B of 15 marks from module III with choice to answer anyone. QV - 2 questions A and B of 15 marks from module IV with choice to answer anyone.
BT04 605 : PROTEIN ENGINEERING

3 hours lecture and 1 hour tutorial per week Module I Primary structure and. its determination - secondary structure - prediction and determination of super secondary structures - protein folding pathways - tertiary structure and domain in proteins - quaternary structure - methods to determine tertiary and quaternary structures - post translational modifications. Module II Structure function relationship of Proteins: DNA binding proteins - prokaryotic and eukaryotic transcription factors - DNA polumerases Membrane proteins and receptors bacteriordopsin phtotosynthetic centres epidermal growth factor - insulin and PDGP receptors and their interaction with effectors. Module III Protein phosphorylation immunoglobulins - Nucleotide binding protiens enzyme serine proteases - ribonuclease lyzozyme. Module IV Protein engineering and Protein Design: Protein data base analysis methods to alter primary structure of proteins Examples of engineered proteins Protein design, principles and examples. Reference: 1. Moody PCE, and AJ Wilkinson, Protein Engineering, IRL Press, oxford. 2. Creighton TE Proteins, Freeman WH.
62
Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern QI - 8 short type questions of 5 marks, 2 from each module QII- 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV- 2 questions A and B of 15 marks from module III with choice to answer any one. QV- 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 606: BIOINFORMATICS

3 hours lecture and 1 hour tutorial per week Module I What is bioinformatics - Scope and history of bioinformatics Internet basics, www, protocols - FTP - Telnet - HTTP, Elementary commands in UNIX, Introduction to PERL (Basic commands, pattern and string matching), BIOPERL (Programme, to transcribe and translate nucleotide sequences). Module II Introduction to databases, Biological databases and their use, Sequential database - NCBI, ture database - PDB, Database search - Enterz, SRS, Algorithms, issues in database search, Sequence submission, Sequin, Bankit, Sakura Database search - FASTA - BLAST. Module III Sequence alignment, Pairwise alignmen Dynamic programming, Multiple sequence alignment. Methods of MSA, Clustal W, Phylogenetic analysis, Tree building methods.- Distance, Parsimony, Maximum likelihood, Fhylogenetic Software, Phylip. Scoring Matrix.-PAM, BLOSUM. Module IV Special topics in bloinformattcs. Protein -structure prediction - different methods cof protein structure prediction, Gene predictions, Genscan, Prccustes, Grail, DNA Mapping and sequencing - Map alignment Shotgun DNA sequencing - Sequence assembly.
63
Reference:
1. 2. 3.
Baxevanis, B. F. Francis Ouellette, Bioinformatics, Wiley. Algorithms on Strings Trees and Sequences, Cambridge University Press, Bioinform'atics Sequence Analysis, Cold Spring Harbor Laboratory. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
Andreas
D.
Dan Gusfield, D. Mount,
2x7.5 2x15
= = = =
15 30 05 50
University Examination Pattern QI - 8 short type questions of 5 marks, 2 from each module QII - 2 questions A and B of 15 marks from module I with choice to answer any one Q III- 2 questions A and B of 15 marks from module II with choice to answer any one Q IV - 2 questions A and B of 15 marks from module III with choice to answer any one Q V - 2 questions A and B of 15 marks from module IV with choice to answer any one
BT04 607(P): BIOPROCESS TECHNOLOGY LAB I

3 hours practical per week 1. Isolation of microbes for the production of antibiotics; Antibiotics sensitivity test against common microbes 2. Enzyme isolation and assay. 3. Enzyme Kinetics. 4. Enzyme immobilization. 5. Production of secondary metabolites and assay.
6.
Estimation of Michaelis menton, parameters, effect of pH and temperature on enzyme activity, kinetics of inhibition.
7. Estimation of biomass. 8. Growth of micro-organisms and estimation of monod parameters. 9. Production of citric acid and alcohol and their estimation. Internal work assessment Regular work and record = 25
64
Test Regularity Total marks = 20 = 05 = 50
BT04 608(F): MINI PROJECT

3 hours practical per week Each student group (not more than 5 members in a group) is expected to complete a mini project on a current topic of bictechnology - a report is to be submitted at the end of the semester - the assessment may be made individually and in groups Internal work assessment Design Attendance Report Total Marks = 25 = 10 = 15 = 50
65
SEVENTH
BT04 701:
SEMESTER
DOWN STREAM PROCESSING
3 hours lecture and 1 hour tutorial per week Module I Role of downstream processing in biotechnology - role and importance of downstream processing in biotechnological processes - problems and requirements of bioproduct purification. Economics of downstream processing in biotechnology - post cutting-strategies - characteristics of biotechnological mixtures process design criteria for various classes of bioproducts (high volume, low-value products and low volume, high value products - physiochemical basis of bioseparation processes. Module II Primary Separations and Recovery Processes: Cell disruption methods for intracellular products - removal of insolubles - biomass (and particulate- debris) separation techniques flocculation and sedimentation - centrifugation and filtration methods. Module III Enrichment operations Membrane based separations - classification and range of membrane systems -molecular weight cut off- types, of membranes and manufacture (isotropic and anisotropic) module types and their advantages (flat plate/hollow tube/spiral wound etc) modes of operation (cross flow and dead end)micro and ultra filitration theory - membrane characteristics (rejection factor, concentration
66
polarization) gel concentration model - fouling and its prevention- basic design and configuration of membrane systems (batch and multi state) - industrial applications of membrane systemsPrecipitation methods (with salts, organic- solvents and polymers, extractive separations, aqueous two phase extraction, super critical extraction) - in situ product removal - integrated bioprocessing. Module IV Classification of chromotographic separations. Typical liquid chromatographic set up principles and working of ion exchange chromatography / adsorption chromatography / partition chromatography and affinity / chromatography, chromatographic theory retention time and factor-selectivity factor) plate model and rate theory. Van Deemier equation and band broadening. Electrophoretic separations (isoelectric focusing /gel electrophoresis /native and SDS page/southern and western blot techniques/capillary electrophoresis) Hybrid separation technologies (membrane chromatography and electro chromatography) Product polishing gel permeation chromatography, dialysis and crystallization. Reference: 1. 2.
3.
Belter P.A and Cussler E. Bioseprations, Wiley. Product Recovery in Bioprocess Technology, BIOTOL series VCH. Asenjo J. M. Separation process in Biotechnology, Marcel Dekker Inc.
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern Q l -8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer anyone. QIV- 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
67
BT04 702: BIOROCESS PLAN T DESIGN

3 hours lecture and 1 hour tutorial per week Module I Mechanical design of process equipment - Introduction to the design of cylindrical and spherical vessels for internal and external pressures, design of heads .and closures nozzles, openings and reinforcements, , design of tall vessels, support for vessels. Module II Detailed process design of sell and tube heat exchangers, evaporators, absorbers and distillation columns. Module III Equivalence and cost comparison - Time value of money and equivalence - equations used in economic anlysis compound - interest as operator unacost - Hoskold's formula. Depreciation and taxes - Nature of depreciation, method of determining depreciation - straight line method, declining balance method, sinking fund method, declining balance method, double declining balance method, sum-of-digits method and units of production method - taxes and depreciation. Module IV Capital requirements and cost of production for process plants - Equipment for process plants, cost indices: engineering news -record construction - cost index - material cost indices, labourcost index equipment costs - William's six-tenth factor Capital requirements - Fixed capital investment and working capital estimation of capital investment - direct and indirect costs - Types of capital cost estimates - order of magnitude estimate, definitive estimate and detailed estimate. Cost factors in capital investment - Estimation of total product cost. Balance sheet and profit and
68
loss account. (Use of Chemical Engineers Handbook by perry and Chilon and IS 2825 : 1969 0 Code for Unfired Pressure Vessels may be permitted for the University Examinations) Reference: 1. Perry, J. H. and Chilton (Ed,)m, Chemical Engineers Handbook. 2. Jelen F.C, Cost and Optimization engineering 3. Peters and Timnerhaus, plant design and economics for chemical engineers. 4. Schweyer, Process Engineering Economics. 5. Tyler, Chemical engg. cost estimation 6. Joshi, M.V, Process Equipment Design. 7. G.S. Davies, Chemical Engineering Economics and Decision Analysis. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern QI - 2 questions A and B of 15 marks from module I with choice to answer any one. QII- 2 questions A and B of 15 marks from module II with choice to answer anyone. QIII- 2 questions A and B of 15 marks from module III with choice to answer any one. QIV-2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 703: RECOMBINANT DNA TECHNOLOGY

3 hours lecture and 1 hour tutorial per week Module I DNA Technologies Introduction of recombinant DNA into a host (bacteria & animals by various methods) Transformation in Vitro packaging into phages - trassfection reporter and gene targeting. Recombinant selection and Screening- use of probes RNA cDNA and DNA nucleic acid hybridizations southern, northern biotting colony and plaque hybridization Screening immunochemical methods. Module II Expression of Cloned Genes: Salient features of prokaryotic and eukaryotic expression systems fusion proteins secreted proteins in vitro gone expression . DNA Amplification: Polymerase chain reaction (PCR) - basic reactions inverse PCR RTPCR- RAGE applications of PCR. Gene Modification : Mutagenesis deletion mutagenesis oligonucleotide directed mutagenesis PCR based mutagenesis - Site directed mutaenesis and its applications. Module III DNA Sequencing: Chemical method of maxam & gilbert enzymatic (diddeoxy chain termination) method of
69
Sanger automated sequencing. DNA mapping and Analysis of DNA Sequences: Restriction mapping- DNA fingerprinting chromosome walking chromosome jumping. Module IV Safety aspects of recombinant DNA technology. Application of r-DNA Technology: Diagnostic s Pathogenesis Genetic diversity RELP analysis and DNA finger printing Theraputic proteins, novel proteins, vaccines, antibodies herbicide resistance, insecticides. Gene Transfer Techniques: CaFO - xoprecipitation electroporation lipofection microinjection. Transgenic Technology: Transgenic mouse transgenic fish transgenic animals pig, rabbit, sheep. Antisense Technology and Applications Reference: 1. Watsor, J. D. Glimath, N, Recobinant DNA, Scientific American Books, W.H. Freeman and Co. New York. 2. Bernur R. Pastrnek J.J. Molecular Biology, Principles and Applications in Recombinant DNA, Panima Publishing Cooperation, New Delhi.
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV- 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer anyone.
70
BT04 704: ENVIRONMENTAL BIOTECHNOLOGY

3 Hours lecture and 1 hour tutorial per week Module I Components of environment and assessment of its quality - Factors of environmental degradation and pollution pollutants and. their types - nature and source. Microbial biodiversity - strategies for accessing - bioprospecting - recovery by the use of environmental DNA Extremophiles and their application Module II Environmental geaomics Deliberate release of recombinant microorganisms - biomarkers and bioreceptors Bioremediation - bioremediation of petroleum based wastes Phyteremediation bioleaching degradation of pesticides, herbicides, polyarotnatic hydrocarbons - xenobiotics metabolic engineering. Module III Waste treatment - Waste disposal and management - Microbiological and biochemical aspects of waste, treatment processes - Microbial strain improvement with a view to develop scavengers - Characteristics of waste water - Aerobic and anerobic waste treatment process (with examples) industrial waste agricultural waste - municipal waste - Biological treatment of solid wastes - Composting and- various types of composting processes. Module IV Downstream processing in biological waste treatment process effluent disposal and reuse Biofilteration for waste gas treatment types of biogas plants and microbial processes involved in biogas generation - composition and purification of biogas - contaminant of biologically
71
toxic wastes - economy of biological treatment process. Reference:
1.
Mooray -Mu- Young, Raina M. Mayer.,
Comprehensive Biotechnology, Premagaon Press.

2.
Environmental Microbiology, ASM Press.

3.
Foster C. F., John
Ware D.A. Environmental Biotechnology. Ellis Horwood Ltd. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern QI -8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer anyone. QIV - 2 questions A and B of 15 marks module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 705 (A): SOFTWARE ENGINEERING

(Common for EE, AI, IC, BM, PM) 3 hours lecture and 1 hour tutorial per week
Module I Introduction - FAQs about software engineering - professional and ethical responsibility system modeling - system engineering process - the software process - life cycle models iteration- specification - design end implementation - Validation- evolution - automated process support - software requirements - functional and non-functional requirements - user requirements - system requirements - SRS - requirements engineering processes - feasibility studies - elicitation and analysis - validation - management system models - context models behavior models - data models - object models - CASE work benches. Module II Software prototyping - prototyping in the software process - rapid prototyping techniques formal specification - formal specification in the software process - interface specification behavior specification - architectural design - system structuring - control models modular decompositions - domain specific architectures - distributed systems architecture objectoriented design - objects and classes - an object oriented design process case study design evolution - real-time software design - system design - real-time executives design with reuse - component-based development - application families - design patterns - user interface design design principles - user interaction - information presentation - user support - interface evaluation. Module III
72
Dependability - critical systems - availability and reliability - - safety - security - critical systems specifications - critical system development - verification and validation - planning software inspection - automated static analysis - clean room software development - software testing - defect testing - integration testing - object-oriented testing - testing workbenches critical system validation -software evolution - legacy systems - software change - software maintenance - architectural evolution - software re-engineering - data re-engineering Module IV Software project management - project planning - scheduling - risk management - managing people - group working - choosing and keeping people - the people capability maturity model software cost estimation - productivity estimation techniques - algorithmic cost modeling, project duration and staffing quality management - quality assurance and standards - quality planning - quality control -software measurement and metrics -process improvement - process and product quality - process analysis and modeling - process measurement - process CMM configuration management - planning - change management - version and release management system building - CASE tools for configuration management. Text Book: 1. Ian Sommeerville, Software Engineering, Pearson Education Asia Reference Book: 1. 2. 3. Pressman R. S., software Engineering, McGraw Hill. Mali R., Fundamentals of Sftware Engineering Prentice Hall of India. Benferooz A, & Hudson F. J., Software Engineering Fundamentals, Oxford University Press. 4. Jalote P., An Integrated Approach to s\Software Engineering, Narosa.
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern Q 1 - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer anyone. QIV - 2 questions A and B of 15 marks module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
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BT04 705 (B) : CHEMICAL ENGINEERING THERMODYNAMICS

3 hours lecture and 1 hour tutorial per week Module I Thermodynamic PROPERTIES Of fluids Reference properties Energy properties derived properties path properties - Maxwell relations heat capacity relations - hear capacity in terms of entropy systematic derivation of thermodynamic relations effect of pressure and volume on heat capacities the coefficient of expansion and isothermal compressibility coefficients - construction of thermodynamic charts. Thermodynamics of flow processes single stage and multi stage compression - Joule Thomson expansion - flow through nozzles and ejectors. Module II Phase equilibra Nature of equilibrium Criteria of equilibrium fugacity calculation of fugacity- activity activity coefficients Properties of solutin - Ideal solution Non ideal solutions - partial molar properties - chemical potential - ?Giibbs Duhem equation Enthalpy and entropy of solution. Module III Vapour liquid equilibrium at low pressure Equality of chemical potentials - Gibbs phase rule - Fugacity as a criterion of equilibrium Vapour liquid phases in equilibrium binary solutions - Wohls equations Van-larr equation.
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Refrigeration Carnot refrigeration cycle air refrigeration cycle - vapour compression cycle choice of refrigerant absorption refrigeration. Module IV Chemical reactions equilibria - Free energy and chemical reactions - feasibility of chemical reaction presentation of free energy data calculation of free energy of reactin - the equilibrium constant evaluation of equilibrium constant from thermal data effect of temperature and pressure on equilibrium constant. Reference Books 1. Smith Vnness and Abott. Introduction to Chemical engineering Thermodynamics. 2. K. V. Narayanan, chemical Engineering thermodynamics. 3. S. . Sandler, Chemical Engineering Thermodynamics. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern Q I - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer anyone. QIV - 2 questions A and B of 15 marks module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 705(C): FOOD BIOTECHNOLOGY

3 hours lecture and 1 hour tutorial per week Module I Technology of conventional and non-conventional fermentation based food products from cereals, Jugumes, Fruits, vegetables, milk, fish and meat. Role of micro organisms in manufacture and spoilage of fermented products. Adulteration in foods - milk, pulses and others. Module II Biotechnological processes in conventional and non-conventional fermentation secondary fermentation of waste generated in selected food fermentation. Pilot and large-scale fermentation, continuous and batch culture process monitoring and control. Module III New and modified carbohydrates, lipids, polysaccharides, proteins and nucleotides New protein foods : SCP mush room food yeasts algal protein production of microbial biomass and economic aspects probiotics. Module IV Genetically modified and transfeneic food development processing - nutriotion and aspect Protein engineering in food biotechnology Biotechnology of food preservation Genomics for food biotechnology Food biotechnology additives like colors, flavours, any vitamins.
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Reference Books 1. Roger A., Gorden B., and John T., Food Biotechnology. 2. Lindsay, Willis, Biotechnology, Challenges for the flavour and food industries, Elsvier Applied Science. 3. Stanbury P. F. and Whnaker A, Principles of Fermentation Technology, Pergamon Press. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern Q I - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer anyone. QIV - 2 questions A and B of 15 marks module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 705 (D) : OPERATIONS RESEARCH

3 hours lecture and 1 hour tutorial per week Objective To provIde knowledge en Linear algebra, linear programming, transportation, assignment and game problems and queing theory Module I: Linear Algebra (13 hours) Vectors - vector space and Euclidean space - vector operations - matrix operations - unit vector sum vector - linear dependence bases - spanning set - rank - simultaneous equations - basic solutions - point sets - lines and hyper planes - linear inequalities - convex sets - extreme points fundamental theorem of linear programming. Module II: Linear Programming (13 hours) Statement of the LP problem - slack and surplus variables - basic feasible solutions - reduction of a feasible solution to basic feasible solution - artificial variables - optimality conditions unbounded solutions - Chames' M method - two phase method - degeneracy duality. Module III: Transportation, Assignment and Game problems (13 hours) Transportation problem - coefficient matrix and its properties - basic set of column vectors linear combination of basic vectors - tableau format - stepping stone algorithm - UV method inequality constraints - degeneracy in transportation problems assignment problem as a maximally degenerate transportation problem - Koning's method - rectangular zero sum games von Neuman's theorem - saddle points - pure and mixed strategies - formulation of the primal and dual LP problem for fixed strategies - dominance - graphical solutions. Module 1V: Queuing (13 hours) Basic structure of queuing models - exponential and Poisson distributions - birth and death
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processes - queuing models based on Poisson inputs and exponential service time basic model with constant welfare and service rate - Finite queue - limited source queue models involving non-exponential distributions - single service model with Poisson arrival and any service time distribution - Poisson arrival with constant service time - Poisson arrival and Erlang service times -priority disciplines - dynamic programming - Bellman's principle of optimality - formulation and solution of simple problems. Text Book: 1. Hadley G., Linear Programming, Addison Wesley 2. HilHer Sc Liberman, Operations Research, Holden Day Inc. 3. Ravindran, Solberg & Phillips, Operations Research, John Wiley. Reference Books: 1. Saskieni, Yaspen .& Friedman, Operations Research: Methods and Problems, Wiley Toppan 2. Wagner, Principles of Operations Research, Prentice Hall of India. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern QI - 8 short type questions of 5 marks, 2 from each module. QII.- 2 questions A and B of 15 marks from module 1 with choice ton answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV - 2 questions A and B of l5 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 705(E) : PLANT BIOTECHNOLOGY & TISSUE CULTURE

3 Hours lecture and 1 hour tutorial per week Module I An outline of Molecular biology: DNA Replication, translation, transcription, and fundamentals of recombinant DNA technology, Gene regulation. Agrobacterium and plant genetic engineering: Agrobacterium mediated gene transfer and cloning. Types of plant vectors and their use in gene manipulation. Module II Plant viruses: Classification diagnosis - remedy- Viruses as a tool to deliver foreign DNA. Developmental aspects of rhizbbium: Legume Symbiosis, Symbiotic Nitrogen fixation, Regulation of nif and nod gene mechanism of nitrogen fixation. Module III Molecular aspects of disease susceptibility and resistance: Transposable elements, factors influencing disease resistance and susceptibility RFLP. Transgenics Herbicide-tolerance insect resistance, viral resistance stress tolerance development of disease resistance plants by introducing Bacillus thuringiensis genes. Module IV Fundamentals of plant tissue culture, medium formulation, plant regeneratin, organogenesis, role of tissue culture in rapid clonal propagation, production of pathogen free plants and synthetic seeds. Protoplast technology, isolation, culture and plant regeneration, protoplast fusion, identification and characterization of somatic hybrids, applications of
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protoplast technology - plant growth factors and plant growth regulators. References: 1. Dodds J .H., Plant Genetic Engineering, Cambridge University Press. 2. Mantal S.H., Mathews J.A.,Mickee R.A. Principles of Plant Biotechnology An Introduction to Genetic Engineering in plants, Blackwell Scientic Publications. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern Q1 - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module Il with choice to answer any one. QIV - 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of l5 marks from module IV with choice to answer any one.
BT04 706(P) : BIO PROCESS TECHNOLOGY LAB

(3 hours practicals per week)
1. 2. 3.
4. 5. 6. 7.
Recovery of products Extra cellular enzyme production and purification Production of intracellular products Cell disruption techniques, solid - liquid separation methods. Filtration, sedimentation, centrifugation, product enrichment operations. Chromatographic techniques Ultra filteration, two phase aqueous extraction Product crystallization and drying.
8.
Internal work assessment Regular work and record Test Regularity
= 25 = 20 = 05
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Total marks = 50
BT04 707(P) : SEMINAR

4 hours per week Each student can take seminars on topics of interest assessed by the faculty members. Internal Marks Allotment Presentation and Discussion Relevance of topic and Literature survey Participation in other Seminars Report Total marks = 25 marks = 10 marks = 05 marks = 20 marks = 50 marks in the field, which will be
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BT04 708 (P) : PROJECT WORK

3hours per week The project is for a duration of two semesters - each student group (not more than 5 members in a group) is expected to develop a complete Project - the seventh semester is mainly for reference and design of experiments - an interim report is to be submitted at the end of the semester the assessment may be made individually and in groups. Internal Marks Allotment Design Attendance Report Total marks = 25 marks = 10 marks = 15 marks = 50 marks
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EIGHTH
SEMESTER
BT04 801 : IMMUNOLOGY & IMMUNOTECHNOLOGY

3 hours lecture and 1 hour tutorial per week Module I The Immune System : Introduction - lymphocytes - their origin arid differentiation - antigens - their structure and classification - complement and their biological functions Module II Humoral Immunity: B-Iymphocytes and, their activation - structure and function of immunoglobulin - Immunoglobulin classes and subclasses - genetic control of antibody production - mono clonal antibodies and diagnosis - idiotypes and idiotypic antibodies major histocompatibility complex. Cellular Immunologu: Thymus derived lymphocytes (T cells) their classifications antigen presenting cells (APC) macrophages langerhanscells their origin and functions mechanisms of phagocytosis identification of cell types of immune system immunosuppression - immune tolerance. Module III Immunity to Infection: Hypersensitivity reactions - mechanisms of T Cell activation cytokines and their role in immune response macrophage activation and granuloma formation. Transplantation: Graft rejection evidence and mechanisms of graft rejection immunosuppressive drugs HLA and disease mechanisms of immunity to tumor antigens. Autoimmunity: Autoantibodies in humans pathogenic mechanisms experimental models of autoimmune disese treatment of autoimmune disorder.
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Module IV Molecular Immunology: Preparation of vaccines application of recombinant DNA technology for the study of the immune systems production of antidiotyoic antibodies 0 catalytic antibodies - application of PCR technology to produce antibodies and other immunological reagents immunotherapy with genetically engineered antibodies. Current topics in Immunology: Hybridoma techniques and monoclonal antibody productin Diagnostic methods : Immunodiffusion, Immunoelectrophoresis, Radioimmunoassay, ELISA, Western blot, Epitope mapping - Trends is Immunology of infectious diseases and tumours. Reference Books 1. Janis Kuby, Immunology, W. H. Freeman & Company. 2. Roitt, I. M., Brostoff J. and male, D. K. Immunology Mosby Publication. 3. Ivan I., Immunological Methods manual, Academic Press. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern Q1 - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module Il with choice to answer any one. QIV - 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of l5 marks from module IV with choice to answer any one.
BT04 802 : BIOETHICS & INTELLECTUAL PROPERTY RIGHTS

3 hours lecture and 1 hour tutorial per week Module I Biotechnology and Bioethics - What is Ethical Biotechnology? (Rights, Confidentiality, Animal Rights, Environmental Ethics, Decision Making) - Biosafety in rDNA research and production, regulation National and International guidelines - Risk Assessment of rDNA products and guidelines - Ethical aspects of rDNA products - Regulations for safe development of transgenic plants. Module II Intellectual Property Rights - Various types- of intellectual property rights (trade marks, copyrights, industrial designs, patents, geographical indicators etc.) - Objectives of the patent system - Basic principles and general requirements of patents (Novelty, Utility non obviousness etc.) and Patent law - Product and process patents. Module III Patenting process in India - Points in maintaining laboratory notebook for an inventor Exercising and enforcing of intellectual property rights - Rights of IPR owner - Licensing agreements - Criteria for patent infringement. TRIPS and other International conventions (Paris Convention, Budapest Treaty) -Various amendments to Patent Law in India and the US - Patent cooperation treaty -IPR and WTO regime. Module IV
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Biotechnological inventions and patent law patentable subjects and protection in biotechnology. The patentability of microorganisms - Diamond vs Chakrabarty case Bioprospecting and biopiracy (case studies of neem, turmeric and Basmati) Traditional knowledge systems - options for protection of traditional knowledge systems Biodiversity and farmer rights - IPR plant genetic resrouces - Plant breeder rights UPOV treaty. Reference Books 1. J. Rehm and G. Reed, Biotechnology Second Edition, Multi Volume Treatise, Vol. 12 Legal Economic and Ethical Dimensions, VCH Publishers. 2. Prabuddha Ganguli, Intellectual Property Rights - Unleashing the knowledge Economy, Tata Mcgraw Hill. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern QI - 8 short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV - 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 803 : METABOLIC
ENGINEERING
3 hours lecture and 1 hour Tutorial per week Module I Introduction- Jacob Monod model, catabolite regulation, glucose effect, camp deficiency, feed back regulation, regulation in branched pathways, differential regulation by isozymes, concerted feed back regulation. Cumulative feed back regulation. Amino acid regulation of RNA synhesis. Energy charge-regulation, amino acid regulation of RNA synthesis, energy charge, regulation, permeability control passive diffusion, facilitated diffusion, active transport group transportation. Module II Synthesis of primary metabolites: Alteration of feed back regulation, limiting accumulation of end products feed back, resistant mutants, alteration of permeability. Biosynthesis of secondary metabolites: Precursor effects, prophophase, idiophase relationship; enzyme induction, feed back regulation, catabolite regulation by passing control of secondary metabolism, producers of secondary, metabolites. Module III Bioconversions: Advantages of Bioconversions; specificity yields, factors Important to bioconversions, regulation of enzyme synthesis, mutation, permeability, co-metabolism, avoidance of product inhibition, mixed or sequential bioconversions insoluble substances. Module IV Regulation of enzyme production Strain selection, improving fermentation, recognizing growth cycle peak, induction, feed back repression, catabolite repression, mutants resistant to
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repression, gene dosage. Reference: 1. Wang D.LC, Cooney C.L., Demain AL, Dunnil P., Humphery A.E. Fermentation and Enzyme Technology, John Wiley and Sons. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module l with choice to answer anyone. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV - 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 804(A) : GENOMICS AND PROTEOMICS

3 hours lecture and 1 hour tutorial per week Module I principles of gene Expression - Genome Mapping - Human Genome Project -Genomes of other organisms - Role of genomics in Drug discovery and development - peptide nucleic acid technology. Module II Genomics in. Biopharmaceutical Industry - Functional Genomes - Pharmacogenetics Genomics in relation to molecular diagnosis. Module III Molecular Therapeutic technologies. Gene Therapy - New Targets for drug discovery Module IV Proteomics: Proteomic Techniques - pharmaceutical Applications - Proteomics in drug discovery - in human. Role of animal models in identification of genes for disorders knockout mice. Reference: 1. A. Sahai, Gehomics and Proteomics, Functional and Computational Aspects, Plenum Publications.
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Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module l with choice to answer anyone. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV - 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one
BT04 804(B) : MOLECULAR MODELLING AND DRUG DFESIGN

3 hours lecture and 1 hour tutorial per week Module 1 Empirical force fields molecular mechanisms : Bond Stretching - Angle Bending - Torsional I terms - Out of plane bonding motions - Electrostatic interactions - Van der Waals, interactions Effective pair Potentials - Hydrogen Bonding. Module II: Simulation o: liquid water - Computer simulation methods Calculation of thermodynamic properties - Phase space - Practical aspects of computer simulation - Boundaries monitoring Equilibrium - Long range process- Analyzing results of simulation and estimating errors. Module III Molecular dynamics simulation Methods:. Molecular dynamics using simple modules - Molecular Dynamics with continuous potentials Running Molecular Dynamics simulation - Constant dynamics - Time dependent properties -Molecular Dynamics as constant temperature and pressure. Drug metabolism Physico chemical principles, radioactivity pharma kinetics. Action of drugs on human bodies. Important unit processes and their applications Bulk drug Manufacturers, Types of Reactions in Bulk drug Manufacture and Processes - Special Requirements for Bulk Drug Manufacture Manufacturing principles.
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Module IV Monte Carlo Simulation Methods:. Metropolics methods Monte Carlo simulation of molecules Monte Carlo simulation o f polymers Calculating chemical potentials - Monte Carlo or Molecular Dynamics. Molecular Modelling to discover and design New Molecules: Molecular modeling in drug discovery Deriving and using 3D Pharma cores - Molecular docking - Structure Based methods to identity lead components Denovo ligand design. Reference Book 1. A. R. Lenon, Molecular Modelling Principles and Applications, Longman. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks
2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern Q l - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV- 2 questions A and B of 15 marks from module III with choice to answer anyone. QV- 2 questions A and B of 15 marks from module IV with choice to answer anyone.
BT04 804(C) : DESIGN OF PROCESS EQUIPMENTS

3 hours lecture and 1 hour tutorial per week Module I Basic considerations in Process Equipment Design - The general design procedure - Fabrication techniques - Equipment classification Material selection - Corrosion prevention - Stresses created due to static and dynamic loads - Elastic instability - Combined stresses and theories of failure - Fatigue - Creep- Temperature effects - Radiation effects - Effect of fabrication methods. Module II Pressure Vessels Operating conditions - Pressure vessel code - Vessels operating at low and elevated temperatures Design conditions-and stresses - Design of shell and its components Supports - Stresses from local loads and thermal gradient - Thermal stresses in cylindrical shell Review-of unfired pressure, vessel codes. Module III Design of storage tasks - Nozzles and mountings - Large capacity storage tanks. Classification of reaction vessels - Heating systems- Design considerations. Types of heat exchangers - Process and Mechanical Design of Shell and Tube Heat Exchangers. Module IV Distillation and Fractionation Equipment - Stresses in column shell Determination of shell thickness - Elastic stability, under compressive stresses - Allowable deflection - Column internal details - Process Design aspects. Reference: 1. Ludwig, E.E, 'Applied Design in Chemical and Petrochemical Plants.
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2. 3.
M.V, Joshi, Process Equipment Design. R K Sinno, An Introduction to Chemical Engineering Design. 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern Q l - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV- 2 questions A and B of 15 marks from module III with choice to answer anyone. QV- 2 questions A and B of 15 marks from module IV with choice to answer anyone. .
BT4 804(D) : SAFETY IN PROCESS PLANTS

3 hours lecture and 1 hour tutorial per week Module I Origin of process hazards, laws, codes, standards, case history. Hazards: Chemical, mechanical and physical - health hazard of industrial substances. Module II Explosion and hazards due to chemical reaction Identification of hazards fire and explosion hazard rating of process plants - HAZOP and HAZAN importance of risk analysis. Module III Consequence analysis Modeling of fire, explosion and toxic gas dispersion. Event probability and failure frequency analysis individual risk and societal risk reliability and risk analysis. Module IV Designing for safety - safety training emergency planning and disaster management case studies. Text Books 1. G. L. Wells: Safety in Process Plant Design, IchemE/Godwin. 2. F. P. Lees: Loss Prevention in Process Industries, Butterworth. 3. A. E. Green: High Risk Technology, Wiley.
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. Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks 2x7.5 2x15 = = = = 15 30 05 50
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of 15 marks from module II with choice to answer any one. QIV - 2 questions A and B of I5 marks from module III with choice to answer anyone. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 804(E): HAZARDOUS WASTE MANAGEMENT

3 hours lecture and 1 hour tutorial per week Module 1 Classification of hazardous wastes Hazardous waste designation system Hazardous Waste (Management and Handling) Rules - European and US Acts. Preparation of a waste inventory - Procedure and considerations - specific and non specific sources - hazardous waste numbers and codes. Module II Generator requirements - transporter requirements - treatment, storage and disposal requirement - ground water monitoring. The hazard ranking system prioritization of actions contingency plans Liabilities. Module III Hazardous waste minimization - benefits elements of programme - waste audit waste exchange recycling. effective waste minimization
Module IV Treatment technologies - Physical, Chemical and Biological Treatment - Management of specific recyclable hazardous waste like precious metals lead acid batteries. Land disposal land treatment - deep well injection - the secures land fill - land fill construction. Reference Books 1. Davis M. L. and Cornwell, D.A., Introduction to Environmental Engineering, McGraw Hill. 2. Liu I (ed)., Environmental Engineers Handbook, Lewis Publishers.
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2x7.5 2x15
= = = =
15 30 05 50
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of l5 marks from module II with choice to answer any one. QIV - 2 questions A and B of l5 marks from module III with choice to answer any one. QV - 2 questions A and B of l5 marks from module IV with choice to answer any one.
BT04 805(A) : BIOPHARMACEUTICAL TECHNOLOGY

3 hours lecture and 1 hour tutorial per week Module I Introduction: Development of Drug and Pharmaceutical Industry, Preclinical studies, Clinical trials. Regulatory aspects in drag development, Role of FDA, Important amendments in drugs regulation. Indian drugs and cosmetic act. Economics of drug industry, pharmaecoaomics. Different classes of therapeutic agents - their uses. Module II Biophamaceutics Drug absorption, distribution, and metabolism (Biotransformation - phase I, II reactions) Pharmacokinetics &. Physico chemical principles affecting all the above plasma drug concentration - time profile - Pharmacokinetic models - one compartment modeling. Pharmacogenomics. Action of drags on human bodies.- general principles,, target of drug action, receptors, receptor theory. Module III Important unit processes and their application: Tablets wet granulation - dry granulation or slugging - direct compression - tablet presses coating of tablets. Capsules Sustained action dosage forms - parental solutions - oral liquids injections - ointments - topical Applications ointments preservation - analytical methods and rest for various drugs and Pharmaceuticals. Packing - Packing Techniques - Quality Management, GMP
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Module IV Pharmaceutical production and their control Therapeutic categories such as Antibodies - Penicillin, Non steroidal contraceptives, Biologicals- insulin, Vaccines (Polio, BDG Influenza), Hormones (Human growth hormone) Analgesics. Reference: 1. Leon Lachman etal, Theory and practice of IndustrialPharmacy, Lea arid Febiger. 2. Richard B. Silverman, The Organic Chemistry of Drug Design and Drug Action, Elsevier, Publications. 3. Rang Dale Riter, Pharmacology, Churchill Livingstone Internal work assessment Assignments Tests Regularity Total marks
(2 X 7.5) (2 X 15)
= = = =
15 30 5 50
University examination Pattern Q1 - 8 Short type questions of 5rnarks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one. QIII - 2 questions A and B of 15 marks from module II with choice to answer any one. QIV - 2 questions A and B of l5 marks from module III with choice to answer any one. QV- 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 805 (B) : ANIMAL
BIOTECHNOLOGY
3 hours lecture l hour tutorial per week Module I Introduction: What is Animal Biotechnology and its sco[pe - animals in Biotechnology - State of the Art. Module II Animal Cell Culture Principles of sterile techniques and cell propagation - Chemically difined and serum Free media for membrane cell culture - scaling up of animal cell cultures - preservation and characterization of animal cells - organ culture - cytotoxity and viability assays Cell cultures as sources of valuable products. Module III Genetic Recombination Tchniques: Mammalian genome, genetic recombination in mammalian cells and embryos. Cloned animals Module IV Protein production by genetically engineered mammalian cell lines - optimization of animal cells growth in bio reactors Emission. Reference Book
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Bernur R. Pastrnek. J.J. , Molecular Biology, Principles and Applications in recombinant DNA, Panima Publishing Cooperation, New Delhi M.
1.
Internal work assessment Assignments Tests Regularity Total marks
(2 X 7.5) (2 X 15)
= = = =
15 30 05 50
University examination Pattern Q l - 8 short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of l5 marks from module I with choice to answer any one QIII- 2 questions A and B of 15 marks from module II with choice to answer anyone. Q1V - 2 questions A and B of 15 marks from module III with choice to answer any one. QV~ 2 questions A and B of 15 marks from module IV with choice to answer any one
BT04 805(C): PROJECT MANAGEMENT

3 hours lecture and I hour tutorial per week Module I Introduction to project management - Definitions and terms such as flow diagrams, bid pre-contract, project report, feasibility studies, detailed engineering man hours, P and I diagram, Plot plan, Utility, Preliminary estimation, Detailed estimation, Cost estimation concepts. Module II Sequence and process of preparing preliminary and final project reports and feasibility studies Demand Analysis - Business and legal procedures of project contracts - Different types of project contracts Scope - Advantages and disadvantages. Module III Cost factors in capital investment Purchased equipment installation Insulation cost Instrumentation and Controls - Piping Electric installations - Building including services Yard improvements - Service facilities. Engineering and Supervision Procurement - Inspection and Expediting - Construction expenses - Contractors fee Contingencies- Start-up expenses - Precommissioning Commissioning. Module IV Planning and control - Bar chart - PERT and CPM - Budgeting and financial control Personnel recruitment and training.
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Internal work assessment Assignments Tests Regularity Total marks (2 X 7.5) (2 X 15) = = = = 15 30 05 50
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of l5 marks from module I with choice to answer any one. QIII - 2 questions A and B of 15 marks from module II with choice to answer any one. QIV-2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 805(D): TRANSPORT PHENOMINA

3 hours lecture and 1 hour tutorial per week Module I : Transport Properties: Theory of viscosity of gases and liquids - thermal conductivity of gases and liquids theory of diffusion in gases and liquids Module II : Shell Momentum Balances: Equation of continuity momentum equation energy for three dimensional flow application of differential equation of fluid flow to specific problems. Module III : Shell Energy Balances: Boundary conditions and temperature distribution solids and laminar flow free and forced convection. Mass Transport: Molar fluxes Ficks law of diffusion diffusion through a stagnant gas film diffusion into a falling film. Module IV Analogy between momentum, heat and mass transfer mechanism of interphase transport two film theory penemation theory Application of transport phenomina in bioprocess engineering. Reference: 1. Bird Stewart and Lighfoot: Transport Phenomena
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Internal work assessment Assignments Tests Regularity Total marks
(2 X 7.5) (2 X 15)
= = = =
15 30 5 50
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII - 2 questions A and B of 15 marks from module I with choice to answer any one QIII- 2 questions A and B of l5 marks from module II with choice to answer any one. QIV- 2 questions A and B of 15 marks from module III with choice to answer any one. QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 805(E) : MATERIAL SCIENCE AND TECHNOLOGY

3 hours lecture and 1 hour tutorial per week Module I Atomic structure, atomic bonding and atomic arrangement, co-ordination number, crystal systems, crystal structure, non crystalline structure and crystal defects. Metallic phases and their properties - single phase metals and alloys, binary equilibria involving solid solution, eutectic and Peritectic systems, iron carbon diagram, plastic deformation, recrystallisation. Elementary study o f various metals and alloys. Module II Organic polymers and their properties - classification, comparison of properties and their relationship with chain structures. Ceramics Comparison of ceramic and non ceramic phases, structure, properties and applications of ceramics. Module III Corrosion different types, mechanism and factors influencing corrosion, corrosion prevention - inhibitors and their applications. Oxidation - aging of rubber, oxidation of metals and radiation damage. Module IV Composite materials - classification - Reinforcements; fillers and additives, processing and applications.
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Characteristic of composite materials - Theory of composites. Reference: 1. J. L. Lee Evans, Selecting Engineering Materials for Chemical a nd Process Plants. 2. Van Vlack, Elements of Material Science. Internal work assessment Assignments Tests Regularity Total marks
(2 X 7.5) (2 X 15)
= = = =
15 30 5 50
University examination Pattern QI - 8 Short type questions of 5 marks, 2 from each module. QII- 2 questions A and B of 15 marks from module I with choice to answer any one. QIII- 2 questions A and B of l5 marks from module II with choice to answer any one. QIV - 2 questions A and B of l5 marks from module III with choice to answer any one QV - 2 questions A and B of 15 marks from module IV with choice to answer any one.
BT04 806(P): IMMUNOLOGY & GENETIC ENGINEERING LAB

3 hours lecture and 1 hour tutorial per week 1
2
Blood grouping. Preparation of antigens-protocol of immunization in rabbits, methods, of bleeding, purification and production of polyclonal antibodies. Separation of lymphocytes from blood. Antigen - antibody reactions - Haemagglutination, Immunodiffusion, mmnunoelectrophorosis Affinity chromatography for Ab purification Flurochrome - Ab conjugation Biotin Ab conjugation and Ab-enzyme conjugation. Immunoprecipitation. Isolation of Immunoglobulins and characterization. Preparation of DNA genomic and plasmid Agarose gel electrophorosis of DNA Preparation of competent cells. Gel electrophoresis of proteins.
3
4
5
6
7 8 9 10 11 12
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13 14
Induction of Lac operon (expression of beta galactosidase and assay). Cloning of DNA into Plasmid vector.
Internal work assessment Regular work and record Test Regularity Total marks = 25 = 20 = 05 = 50
BT04 807(P): PROJECT WORK

7 hours project work per week This project work is the continuation of the seventh semester project the eighth semester is for the development of the project a detailed report is to be submitted at the end of the semester - the assessment may be made individually and in groups. Internal work Allotment Design & development Testing and Installation Report Total marks : 40 : 40 : 20 : 100
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BT04 808(P): VIVA VOCE

There is only University examination for this - the University will appoint examiners for conducting the viva voce examination the examiners will ask questions from subjects studied for the B. Tech course, project and seminar reports of the student - the relative weightage should be as follows. Internal work Assessment Subject Project Seminar Total
: : : :
40 marks 40 marks 20 marks 100 marks
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BT - 2004 Syllabus

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BT - 2004 Syllabus

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SCHEME OF EXAMINATION & SYLLABI

B. Tech. Degree Course of C A L IC U T U N IV E R S IT Y

COMBINED FIRST AND SECOND SEMESTER

Session Uni./Exam Marks Hrs Marks .

Chemistry Lab(A) Humanities Engineering Graphics(A) Engineering Mechanics(A) Basic Electronics

Note : Details of Common Course

Hours/Week Session University Marks Exam L T P/D Hrs Marks

100 100 100 100 100 100 100 100

University Exam Hrs Marks

100 100 100 100 100 100 100 100

University Exam Hrs Marks

100 100 100 100 100 100 100 100

Hours/Week Session University Marks Exam

100 100 100 100 100 100 100 -

Bio Process Technology Lab I Mini Project

Subject Downstream Processing Bioprocess Plant Design Recombinant DNA Technology

Hours/Week Session University Marks Exam

100 100 100 100 100 100 -

Seminar Project Work

University Exam Hrs Marks

Immunology & Genetic Engineering Lab

Project Work Viva Voce

100 100 100 100 100 100 100 100

AGGREGATE FOR EIGHT SEMESTERS : 5300 ELECTIVE II

EN04- 101: MATHEMATICS I

EN04 -102: MATHEMATICS II

EN04- 103A: ENGINEERING PHYSICS(A)

EN04-I03A(P): PHYSICS LAB(A)

10. 11. 12.

14. 15. 16. 17. 18. 19. 20. 21.

EN04-104A: ENGINEERING CHEMISTRY(A)

9. 10. 11. 12. 13.

17. Preparation of some liquid crystals and study of their properties.

EN04 - 107A: ENGINEERING MECHANICS(A)

BM04 -109 : BASIC ELECTRICAL ENGINEERING

BM04 - 110(P) : MECHANICAL WORKSHOP

=30 =20 =50

BM04 - 111(P): ELECTRICAL AND ELECTRONICS WORKSHOP

Part A: Electrical Workshop (2 hours per alternate weeks)

Part B - Electronics Workshop (2 hours per alternate weeks)

Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks

BT04 302 : COMPUTER PROGRAMMING IN C

BT04 303 : CELL BIOLOGY

Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks

BT04 304 : CHEMICAL ENGINEERING I

BT04 305 : MICROBIOLOGY

BM04 306 : BIOCHEMISTRY I

BT04 307(P) : MICROBIOLOGY LAB

BT04 308(P): BIOCHEMISTERY LAB

EN04 401A : ENGINEERING MATHEMATICS - IV

Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks

EN04 402 : ENVIRONMENTAL STUDIES

Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks

BT04 404 : CHEMICAL ENGINEERING II

Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks

BT04 405 : BIO PROCESS PRINCIPLES

BT04 406 : ANALYTICAL TECHNIQUES BIOTECHNOLOGY

BT04 407(P) : CHEMICAL ENGINEERING LAB I

BT04 408(P) : BIO-ANALYTICAL TECHNIQUES LAB

BT04 501: INDUSTRIAL BIOTECHNOLOGY

Internal work assessment Assignments (minimum 2) 2 tests Regularity Total marks

BT04 502 : MASS TRASFER AND SEPARTION PROCESSES

BT04 503: MOLECULAR BIOLOGY