SAII{|:[ TOUIS UNIVERSITY COLLEGE OE}.

IATT'RjAI, SCIENCES DEPARTMEMT OF CEEMTSTRY

I. IT.

COURSE NUMBER: Chem

(Lecture - 3 units, Laboratory - 2 uni-ts)

Drincinloq r !ar:ur!,auu nf Rir-,r-homi qf rrr

4/L

DESCRIPTI\IE TITLE:
PREREQUISITES:

IfI.

General and fnorgani-c Chemistry Organic Chemistry College Algebra Plane TriqonometrV

IV.

COURSE DESCRIPTION:

The presentation and interpretation of biochemical concepts in the lecture course, is i-n constant reference to the cell, giving th students in the paramedi-cal fields, brief glimpses of tfre structure and function of the biomolecufes composing the cell. The emphasis is on the ciinical implications from the Concepts presented, So designed aS to enable the students to understand and help them appreciate their values i1 expJ-aining thej-r everyday life experiences. Furthermore, a close rel ationsni-p of lhe principles of biochemistry to

nornral and pathological- physiclogy is given adequate attention. The activitres in the laboratory are those of clualitati-,re Lests arrd F^rocedui:es necessary in char.rcterizlng biological specimens such as b.lood, feces, urine and saliva from clata pertaining to biochemical contents '
COI'RSE OB.TECTTVES:

V.

At the end of the course, the studr:rii-s

should be able to: A. Cogmitive:

1.

2. 3.
B.

Develop an understanding of the numerous biologlcal Structures and processes, and the mechanisms of biological phenomena at a molecular Ieve!; Deterrnrne the appropriate tesls and meLhods irr studyi_ng the biochemj-cal character of blood' urj-ne, feces, saliva and othcr biologrcal fluids; Disciiss the dif ferent' inetabciic pathways '

Affeetiwe: 1. Correlate the stluctDres and functions of the <lifferent biomoier:ules of the cel} and the varic;iis tissues and sYstem-s of the body; 2. Apprecr aie the v.il 'Je of r:liemical knowledge i.n keePi rrg orteself i n good hrealth by underst-andi i'g the ef f ec|'; lf noi.1 *t-ion and other en.l-'i ronmen.r;;1

aval1s of.

hazards on the biochemistry and materiafs

he

C.

Psyehonotor:
1

use certain basic principles to analyze commonly

problems

3I.

molecule.
COT'RSE OIITLINE: ITOLECUTAR A}.IATO}Nr

perform basic chemical tests of the different biomolecules and their precursor unlts or building blocks; Trace the different metaboric pathways and compute for the the bioenerg.etics behind catibolism of the

;:::;il?.:i"::1,:::i:::

in

terms

of rheii

Intrcduction Biochemistry as a ,Discipline and rnterdisciplinary Science Review of Rerated Topics from prerequisite subjects organelles of the ce11 anci their Biomorecules Structure and Functions of proteins' Amino Aclds: Classes and Structures. Acid-Base properties of Amino Acids Reacti ons of the Amino, Carboxyl and R_ Groups Peptide Bond and peptide Synthesis Levels of organization of protein l4olecutes Classification of proteins Denaturation of protei_ns
.

Glycoproteins
Unavai

Structure and Functions of Carbohvdrates Classification Simple Sugars: Structures and properties Typical Carbohydrates
Proteoglycans lable Carbohvdrates

Structure and Functions of Lipids Classification The Fa'uty Acids: Structures and properties Typical Lipids Lipoproteins: Biological Membranes
Proteoglycans

The DNA Molecule

Structure and Functl ons of Nucleic Acids Structural Components and Features

Thre RNA Molecule

Genetic

Reactions of Pyrimidines and Purines Environmental Hazards Mutations, Mutagerrs and Repair Mechanisms Carcinogens and Carcinogenic l4utagens

Protein Synthesis

Code

Enzymes

Classifi-cation and Nomenclature Typical Enzymes Enzyme Activity Factors Affecting Enzyme Activity Clinical Slgnificance of Enzymes f
Vitamlns and
Hormones

Chemical Nature

Chemlcal Nature Sources or Sites of Formation Adsorption and Functions Diseases caused by Over/Under supply of Vitafiins and Hyper/hyposecretion of hormones Correlation with Other Biomol-ecules

MOTECUI,AR PgYSIOTOGY

Biochemistry of Body Activitles Digestion Absorption Respiration Metabolism of Proteirrs, Carbohydrates, Lipi-ds Nuclelc Aci-ds

and

Biochemistry of U::ine Kidney Function: prccesses Involved in Urj-ne Formation Physical Properties of Urine
Composition of Uri-ne

Clinical Implications from Urine Arralysis

10 Biochemistry of Blood Functions of Blood Chemistry of Blood Coagulat.ion Composition of Blood Diseases Related to Blood Clinical Implications from Blood Arralysis

Chen
I,ABORATORY

4L

ACTIVITIES

1 2 4 5 6 7 B 5 10 11 n 13 I4 I5 16 71 79 20 27 22 23 24 25 26 21 2B 29 30
VII .
1B
J

pH and Buffers Osmotic Behavi-or

DIA-LVS1S

of

Red Blood Cells

General Characteristics of Proteins Color Tests for Proteins and Specific Amino Acids Chromatography of Amino Acids Denaturation of Proteins Identification of Unknown Amino Acid General Characteristics of Carbohydrates

Tests for Carbohydrates Formation of Osazones

Polysaccharides Polarimetry

identification of an Unknown Carbohvdrate Properties of Lipids Saponification of Fats

Cholesterol
Enzymes

Prenaraf i on and Proner:ties of Nucleic Acids

Inorgianic Elements in Biological Materials

L!vtJvl

Factors Influencing
Sal-iva
Feces

Enzyme

Action

Ptyalin Gastric Analysis

Normal Constituents cf Urine

Pathological Constituents of Urine Tests for Blood Inorganic Elements in Blood

Plasma
COTIRSE REQUIRB.{E}IIS :

Prelims, mi-dterms and final examinations

Qui z zes

Laboratory Reports Journal Reports on Clinical Aspects of Biochemistry Laboratory experimenlat Role Playing Film Viewing Simulation
j-on

VIII

COIJRSE

STRATEGIES: Lectures

IX. X.

COURSE TEXTBOOK:

Sylianco, Clara. Modern Bi.ochremistrv. Caloocan City: Philippine Graphic Arts, 1981.

REFERENCES:

rntroduction to orqanic and Bj_olosicaI Chemistrv. New Ycrk: MacMill_an, 1987. campbell, Peter N. and Anthony D. smith. Biochemistrv Illustsated. London: Harcourt Publishers Limited, 2000. Chen, Philip. Chemistrv: Inorqanic, Oroanic and Bioloqical. Second Edition. New York: Barnes and Noble, 19j9. Lehninger, Albert. Biochemistrv. Znd Edition. New york: Worth Publishers Inc., 1975. I'4atthews, christopher K. And K.E. Van Holde. Biochemistrv. US: Benjamin/Cummings publishing Co., fnc., 1996. Montgomery, Rex . Bi.ochemistrv. Fif th edition. Missouri : C.U. Mosby Co., 1990 Smith, Emil. Principles of Biochemistrv. New York: Wiley
and Sons, 1918. Stephenson, William. Concepts in Biochemistrv. New York: Wiley arrd Sons, 1918. White, Abraham. Principles in Biochemistrv. New York:
McGraw

Baum, stuart.

Wi-lbraham, Anthony. Introduction to Organic and Bioloqical Chemistrv. USA: Cumminqs Publication, 1984.

Hill Co.,

1978.