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Data Sheet Data Sheet

Sterile Millex GP and HP Syringe Filters with the Millipore Express PLUS Membrane
Benefit from the fastest flow rates and lowest protein binding with Millipores new sterile Millex GP and HP syringe filters!
These filters use the popular Millipore Express PLUS PES membrane in a 33 mm diameter. The Express PLUS membrane is designed with an asymmetric pore distribution to provide the fastest flow rate on the filter market today. Plus, the membrane binds up to 8x less protein than competing brands. These 33 mm Millex filters with the Express PLUS membrane are available in 0.22 m (GP) and 0.45 m (HP) pore sizes to suit your filtration needs. Millipores family of Millex filter units has set the standard for reliable small volume filtration. Millex filters are available in 4, 13, 25, 33, and 50 mm diameters with Express PLUS (PES), Durapore (PVDF), Fluoropore, glass fiber, mixed cellulose esters (MCE), and LCR membranes.

Features
aster flow from the asymmetric pore F structure design ore surface area than other 25mm M diameter devices ow protein binding properties of L the Express PLUS PES membrane for higher recovery Provided sterilized in individual blister packs

GP/HP Design Features


arger surface area than traditional L 25 mm filters gives you faster flow, higher throughput, less clogging and less pressure needed to filter solutions. ower hold-up volume (<100 L) for L more sample recovery ow protein binding properties of the L Express PLUS PES membrane reduces sample loss vermold device design improves O burst resistance and allows for higher operating pressures and faster filtration

SPeciFicationS
all Millex Filters
Applications: Tissue culture media/additives Buffers Biological solutions Membranes Millipore Express PLUS (PES): Fast flow and low protein binding Durapore (PVDF): Ultra low protein binding Mixes cellulose esters (MCE): General purpose, binds trace proteins Millipore LCR (hydrophilic PTFE): Broad chemical compatibility Process Volume: < 1 mL 1-10 mL 10-100 mL 10-200 mL Up to 4,000 mL Millex Filter Diameter: 4 mm 13 mm 25 mm 33 mm 50 mm

Sterile Millex GP and HP filters


Sterile Millex GP and HP filters demonstrated much lower protein binding compared to equivalent competitor filters.

Low Protein Binding Goat Anti-Rabbit IgG (g)


600

Protein Binding (g/device)

500 400 300 200 100 0 0.2 m "GP" 0.45 m "HP" 0.2 m 0.45 m 0.2 m 0.45 m

Millipore Millex, 33 mm

Brand A, 32 mm

Brand B, 25 mm

Sterile syringe filter units with PES membrane Figure 1. Sterile syringe filters with either a 0.22 m or 0.45 m with PES membrane were challenged with goat anti-rabbit IgG testing for protein binding properties.

Sterile 0.22 m SyrinGe FilterS


The improved sterile 33 mm Millex GP syringe filter had the fastest flow, outperforming competitor brands when filtering FBS.
0.2 m PES Syringe 10% FBS in DMEM 0.2 m PES Syringe 0.2 m PES Syringe 10% FBS in DMEM 10% FBS in DMEM
Improved Millex GP Brand A Brand B Improved Millex GP Improved Millex GP Brand A Brand A 3.0 3.5 Brand B Brand B Old Millex GP Old Millex GP Millex GV Millex GV 4.0 Old Millex GP Millex GV

Filtrate Volume (mL) Filtrate Volume (mL) Filtrate Volume (mL)

200 150 200 200 100 150 150

50 100 100 0 50 0 50 0 0 0.5 1.0 1.5 2.0 2.5

Flow Time (Minutes)

0 0.5 1.0 1.5 2.0 2.5 3.5 Figure 2. Comparable sterile syringe filters with 0.2 m PES membranes were3.0 challenged with 10% FBS 4.0 0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0

in DMEM testing for flow rate properties. Flow Time (Minutes) Flow Time (Minutes)

Sterile 0.45 m SyrinGe FilterS


The sterile 33 mm Millex HP has a significantly faster (>2x) flow time without clogging as seen in two 0.45 m PES Syringe comparable competitor syringe filter units.
0.025% Dairy Whey Filtrate Volume (mL) Filtrate Volume (mL) Filtrate Volume (mL)
200 150 200 200 100 150 150

0.45 m PES Syringe 0.45 m PES Syringe 0.025% Dairy Whey 0.025% Dairy Whey

Millex HP Brand A Brand B Millex HP Millex HP Brand A Brand A Brand B Brand B

50 100 100 0 50 0 50 0 0 0 0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0

4.5

5.0

Flow Time (Minutes)


0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0 3.5 3.5 4.0 4.0 4.5 4.5 5.0 5.0

Flow Time (Minutes) Flow Time (Minutes) Figure 3. Comparable sterile syringe filters with 0.45 m PES membranes were challenged with 0.025% dairy whey testing for flow rate properties.

The sterile 33 mm Millex HP has a significantly faster (>2x) flow time that the competitors, one of whom had 0.45 m PES Syringe Millex HP 0.025% clogging problems was not able to complete the test. Peptone Hy Soy
Filtrate Volume (mL) Filtrate Volume (mL) Filtrate Volume (mL)
200 150 200 200 100 150 150
Brand A Brand B Millex HP Millex HP Brand A Brand A Brand B Brand B

0.45 m PES Syringe 0.45 m PES Syringe 0.025% Peptone Hy Soy 0.025% Peptone Hy Soy

50 100 100 0 50 0 50 0 0 0 0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0

Flow Time (Minutes)


0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0 3.5 3.5 4.0 4.0 4.5 4.5 5.0 5.0

Flow Time (Minutes) Flow Time (Minutes) Figure 4. Comparable sterile syringe filters with 0.45 m PES membranes were challenged with 0.025% peptone hy soy testing for flow rate properties.

orDerinG inForMation
Millex Filters with the express PluS PeS Membrane
Description Qty/Pk catalogue no.

Millex-GP, 33 mm, Express PLUS PES, 0.22 m pore size, sterile Millex-GP, 33 mm, Express PLUS PES, 0.22 m pore size, sterile Medical Millex-GP, 33 mm, Express PLUS PES, 0.22 m pore size, sterile Millex-HP, 33 mm, Express PLUS PES, 0.45 m pore size, sterile Millex-HP, 33 mm, Express PLUS PES, 0.45 m pore size, sterile Medical Millex-HP, 33 mm, Express PLUS PES, 0.22 m pore size, sterile

50 250 50 50 250 50

SLGP033RS SLGP033RB SLGPM33RS SLHP033RS SLHP033RB SLHPM33RS

additional 33 mm Millex Filters for cell culture


Description Qty/Pk catalogue no.

Millex-GV, 33 mm PVDF membrane, 0.22 m pore size, sterile Millex-HV, 33 mm PVDF, 0.45 m pore size, sterile Millex-GS, 33 mm MCE membrane, 0.22 m pore size, sterile Millex-HA, 33 mm MCE membrane, 0.45 m pore size, sterile

50 50 50 50

SLGV033RS SLHV033RS SLGS033SS SLHA033RS

to Place an orDer
Call US toll free 1-800-MILLIPORE or visit www.millipore.com/offices to find your local office.

For ProDuct or aPPlication inForMation


Visit www.millipore.com/support to contact our technical service

www.millipore.com/offices

department or find your local representative.


Millipore, Millex, Durapore, and Millipore Express are registered trademarks of Millipore Corporation. The M mark, Advancing Life Science Together, and Fluoropore are trademarks of Millipore Corporation. Lit. No. DS1196EN00 01/09 Printed in U.S.A. BS-GEN-08-01288 2009 Millipore Corporation, Billerica, MA 01821 U.S.A. All rights reserved.

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