Product Information

S1230 Flavopiridol
CDK

Novel Life Science Reagents

for Cell Signaling Research

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OH O

Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 401.84 C21H20ClNO5 DMSO 99% at -20 2 years 146426-40-6
HO HO N

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Cl

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Synonyms: HMR-1275,

Alvocidib, L868275

(chemistry support)

techbio@selleckchem.com
(bio support)

Biological Activity
Nanomolar concentrations of flavopiridol inhibited rhabdoid cell growth (IC50-200nmol/L) , induced G1and G2 arrest, and apoptosis in vitro in a concentration-dependent manner. These effects were correlated with the down-modulation of cyclin D1, up-regulation of p21, and induction of caspase 3/7 activities. Flavopiridol (at 7.5 mg/kg) significantly inhibited the growth of xenografted rhabdoid tumors, and its effect was correlated with the induction of p21 and down-modulation of cyclin D1.[2] Exposure of HNSCC cells to flavopiridol diminished cdc2 and cdk2 activity and potently inhibited cell proliferation (IC50=43-83 nM), which was concomitant with the appearance of cells with a sub-G1 DNA content.[3]

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References
[1] Lloyd R Kelland . Expert Opinion on Investigational Drugs. 2000 December;9(12):2903-2911 [2] Melissa E. Smith et al. Clin Cancer Res.2008 January 15;14:523-532 [3] Vyomesh Patel et al. The Journal of Clinical Investigation. 1998 November;102(9):1674-1681

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA

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Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

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