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Immunoassays & MILLIPLEX map Kits

Multiplexing using the Luminex technology


Analyte Quarterly Q3 2011
Bone Metabolism Cancer Biomarkers Cardiovascular Disease Cell Signaling Inflammation/Immunology Metabolism Neuroscience Toxicity

EMD Millipore is a division of Merck KGaA, Darmstadt, Germany

The Latest in Multiplexing


MILLIPLEX map Multiplex Immunoassay Kits
Magnetic Bead Format
Kit Akt-mTOR Phosphoprotein 11-Plex Akt-mTOR Total 11-Plex Circulating Cancer Biomarker Panel 2 Species Human Cat. No. 48-611MAG

Discover the Latest in Innovative and Unique Assay Kits, Instruments and Services
MAGPIX Instrument:
Multiplex analyte detection system (Read more on page 19.)

Services:
SignalProfiler Services (Read more on page 22.)

Human Human

48-612MAG HCCBP2MAG-58K MCYTOMAG-70K CCYTOMAG-90K MPEQMAG-103K MGAMMAG-300K HNPMAG-35K RMNPMAG-83K

Cytokine/ Mouse Chemokine Panel 1 Cytokine/ Chemokine EpiQuant Phosphothreonine Immunoglobin Isotyping Neuropeptide Neuropeptide Canine Human Mouse Human Mouse/Rat

CoMINg THIS YEAR! EMD Multiplex Kits in the MILLIPLEX map Format:
Human Mitochondrial Oxidative Phosphorylation Human Heat Shock Protein Human Phospho-EGFR Profiler

Non-Magnetic Bead Format


MAPmate* NFB Total NFB Total Rb Total Rb (Thr252) Rb (Thr826) Rb (Ser811) Cat. No. 46-701 46-702 46-703 46-704 46-705 46-706 MAPmate* Lyn Total Lyn (Tyr397) Src Total Src (Tyr419) Src (Tyr530) Lck (Tyr394) Cat. No. 46-707 46-708 46-709 46-710 46-711 46-712

ELISA Kits
Kit
For Research Use Only.

Species Human Human

Cat. No. EZHS100B-33K EZHNPS-34K

S100B Neuropeptide S

ELIS A / RIA

Immunoassays & Multiplex Kits


EMD Millipore provides an unparalleled level of peer supportscientists working with scientists to provide you with the quality tools and services you need to do your best work. With a wide range of immunoassay kits, we advance your research in many therapeutic areas including metabolic disease (diabetes, obesity, cardiovascular), inflammation, immunology, neuroscience, oncology and toxicity. These include MILLIPLEX map high content multiplex biomarker panels utilizing the Luminex xMAP technology platform. We offer the broadest selection of ELISAs and RIAs as well as the largest selection of multiplexing analytes and applications of any Luminex partner.

ELISA Neuroscience
Kit a-Synuclein Amyloid Beta, 1-40 Amyloid Beta, 1-42 Amyloid Beta, SET Amyloid Beta (Brain), 1-40 Amyloid Beta (Brain), 1-42 Amyloid Beta (Brain), SET ChemiKine Neurotrophin 3, Sandwich ChemiKine Nerve Growth Factor, Sandwich ChemiKine Brain Derived Neurotrophic Factor, Sandwich ChemiKine Pigment Epithelium Derived Factor, Sandwich Species Human/ Mouse/Rat Human Human Human Human Human Human Human/Rat Cat. No. NS400 EZHS40 EZHS42 EZHS-SET EZBRAIN40 EZBRAIN42 EZBRAIN-SET CYT302 Kit Glial fibrillary acidic protein (GFAP) Neuropeptide S NEW! Neuropeptide Y (NPY) Neuropeptide Y (NPY) Nitrotyrosine OxyELISA Oxidized Protein Quantitation Phosphorylated Neurofilament (pNF-H) S100B Human sICAM-1 Mouse/Rat CYT304 sVCAM-1
NEW!

Species Human/ Mouse/Rat Human Human Mouse/Rat

Cat. No. NS830 EZHNPS-34K EZHNPY-25K EZRMNPY-27K

Multi-species 17-376 Multi-species S7250 Multi-species NS170 Human Mouse Human Human EZHS100B-33K EZMSAA3-12K ECM335 ECM340

Human/Rat

CYT306

Human

CYT420

ELISA Cell-based Assays


Dual Detect CELISAs
Description ErbB2 (Tyr1248) H2A.X (Ser139) Cat. No. 17-490 17-720
For Research Use Only.

Special discount on select ELISAs, see page 3 for details.

millipore.com/analytes_Q3
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ELIS A / RIA

ELISA Circulating Biomarkers


Kit Adiponectin Adiponectin Adiponectin Adiponectin Adiponectin High Molecular Weight Adipsin AGF (ANGPTL6) Amylin (active) Amylin (total) Apo AIV Apo AV BDNF Chemerin C-Peptide C-Peptide 2 CRP CRP CRP FGF-21 FGF-21 FGF-23 FGF-23* Fibronectin (Quantimatrix) Ghrelin (active) Ghrelin (active) Ghrelin (total) Ghrelin (total) GIP (total) GIP (total) GLP-1 (active) GLP-1 (total) GLP-2 (total) Growth Hormone ICAM-3 IFNa Insulin
For Research Use Only. NEW!

Species Human Mouse Rat Canine Human Mouse Human Human Human Human Human Human/Rat Human Human Rat/Mouse Human Rat Canine Human Rat/Mouse Human Rat/Mouse Human Human Rat/Mouse Human Rat/Mouse Human Rat/Mouse Multispecies Multispecies Human/Rat Rat/Mouse Human Human Human Rat/Mouse Human

Cat. No. EZHADP-61K EZMADP-60K EZRADP-62K EZCADP63K EZHMWA-64K EZMADPSN-22K EZHAGF-28K EZHA-52K EZHAT-51K EZHAP0A4-73K EZHAP0AV71K CYT306 EZHCMRN-57K EZHCP-20K EZRMCP2-21K CYT298 CYT294 CYT296 EZHFGF21-19K EZRMFGF21-26K EZHFGF23-32K ECM300 EZGRA-88K EZRGRA-90K EZGRT-89K EZRGRT-91K EZHGIP-54K EZRMGIP-55K EGLP-35K EZGLP1T-36K EZGLP2-37K EZRMGH-45K ECM337 Cyt271 EZHI-14K EZRMI-13K EZHIASF-14K

Kit Laminin Leptin Dual Range Leptin Leptin Leptin ChemiKine Nerve Growth Factor Omentin-1 Pancreatic Polypeptide ChemiKine PEDF Procollagen Type IIA N-Propeptide (PIIANP) Proinsulin (Intact) Proinsulin (total) PYY (total) RBP4 Resistin sCD26 sE-Selectin sICAM-2 sL-Selectin
NEW!

Species Human Human Mouse Rat Canine Mouse/Rat Human Human Human Human Human Human Human Human Human Human Human Human Human

Cat. No. ECM310 EZHL-80SK EZML-82K EZRL-83K EZCL-31K CYT304 EZH0MNTN1-29K EZHPP-40K CYT420 EZPIIANP-53K EZHIPI-17K EZHPI-15K EZHPYYT66K EZHRBP4-18K EZHR-95K ECM345 ECM330 ECM346 ECM331

ELISA other Assays


EZ-Transcription Factor
Description AP-1 Family c-Fos c-Jun ErbB2 (Tyr1248) HDAC Jun/Fos NFB Family NFB p50 NFB p50/p65 NFB p65 PI3 Kinase Activity/Inhibitor PhosphaFluor HTS OmniPhosphatase Ras Activation ssDNA Apoptosis Universal TF Colorimetric Cat. No. 70-550 70-545 70-540 17-490 17-374 70-546 70-560 70-515 70-510 70-520 17-493 17-448 17-497 APT225 70-501 70-601 70-646 70-660 70-615 70-610 70-620 Chemiluminescent Cat. No. 70-650 70-645 70-640

Insulin Insulin (Animal Serum Free)

* Coming Soon Solid Plate Format

CU.S. Patent #: 5,541,066: 5,780,240

ELIS A / RIA

ELISA other Assays


HTS cAMP / cgMP
Description cAMP - 192 Assays cAMP - 768 Assays cAMP - 960 Assays cAMP - 3840 Assays cGMP - 192 Assays 17-598 Colorimetric Cat. No. 17-498 Chemiluminescent Cat. No. 17-418 17-416 17-518 17-516 17-419

RIA
Kit Adiponectin Adiponectin C-Peptide C-Peptide C-Peptide C-Peptide Ghrelin (active) Ghrelin (total) GLP-1 (active) GLP-1 (total) Glucagon Insulin Insulin Insulin Lispro Cat. No. 17-455 17-460 17-463 17-479 17-483 17-485 17-465 17-473 17-469 17-487 17-476 17-477 17-467 17-457 17-456 17-462 17-461 17-480 17-484 17-459 17-486 17-466 17-474 17-470 17-488 Insulin Specific Insulin Ultra Sensitive Insulin Leptin Leptin Leptin Leptin Proinsulin PYY PYY (3-36) Specific PYY (total) Human Human Rat Human Mouse Rat Multi-species Human Rat/Mouse Human Human Species Human Mouse Human Rat Canine Porcine Human Human Multi-species Multi-species Multi-species Rat Porcine Cat. No. HADP-61HK MADP-60HK HCP-20K RCP-21K CCP-24HK PCP-22K GHRA-88HK GHRT-89HK GLP1A-35HK GLP1T-36HK GL-32K RI-13K PI-12K LPI-16K HI-14K HI-11K SRI-13K HL-81K ML-82K RL-83K XL-85K HPI-15K RMPYY-68HK PYY-67HK PYYT-66HK

ELISA Cell Signaling / Intracellular


Star ELISAs
Description AKT1 (total) EGFR (total) erk 1/2 (total) FAK (total) Insulin Receptor (b subunit) (total) IB (total) JNK 1/2 (total) MEK1 (total) met (total) p38a (total) p53 (total) PRAS40 (total) Src (total) phospho-Akt (Ser473) phospho-Akt (Thr308) phospho-EGFR (Tyr1068) phospho-EGFR (Tyr1173) phospho-FAK (Tyr397) phospho-IR (b Subunit) (Tyr 1162/1163) phospho-IRS1 (Ser307 mouse/Ser312 Human) phospho-IB (Ser32) phospho-JNK 1/2 (Thr183/Tyr185) phospho-MEK1 (Ser218/222) phospho-MET (Tyr1230/Tyr1234/Tyr1235) phospho-p38a (Thr180/Tyr182) phospho-p53 (Ser15) phospho-PRAS40 (Thr246) phospho-Src (Tyr418)

Special % off Discount on Select ELISAs! Scan the QR Code to Find out More.

For Research Use Only.

17-475 17-478 17-468

MI LLI PLEX

MAP

CI RCU L ATINg

MILLIPLEX map
The broadest selection of analytes across a wide range of disease states, including metabolic disease, inflammation, neurodegenerative disease, renal toxicity, cancer and more. All the components and reagents you need to detect multiple analytes simultaneously in a small sample size (10-50 L)all in a single kit, using a single catalogue number. Available in both magnetic and non-magnetic bead format. Magnetic polystyrene beads contain encapsulated magnetite with bead surface chemistries that are comparable to nonmagnetic beads. New magnetic-bead panels will be introduced into our portfolio each quarter!

Your Source for Simultaneous Multi-Analyte Detection the Voice of Luminex xMAP Technology
Select a premixed kit or choose analytes within a panel to design a custom kit. Quality controls provided to qualify assay performance. Analytically validated panels that yield consistent analyte profiles irrespective of plex size. Standardized standard curve ranges across analytes and lots to ensure lot-to-lot consistency. Panels meet stringent manufacturing criteria to ensure batch-to-batch reproducibility. Environmentally friendly packaging: our boxes are 100% recyclable to reduce ecological footprints. Consolidated packaging available for larger orders to reduce storage needs.

For Research Use Only.

millipore.com/analytes_Q3
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Metabolism
Human Metabolic Hormone
(Cat. No. HMH-34K) (Cat. No. HMHMAG-34K)
IL-6 Amylin (active) Amylin (total) C-Peptide Ghrelin (active) GIP (total) GLP-1 (active) Glucagon Insulin Leptin MCP-1 Pancreatic Polypeptide PYY (total) TNFa

Non-Human Primate Metabolic Hormone


(Cat. No. NHPMHMAG-45K)
IL-6 Amylin (active) C-Peptide Ghrelin (active) GIP (total) GLP-1 (active) Glucagon Insulin Leptin MCP-1 Pancreatic Polypeptide PYY (total) TNFa

Canine Adipokine
(Cat. No. CADPK-91K)
Adiponectin

M I LLI PLEX MAP CI RCU L ATI Ng

Resistin

M ETA Bo LI SM

Human Adipocyte
Cell culture samples (Cat. No. HADCYT-61K) MB Format Coming Soon*
IL-1b IL-6 IL-8 Adiponectin HGF Leptin MCP-1 NGF PAI-1 (active) PAI-1 (total) Resistin TNFa

Human Adipokine Panel A Mouse Metabolic Hormone


(Cat. No. MMHMAG-44K)
IL-6 Amylin (active) C-Peptide 2 Ghrelin (active) GIP (total) GLP-1 (active) Glucagon Insulin Leptin MCP-1 Pancreatic Polypeptide PYY (total) Resistin TNFa

Serum/plasma samples (Cat. No. HADK1-61K-A) MB Format Coming Soon*


Adiponectin PAI-1 (active) PAI-1 (total) Resistin

Mouse Adipocyte
Cell culture samples (Cat. No. MADPCYT-72K)
IL-6 Adiponectin Leptin MCP-1 PAI-1 (total) Resistin TNFa

Human Adipokine Panel B


Serum/plasma samples (Cat. No. HADK2-61K-B) MB Format Coming Soon*
IL-1b IL-6 Leptin MCP-1 NGF TNFa

Rat Metabolic Hormone


(Cat. No. RMHMAG-84K)
IL-6 Amylin (active) C-Peptide 2 Ghrelin (active) GIP (total) GLP-1 (active) Glucagon Insulin Leptin MCP-1 Pancreatic Polypeptide PYY (total) TNFa

IL-8 HGF Insulin

Rat Adipocyte
Cell culture samples (Cat. No. RADPCYT-82K)
IL-1b MCP-1 PAI-1 (active) PAI-1 (total) TNFa IL-6 Adiponectin Leptin

Mouse Adipokine
Serum/plasma samples (Cat. No. MADPK-71K)
IL-6 Insulin Leptin MCP-1 PAI-1 (total) Resistin TNFa

Human Liver Protein


(Cat. No. HLPP-57K) (Cat. No. HLPPMAG-57K)
AFP FGF-19 FGF-21 FGF-23 HGF ANGPTL3 ANGPTL4 ANGPTL6 FABP1
For Research Use Only.

Rat Adipokine
Serum/plasma samples (Cat. No. RADPK-81K)
IL-1b IL-6 Insulin
Call for Availability * Coming Soon Magnetic Bead Format Cannot be plexed together: 1) Amylin (active) and Amylin (total) 2) PAI-1 (active) and PAI-1 (total)

MCP-1 PAI-1 (active) PAI-1 (total) TNFa

Leptin

See our website for Single Plex and Premixed Kit catalogue numbers.

Metabolism
Human Gut Hormone
(Cat. No. HGT-68K)
Amylin (active)

Mouse Endocrine
(Cat. No. MENDO-75K)
Amylin (active) GLP-1 (active) Glucagon Insulin Leptin

Canine Pituitary
(Cat. No. CPTMAG-96K)
ACTH BDNF FSH GH LH Prolactin TSH
NEW!

Insulin Leptin Pancreatic Polypeptide PYY (total)

M I LLI PLEX MAP CI RCU L ATI Ng

M ETA Bo LI SM

Amylin (total) Ghrelin (active) GIP (total) GLP-1 (active)

Rat Endocrine
(Cat. No. RENDO-85K)

Rat Stress Hormone


(Cat. No. RSH69K)
ACTH Corticosterone melatonin

Mouse Gut Hormone


(Cat. No. MGT-78K)
Amylin (active) Ghrelin (active) GIP (total) GLP-1 (active) Insulin Leptin Pancreatic Polypeptide PYY (total)

Amylin (active) GLP-1 (active) Glucagon

Insulin Leptin

Human Pituitary
(Cat. No. HPT-66K)
ACTH FSH LH Prolactin TSH

Multi Species Steroid/ Thyroid Hormone


(Cat. No. STTHMAG-21K)
Cortisol Estradiol T3 T4
n

Rat Gut Hormone


(Cat. No. RGT-88K)
Amylin (active) Ghrelin (active) GIP (total) GLP-1 (active) Insulin Leptin Pancreatic Polypeptide PYY (total)

GH

Human Pituitary
MB Format Coming Soon*
ACTH AGRP BDNF CNTF GH LH Prolactin TSH

Progesterone

Rat Thyroid Three Plex


(Cat. No. RTHY-30K-03)
T3 T4 TSH

Canine Gut Hormone


(Cat. No. CGT-98K) (Cat. No. CGTMAG-98K)
Amylin (total) Ghrelin (active) GIP (total) GLP-1 (active) Glucagon Insulin Leptin Pancreatic Polypeptide PYY (total)

FSH

Rat Thyroid Two Plex Non-Human Primate Pituitary


MB Format Coming Soon*
ACTH AGRP BDNF CNTF GH LH Prolactin TSH

(Cat. No. RTHY-30K-T3T4)


T3 T4

Rat Thyroid Single Plex


(Cat. No. RTHY-30K-TSH)
TSH

Human Endocrine
(Cat. No. HENDO-65K)
Amylin (active) Amylin (total) C-Peptide GLP-1 (active)
For Research Use Only.

FSH

Human IGF Binding Protein


(Cat. No. HIGFBP-53K)
IGFBP1
NEW!

Glucagon Insulin Leptin

Rat Pituitary
(Cat. No. RPT-86K) (Cat. No. RPTMAG-86K)
ACTH BDNF LH Prolactin TSH

IGFBP5 IGFBP6 IGFBP7

IGFBP2 IGFBP3 IGFBP4

Call for Availability * Coming Soon


n

FSH GH

Requires Sample Extraction Panel Only Premix Magnetic Bead Format

Cannot be plexed together: Amylin (active) and Amylin (total)

See our website for Single Plex and Premixed Kit catalogue numbers.

Metabolism
Mouse IGF Binding Protein
(Cat. No. MIGFBP-43K) (Cat. No. MIGFBPMAG-43K)
IGFBP1 IGFBP2 IGFBP3 IGFBP5 IGFBP6 IGFBP7

Bone Metabolism
METABoLISM / BoNE METABoLISM

Human Bone Panel 1A


Serum/plasma samples (Cat. No. HBN1A-51K)
ACTH Insulin Leptin OPG Osteocalcin Osteopontin PTH

Mouse Bone Panel 2B


Tissue culture samples (Cat. No. MBN2B-41K)
IL-6 ACTH Insulin Leptin Osteocalcin RANKL TNFa

Human Brain-Derived Protein


(Cat. No. HBDP-33K)
ACTH AGRP BDNF CNTF FSH GH LH Prolactin TSH

Human Bone Panel 1B


Tissue culture samples (Cat. No. HBN1B-51K)
IL-1b IL-6 ACTH Adiponectin OPG Osteocalcin Osteopontin PTH TNFa

Rat Bone Panel 1


(Cat. No. RBN1-31K)
ACTH Insulin Leptin OPG

Rat Bone Panel 2


(Cat. No. RBN2-31K)
ACTH Insulin Leptin RANKL

Single Plex Kits


Adiponectin (Mouse) Adiponectin (Rat) IGF-1 (Mouse/Rat) IGF-1 (Human)
n

Insulin IGF-1 (Human)*


n

Leptin

IGF-2 (Human)*n

Mouse Bone Panel 1A


Serum/plasma samples (Cat. No. MBN1A-41K)
IL-6 ACTH Insulin Leptin OPG TNFa

Rat Bone Panel 3


(Cat. No. RBN3-31K)
Osteocalcin Osteopontin PTH

Single Plex Bone Kits


OPG (Mouse, Rat) Osteocalcin (Mouse, Rat) RANKL (Human, Mouse, Rat)

Mouse Bone Panel 1B


Tissue culture samples (Cat. No. MBN1B-41K)
IL-6 ACTH Insulin Leptin OPG Osteocalcin TNFa

Mouse Bone Panel 2A


Serum/plasma samples (Cat. No. MBN2A-41K)
IL-6 ACTH Insulin Leptin RANKL TNFa

For Research Use Only.

* Coming Soon
n

Requires Sample Extraction Magnetic Bead Format See our website for Single Plex and Premixed Kit catalogue numbers.

Cardiovascular
Human CVD1
(Cat. No. HCVD1-67AK)
Adiponectin sE-Selectin slCAM-1 sVCAM-1

Cancer Biomarker
Rat CVD1
(Cat. No. RCVD1-89K)
IL-6 BNP MCP-1 MPO PAI-1 TNFa Troponin I Troponin T VEGF von Willebrand Factor

Human Circulating Cancer Biomarker Panel 1


Serum samples (Cat. No. HCCBP1MAG-58K)
IL-6 IL-8 AFP CA125 CA15-3 MIF Osteopontin Prolactin PSA (free) PSA (total) SCF SDF-1a+b/CXCL12 sFas sFasL TGFa TNFa TRAIL VEGF

CV D / C A NCER

MMP-9 MPO PAI-1 (total)

Human CVD2
(Acute phase proteins) (Cat. No. HCVD2-67BK)
CRP Serum Amyloid A Serum Amyloid P

TIMP-1

Rat CVD2
(Cat. No. RCVD2-89K)
sE-Selectin sICAM-1

CA19-9 CEA CYFRA21-1 FGF2/bFGF HCGb

Human CVD3
(Cat. No. HCVD3-67CK)
IL-1b IL-6 IL-8 IL-10 IFN MCP-1 NT-proBNP TNFa VEGF

Rat CVD3
(Cat. No. RCVD3-89K)
Adiponectin Fibrinogen

He4 HGF Leptin

Single Plex CVD Kits


Fibrinogen (Human) Haptoglobin (Human) CRP (Rat/Mouse) Apo CII Apo CIII Apo e

Human Circulating Cancer Biomarker Panel 2


(Cat. No. HCCBP2MAG-58K) NEW!
Antithrombin III Coagulation factor XIII Complement factor H (CFH) Extracellular matrix protein 1 (ECM1) Vitamin D binding protein Vitronectin

Human Apolipoproteins
(Cat. No. APO-62K)
Apo AI Apo AII Apo B

Mouse CVD1
(Cat. No. MCVD1-77AK)
MMP-9 PAI-1 (total) sE-Selectin slCAM-1 sVCAM-1

Human Cancer Biomarker


(Cat. No. 48-020)
CA-125 IGF-II Leptin MIF Osteopontin Prolactin

Mouse CVD2
(Cat. No. MCVD277BK)
Adiponectin Apo AI Apo e Fibrinogen

For Research Use Only.

* Coming Soon
n

Requires Sample Extraction Magnetic Bead Format

Cannot be plexed together: 1) PSA (free) and PSA (total) 2) CA19-9 and SDF-1a+b/CXCL12

See our website for Single Plex and Premixed Kit catalogue numbers.

Cancer Biomarker
Human Angiogenesis/ Growth Factor
MB Format Coming Soon*
Angiopoietin-2 BMP-9 EGF Endoglin Endothelin-1 FGF-1/FGF-acidic FGF-2/FGF-basic Follistatin G-CSF HB-EGF HGF IL-8 Leptin PLGF VEGF-A VEGF-C VEGF-D

Neuroscience
Human Neurodegenerative Disease Panel 2
(Cat. No. HNDG2-36K)
Complement C4 CRP SAP MIP-4 PEDF a1-Antitrypsin

Toxicity
C A NCER / NEU RoSCI ENCE / ToX I C I T Y

Human Kidney Toxicity Panel 1


Serum samples (Cat. No. HKTX1-38K) (Cat. No. HKTX1MAG-38K)
KIM-1 Osteopontin Renin TFF-3

Human Neurodegenerative Disease Panel 3


(Cat. No. HNDG3-36K)
BDNF Cathepsin D MPO PAI-1 (total) PDGF-AA PDGF-AB/BB RANTES sICAM-1 sNCAM sVCAM-1

Human Kidney Toxicity Panel 2


Serum samples (Cat. No. HKTX2-38K) (Cat. No. HKTX2MAG-38K)
b-2-Microglobulin Clusterin Cystatin C

Neuroscience
Human Neuropeptide
n

Human Neurodegenerative Disease Panel 4


(Cat. No. HNDG4-36K)
S100B Ab1-40 Ab1-42 GDNF sRAGE

Human Kidney Toxicity Panel 3


Urine samples (Cat. No. HKTX3-38K) (Cat. No. HKTX3MAG-38K)
KIM-1 Renin

(Cat. No. HNP-35K) (Cat. No. HNPMAG-35K) NEW!


a-MSH b-Endorphin Cortisol melatonin Neurotensin Orexin A Oxytocin Substance P

Human Neurological Disorders Panel 1*


n

TFF-3

Mouse/Rat Neuropeptide
(Cat. No. RMNPMAG-83K) NEW!
a-MSH b-Endorphin Cortisol melatonin Neurotensin Orexin A Oxytocin Substance P

BDNF GFAP mBP NGF-b

NSE PARK5/UCHL1 PARK7/DJ1

Human Kidney Toxicity Panel 4


Urine samples (Cat. No. HKTX4-38K) (Cat. No. HKTX4MAG-38K
Albumin b-2-Microglobulin Clusterin Cystatin C Osteopontin

Human Neurological Disorders Panel 2


MB Format Coming Soon*
AGP Ceruloplasmin Haptoglobin SAP

Human Neurodegenerative Disease Panel 1


(Cat. No. HNDG1-36K)
a2-Macroglobulin Apo AI Apo CIII Apo e Complement C3 Complement Factor H Prealbumin

Rat Kidney Toxicity Panel 1


(Cat. No. RKTX1-37K)
Clusterin Osteopontin KIM-1

Human Neurodisorders Panel 3


MB Format Coming Soon*
a-Synuclein NFH NFL Tau (Thr231) Tau (total)

Rat Kidney Toxicity Panel 2


(Cat. No. RKTX2-37K)
Albumin b-2-Microglobulin

For Research Use Only.

* Coming Soon
n

Cystatin C

Requires Sample Extraction Magnetic Bead Format

Inflammation / Immunology
I N F L A M M ATI o N / I M M U No Lo gY

Human Cytokine/ Chemokine Panel I


(Cat. No. MPXHCYTO-60K) (Cat. No. HCYTOMAG-60K)
IL-1a IL-1b IL-1ra IL-2 sIL-2Ra IL-3 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 IL-10 IL-12 (p40) IL-12 (p70) IL-13 IL-15 IL-17A sCD40L EGF Eotaxin FGF-2 Flt-3 ligand Fractalkine G-CSF GM-CSF GRO IFNa2 IFN IP-10 MCP-1/CCL2/MCAF MCP-3/CCL7 MDC/CCL22 MIP-1a MIP-1b PDGF-AA PDGF-AB/BB RANTES TGFa TNFa TNFb VEGF

Human Cytokine/ Chemokine Panel II


(Cat. No. MPXHCYP2-62K) (Cat. No. HCYP2MAG-62K)
IL-16 IL-20 IL-21 IL-23 IL-28a IL-33/NF-HEV (mature) 6Ckine/CCL21 BCA-1/CXCL13 CTACK/CCL27 ENA-78/CXCL5 Eotaxin-2/CCL24/MPIF-2 Eotaxin-3/CCL26 I-309/CCL1 LIF MCP-2 MCP-4 MIP-1d (MIP-5/CCL15) SCF SDF-1a+b/CXCL12 TARC/CCL17 TPO TRAIL/TNFSF10 TSLP

Human High Sensitivity Cytokine/Chemokine


(Cat. No. HSCYTO-60SK) (Cat. No. HSCYTMAG-60SK)
IL-1b IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-10 IL-12 (p70) IL-13 GM-CSF IFN TNFa

Human Soluble Cytokine Recepter


(Cat. No. HSCR-32K)
sCD30 sEGFR sgp130 sIL-1RI sIL-1RII sIL-2Ra sIL-4R sIL-6R sRAGE sTNF RI sTNF RII sVEGF R1 sVEGF R2 sVEGF R3

Human MMP 1
(Cat. No. HMMP1-55K)
MMP-3 MMP-12 MMP-13

Human Cytokine/ Chemokine Panel III


(Cat. No. MPXHCYP3-63K) (Cat. No. HCYP3MAG-63K)
IL-11 IL-29/IFN2 HCC-1/CCL14a I-TAC/CXCL11 LIX/CXCL6/GCP-2 Lymphotactin M-CSF MIG/CXCL9 MIP-3a/CCL20 MIP-3b/CCL19 NAP-2/CXCL7

Human MMP 2
(Cat. No. HMMP2-55K)
MMP-1 MMP-2 MMP-7 MMP-9 MMP-10

For Research Use Only.

Magnetic Bead Format Cannot be plexed with other analytes in serum/plasma: 1) PDGF-AA. PDGF-AB/BB and RANTES 2) HCC-1/CCL14a and NAP-2/CXCL7

10

See our website for Single Plex and Premixed Kit catalogue numbers.

Inflammation / Immunology
I NF L A M M ATI o N / I M M U No Lo gY

Human TIMP 1
Serum samples (Cat. No. HTIMP1-54K)
TIMP-1 TIMP-2

Non-human Primate Cytokine/Chemokine


(Cat. No. MPXPRCYTO-40K) (Cat. No. PRCYTOMAG-40K)
IL-1b IL-1ra IL-18 sCD40L G-CSF GM-CSF IFN MCP-1/CCL2/MCAF MIP-1a MIP-1b TGFa TNFa VEGF

Mouse Cytokine/ Chemokine Panel II


(Cat. No. MPXMCYP2-73K) (Cat. No. MCYP2MAG-73K)
IL-16 IL-21 IL-22 IL-25/IL-17E IL-28B EPO Exodus-2 Fractalkine MCP-5 MIP-3a MIP-3b TARC

Human TIMP 2
Cell culture samples (Cat. No. HTIMP2-54K)
TIMP-1 TIMP-2 TIMP-3 TIMP-4

IL-2 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12/23 (p40) IL-13 IL-15 IL-17A

Human Sepsis 1
(Cat. No. HSEP-63K)
MIF PAI-1 (total) sFas sFasL sICAM-1 sVCAM-1

Mouse Cytokine/ Chemokine Panel III


(Cat. No. MPXMCYP3-74K) (Cat. No. MCYP3MAG-74K)
IL-20 IL-23 IL-27 IL-33 MDC TIMP-1

Human Sepsis 2*
IL-1a IL-8 Granzyme B HSP70 MIP-1a MIP-1b MMP-8

Mouse Cytokine/ Chemokine Panel I


(Cat. No. MPXMCYTO-70K) (Cat. No. MCYTOMAG-70K) NEW!
IL-1a IL-1b IL-2 G-CSF GM-CSF IFN IP-10 KC LIF LIX MCP-1/CCL2/MCAF M-CSF MIG MIP-1a MIP-1b MIP-2 RANTES TNFa VEGF

Mouse Soluble Cytokine Receptor


(Cat. No. MSCR-42K)
sCD30 sgp130 sIL-1RI sIL-1RII sIL-2Ra sIL-4R sIL-6R sRAGE sTNF RI sTNF RII sVEGF R1 sVEGF R2 sVEGF R3

Human Sepsis Panel 3*


Lipocalin-1 Thrombospondin-1 (TSP-1) Lactotransferrin (LTF) Neutrophil Elastase-2 (ELA2) Resistin

IL-3 IL-4 IL-5 IL-6 IL-7 IL-9 IL-10 IL-12 (p40) IL-12 (p70) IL-13 IL-15 IL-17A Eotaxin

For Research Use Only.

* Coming Soon Magnetic Bead Format See our website for Single Plex and Premixed Kit catalogue numbers.

11

I N F L A MMAT I o N / I M M U No Lo gY / S KIN / I SoT Y PINg

Inflammation / Immunology
Rat Cytokine/Chemokine
(Cat. No. RCYTO-80K) (Cat. No. RCYTOMAG-80K)
IL-1a IL-1b IL-2 IL-4 IL-5 IL-6 IL-10 IL-12 (p70) IL-13 IL-17A IL-18 Eotaxin G-CSF GM-CSF GRO/KC IFN IP-10 Leptin MCP-1/CCL2/MCAF MIP-1a RANTES TNFa VEGF

Skin
Human Skin
(Cat. No. SKIN-50K)
Cortisol Fibronectin Human Serum Albumin (HSA) Involucrin LPS Keratin-6 Keratin-1,10

Isotyping
Human Immunoglobulin Isotyping
(Cat. No. HGAM-301) (Cat. No. HGAMMAG-301K)
IgA IgG1 IgG2 IgG3 IgG4 IgM

Mouse Immunoglobulin Isotyping


(Cat. No. MGAM-300) (Cat. No. MGAMMAG-300K) NEW!
IgA IgG1 IgG2a IgG2b IgG3 IgM

Canine Cytokine/Chemokine
(Cat. No. CCYTO-90K) (Cat. No. CCYTOMAG-90K) NEW!
IL-2 IL-4 IL-6 IL-7 IL-8 IL-10 IL-15 IL-18 GM-CSF IFN IP-10 KC-like MCP-1/CCL2/MCAF TNFa

Rat Immunoglobulin Isotyping


(Cat. No. RGAMMAG-302K)
IgG1 IgG2a IgG2b IgG2c IgA IgE IgM

Single Plex IgE


IgE (Human) IgE (Mouse)

Multi-species TGFb 1-plex


(Cat. No. TGFB-64K-01)
TGFb1

Multi-species TGFb 3-plex


(Cat. No. TGFB-64K-03)
TGFb1 TGFb2 TGFb3

For Research Use Only.

*Coming Soon

Call for availability in the magnetic bead panel. Panel Only Premix Magnetic Bead Format See our website for Single Plex and Premixed Kit catalogue numbers.

12

Cell Signaling & Phosphoprotein Detection


New Challenges, Faster Answers
Multiplexing, using the Luminex xMAP platform, provides faster answers to these cell signaling questions compared to traditional Western blots, mass spectrometry analysis, and radioactive phosphorylation assays that require large amounts of sample. EMD Millipore is proud to provide you with three MILLIPLEX map cell signaling portfolios based on the Luminex xMAP platform.

MILLIPLEX map Traditional Cell Signaling Assays


Our traditional cell signaling kits and MAPmates offer you the ability to: Measure multiple total or phosphorylated proteins along a signaling pathway, in a single sample Simultaneously measure sites in multiple pathways Conduct all necessary measurements using minimal sample volume Choose from analytically validated kits or design your custom assay with our MAPmates MI L L I PL EX m a p C EL L SI gN AL INg

MILLIPLEX map Cellular Metabolism Assays MILLIPLEX map Cell Signaling Assays MILLIPLEX map EpiQuant Cell Signaling Assays

Cellular Metabolism Assays


Introducing EMD Millipore's newest product portfolio for the Luminex xMAP platform, Cellular Metabolism. These panels will enable you to: Measure analytes within the panels in small sample sizes of cell lysate or tissue extract. Examine intracellular pathways regulating cellular metabolism and energy production Facilitate research areas such as mitochondrial dysfunction and toxicity, metabolic disorders, neurological disorders, cancer and aging.

MILLIPLEX map EpiQuant Assays


Introducing EpiQuant technology as part of the MILLIPLEX map portfolio. The union of two powerful technologiesEMD Millipores EpiQuant technology and the Luminex xMAP platform provides you with the most advanced quantitative cell signaling assays. Answering the challenges of multiplex cell signaling, MILLIPLEX map EpiQuant panels enable you to: Obtain quantitative results at picomolar sensitivities Measure phosphorylation concentrations of multiple sites on the same protein all in one well Measure both total and phospho-protein
For Research Use Only.

all in the same well Customize your assay by selecting analytes you want to study millipore.com/analytes_Q3 Design small- or large-plexed panels with ease
13

Cellular Metabolism Assays


Multispecies Pyrvate Dehydrogenase (PDH)
MB Format Coming Soon*
Analyte PDH PDH PDH PDH Total 3 (Ser232) (Ser293) (Ser300) Phosphorylated

Human Fatty Acid Oxidation Panel 1


CELL SIgNALINg CELLULAR METABoLISM
MB Format Coming Soon*
Analyte Acetyl-CoA acyltransferase 2 (ACAA2) Peroxisomal bifunctional enzyme (LPBE/ECHD) Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) Mitochondrial trifunctional protein (HADHA / HADHB (TFP)

Human Fatty Acid Oxidation Panel 2


MB Format Coming Soon*
Analyte Carnitine palmitoyltransferase 2 (CPT2) 2,4-dienoyl-CoA reductase (DECR1) Electron transfer flavoprotein, mitochondrial (ETF) Medium-chain acyl-CoA dehydrogenase (MCAD) Peroxisomal multifunctional enzyme 2 (MFE2)

For Research Use Only.

14

Cell Signaling/Phosphoprotein Detection


Human Multi-Pathway - 8 Plex
(Cat. No. 48-680)
Analyte CREB Erk/MAPK 1/2 IBa JNK p38 p70 S6 Kinase STAT3 STAT5A/B Total Phosphorylated 3 (Ser133) 3 (Thr185/Tyr187) 3 (Ser32) 3 (Thr183/Tyr185) 3 (Thr180/Tyr182) 3 (Thr412) 3 (Ser727) 3 (Tyr694/699)

Human SRC Family Kinase - 8 Plex


(Cat. No. 48-650)
Analyte Blk Fgr Fyn Hck Lck Lyn Src Yes Total Phosphorylated 3 (pan Tyr) 3 (pan Tyr)

C ELL S I g NA L I Ng / PH o SPHo PRoT EIN DET ECT IoN

3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr)

Human T Cell Receptor - 7 Plex


(Cat. No. 48-690)
Analyte CD3e CREB Erk/MAPK 1/2 LAT Lck Syk ZAP-70 Total Phosphorylated 3 (pan Tyr) 3 (Ser133) 3 (Thr185/Tyr187) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr)

Human Akt / mTOR - 11 Plex


(Cat. No. 48-611) (Cat. No. 48-611MAG) NEW!
Analyte Akt GSK3a GSK3b IGF1R IR IRS1 mTOR p70 S6 Kinase PTEN RPS6 TSC2 Total Phosphorylated 3 (Ser473) 3 (Ser21) 3 (Ser9) 3 (Tyr1135/1136) 3 (Tyr1162/1163) 3 (Ser312) 3 (Ser2448) 3 (Thr412) 3 (Ser380) 3 (Ser235/236) 3 (Ser939)

Human Apoptosis - 3 Plex


(Cat. No. 48-670)
Analyte Active Caspase 3 Active Cleaved PARP GAPDH Total 3 3 3 Phosphorylated

Human Total Akt/mTOR - 11 Plex


(Cat. No. 48-612MAG) NEW!
Analyte Akt GSK3a GSK3b IGF1R IR IRS1 mTOR p70S6 Kinase PTEN RPS6 TSC2 Total 3 3 3 3 3 3 3 3 3 3 3
For Research Use Only.

Human MAPK/SAPK - 10 Plex


(Cat. No. 48-660)
Analyte ATF2 ErK/MAPK 1/2 HSP27 JNK c-Jun MEK1 MSK1 p38 (SAPK2A/B) p53 STAT1 Total Phosphorylated 3 (Thr69/71) 3 (Thr185/Tyr187) 3 (Ser78) 3 (Thr183/Tyr185) 3 (Ser73) 3 (Ser222) 3 (Ser212) 3 (Thr180/Tyr182) 3 (Ser15) 3 (Tyr707)

Phosphorylated

Magnetic Bead Format

15

Cell Signaling/Phosphoprotein Detection


Human STAT - 5 Plex
(Cat. No. 48-610)
Analyte STAT1 STAT2 Total Phosphorylated 3 (Tyr701) 3 (Tyr690) 3 (Tyr705) 3 (Tyr694/699) 3 (Tyr641)

The following MAPmates should not be plexed together: MAPmates that require a different assay buffer Phosphospecific and total MAPmate pairs, e.g. total GSK3b and GSK3b (Ser 9) Pan Tyr and site-specific MAPmates, e.g. PhosphoEGF Receptor and HSP27 (Ser78) More than 1 phospho-MAPmate for a single target (Akt, STAT3, p53, Lyn, Src, Rb)

C EL L S I g N AL INg / PHo SPH oPRoT EI N DETECTI o N

STAT3 STAT5A/B STAT6

Buffer & Detection Kit

(Cat. No. 48-602)

Required to run all MAPmate assays.

MAPmates
Analyte Akt/PKB (assay buffer 1) Akt/PKB (assay buffer 1) Akt/PKB (assay buffer 2) ATF2 BAD Active Caspase 3 CREB EGF-Receptor Erb-B2/HER2 Erk/MAPK 1/2 GSK3b H2A.X HIF-1a HSP27 IGF1R IBa IR IRS1 JNK c-Jun c-Kit Lck Lck Lyn c-Met/HGFR MEK1 MSK1 3 3 3 3 3 3 3 3 3 3 (Ser78) 3 (PanTyr) 3 (Ser32) 3 (Tyr1162/1163) 3 (PanTyr) 3 (Thr183/Tyr185) 3 (Ser73) 3 (PanTyr) 3 (PanTyr) 3 (Tyr394) 3 3 3 3 3 (Tyr397) 3 (PanTyr) 3 (Ser222) 3 (Ser212) 3 3 3 3 3 3 3 3 3 3 (Ser133) 3 (PanTyr) 3 (PanTyr) 3 (Thr185/Tyr187) 3 (Ser9) 3 (Ser139) Total 3 Phosphorylated 3 (Ser473) 3 (Thr308) 3 (Ser473) 3 (Thr69/71) 3 (Ser112) Analyte mTOR NFB p21 p38 (SAPK2A/B) p53 p53 p70 S6 Kinase Cleaved PARP PDGF Receptor a PDGF Receptor b PRAS40 PTEN Rb Rb Rb Rsk1 Src Src STAT1 STAT2 STAT3 STAT3 STAT5A/B STAT6 ZAP-70 GAPDH 3 (Human) 3 3 3 3 3 3 3 3 3 3 (PanTyr) 3 (PanTyr, mouse) 3 (Thr246) 3 (Ser380) 3 (Thr826) 3 (Thr252) 3 (Ser811) 3 (Ser380) 3 (Tyr419) 3 (Tyr530) 3 (Tyr701) 3 (Tyr690) 3 (Tyr705) 3 (Ser727) 3 (Tyr694/699) 3 (Tyr641) 3 (PanTyr) Total 3 3 3 3 3 3 (Thr180/Tyr182) 3 (Ser15) 3 (Ser46) 3 (Thr412) Phosphorylated 3 (Ser2448) 3 (Ser536)

For Research Use Only.

16

Magnetic Bead Format

MILLIPLEX

map

EpiQuant

Sample Preparation Kit


(Cat. No. MPEQ-SP)
A sample prep kit containing all the reagents you need to prepare up to 5 mL of sample lysates, including: Cell lysis Protein denaturing Protein fragmentation Required to run EpiQuant multiplex assays

EGFR Signaling Pathway Panel


(Cat. No. MPEQMAG-110K)
CSK (Tyr304) EgFR/HER1 Total EGFR/HER1 (Tyr1069/1092) EGFR/HER1 (Tyr1110/1125) ErbB2/HER2 (Tyr1023) ErbB3/HER3 (Tyr1197/1199/1262/1276/1298/1307) ERK 1/2 (Tyr204/187) FAK (Tyr397/407) FAK (Tyr861) FRS2 (Tyr436) Gab1 (Tyr285/307/317) Gab2 (Tyr266) Gab2 (Tyr584) Gab2 (Tyr614) PI3Kp110 (Tyr485) PKC (Tyr502) PLC1 (Tyr1253) PLC2 (Tyr1192-1217) Shc (Tyr349/350) SPRY2 (Tyr55) STAT3 (Tyr705) TAFII68 Total (loading control)

MI L L I PL EX
map

E PI Q UAN T

Phosphotyrosine Cell Signaling Panel 1


(Cat. No. MPEQ-100K)
Cbl (Tyr700/731/774) Crk (Tyr221/239) CUB domain containing protein 1 (Tyr734) EGFR (Tyr1110/1125) Ezrin (Tyr477) FAK (Tyr397/407) FAK (Tyr861) FRS2 (Tyr436) Fyb (Tyr97/651) Gab1 (Tyr285/307/317) Gab2 (Tyr266) Gab2 (Tyr584) Growth hormone receptor (Tyr566) HER2 (Tyr1023) HGFR (Tyr1003) IL-15Ra chain (Tyr227) IRS1 (Tyr612) ITK (Tyr180) JAK3 (Tyr785) JNK 1/2/3 (Tyr185/185/223)
Magnetic Bead Format

LAT (Tyr255) p38/MAPKa (Tyr181) PDK1 (Tyr373/376) PI3K p110 (Tyr485) Plakoglobin/-catenin (Tyr548) PLC1 (Tyr1253) PLC2 (Tyr1197/1217) Raf-1 (Tyr340/341) Rap GEF1/GRF2 (Tyr504) SCF38 (Tyr20) SH2 domain containing protein 3A (Tyr231) SH2 domain containing protein 3A (Tyr95) Shc (Tyr349/350) SPTAN1 (Tyr1176) STAT3 (Tyr705) Transferrin Receptor (Tyr20) Tyrosine Protein Kinase Tec (Tyr206) VEGFR1 (Tyr1169) WASP (Tyr291) ZAP70 (Tyr126)
For Research Use Only.

17

MILLIPLEX

map

EpiQuant

Phosphotyrosine Cell Signaling Panel 2*


AXL (Tyr772) AXL (Tyr859) Eph A1 (Tyr930) EPOR (Tyr426) FRK (Tyr46/53) FYB (Tyr755/757) GHR (Tyr487) LSR (Tyr615/616) PDGFRb(tYR63/71/75) PSTPIP1 (Tyr344) Rai-like protein (Tyr424) Rai-like protein (Tyr465) RET (Tyr1062/1090/1096) RET (Tyr826) Ron/MSP-R (Tyr1353-1360) SYK (Tyr629/630) Vanilloid receptor-like channel 2 (Tyr411) Vav1 (Tyr142/160/174)

E PI Q UA N T

GSK3a/b (Tyr 279/216) Heterogeneous nuclear ribonucleoprotein (Tyr72) Kit/SCFR (Tyr545) Kit/SCFR (Tyr936) LSR (Tyr406/407)

MIL L IPL EX

map

Phosphothreonine Cell Signaling Panel 1


AKT1 substrate 1 (Thr246) CAM kinase 1a (ThrT177) CAMKKa (Thr108) CDC34 (Thr233) ERa (Thr311)

NEW!

IRS1 (Thr88) NFB1 (Thr931) Occludin (Thr404) Period circadian protein 3 (Thr635) PKCe (Thyr566) Myt1 (Thr495) Ser/Thr protein kinase N (Thr780)

Glutamine dependent carbamoylphosphate synthase (Thr1037) IBa (Thr291) IKKa (Thr23)

For Research Use Only.

* Coming Soon

18

Magnetic Bead Format

Instrumentation & Software


As a Luminex partner, EMD Millipore is a distributor of Luminex instruments, accessories and software. We were there at the beginning to help validate Luminex as a standard of multiplexing, and our ongoing dedication and experience in this technology enable you to gain more information faster, without compromising reliability. Visit our website for more information on the following technology.

NEW!

MAgPIX System
(Cat. No. 40-042 - MAGPIX) (Cat. No. 40-043 - MAGPIX with MILLIPLEX Analyst Software)

Combined with our MILLIPLEX map magnetic bead-based multi-analyte panels, analysis software and technical support, the new Luminex MAGPIX system provides a complete solution for rapid, accurate biomarker quantitation in a variety of sample matrices. This affordable system can perform up to 50 tests simultaneously in a single reaction volume, greatly reducing sample input, reagents and labor while improving productivity. The MAGPIX system features an innovative design based on CCD imaging technology that enables for a more compact, robust system. In addition, it is easy to operate and maintain with streamlined start-up and shutdown protocols and minimal maintenance requirements. INSTRUMENTATIoN / SoFTWARE
For Research Use Only.

millipore.com/analytes_Q3
19

Luminex 200 System


(Cat No. 40-012- MILLIPLEX Analyzer) (Cat No. 40-013 - MILLIPLEX Analyzer with MILLIPLEX Analyst Software)

MILLIPLEX Analyzer, the Luminex 200 System, is a compact lab analysis system that integrates lasers, optics, fluidics, a controller, advanced digital signal processing, an XY Platform, the newest version analysis software, and a PC with monitor. Specifically designed to enhance the use of xMAP technology, this system enables simultaneous assays of up to 100 analytes per well of a microtiter plate. Key features include: flexible data analysis package, user friendly functions, flexible assay design features, bar code reader for enhanced efficiency and multiple formats for generating data reports.

MILLIPLEX Analyst Software


(Cat. No. 40-266 - For a single computer) (Cat. No. 40-265 - For three computers)

Data Analysis Software, MILLIPLEX Analyst, developed exclusively for EMD Millipore by VigeneTech, provides a whole new level of data analysis, incorporating tried-and-true algorithms to provide the performance you need, even when faced with the most challenging multiplexing data sets. Also included are report formats and enhanced presentation features that youve requested to display your information clearly and accurately.

Luminex FLEXMAP 3D System


(Cat. No. 40-014 - FLEXMAP 3D) (Cat. No. 40-022 - FLEXMAP 3D with MILLIPLEX Analyst Software)

The FLEXMAP 3D system combines differentially dyed fluorescent microsphere sets with an innovative instrument design that can accommodate measuring the concentrations of up to 500 unique analytes within a single sample rapidly and precisely. Featuressuch as
For Research Use Only.

automated probe height adjustment, simplified routine maintenance operations and an intuitive software interfacemake FLEXMAP 3D a flexible and easy-to-use multiplexing.

20

NEW! ELx50/8M Microplate Strip Washer for 96-Well Biomagnetic Separation


(Cat. Nos. are based on power/power cord requirements. Please confirm with your sales representative which item will suit your needs.)

EMD Millipore, the leading provider of multiplex immunodetection kits, in partnership with BioTek, the world leader in microplate washing, now offers the new ELx50/8M microplate strip washer for biomagnetic separation and washing of MILLIPLEX map magnetic bead assays. The ELx50/8M Microplate Washer is a welcome upgrade from manual processing that brings to your lab an all inclusive wash solution with consistent performance and unattended operation.

MultiScreen HTS Filter Plates 96-well filter plates for sample isolation and purification
Cat. No. MABVN 1B50 (50-pk. opaque plates) Cat. No. MXPLATE (2-pk. opaque plate)

IN S T RUMEN TAT I o N / S o F T WARE

At every stage of the drug discovery process samples must be isolated, purified and prepared prior to testing. In today's fast paced environment, rapid, automated and simple sample preparation is a must. MultiScreen plates offer diverse and versatile formats for a variety of preparative methods.

Handheld Magnetic Separator Block for 96-Well Flat Bottom Plates or 96-Well Conical Well Plates
(Cat. No. 40-285)

The Handheld Magnetic Separator Block offers a low cost option for biomagnetic separation. Magnets are positioned around the bottom of the well to pull the beads to the side of the well. The top magnetic frame is white polycarbonate, with a corrosion resistant steel plate underneath, all
For Research Use Only.

mounted to a polypropylene base. An adjustable clip system holds a wide variety of microplates to the separator block, and an O-Ring on the base plate facilitates gripping.
21

Discovery & Development Solutions


Speed your time to discovery by leveraging our target profiling and clinical lab contract services that help you prioritize potential drug candidates, screen many biomarkers simultaneously, and conduct research and clinical studies.

BioPharma Services
Dedicated to large molecule bioanalysis Pharmacokinetics Analysis Tiered Immunogenicity Testing Biomarker Analytical Services cGMP Potency Assays Contact the BioPharma Services group serving your area and visit www.millipore.com/BioPharma for more information.

MILLIPLEX map Traditional Cell Signaling Assays


Results essential to your success Target Profiling Safety and Liability testing Pathway Analysis Contact the Lead Discovery Services team at: drugdiscovery@EMDMillipore.com, or visit www.millipore.com/LeadDiscovery.

North America
Phone: 1-800-645-5476 1-636-441-8400 Email: BioMarker_Services@millipore.com

NEW! SignalProfiler Services


SignalProfiler service employs MILLIPLEX MAPmates cell signaling kits to profile samples against a panel of 90+ immunoassays detecting modified and total proteins. Use this service to measure the effectiveness of kinase inhibitors and GPCR ligands by measuring changes in signaling cascades in relevant cell backgrounds. In addition, you can now study early signaling events leading to cellular toxicity to help assess potential compound liabilities in early stages of drug development.

Europe
Phone: +44-(0)-1235-444166 Email: Oxford_BMS_EU@millipore.com

For Research Use Only.

millipore.com/BioMarker_Services_Q3
22

Scepter 2.0 is Here!

The Next Generation of Automated Cell Counting

Scepter Features
Integrated Display Histogram data on cell populations Cell concentration, mean cell volume, and cell size Can apply custom gating Gain insight into cell health Handheld Pipette Compact, easy to use Ergonomic action feels like pipetting On-screen instructions Plastic Consumable Sensors Detect cells of varying size ranges with 2 sensor types Discriminate cell sizes with sub-micron resolution Discriminate cell volumes with sub-picoliter resolution

NEW Scepter Software Pro


Compare several samples and data sets side by side using histogram overlay and multiparametric tables Save and create gating methods to be used from one experiment to the next Create attractive graphical presentations and reports with your data For more information, please visit: www.millipore.com/CellularAnalysis

For Research Use Only.

23

easyCyte Benchtop Flow Cytometry

Multiplexed cellular analysis from 58 parameters


Flow cytometry delivers robust, high-content data in far less time than traditional methods by measuring multiple parameters on hundreds of cells per second. The compact guava easyCyte line brings this

These technologies offer you the ability to:


Run minimal sample volumes without sheath fluid using patented microcapillary technology Reliably load single samples or 96-well microplates with flexible instrument formats View up to 8 cellular parameters in real time for multiplexed analysis and easily compare different experiments Use optimized assays to remove the guesswork while expediting results

analytical power directly to the laboratory bench with its novel microcapillary technology enabling ease of use and lower sample and reagent costs. These instruments contain up to 2 lasers, and from 58 parameters and flexible formats for manual or automated walk-away loading. This complete end-to-end solution enables high quality results and includes validated reagents and full service support.

FlowCellect Kits
FlowCellect Kits are EMD Millipore's proprietary multiparameter flow cytometry kits for cellular analysis. Each kit has a unique combination of directly conjugated antibodies, and/or fluorescent dyes and protein reporters to monitor changes in protein expression and post translational modification. The kits also contain complete buffer sets, protocols and pre-definded gate settings. They are fully optimized for "plug-andplay" cellular analysis on guava and other cytometers. For a complete listing of kits visit: www.millipore.com/flowcytometry

For Research Use Only.

24

My Notes

25

Contact Us
In the U.S. and Canada, call toll-free 1 800-Millipore (1-800-645-5476) In Europe, please call Customer Service: France: 0825 045 645 Germany: 01805 045 645 Italy: 848 845 645 Spain: 901 516 645 UK: 0870 900 46 45 For other countries across Europe, please call: +44 (0) 115 943 0840, or visit: www.millipore.com/offices For Technical Service, please visit www.millipore.com/techservice

Get Connected!
Join EMD Millipore Bioscience on your favorite social media outlet for the latest updates, news, products, innovations and contests! facebook.com/EMDMilliporeBioscience twitter.com/EMDMilliporeBio

www.emdmillipore.com

The M logo is a trademark of Merck KGaA, Darmstadt, Germany. guava, MILLIPLEX, MultiScreen and OxyELISA are registered trademarks of Millipore Corporation. ChemiKine, easyCyte, Epiquant, FlowCellect, Scepter, ToxReporter, MAPmates, and SignalProfiler are trademarks of Millipore Corporation. FLEXMAP 3D, Luminex, MAGPIX and xMAP are registered trademarks of Luminex Corporation. Luminex 200 is a trademark of Luminex Corporation. Biotek is a registered trademark of BioTek Insturments Vigene Tech is a trademark of Vigene Tech, Inc. Lit. No. PF1089EN00 (EMD) Rev. N 06/2011 LS-SBU-11-04066 2011 Millipore Corporation, Billerica, Massachusetts 01821 U.S.A. All Rights Reserved.

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