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  • Antigen Processing and Presentation

    Transféré par

    Kalpajit Banik
    32 vues5 pages
    Antigen processing involves the degradation of protein antigens into peptides by antigen-presenting cells, which then associate these peptides with MHC molecules and display them on their surface for recognition by T cells. T cells recognize antigens through a ternary complex of the T cell receptor, antigen peptide, and MHC molecule, while B cells recognize antigens through direct binding of membrane-bound immunoglobulin. Thymus-dependent antigens are soluble proteins that induce affinity maturation, isotype switching, and immunological memory, while thymus-independent antigens are bacterial cell wall components or polysaccharides that induce a polyclonal response without memory.

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    Antigen processing involves the degradation of protein antigens into peptides by antigen-presenting cells, which then associate these peptides with MHC molecules and display them on their surface for recognition by T cells. T cells recognize antigens through a ternary complex of the T cell receptor, antigen peptide, and MHC molecule, while B cells recognize antigens through direct binding of membrane-bound immunoglobulin. Thymus-dependent antigens are soluble proteins that induce affinity maturation, isotype switching, and immunological memory, while thymus-independent antigens are bacterial cell wall components or polysaccharides that induce a polyclonal response without memory.

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    32 vues5 pages

    Antigen Processing and Presentation

    Transféré par

    Kalpajit Banik
    Antigen processing involves the degradation of protein antigens into peptides by antigen-presenting cells, which then associate these peptides with MHC molecules and display them on their surface for recognition by T cells. T cells recognize antigens through a ternary complex of the T cell receptor, antigen peptide, and MHC molecule, while B cells recognize antigens through direct binding of membrane-bound immunoglobulin. Thymus-dependent antigens are soluble proteins that induce affinity maturation, isotype switching, and immunological memory, while thymus-independent antigens are bacterial cell wall components or polysaccharides that induce a polyclonal response without memory.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 5

    Antigen Processing & Presentation

    Degradation of protein antigen into peptides by a sequence of events called Antigen Processing . Association of degraded peptides with MHC molecules & display on the cell surface for recognition by T cells is Ag presentation.

    Ag recognition by T cells & B cells


    Characteristic Interaction with Antigen Binding of soluble Ag Involvement of MHC molecules Chemical nature of antigens Epitope properties B cells Binary complex of membrane Ig & Ag Yes Not required Protein, Polysaccharide, Lipid T cells Ternary complex of TCR, Ag & MHC No Required to display the processed antigen Mostly protein.

    Accessible ,hydrophobic, Linear peptides produced mobile peptide containing by processing of Ag & bound to MHC molecules sequential or Nonsequential amino acid.

    Properties of TD & TI Antigens


    TI Antigen Property Chemical nature TD Antigen Soluble protein Type 1 Bacterial Cell wall components (LPS) Type 2 Polymeric protein Ag, Capsular polysaccharides

    Humoral Response

    Isotype switching
    Affinity maturation Immunological memory Polyclonal activation

    Yes
    Yes Yes No

    No
    No No Yes ( High doses)

    Limited
    No No No

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