relationships between these B-vitamins and the prevention of or treatment of dementia, including Alzheimers disease (AD).

A recent study showed folate deficiency alone may precede AD and vascular dementia onset,6 with another supporting that folate and B12 are clearly associated with the development of AD7. TECHNICAL SUMMARY SHEET Brain Support Softgels (VL153) Indications Brain Support Softgels has the following benefits: Promotes healthy circulation Provides antioxidant protection May keep homocysteine levels in check Brain Health Background & Application A healthy brain is maintained in part by a healthy diet. Mental stimulation, exercise and injury prevention also weigh in. All of these elements support healthy circulation to the brain in order for it to function well. Certain nutrients that may be lacking in the typical American diet influence blood flow to the brain and beyond. Research shows the important role some nutrients play in improving memory and cognition. Research Summaries Fish Oils It is well established that DHA is taken up by brain cells, especially important for prenatal and postnatal brain development. One study showed that intake of DHA and phosphatidylcholine improved mazelearning ability and brain function in both old and young mice1. Another showed that DHA acts as a precursor to neuroprotective signaling responses to ischemia-repurfusion, suggesting therapeutic use for stroke, neurotrauma, spinal cord injury, and neurodegenerative diseases2. Phosphatides Multiple clinical trials have been done using the trademarked SerinAid complex. Results from these show improvements in cognitive measures such as memory, mood, and behavior in both elderly and/or Alzheimers patients. In a majority of the trials, patients were given a placebo or 300mg of SerinAid daily for a range of 60-180 days3. Vitamins B6, B12, Folate B-vitamins play multiple roles in brain health. Deficiencies of these result in neurological pathologies, in part due to subsequent elevation of homocysteine levels4. Elevated homocysteine levels in the brain are neurotoxic and have negative vascular effects5. A number of studies show Ginkgo Biloba The Journal of the American Medical Association published results of a 52-week study utilizing ginkgo showing improvements in mental performance in about 1/3 of AD patients studied8. Another showed that supplementation with 80 mg of ginkgo three times daily for three months showed improvements in memory, attention, and psychomotor performance in AD patients compared to placebo after one month9. Our Product Our product contains 300 mg EPA, 200 mg DHA, 120 mg Ginkgo biloba, 100 mg SerinAid phosphatidylserine complex, phosphatidylcholine, inositol, rosemary, vitamins B6, B12 and folate, and vitamin E. Dosage Take one softgel twice daily. Specifications Product Name: Label Claim: How Supplied: Drop Count: Product Code: References
1. Lim SY, et al. Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice. 2000;130:1629-1632. Journal of Nutrition. Bazan NG. Neuroprotectin D1 (NPD1):a DHA-derived mediator that protects brain and retina against cell injuryinduced oxidative stress. Apr 2005;15(2):159-66. Brain Pathology For all SerinAid abstracts, see: www.cheminutra.com/research.html The Physicians Desk Reference for Nutritional Supplements, 2001. Medical Economics Company, Inc. Montvale, NJ. Garcia A, et al. Homocysteine and cognitive function in elderly people. Oct 2004;171(8) Can Med Assoc Jour Quandri P, et al. Homocysteine, folate, and vitamin B12 in mild cognitive impairment, Alzheimer disease and vascular dementia. 2004;80:114-22 Amer Jour Clin Nutr Wang BA, et al. Vitamin B12 and folate in relation to the development of AD. 2001;56:1188-1194 Neurology LeBar PL, et al. A placebo-controlled, double-blind, randomized trial of an extract of ginkgo biloba for dementia. 1997;278(16):1327-1333 Jour Amer Med Assoc. Hofferberth B. The efficacy of Egb761 in patients with senile dementia of the AD type, a double-blind, placebo-controlled study n different levels of investigation.1994;9:215-22. Human Psychopharmacology Clinical and Experimental.

Brain Support Softgels Supports Brain Health Softgel capsule 60, 120 ct VL153

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