Clinical Medications Worksheets

Generic Name Trade Name Classification Dose Route Time/frequency

linezolid Zyvox anti-infectives,
oxazolidinones
Peak Onset Duration
End of infusion Rapid 12 hr
Why is your patient getting this medication
Complicated skin/skin structure infections caused by
Staphylococcus aureus (methicillin-susceptible and -resistant
strains), Uncomplicated skin/skin structure infections caused
by Staphylococcus aureus (methicillin-susceptible and
-resistant strains)
Mechanism of action and indications
(Why med ordered)
Inhibits bacterial protein synthesis at the level of the 23S
ribosome of the 50S subunit. Bactericidal action against
streptococci; bacteriostatic action against enterococci and
staphylococci.
Interactions with other patient drugs, OTC or herbal
medicines (ask patient specifically)
Xopenex: Patients should be closely monitored for blood
pressure and pulse rate changes during coadministration of
beta-adrenergic agonists with MAOIs or other agents that
possess MAOI activity (e.g., furazolidone, linezolid,
procarbazine). Preferably, at least 14 days should elapse
between discontinuation of MAOI therapy and initiation of
treatment with beta-adrenergic agonists.
Because of monoamine oxidase inhibitory properties,
consumption of large amounts of foods or beverages
containing tyramine should be avoided (↑ risk of pressor
response.)
Nursing Process- Assessment Assessment
(Pre-administration assessment) Why would you hold or not give this med?
Assess for infection (vital signs; appearance of recurrent nausea and vomiting, unexplained
wound, sputum, urine, and stool; WBC) at acidosis or low bicarbonate levels. If optic
beginning of and during therapy. Obtain neuropathy occurs therapy should be
specimens for culture and sensitivity prior to reconsidered
initiating therapy. First dose may be given before
receiving
600mg IV Q 12 hrs
Normal dosage range
600 mg every 12 hr for 14-28 days
RATE: Administer over 30-120 minutes.
For IV meds, compatibility with IV drips and/or solutions
Do not piggyback into other IV lines. Flush line before and after
infusion.
Y-Site Incompatibility: amphotericin B, chlorpromazine, diazepam,
pentamidine, phenytoin
Nursing Implications (what to focus on)
Contraindications/warnings/interactions
Hypersensitivity
Common side effects
PSEUDOMEMBRANOUS COLITIS
Lab value alterations caused by medicine
May cause bone marrow suppression, anemia, leukopenia,
pancytopenia. Monitor CBC and platelet count weekly, especially in
patients who are at risk for increased bleeding, who have pre-existing
bone marrow suppression, who receive concurrent medications that
may cause myelosuppression, or who may require >2 weeks of therapy.
Discontinue therapy if bone marrow suppression occurs or worsens.
May cause ↑ AST, ALT, LDH, alkaline phosphatase and BUN
Be sure to teach the patient the following about this medication
Advise patients taking oral linezolid to take as directed, for full course
of therapy, even if feeling better. Take missed doses as soon as
remembered unless almost time for next dose; do not double dose.
Instruct patient to avoid large quantities of foods or beverages
containing tyramine (May cause hypertensive response). Instruct
patient to notify health care professional if patient has a history of
hypertension and before patient takes other Rx, OTC, or herbal
products, especially cold remedies, decongestants, or antidepressants.
Advise patient to notify health care professional if no improvement is
seen in a few days.
Evaluation
Check after giving
Improvement of infection