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  • Animal Models To Test Vaccines (Harriet Robinson)

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    National Press Foundation
    29 vues10 pages
    Virus non-human primates The Exposure (Challenge) Regimen Single high dose Repeat Moderate Dose "laboratory" Rhesus macaque Bred in Primate Colonies Specific pathogen free (SPF) Genetically selected Randomized - control (placebo) group - Test group.

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    Animal Models to Test Vaccines (Harriet Robinson)

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    Virus non-human primates The Exposure (Challenge) Regimen Single high dose Repeat Moderate Dose "laboratory" Rhesus macaque Bred in Primate Colonies Specific pathogen free (SPF) Genetically selected Randomized - control (placebo) group - Test group.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    29 vues10 pages

    Animal Models To Test Vaccines (Harriet Robinson)

    Transféré par

    National Press Foundation
    Virus non-human primates The Exposure (Challenge) Regimen Single high dose Repeat Moderate Dose "laboratory" Rhesus macaque Bred in Primate Colonies Specific pathogen free (SPF) Genetically selected Randomized - control (placebo) group - Test group.

    Droits d'auteur :

    Attribution Non-Commercial (BY-NC)
    Téléchargez comme PDF, TXT ou lisez en ligne sur Scribd
    Signaler comme contenu inapproprié
    sur 10

    AnimalModelstoTest HIV/AIDSVaccines

    HarrietL.Robinson CSO,GeoVaxInc. Smyrna,GA

    TheVirus nonhumanprimates

    TheExposure(Challenge)Regimen
    Singlehighdose Repeatmoderatedose

    LaboratoryNonHumanPrimates
    Rhesusmacaque BredinPrimateColonies Specificpathogenfree(SPF) Geneticallyselected Randomized
    Control(placebo)group Testgroup Rhesusmacaque

    StatisticalPower
    Minimalsamplesizetodetect aneffectofagivensize

    ImportantCharacteristicsofChallengeVirus
    SequencerelationshiptoVaccine
    Homologous same Heterologous different

    Tropism(targetCD4cell)
    CCR5 memory,mucosalsurfaces CXCR4 nave,blood

    Neutralizationcharacteristics
    TheVirus
    SIV SHIV

    Tier1 easytoneutralize Tier2 hardtoneutralize Tier3 veryhardtoneutralize

    SIVorSHIV
    SIV naturalinfection SHIV laboratoryconstruct
    MostrepresentativeofHIVinfections

    Exposure(Challenge)Regimen
    Singlehighdose
    Intravenous Rectal Vaginal Penile Oral

    MultipleModeratedose
    Rectal Vaginal

    HighChallengeDose, RelativetoTypicalHumanInfections
    Single High Dose
    1.000

    SingleHighDoseChallenge
    Vaccinate Single, HighDose Challenge

    12

    months

    Veryhardtopreventinfection
    Monitorforcontrolofinfection PrimarilyCD8Tcellmediated (whitebloodcellsthatkillinfectedcells) Vaccineshaveachieved100to1000fold reductionsinlevelsofvirus

    ModerateChallengeDose

    Repeat Moderate Dose

    MultipleModerateDoseChallenge
    Vaccinate Multiple ModerateDose Challenges

    12

    months

    Canpreventinfection
    Monitorforinfection(acquisition) Primarilyantibodymediated (Antibodycanblockvirusbeforeitinfects) Vaccineshaveachievedupto70%prevention

    HandyGuidetoAcronyms
    Rhesusmacaquegenetics
    Mamutype affectssusceptibilitytocytolytic CD8Tcells TRIM5 type canlimit(restrict)infection

    Challengevirusdesignations
    TwomostwidelyusedSIVs
    SIVmac251 Tier3neutralization,noTRIMrestriction SIVsmE660 Tier2neutralization,TRIMrestriction

    TwomostwidelyusedSHIVs
    SHIV162P3 CCR5tropicSHIV,currentuse SHIV89.6P CXCR4tropic,usedinearlystudies

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