Final Sheet Win

SL. NO.
ACCESSION ID PROTEIN NAME
Q8IV10|Q8IV10_HUMAN
1 530 WD repeat domain 21A
WD repeat domain phosphoinositide-interacting
2 WIPI1_HUMAN 365 protein 1
3 Q3KQZ0_HUMAN 269 NUP214 protein

>Q86SY2| Full-length cDNA clone CS0DJ006YD20 of T cells
4 Q86SY2_HUMAN 513 (Jurkat cell line) of Homo sapiens
>Q86XD3|
5 Q86XD3_HUMAN 521 Nucleoporin 214kDa
Q9H6U6|BCAS3_HUMAN
6 690 Breast carcinoma-amplified sequence 3
Q8WV16|WD21 A_HUMAN
7 611 WD repeat-containing protein 21A
Q8NBB8|Q8NBB8_HUMAN
8 567 cDNA FLJ33743 fis, clone BRAWH2019055
Q8WVG2|
9 Q8WVG2_HUMAN 612 WDR37 protein
10 Q2MCP6_HUMAN WDR45-like protein
11 Q17RM0_HUMAN BCAS3 protein
Q8NBB8|Q8NBB8_HUMAN
12 567 cDNA FLJ33743 fis, clone BRAWH2019055
Q8NA75|WD21C_HUMAN
13 565 WD repeat-containing protein 21C
Q8IWG1|WDR63_HUMAN
14 536 WD repeat-containing protein 63
Q8WVS4|WDR60_HUMAN
16 WD40B_HUMAN 417 WD repeat-containing protein 40B
Q9H9M3|Q9H9M3_HUMAN
17 701 cDNA FLJ12657 fis, clone NT2RM4002140
18 Q5JB47_HUMAN 352 Achalasia variant

cDNA FLJ75315, highly similar to Homo sapiens
19 A8K988_HUMAN WD repeat domain 63, mRNA
20 A0AVI9_HUMAN WD repeat domain 78
21 DMWD_HUMAN Dystrophia myotonica WD repeat-containing protein

22 Q0VA87_HUMAN WDR90 protein
23 Q0VA88_HUMAN WDR90 protein
Q8TCJ8|Q8TCJ8_HUMAN
24 598 Putative uncharacterized protein DKFZp564C172
Q8WUA4|TF3C2_HUMAN
25 608 General transcription factor 3C polypeptide 2
Q8IUW4|Q8IUW4_HUMAN
26 529 DNAI2 protein
27 PWP1_HUMAN Periodic tryptophan protein 1 homolog
Q8NCK5|Q8NCK5_HUMAN
28 572 cDNA FLJ90195 fis, clone MAMMA1001310
Q9BQ67|GRWD1_HUMAN
29 660
Q9UI46|DNAI1_HUMAN Glutamate-rich WD repeat-containing protein 1
30 746 Dynein intermediate chain 1, axonemal
31 A8K3R6_HUMAN PWP1 homolog (S. cerevisiae) (PWP1), mRNA
32 A0MNN5_HUMAN CDW4/GRWD1
WD repeat domain 78 (WDR78), transcript variant
33 A8K9W5_HUMAN 1, mRNA
34 DC1I1_HUMAN Cytoplasmic dynein 1 intermediate chain 1WD40
Q8N1S1|Q8N1S1_HUMAN cDNA FLJ37927 fis, clone CTONG2001428, weakly
35 546 similar to Xenopus laevis fizzy1 mRNA
Q8N542|Q8N542_HUMAN
36 555 DYNC1I1 protein
Q8NDM7|CJ079_HUMAN
37 575 WD repeat-containing protein C10orf79
Q8TBF7|Q8TBF7_HUMAN
Q96EX3|WDR34_HUMAN
Q9GZS0|DNAI2_HUMAN
40 683 Dynein intermediate chain 2, axonemal
Q9ULI1|Q9ULI1_HUMAN Leucine-rich repeat and WD repeat-containing
41 750 protein KIAA1239
Dynein, cytoplasmic, intermediate polypeptide
42 A4D1I7_HUMAN 1
43 A6NK54_HUMAN Uncharacterized protein WDR91
>Q7Z4X1|Q7Z4X1_HUMAN
44 508 Cytoplasmic dynein intermediate chain 2C
>Q7Z6M0|
45 Q7Z6M0_HUMAN 512 DYNC1I1 protein
Q8IY52|Q8IY52_HUMAN
47 WDR32_HUMAN 367 WD repeat-containing protein 32
48 Q5SRN1_HUMAN 379 Cell division cycle 40 homolog

49 Q05CI4_HUMAN WDR76 protein
50 DC1I2_HUMAN Cytoplasmic dynein 1 intermediate chain 2

SEC31-like 2 (S. cerevisiae) (SEC31L2), transcript
51 A8K1R0_HUMAN variant 2, mRNA
52 Q32LY9_HUMAN 264 DYNC1I2 protein
53 Q5BJF8_HUMAN 347 DYNC1I2 protein
>Q86Y31|Q86Y31_HUMAN
54 523 CDC20-like protein form 3
55 524 CDC20-like protein form 2
56 525 CDC20 cell division cycle 20 homolog B

58 Q24JR4_HUMAN WDR81 protein
Q96MT7|WDR52_HUMAN
Q9NW82|WDR70_HUMAN
62 Q9UM11|FZR_HUMAN 752 Fizzy-related protein homolog
63 A0MNP2_HUMAN CDW11/WDR57
65 A2IDB8_HUMAN WD repeat domain 24
Sterol regulatory element-binding protein cleavage-
66 SCAP_HUMAN activating protein
Q8NBG0|Q8NBG0_HUMAN cDNA FLJ33278 fis, clone ASTRO2008508, weakly
67 568 similar to TIPD PROTEIN
Q8TEB1|WDR23_HUMAN
69 CDC20_HUMAN Cell division cycle protein 20 homolog

guanine nucleotide binding protein (G protein), beta
70 A8K2R5_HUMAN 5(GNB5), transcript variant 1, mRNA
71 Q4G1A2_HUMAN 280 SPAG16 protein
Q8N0X2|SPG16_HUMAN
72 542 Sperm-associated antigen 16 protein
73 WD42A_HUMAN 397 WD repeat-containing protein 42A
guanine nucleotide binding protein (G protein), beta
74 A8K3F6_HUMAN polypeptide 4 (GNB4), mRNA
75 PLRG1_HUMAN Pleiotropic regulator 1
Q8TBY9|WDR66_HUMAN
WD N termini
1 A8MTA5_HUMAN Uncharacterized protein SEC13
2 A8MTC1_HUMAN
3 Q4VXT1_HUMAN 285
Q9BVM5|Q9BVM5_HUMAN
5 674 WDR4 protein
6 Q6ZW40_HUMAN 495 cDNA FLJ41631 fis, clone DFNES2011499
Q8N797|Q8N797_HUMAN
7 558 CDNA FLJ25882 fis, clone CBR02655
cDNA FLJ16457 fis, clone BRAWH3009017,
8 Q6ZN41_HUMAN 488 moderately similar to SEL-10 protein
Q8TEA6|Q8TEA6_HUMAN
9 600 CDNA FLJ23731 fis, clone HEP14545
10 A6NGM1_HUMAN Uncharacterized protein EDC4
11 A6NGZ9_HUMAN Uncharacterized protein BUB3
cDNA FLJ75002, highly similar to Homo sapiens,

neural cell expressed,developmentally down-
12 A8K1Z3_HUMAN regulated gene 1
13 A0MNP0_HUMAN CDW9/WDR51B
Wd middle
Q9NXK4|Q9NXK4_HUMAN
1 730 CDNA FLJ20195 fis, clone COLF0930
Mediator of RNA polymerase II transcription subunit

2 MED16_HUMAN 762 16
Q9NUL1|Q9NUL1_HUMAN
3 720 cDNA FLJ11294 fis, clone PLACE1009708
Q8NFH4|NUP37_HUMAN
4 580 Nucleoporin Nup37
Q9C0C7|AMRA1_HUMAN Activating molecule in BECN1-regulated autophagy
5 679 protein 1
WD dispersed
dynein, axonemal, intermediate polypeptide 1,
1 A8K3T1_HUMAN mRNA

2 A8K619_HUMAN SREBP cleavage-activating protein (SCAP), mRNA
3 A8K7E5_HUMAN WD repeat domain 25 (WDR25), mRNA
prolactin regulatory element binding (PREB),
4 A8K813_HUMAN mRNA
5 A8K976_HUMAN WD repeat domain 37 (WDR37), mRNA
WD repeat domain 23 (WDR23), transcript variant
6 A8K9T2_HUMAN 1, mRNA
SEC31-like 2 (S. cerevisiae) (SEC31L2), transcript
7 A8KAL6_HUMAN variant 2, mRNA
8 A8MTP5_HUMAN Uncharacterized protein RFWD2
9 O00149_HUMAN Embryonic ectoderm development protein homolog

10 GBB5_HUMAN Guanine nucleotide-binding protein subunit beta-5
11 WDR62_HUMAN WD repeat-containing protein 62

12 U3IP2_HUMAN U3 small nucleolar RNA-interacting protein 2
13 CSTF1_HUMAN Cleavage stimulation factor 50 kDa subunit
14 Q05DB2_HUMAN PREB protein

15 Q06DW8_HUMAN WDR13
16 Q06DX0_HUMAN WDR13
17 Q08ET9_HUMAN WRAP53
18 RBBP4_HUMAN Histone-binding protein RBBP4

19 AAMP_HUMAN Angio-associated migratory cell protein
20 Q14CB5_HUMAN MAPKBP1 protein
21 Q14CD8_HUMAN MAPKBP1 protein
22 Q15010_HUMAN KIAA0023 protein

Q8N7X6|Q8N7X6_HUMAN
23 561 cDNA FLJ40237 fis, clone TESTI2023414
cDNA FLJ90138 fis, clone HEMBB1000905, weakly
Q8N2L6|Q8N2L6_HUMAN similar to TRANSCRIPTIONAL REPRESSOR
24 551 RCO-1
Q8N202|Q8N202_HUMAN
25 549 cDNA FLJ36483 fis, clone THYMU2017601
26 Q6JZZ5_HUMAN 452 Androgen receptor cofactor p44
27 Q6NTH2_HUMAN 456 EED protein
28 Q6NUQ0_HUMAN 457 WD repeat domain 33

>Q7Z573|Q7Z573_HUMAN
29 509 Putative uncharacterized protein
Q8N136|WDR69_HUMAN
31 WD40C_HUMAN 418 WD repeat-containing protein 40C
32 Q58EZ8_HUMAN 317
33 RBBP7_HUMAN Histone-binding protein RBBP7
34 Q4G115_HUMAN 279 DNAI2 protein

35 Q4V334_HUMAN 281
36 Q5JNZ9_HUMAN 354 Retinoblastoma binding protein 7
37 Q5JPH5_HUMAN 358 Putative uncharacterized protein DKFZp686P0251

Cleavage stimulation factor, 3' pre-RNA, subunit 1,
38 Q5QPD8_HUMAN 368 50kDa
39 WD40A_HUMAN 393 WD repeat-containing protein 40A
Q8NFH3|NUP43_HUMAN
40 579 Nucleoporin Nup43
Q8TBZ3|WDR20_HUMAN
Q8TEQ6|GEMI5_HUMAN
42 605 Gem-associated protein 5
Q96LY9|Q96LY9_HUMAN
Q96MR6|WDR65_HUMAN
Q96LY9|Q96LY9_HUMAN
Q96MR6|WDR65_HUMAN
Q96MX6|WDR92_HUMAN
Q9BQA1|MEP50_HUMAN
48 662 Methylosome protein 50
Q9BRP4|PAAF1_HUMAN
49 664 Proteasomal ATPase-associated factor 1
Q9BUR4|WDR79_HUMAN
Q9BV38|WDR18_HUMAN
Q9BZH6|BRWD2_HUMAN
52 677 Bromodomain and WD repeat-containing protein 2
Q9H1Z4|WDR13_HUMAN
Q9H977|WDR54_HUMAN
cDNA FLJ12463 fis, clone NT2RM1000772 , weakly
Q9H9Z0|Q9H9Z0_HUMAN similar to VEGETATIBLE INCOMPATIBILITY
55 702 PROTEIN HET-E-1
Q9HCU5|PREB_HUMAN
56 711 Prolactin regulatory element-binding protein
Q9NRG9|AAAS_HUMAN
57 715 Aladin
Q9NXC5|Q9NXC5_HUMAN
58 729 CDNA FLJ20323 fis, clone HEP09648
Q9NXT1|Q9NXT1_HUMAN
59 731 CDNA FLJ20069 fis, clone COL01816
60 Q9NZJ0|DTL_HUMAN 733 Denticleless protein homolog
Q9UG25|Q9UG25_HUMAN
61 745 Putative uncharacterized protein DKFZp564A122
Q9UNY7|Q9UNY7_HUMAN
62 755 WAIT-1
64 Q53S84_HUMAN Putative uncharacterized protein DNCI2 [Fragment]
65 DMXL1_HUMAN 765 DmX-like protein 1
WD repeat domain phosphoinositide-interacting
66 WIPI2_HUMAN 768 protein 2
cDNA FLJ90410 fis, clone NT2RP3000011, weakly
Q8NC90|Q8NC90_HUMAN similar to VEGETATIBLE INCOMPATIBILITY
Q96S15|WDR24_HUMAN
Uncharacterized protein PAAF1(proteasomal
69 A6NDR5_HUMAN ATPase-associated factor 1)
70 A6NFL0_HUMAN Uncharacterized protein ENSP00000306791
71 STRAP_HUMAN 763 Serine-threonine kinase receptor-associated protein
72 TBL2_HUMAN 767 Transducin beta-like 2 protein

Q8IZU2|WDR17_HUMAN
74 A6NMC6_HUMAN Uncharacterized protein WDR64
75 A8K272_HUMAN retinoblastoma binding protein 5, mRNA
76 RBBP5_HUMAN Retinoblastoma-binding protein 5
>Q7Z6D8|
77 Q7Z6D8_HUMAN 511 Retinoblastoma binding protein 5
Q8NDZ7|Q8NDZ7_HUMAN
78 576 RBBP5 protein
Q8IWA0|WDR75_HUMAN
80 WD42B_HUMAN WD repeat-containing protein 42B
81 A6NM93_HUMAN Uncharacterized protein MAPKBP1
82 A6NJ42_HUMAN Uncharacterized protein BUB3
Q8ND98|Q8ND98_HUMAN
83 573 Putative uncharacterized protein DKFZp434B156
84 A8K8P9_HUMAN cDNA FLJ78549
85 A6NGH5_HUMAN Uncharacterized protein WDR45
Q8N7W3|
86 Q8N7W3_HUMAN 560 cDNA FLJ40281 fis, clone TESTI2027503
87 A8MWR8_HUMAN Uncharacterized protein SEC13
Q7LDA5|Q7LDA5_HUMAN Embryonic ectoderm development protein short

88 504 isoform
>Q7LDG8|
89 Q7LDG8_HUMAN 505 Embryonic ectoderm development protein
Q8IU52|Q8IU52_HUMAN
90 528 TUWD12
91 Q4VXS9_HUMAN 283
92 Q4VXT0_HUMAN 284
Q8WUW6|
93 Q8WUW6_HUMAN 610 DMWD protein
cDNA FLJ12165 fis, clone MAMMA1000612,
Q9HA66|Q9HA66_HUMAN moderately similar to Homo sapiens G protein beta
94 703 subunit mRNA
Q9NSS8|Q9NSS8_HUMAN
95 719 Putative uncharacterized protein DKFZp434D199
96 Q96S15|WDR24_HUMAN 654
WD repeat-containing protein 24
97
Q96LM8|Q96LM8_HUMAN
98 643 CDNA FLJ25361 fis, clone TST01713
>Q86W42|THOC6_HUMAN
99 519 THO complex subunit 6 homolog
Q96RY7|IF140_HUMAN
100 653 Intraflagellar transport 140 homolog
Q96LM8|Q96LM8_HUMAN
101 643 CDNA FLJ25361 fis, clone TST01713
102 A8K8G5_HUMAN WD repeat domain 74 (WDR74), mRNA
103 A8KA70_HUMAN WD repeat domain 40A (WDR40A), mRNA
Serine/threonine-protein phosphatase 2A 55 kDa

105 2ABA_HUMAN regulatory subunit B alpha isoform
>Q7Z4V7|Q7Z4V7_HUMAN
106 507 Protein phosphatase 2A1 B gamma subunit
107 SC31A_HUMAN Protein transport protein Sec31A

signal transducer and activator of transcription 3
108 A8KAI6_HUMAN interacting protein 1, mRNA
Q8TDJ6|DMXL2_HUMAN
109 599 DmX-like protein 2
110 RAE1L_HUMAN mRNA export factor
111 Q5TFT1_HUMAN 405 OTTHUMP00000017265

Q8TBB7|Q8TBB7_HUMAN
112 590 WDR22 protein
Q8N5U4|Q8N5U4_HUMAN
113 557 PEX7 protein
Q8N221|Q8N221_HUMAN
115 550 cDNA FLJ36290 fis, clone THYMU2003932
WD repeat domain 4 (WDR4), transcript variant 2,
116 A8KA58_HUMAN mRNA
117 Q5J8M4_HUMAN 350 Migration-inducing gene 14

118 A8MXL6_HUMAN Uncharacterized protein SEC13
119 Q06DW9_HUMAN WDR13
120 Q6NZ53_HUMAN 459 THOC3 protein

Q9NWT1|PK1IP_HUMAN
121 727 p21-activated protein kinase-interacting protein 1
Q8WUI5|Q8WUI5_HUMAN
122 609 GBL protein
123 Q6P048_HUMAN 460 WDR90 protein
124 Q6PIM1_HUMAN 470 WDFY4 protein
125 Q5J8M6_HUMAN 351 Proliferation-inducing gene 21
126 522 LST8
127 Q3B794_HUMAN 266 STXBP5 protein

Q9UFT3|Q9UFT3_HUMAN
128 742 Putative uncharacterized protein DKFZp586O1922
129 Q6FHM2_HUMAN 447 GNB2 protein
Q96J01|THOC3_HUMAN
130 639 THO complex subunit 3
Q96JK2|WDR22_HUMAN
132 CAF1B_HUMAN Chromatin assembly factor 1 subunit B

Q8NA23|WDR31_HUMAN
Q9HAD4|WDR41_HUMAN
Q8NEC4|Q8NEC4_HUMAN
135 577 PPP2R2C protein
136 Q6FGN1_HUMAN 445 PEX7 protein

Q96J01|THOC3_HUMAN
138 639 THO complex subunit 3
Q96JK2|WDR22_HUMAN
140 A8MSY7_HUMAN Uncharacterized protein PPP2R2C
141 A8MU22_HUMAN Uncharacterized protein PPP2R2B
Q9BTY4|Q9BTY4_HUMAN
143 PEX7_HUMAN Peroxisomal targeting signal 2 receptor

protein phosphatase 2, regulatory subunit B, delta
144 A8KAK0_HUMAN isoform (PPP2R2D), transcript variant 1, mRNA
Guanine nucleotide-binding protein G(I)/G(S)/G(T)

145 GBB3_HUMAN subunit beta-3

148 Q5VLR4_HUMAN 414 Lung cancer oncogene 7
Q9P2H3|IFT80_HUMAN
Q8TAF3|WDR48_HUMAN
>Q86VZ2|WDR5B_HUMAN
151 518 WD repeat-containing protein 5B
Q8N1V2|WDR16_HUMAN
154 A8MPU4_HUMAN Uncharacterized protein WDR1
156 ELP2_HUMAN 449 Elongator complex protein 2
157 Q4ZG01_HUMAN 288 Putative uncharacterized protein KIAA1336
Q9P2L0|WDR35_HUMAN
Q9BVC4|Q9BVC4_HUMAN
159 673 G protein beta subunit-like
160 Q5M800_HUMAN 363 G protein beta subunit-like
Q9H6Y2|WDR55_HUMAN
Uncharacterized protein
ENSP00000320648(apoptotic peptidase activating
162 A6NE52_HUMAN factor 1)
Q9BRX9|MORG1_HUMAN
163 665 Mitogen-activated protein kinase organizer 1
Q9HC35|EMAL4_HUMAN
164 709 Echinoderm microtubule-associated protein-like 4
RAE1 RNA export 1 homolog (S. pombe) (RAE1),
165 A8K882_HUMAN mRNA
166 A8MV37_HUMAN Uncharacterized protein SEC13
Q96FK6|WDR89_HUMAN
168 EIF3I_HUMAN Eukaryotic translation initiation factor 3 subunit I
169 Q49AJ8_HUMAN 275 MAPKBP1 protein

Q9H5W7|
170 Q9H5W7_HUMAN 688 CDNA: FLJ22921 fis, clone KAT06711
Q96FK6|WDR89_HUMAN
Q9BYB4|GNB1L_HUMAN Guanine nucleotide-binding protein subunit beta-
172 676 like protein 1
173 A8K8H8_HUMAN cDNA FLJ77821

174 ARC1B_HUMAN Actin-related protein 2/3 complex subunit 1B
175 SEC13_HUMAN Protein SEC13 homolog

Q9HBG5|Q9HBG5_HUMAN
176 707 WDR10p-L
Q8IV35|WDR49_HUMAN
>Q8TCI4|Q8TCI4_HUMAN
179 597 CDNA FLJ23854 fis, clone LNG06315
Q8N1Y0|Q8N1Y0_HUMAN
180 548 cDNA FLJ37293 fis, clone BRAMY2014813

excision repair cross-complementing rodent repair
deficiency, complementation group 8 (ERCC8),
181 A8K3W1_HUMAN transcript variant 1, mRNA
182 BUB3_HUMAN Mitotic checkpoint protein BUB3

Q8NEZ3|WDR19_HUMAN
Actin related protein 2/3 complex, subunit 1A,
184 A4D276_HUMAN 41kDa
>Q7Z5U6|WDR53_HUMAN
Q9BVA0|KTNB1_HUMAN
186 672 Katanin p80 WD40-containing subunit B1
Actin related protein 2/3 complex, subunit 1B,

187 A4D275_HUMAN 41kDa
Q8NHV4|NEDD1_HUMAN
188 584 Protein NEDD1
189 Q3KRB0_HUMAN 270 WDR67 protein
Q9GZS3|WDR61_HUMAN
191 CIAO1_HUMAN Protein CIAO1

Guanine nucleotide-binding protein subunit beta-2-
192 GBLP_HUMAN like 1
Q8NBT0|WD51A_HUMAN
193 569 WD repeat-containing protein 51A
cDNA FLJ16635 fis, clone TESTI4025268, weakly
similar to 77 kDa echinoderm microtubule-
195 Q6ZMW3_HUMAN 486 associated protein
Q9HAT9|Q9HAT9_HUMAN
196 705 SPG protein
Q9HBG6|IF122_HUMAN
Q8TC06|Q8TC06_HUMAN
Q8TC44|WD51B_HUMAN
199 596 WD repeat-containing protein 51B
cDNA FLJ10897 fis, clone NT2RP5003477, weakly
Q9NV68|Q9NV68_HUMAN similar to VEGETATIBLE INCOMPATIBILITY
202 TBL3_HUMAN WD repeat-containing protein SAZD

Uncharacterized protein PPP2R2B(Protein
phosphatase PP2A 55 kDa regulatory subunit
(Protein phosphatase PP2A regulatory subunit B))
203 A6NEJ2_HUMAN
204 A7E2C8_HUMAN WD repeat domain 7
embryonic ectoderm development (EED), transcript
205 A8K7V5_HUMAN variant 1, mRNA
Q96Q25|Q96Q25_HUMAN
206 652 KM-PA-2 protein
Q9NQW1|SC31B_HUMAN
207 714 Protein transport protein Sec31B
WD repeat domain 1 (WDR1), transcript variant 1,
208 A8K6E9_HUMAN mRNA
WD repeats only at
terminal and center Positional positinal
Analysis anal
of th
position Nuber of proteins 1
C termini 76
N termini 14 0.9 5.26%
Middle position 5
0.8 14
0.7
0.6
0.5
0.4
0.3
0.2
0.1
80.00%
0
Row 1
0.5
0.4
0.3
0.2
0.1
WD repeats which are 80.00%
dispersed through out the 0
protein Number of proteins Row 1
proteins lacking WD at N
termini 66
proteins lacking WD at
middle region 16 Positional analysis of
Protein lacking WD domain
at C termini 13 1
0.9 13.68%
0.8
0.7
0.6 16
0.5
0.4
0.3 69.47%
0.2
0.1
0
WD repeats which are Row 1
dispersed through out the
protein Number of proteins
Proteins having more WD
repeats at C termini than N
termini and middle position 131
Proteins having more WD
repeats at middle than N
termini and C-termini 20 5.63%
Proteins having more WD 12.50%
repeats at N termini than C
termini and middle position 9
81.88%
81.88%
biological process number of proteins

cell cycle 40
regulation of transcription 20
cell communication 19
protein metabolism 4
cell organization 24
function analysis
37.38%
18.69%
22.43%
17.76%
3.74%
17.76%
3.74%
DOMAIN
ARCHITECTURE GENE ID N-TERMINI MIDDLE C- TERMINI
2WD WDR21A 2
2WD WIPI1 2
2WD NUP214 2
2WD 2
2WD NUP214 2
2WD BCAS3 2
2WD WDR21A 2
2WD 2
2WD WDR37 2
2WD WDR45L 2
2WD BCAS3 2
2WD WD 2
2WD 2
3WD WDR63 3
3WD WDR60 3
3WD WDR40B 3
3WD 3
3WD AAAS 3
3WD WDR63 3
3WD40 WD78 3
4WD DMWD 4
4WD WDR90 4
4WD WDR90 4
4WD 4
4WD GTF3C2 4
4WD DNAI2 4
4WD PWP1 4
4WD 4
4WD GRWD1 4
4WD 4
4WD40 PWP1 4
4(WD40) GRWD1 4
5WD WDR78 5
5WD DYNC1I1 5
5WD 5
5WD DYNC1I1 5
5WD C10orf79 5
5WD DYNC1I1 5
5WD WDR34 5
5WD DNAI2 5
5WD 5
5wd40 DYNC1I1 5
5wd wdr91 5
5WD DYNC1I2 5
5WD DYNC1I1 5
5WD DYNC1I1 5
5WD WDR32 5
5WD CDC40 5
5WD WDR76 5
5WD DYNC1I2 5
5wd40 SEC31B 5
5WD DYNC1I2 5
5WD DYNC1I2 5
5WD CDC20B 5
5WD CDC20B 5
5WD CDC20B 5
6WD WDR44 6
6WD WDR81 6
6WD WDR25 6
6WD WDR52 6
6WD 6
6WD 6
6(WD40) WDR57 6
6(WD40) WDR76 6
6(WD40) WDR24 6
6WD SCAP 6
7WD 7
7WD WDR23 7
7WD CDC20 7
7wd40 GNB5 7
7WD SPAG16 7
7WD SPAG16 7
7WD WDR42A 7
7wd40 GNB4 7
7WD PLRG1 7
9WD WDR66 9
1WD 1
1WD 1
1WD 1
1WD Wdr81 1
1WD WDR4 1
1WD 1
1WD 1
2WD 2
2WD 2
1wd40 3
3wd40 3
6wd41 NEDD8 6
7(WD40) WDR51B 7
7(WD40) WDR53 7
1WD 1
1WD 1
2WD 2
3WD NUP37 3
3WD AMBRA1 3
4wd40 DNAI1 0 2 2
6WD SCAP 0 2 4
6WD WDR25 0 4 2
4WD PREB 0 2 2
6WD 0 2 4
7WD WDR23 0 1 6
5WD SEC31B 0 2 3
6WD 0 1 5
6WD EED 0 2 4
5WD GNB5 0 2 3
12WD WDR62 0 2 10
6WD RRP9 0 1 5
6WD CSTF1 0 1 5
4WD PREB 0 2 2
5WD WDR13 0 2 3
5WD WDR13 0 2 3
5WD WDR79 0 1 4
6WD RBBP4 0 1 5
8WD AAMP 0 2 6
12WD MAPKBP1 0 2 10
12WD MAPKBP1 0 2 10
2WD NUP214 0 1 1
5WD 0 1 4
5WD 0 1 4
6WD 0 2 4
6WD WDR77 0 2 4
5WD EED 0 2 3
3WD WDR33 0 1 2
5WD 0 2 3
8WD WDR69 0 2 6
4WD WDR40C 0 1 3
12WD 0 3 9
6WD RBBP7 0 1 5
5WD DNAI2 0 2 3
8WD 0 1 7
6WD RBBP7 0 1 5
4WD 0 1 3
6WD 0 1 5
4WD WDR40A 0 1 3
5WD NUP43 0 2 3
4WD WDR20 0 1 3
12WD GEMIN5 0 3 9
2WD 0 1 2
6WD WDR65 0 1 5
2WD 0 1 2
6WD WDR65 0 1 5
4wd WDR92 0 2 2
6WD WDR77 0 3 3
6WD PAAF1 0 3 3
5WD WDR79 0 1 4
4WD WDR18 0 2 2
6WD BRWD2 0 2 4
5WD WDR13 0 1 4
3WD WDR54 0 1 2
5WD 0 1 4
4WD PREB 0 1 3
4WD AAAS 0 1 3
4WD 0 1 3
6WD 0 3 3
6WD 0 3 3
3WD 0 1 2
6WD 0 2 4
6WD 0 1 5
5wd DNCI2 0 2 3
10WD DMXL1 0 3 8
3(WD) WIPI2 0 2 1
4WD 2 0 2
6WD WDR24 WD 2 0 4
6wd40
PAAF1 3 0 3
3wd40 PPP2R2B 3 0 3
7WD STRAP 1 0 3
5WD TBL2 1 0 3
11WD WDR17 1 0 10
5WD40 2 0 3
5wd40 GTF2IRD1 2 0 3
5WD RBBP5 2 0 3
5WD RBBP5 2 0 3
5WD RBBP5 2 0 3
8WD WDR75 2 0 6
7wd40 WDR42B 3 0 4
12wd40 3 0 9
6wd 4 0 2
2WD 1 1 0
3WD 1 2 0
3wd40 2 1 0
2WD 1 1 0
3WD 2 1 0
5WD EED 2 3 0
WD EED 2 4 0
4WD WDR51B 2 2 0
2WD 1 1 0
2WD 1 1 0
2WD DMWD 1 1 0
4WD 1 3 0
2WD 1 1 0
6wD 2 4
3WD 1 1 1
3WD THOC6 1 1 1
3WD IFT140 1 1 1
3WD 1 1 1
3WD WDR74 1 1 1
4WD WDR40A 1 1 2
5WD WDR68 1 1 3
6WD PPP2R2A 1 1 4
6WD PPP2R2C 1 1 4
6WD SEC31A 1 1 4
10WD ELP2 1 1 8
12WD DMXL2 1 1 10
4WD RAE1 1 2 1
5WD AHI1 1 2 1
4WD WDR22 1 2 1
4WD PEX7 1 2 1
4WD WDR4 1 2 1
4WD 1 2 1
4WD WDR4 1 2 1
4WD RAE1 1 2 1
5WD 1 2 2
5WD WDR13 1 2 2
5WD THOC3 1 2 2
5WD 1 2 2
G protein
beta
5WD subunit-like 1 2 2
5WD WDR90 1 2 2
5WD WDFY4 1 2 2
5WD GNB2L1 1 2 2
G protein
beta
5WD subunit-like 1 2 2
5WD STXBP5 1 2 2
5WD 1 2 2
5WD GNB2 1 2 2
6WD THOC3 1 2 3
6WD WDR22 1 2 3
5WD CHAF1B 1 2 2
6WD 1 2 3
6WD WDR41 1 2 3
6WD PPP2R2C 1 2 3
6WD PEX7 1 2 3
6WD WDR82 1 2 3
6WD THOC3 1 2 3
6WD WDR22 1 2 3
6WD 1 2 3
6WD 1 2 3
6WD IFT122 1 2 3
6WD PEX7 1 2 3
7WD PPP2R2D 1 2 4
7WD GNB3 1 2 4
7WD Wdr5 1 2 4
7WD GNB1 1 2 4
7WD GNB2L1 1 2 4
7WD 1 2 4
7WD WDR48 1 2 4
7WD WDR5B 1 2 4
7WD GNB2 1 2 4
11WD WDR16 1 2 8
11WD 1 2 8
11WD WDR1 1 2 8
12WD ELP2 1 2 9
5WD 1 3 1
5WD 1 3 1
6WD GBL 1 3 2
6WD GBL 1 3 2
6WD WDR55 1 3 2
6wd40
APAF1 1 3 2
mitogen-
activated
protein
kinase
7WD organizer 1 1 3 3
9WD EML4 WD 1 3 5
4WD RAE1 2 1 1
5WD 2 1 2
5WD WDR89 2 1 2
5WD EIF3I 2 1 2
5WD MAPKBP1 2 1 2
5WD 2 1 2
5WD WDR89 2 1 2
6WD GNB1L 2 1 3
6WD TTC8 2 1 3
6WD ARPC1B 2 1 3
6WD SEC13 2 1 3
7WD IFT122 2 1 4
7WD WDR72 2 1 4
8WD WDR49 2 1 5
5WD 2 2 1
5WD 2 2 1
5wd40 ERCC8 2 2 1
6WD BUB3 2 2 2
5WD WDR19 2 2 1
6wd40
ARPC1B 2 2 2
6WD WDR53 2 2 2
6WD KATNB1 2 2 2
6wd40
ARPC1B 2 2 2
6WD NEDD1 2 2 2
7WD WDR67 2 2 3
7WD WDR61 2 2 3
7WD CIAO1 2 2 3
7WD GNB2L1 2 2 3
7WD 2 2 3
7WD WDR38 2 2 3
7WD C5orf27 2 2 3
7WD IFT122 2 2 3
7WD IFT122 2 2 3
7WD IFT122 2 2 3
7WD WDR51B 2 2 3
8WD 2 2 4
7WD WDR7 2 2 5
10WD TBL3 2 2 6
6wd40
2 3 1
5WD40 WDR7 WD 4 0 1
6WD EED 4 1 1
7WD BOP1 WD 4 2 1
5WD SEC31B 5 0 0
11WD WDR1 5 2 4
Positional
Analysis
ositional positinal
Analysis analysis
of the WD repeats
5.26%
14.74%
C termini
N terminiColumn A
Middle position
Row 1
C termini
N terminiColumn A
Middle position
Row 1
Positional analysis of WD domain
13.68%
proteins lacking WD
at N termini
16.84%
proteins lacking WD
at middle region
Protein lacking WD
domain at C termini
Row 1
5.63%
12.50%
Proteins having more
WD repeats at C
termini than N ter-
WD repeats at
middle than N termini
WD repeats at N
termini than C ter-
middle than N termini
WD repeats at N
termini than C ter-
nalysis
cell cycle
%
regulation of
transcription
22.43% cell communication
protein metabolism
cell organization
protein metabolism
cell organization
FUNCTION
autophagy
protein export from nucleus , transport , protein

transport , mRNA transport , intracellular protein
transport across a membrane

nucleus
Gene Ontology is not available.

nucleus

nucleocytoplasmic transport , regulation of

nucleocytoplasmic transport

meiosis
transcription , transcription, DNA-dependent , 5S

class rRNA transcription , tRNA transcription from
RNA polymerase III promoter
cell projection organization and biogenesis , cilium
biogenesis
transcription
nucleus
transcription
nucleus

vesicle transport along microtubule
vesicle transport along microtubule, microtubule motor

activity,protein binding

biogenesis
Motor activity,vesicle transport along

microtubule,Cytoplasmic dynein complex
microtubule-based movemen,microtubule motor

activity
vesicle transport along microtubule

kinase activity
mRNA processing , RNA splicing

microtubule-based movemen
transport , protein transport , vesicle-mediated

transport
microtubule-based movement

rhodopsin-like receptor activity,G-protein coupled
receptor protein signaling pathway
nucleus
regulation of progression through cell cycle

RNA splicing,Nuclear mRNA splicing, via spliceosome
lipid metabolic process , positive regulation of sterol
regulatory element binding pro , steroid metabolic
process , cholesterol metabolic process , negative
regulation of cholesterol biosynthetic process ,
positive regulation of low-density lipoprotein receptor
bios
ubiquitin-dependent protein catabolic process ,

ubiquitin cycle , cell cycle , mitosis , cell division
signal transduction
cell projection organization and biogenesis

signal transduction
mRNA processing , RNA splicing
tRNA processing , biological_process
protein modification process , protein modification

process , proteolysis , ubiquitin-dependent protein
catabolic process , ubiquitin cycle , anatomical
structure morphogenesis
Gene Ontology is not available
transcription,regulation of transcription from RNA

polymerase II promoter,transcription initiation from
RNA polymerase II promoter
transport , protein transport , mRNA transport ,

intracellular protein transport across a membrane
autophagy , multicellular organismal development ,
nervous system development , cell differentiation

lipid metabolic process , positive regulation of sterol
regulatory element binding pro , steroid metabolic
process , cholesterol metabolic process , negative
regulation of cholesterol biosynthetic process ,
positive regulation of low-density lipoprotein receptor
bios

transcription , regulation of transcription, DNA-
dependent , transport , protein transport ,
vesicle-mediated transport

transport
protein binding,histone methyltransferase activity

regulation of transcription from RNA polymerase II
promoter,protein modification
process,proteolysis,ubiquitin-dependent protein
catabolic process,ubiquitin cycle

rRNA processing
mRNA polyadenylation , mRNA cleavage , RNA

processing , mRNA processing
nucleus
nucleus
DNA replication , chromatin remodeling ,
dependent , cell cycle , negative regulation of cell
proliferation , chromatin modification
cell motility
phosphoenolpyruvate-dependent sugar
phosphotransferase syste

receptor activity,signal transduction
postreplication repair , phosphate transport ,

spermatogenesis
protein phosphatase type 2A regulator activity ,signal

transduction
DNA replication , transcription , regulation of

transcription, DNA-dependent , multicellular
organismal development , cell proliferation ,
chromatin modification

biogenesis
DNA replication , transcription , regulation of

transcription, DNA-dependent , multicellular
organismal development , cell proliferation ,

spliceosomal snRNP biogenesis , nuclear mRNA

splicing, via spliceosome , mRNA processing ,
protein complex assembly , RNA splicing
membrane , integral to membrane

translation , tRNA aminoacylation for protein
translation , apoptosis
protein binding
nucleus

nucleocytoplasmic transport , regulation of
nucleocytoplasmic transport
Negative regulation of transcription
proteolysis
function-protein binding
Biological Process
negative regulation of transcription from RNA

polymerase II promoter,mRNA processing,RNA
splicing
biological_process

dependent , multicellular organismal development
protein binding
protein binding,
protein binding
nucleus
meiosis
cell communication
protein binding
protein amino acid dephosphorylation , signal

transduction
signal transduction,protein phosphatase type 2A

regulator activity
transport , ER to Golgi vesicle-mediated transport ,

protein transport , vesicle-mediated transport
dependent , regulation of transcription from RNA
polymerase II promoter
translational initiation
mRNA export from nucleus

transport , visual perception , sensory perception

of sound , ether lipid biosynthetic process , protein
transport , protein import into peroxisome matrix ,
response to stimulus
nucleus
mRNA processing , transport , RNA splicing ,

mRNA transport

transporter activity,transport
receptor binding, protein binding

transport
signal transduction , G-protein coupled receptor
protein signaling pathway
mRNA transpor
DNA replication , DNA repair , DNA replication-

dependent nucleosome assembly , transcription ,
regulation of transcription, DNA-dependent , protein
complex assembly , response to DNA damage
stimulus , cell cycle
protein phosphatase type 2A regulator activity,signal

transduction
nucleus
mRNA transpor
cytoplasm

signal transduction,protein phosphatase type 2A

regulator activity

protein signaling pathway , regulation of blood
pressure
skeletal development
signal transduction , acetylcholine receptor signaling,

muscarinic pathway , Ras protein signal transduction
receptor binding , protein binding
lysosome
ubiquitin cycle
protein signaling pathway
protein binding
dependent sensory perception
, regulation of sound from RNA
of transcription
polymerase II promoter

Gene Ontology is not available
proteolysis

translation , regulation of translational initiation

G-protein coupled receptor protein signaling pathway ,
intracellular signaling cascade
visual perception,cell projection organization and
biogenesis,response to stimulus
cell motility , cell adhesion
transport , intracellular protein transport , protein
transport
cytoplasm
calcium ion binding

protein polyubiquitination , transcription-coupled
nucleotide-excision repair , nucleotide-excision
repair , transcription , regulation of transcription,
DNA-dependent , response to DNA damage
stimulus , response to oxidative stress , sensory
perception of sound , response to UV , positive
regulation of DNA repair , protein autoubiquitination
mitotic sister chromatid segregation , chromosome

segregation , mitosis , mitotic cell cycle checkpoint
, mitotic cell cycle spindle assembly checkpoint ,
cell proliferation
intracellular protein transport , vesicle-mediated
transport
protein targeting , negative regulation of microtubule

depolymerization , cell cycle , mitosis , positive
regulation of microtubule depolymerization , cell
division

regulation of Rab GTPase activity

promoter , positive regulation of cell proliferation
receptor binding , protein binding
cytoplasm
cytoplasm
cytoplasm
biological_process
rRNA processing , G-protein signaling, coupled to
cGMP nucleotide second messe
proteolysis
rRNA processing , ribosome biogenesis and assembly
transport , protein transport , vesicle-mediated transport
sensory perception of sound

process
cell cycle
cell cycle
cell cycle
cell cycle
cell organization
cell cycle
transcriptin regulation
cell organization
transcriptin regulation
regulation of transcription
cell cycle
cell organization
cell organization
cell organization
cell organization
cell organization
cell organization
cell cycle
cell cycle
cell communication
cell cycle
cell organization
energy metabolism
cell cycle
cell communication
cell cycle
cell cycle
cell communication
cell organization
cell organization
cell cycle
cell organization
cell cycle
cell cycle
energy metabolism
cell cycle
transcription regulation
cell organization
cell organization
cell cycle
cell cycle
energy metabolism
energy metabolism
cell cycle
cell communication
cell cycle
cell communication
cell organization
cell organization
cell cycle
cell cycle
cell cycle
protein metabolism
cell communication
cell cycle
cell communication
cell communication
cell communication
cell cycle
cell organization
cell organization
cell communication
cell organization
cell organization
cell organization
cell cycle
cell cycle
cell comuication
cell cycle
cell communication
cell cycle
cell comuication
cell communication
cell comuication
cell comuication
cell cycle
cell comuication
cell cycle
protein metabolism
cell communication
cell communication
mTOR signaling pathway
protein metabolism
cell cycle
cell organization
energy metabolism
cell communication
cell communication
cell cycle
cell cycle
cell cycle
cell cycle
cell cycle
cell cycle
cell cycle
cell organization
cell communication
cell communication
protein metabolism
cell organization
cell cycle
cell communication
description
This gene encodes a WD repeat-containing protein. Multiple alternatively

spliced transcript variants have been found for this gene, but the full-
length nature of some variants has not been defined.
The nuclear pore complex is a massive structure that extends across the
nuclear envelope, forming a gateway that regulates the flow of
macromolecules between the nucleus and the cytoplasm. Nucleoporins
are the main components of the nuclear pore complex in eukaryotic cells.
This gene is a member of the FG-repeat-containing nucleoporins. The
protein encoded by this gene is localized to the cytoplasmic face of the
nuclear pore complex where it is required for proper cell cycle
progression and nucleocytoplasmic transport. The 3' portion of this gene
forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9)
translocation associated with acute myeloid leukemia and
myelodysplastic syndrome.
This gene encodes a WD repeat-containing protein. Multiple alternatively

spliced transcript variants have been found for this gene, but the full-
length nature of some variants has not been defined.
This gene encodes a member of the WD repeat protein family. WD

repeats are minimally conserved regions of approximately 40 amino acids
typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate
formation of heterotrimeric or multiprotein complexes. Members of this
family are involved in a variety of cellular processes, including cell cycle
progression, signal transduction, apoptosis, and gene regulation.
This gene encodes a member of the WIPI or SVP1 family of WD40
repeat-containing proteins. The protein contains seven WD40 repeats
that are thought to fold into a beta-propeller structure that mediates
protein-protein interactions, and a conserved motif for interaction with
phospholipids. The human genome contains several pseudogenes of this
gene.
could have a regulatory function in meiosis.
may play an important role in cell growth and/or transcription.
may play an important role in cell growth and/or transcription.

which functions in two different cellular processes: pre-mRNA splicing
and cell cycle progression. It suggests that this protein may play a role in
cell cycle progression.
This gene encodes a protein of unknown function. The protein has

moderate similarity to rat VAP1 protein which is an endosomal
membrane-associated protein, containing a putative Ca2+/calmodulin-
dependent kinase II phosphorylation site.
SREBP control of lipid synthesis
CDC20 appears to act as a regulatory protein interacting with several

other proteins at multiple points in the cell cycle. It is required for two
microtubule-dependent processes, nuclear movement prior to anaphase
and chromosome separation.
necessary for sperm flagellar function.
necessary for sperm flagellar function.
necessary for spliceosome assembly and for pre-mrna splicing.
required for 7-methylguanosine modification of trna.
ubiquitin-like protein which plays an important role in cell cycle control

and embryogenesis. covalent attachment to its substrates requires prior
activation by the e1 complex ube1c- appbp1 and linkage to the e2
enzyme ube2m. attachment of nedd8 to cullins activates their associated
e3 ubiquitin ligase activity, and thus promotes polyubiquitination and
proteasomal degradation of cyclins and other regulatory proteins
Mutations in this gene result in abnormal ciliary ultrastructure and
function associated with primary ciliary dyskinesia (PCD) and Kartagener
syndrome.
SREBP control of lipid synthesis

This gene encodes a member of the Polycomb-group (PcG) family. PcG
family members form multimeric protein complexes, which are involved in
maintaining the transcriptional repressive state of genes over successive
cell generations. This protein interacts with enhancer of zeste 2, the
cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1)
MA protein, and histone deacetylase proteins. This protein mediates
repression of gene activity through histone deacetylation, and may act as
a specific regulator of integrin function. Two transcript variants encoding
distinct isoforms have been identified for this gene.
This gene encodes a member of the WD repeat protein family. WD

repeats are minimally conserved regions of approximately 40 amino acids
typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate
formation of heterotrimeric or multiprotein complexes. Members of this
family are involved in a variety of cellular processes, including cell cycle
progression, signal transduction, apoptosis, and gene regulation. This
gene is highly expressed in testis and the protein is localized to the
nucleus. This gene may play important roles in the mechanisms of
cytodifferentiation and/or DNA recombination. Multiple alternatively
spliced transcript variants encoding distinct isoforms have been found for
this gene.
the smn complex plays an essential role in spliceosomal snrnp assembly
in the cytoplasm and is required for pre-mrna splicing in the nucleus. it
may also play a role in the metabolism of snornps.
0
The protein encoded by this gene is a member of a superfamily of WD
repeat proteins. The function of this protein is not yet determined;
however, other related family members perform functions involved in
regulatory processes.
the smn complex plays an essential role in spliceosomal snrnp assembly

in the cytoplasm and is required for pre-mrna splicing in the nucleus.
strap may play a role in the cellular distribution of the smn complex.
This gene encodes a member of the beta-transducin protein family. Most

proteins of the beta-transducin family are involved in regulatory functions.
This protein is possibly involved in some intracellular signaling pathway.
This gene is deleted in Williams-Beuren syndrome, a developmental
disorder caused by deletion of multiple genes at 7q11.23. Alternative
splicing of this gene generates 2 transcript variants.
The protein encoded by this gene is a ubiquitously expressed nuclear

protein and belongs to a highly conserved subfamily of WD-repeat
proteins. It is found among several proteins that bind directly to
retinoblastoma protein, which regulates cell proliferation. The encoded
protein interacts preferentially with the underphosphorylated
retinoblastoma protein via the E1A-binding pocket B.

could have a regulatory function in meiosis.

The product of this gene belongs to the phosphatase 2 regulatory subunit
B family. Protein phosphatase 2 is one of the four major Ser/Thr
phosphatases, and it is implicated in the negative control of cell growth
and division. It consists of a common heteromeric core enzyme, which is
composed of a catalytic subunit and a constant regulatory subunit, that
associates with a variety of regulatory subunits. The B regulatory subunit
might modulate substrate selectivity and catalytic activity. This gene
encodes an alpha isoform of the regulatory subunit B55 subfamily.
The product of this gene belongs to the phosphatase 2 regulatory subunit

B family. Protein phosphatase 2 is one of the four major Ser/Thr
phosphatases, and it is implicated in the negative control of cell growth
and division. It consists of a common heteromeric core enzyme, which is
composed of a catalytic subunit and a constant regulatory subunit, that
associates with a variety of regulatory subunits. The B regulatory subunit
might modulate substrate selectivity and catalytic activity. This gene
encodes a gamma isoform of the regulatory subunit B55 subfamily.
Alternatively spliced transcript variants encoding different isoforms have
been identified.
The protein encoded by this gene is similar to yeast Sec31 protein. Yeast
Sec31 protein is known to be a component of the COPII protein complex
which is responsible for vesicle budding from endoplasmic reticulum
(ER). This protein was found to colocalize with SEC13, one of the other
components of COPII , in the subcellular structures corresponding to the
vesicle transport function. An immunodepletion experiment confirmed
that this protein is required for ER-Golgi transport. Alternatively spliced
transcript variants encoding distinct isoforms have been observed.
binds to the n-terminal pts2-type peroxisomal targeting signal and plays
an essential role in peroxisomal protein import.
required for 7-methylguanosine modification of trna.
binds mrna. may function in nucleocytoplasmic transport and in directly or

indirectly attaching cytoplasmic mrnps to the cytoskeleton.
seems to bind protein kinase c acting as an intracellular receptor to

anchor the activated pkc to the cytoskeleton (by similarity).
plays a regulatory role in calcium-dependent exocytosis and

neurotransmitter release. inhibits membrane fusion between transport
vesicles and the plasma membrane. may modulate the assembly of
trans-snare complexes between transport vesicles and the plasma
membrane. inhibits translocation of glut4 from intracellular vesicles to the
plasma membrane. competes with stxbp1 for stx1 binding (by similarity).
complex that is thought to mediate chromatin assembly in dna replication
and dna repair. assembles histone octamers onto replicating dna in vitro.
caf-1 performs the first step of the nucleosome assembly process,
bringing newly synthesized histones h3 and h4 to replicating dna;
histones h2a/h2b can bind to this chromatin precursor subsequent to dna
replication to complete the histone octamer. the ccr4-not complex
functions as general transcription regulation complex.
the b regulatory subunit might modulate substrate selectivity and catalytic

activity, and also might direct the localization of the catalytic enzyme to a
particular subcellular compartment.

0
involved in transcription
seems to bind protein kinase c acting as an intracellular receptor to

anchor the activated pkc to the cytoskeleton (by similarity).
0
0
PATHWAY
RAN regulation pathway,MAPK cascade. Part I. Map 3 - ERK nucleocytoplasmic shuttling

FAS signaling cascades. Part 2,Caspase cascade activation by FADD and RIPK proteins
Attenuation of GPCR Signaling,ß-arrestins in GPCR Desensitization

Regulation of lipid metabolism via LXR, NF-Y and SREBP,Regulation of fatty acid desaturase 2
protein degradation; protein ubiquitinylation.TGF-beta receptor signaling
Rhodopsin phototransduction cascade in retina - the key role of Ca2+ transport
G-protein coupled receptor protein signaling pathway

RAN regulation pathway
Regulation of lipid metabolism via LXR, NF-Y and SREBP,Regulation of fatty acid desaturase 2
CREB pathway,Angiotensin activation of Akt,Angiotensin activation of ERK,Angiotensin signaling via
PYK2,Angiotensin signaling via STATs,Activation of PKC via G protein coupled receptor,G-Protein
alpha-12 signaling pathway,Membrane trafficking and signal transduction of G-alpha (i) heterotrimeric
G-protein,Transcription factor Tubby signaling pathways,G-Proteins mediated regulation MARK-ERK
signaling,A2BR signaling via G-alpha-q: RSK and JNK specific pathways (map 2a),CXCR4 signaling
pathway,ICOS-ICOSL pathway in T-helper cell

Ligand-Dependent Transcription of Retinoid-Target genes,P53 signaling pathway,Estrogen receptor
signaling pathway,ATM-H2AX-NFBD1 DNA damage response,Role of heterochromatin protein 1
(HP1) family in transcriptional silencing,,Formation of Sin3A and NuRD complexes and their role in
Ligand-Dependent Transcription of Retinoid-Target genes,P53 signaling pathway,Estrogen receptor

signaling pathway,ATM-H2AX-NFBD1 DNA damage response,Role of heterochromatin protein 1
(HP1) family in transcriptional silencing,,Formation of Sin3A and NuRD complexes and their role in
RNA polymerase III transcription pathway
Regulation And Function Of ChREBP in Liver

Regulation of translation initiation

CREB pathway,Angiotensin activation of Akt,Angiotensin activation of ERK,Angiotensin signaling via
PYK2,Angiotensin signaling via STATs,Activation of PKC via G protein coupled receptor,G-Protein
alpha-12 signaling pathway,G-protein families signaling pathway,Membrane trafficking and signal
transduction of G-alpha (i) heterotrimeric G-protein,Transcription factor Tubby signaling pathways,G-
Proteins mediated regulation MARK-ERK signaling,ChREBP regulation pathway,Rhodopsin
phototransduction cascade in retina - the key role of Ca2+ transport,Putative erythropoietin signaling
pathway (part 2),A2B receptor: action via G-protein alpha s (map 1),A2BR signaling via G-protein
beta/gamma dimer. Activation of PI3K, PLCB and PLA2,A2BR signaling via G-beta/gamma dimer.
RGS and CaM-related GIRK regulation,A2BR signaling via G-beta/gamma dimer. Activation of PH-
domain proteins. (map 2),A2B Receptor: Action via G-alpha s. (map 2),A2BR signaling via G-alpha-q:
Inhibition of TKR-specific PI3K activation (map 1a),A2BR signaling via G-beta/gamma dimer.
Activation of PH-domain proteins. (map 1),A2B Receptor: Action via G-alpha s. (map 2),A2BR
signaling via G-alpha-q: Inhibition of TKR-specific PI3K activation (map 1a),A2BR signaling via G-
alpha-q: Inhibition of TKR-specific PI3K activation (map 1b),A2BR signaling via G-alpha-q: Inhibition of
TKR-specific PI3K activation (map 1b),A2BR signaling via G-alpha-q: PRKCA - RSK & JNK specific
pathways (map 2c),A2BR signaling via G-alpha-q: PRKCB/G/Q specific pathways (map 3a),A2BR
signaling via G-alpha-q: PRKCE - RASGRP specific pathways (map 3b),Regulation of fatty acid
metabolic enzymes FACL, ACADM, FASN and SCD via adenosin receptor activation,Angiotensin
signaling via beta-arrestin,Calcium signaling,IP3 signaling,CXCR4 signaling pathway,ICOS-ICOSL
pathway in T-helper cell,G-Protein alpha-i signaling cascades,G-Protein alpha-q signaling cascades,G-
Protein alpha-s signaling cascades,G-Protein beta/gamma signaling cascades,PDGF signaling via
MAPK cascades,cAMP signaling,cAMP signaling,Ceramide-dependent NO antiapoptotic action,PKA
signaling,PIP3 signaling in cardiac myocytes,PIP3 signaling in B lymphocytes
Regulation And Function Of ChREBP in Liver

Agrin in Postsynaptic Differentiation ,Alternative Complement Pathway ,Angiotensin II
mediated activation of JNK Pathway via Pyk2 dependent signaling ,Basic Mechanisms of
SUMOylation ,CDK Regulation of DNA Replication ,Complement Pathway ,ER–associated
degradation (ERAD) Pathway ,FAS signaling pathway ( CD95 ) ,fMLP induced chemokine
gene expression in HMC-1 cells ,How does salmonella hijack a cell ,How Progesterone
Initiates Oocyte Membrane ,Influence of Ras and Rho proteins on G1 to S Transition ,Links
between Pyk2 and Map Kinases ,MAPKinase Signaling Pathway ,Mechanisms of
transcriptional repression by DNA methylation ,METS affect on Macrophage Differentiation
,Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling ,Rac 1 cell
motility signaling pathway Ras-Independent pathway in NK cell-mediated cytotoxicity
,Regulation of p27 Phosphorylation during Cell Cycle Progression ,Regulation of
Spermatogenesis by CREM ,Regulation of transcriptional activity by PML Rho cell motility
signaling pathway ,Role of Parkin in the Ubiquitin-Proteasomal Pathway ,Role of PI3K
subunit p85 in regulation of Actin Organization and Cell Migration ,Signaling of Hepatocyte
Growth Factor Receptor ,Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle
,SUMOylation as a mechanism to modulate CtBP-dependent gene responses ,Sumoylation by
RanBP2 Regulates Transcriptional Repression TNFR1 Signaling Pathway ,Y branching of
actin filaments
Pathway for ARPC1B: hsa04810 Regulation of actin cytoskeleton
Pathway for ARPC1B: hsa04810 Regulation of actin cytoskeleton

deaseses
a chromosomal aberration involving nup214 is found in a subset of acute myeloid leukemia (aml);
also known as acute non- lymphocytic leukemia. translocation t(6;9)(p23;q34) with dek. it results
in the formation of a dek-can fusion gene.
a chromosomal aberration involving nup214 is found in a subset of acute myeloid leukemia (aml);
also known as acute non- lymphocytic leukemia. translocation t(6;9)(p23;q34) with dek. it results
in the formation of a dek-can fusion gene.
may have a role in the development of mental symptoms in severe cases of myotonic dystrophy.
defects in ahi1 are the cause of joubert syndrome 3 (jbts3) [mim:608629]. joubert syndrome is an
autosomal recessive brain congenital malformation of the cerebellar vermis and brainstem with
abnormalities of axonal decussation (crossing in the brain) affecting the corticospinal tract and
superior cerebellar peduncles. individuals with joubert syndrome have motor and behavioral
abnormalities, including an inability to walk due to severe clumsiness and 'mirror' movements, and
cognitive and behavioral disturbances.
defects in pex7 are the cause of peroxisome biogenesis disorder complementation group 11 (pbd-
cg11) [mim:601757]. pbd refers to a group of peroxisomal disorders arising from a failure of
protein import into the peroxisomal membrane or matrix. the pbd group is comprised of four
disorders: zellweger syndrome (zws), neonatal adrenoleukodystrophy (nald), infantile refsum
disease (ird), and classical rhizomelic chondrodysplasia punctata (rcdp). zws, nald and ird are
distinct from rcdp and constitute a clinical continuum of overlapping phenotypes known as the
zellweger spectrum. the pbd group is genetically heterogeneous with at least 13 distinct genetic
groups as concluded from complementation studies.

sl.no acc id protein name domain architecture
WD+1
A0AV58_HUMA Striatin, calmodulin binding
1 N protein 3 1(Striatin)+5(WD40)
A1L4B3_HUMA 1(LisH)+8(WD40)
2 N Transducin (Beta)-like 1Y-linked
A2RUS4_HUMA
3 N WD repeat domain 36 3wd+1utp
A3EXK9_HUMA ATG16 autophagy related 16-like 1(ATG16)+6(wd40)

4 N protein 1
A3EXL0_HUMA ATG16 autophagy related 16-like 1(ATG16)+6(wd40)

5 N protein 1
A6H8Y6_HUMA
6 N EML4 protein 1(HELP)+1wd40
Uncharacterized protein TLE1 1TLE_N+6wd40
A6NFH2_HUMA
7 N
A6NHD5_HUMA Neurobeachin-like 1 1Beach+2wd40

8 N
Uncharacterized protein Striatin+5wd40

A6NHZ7_HUMA STRN3(nuclear autoantigen
9 N isoform 1)
A6NIN2_HUMA
10 N Uncharacterized protein EML5 3WD+1(HELP)+2wd40
A6NIY7_HUMA
11 N Uncharacterized protein TLE4 TLE_N+6wd40
cDNA FLJ76323, highly similar
A8K044_HUMA to Homo sapiens transducin
12 N (beta)-like 1X-linked, Mrna 1(LisH)+ 8wd40

to Homo sapiens F-box and WD-
A8K0Q6_HUMA 40 domain protein 8 (FBXW8),
13 N transcript variant 2, mRNA 1(F-box)+1wd40

A8K3R2_HUMA to Homo sapiens block of
14 N proliferation 1, mRNA 1(BOP1NT)+2wd40

to Homo sapiens transducin-like
enhancer of split 1 (E(sp1)
A8K495_HUMA homolog, Drosophila) (TLE1),
15 N mRNA 1(TLE_N)+6wd40

to Homo sapiens transducin
(beta)-like 1X-linked (TBL1X),
16 A8K4J7_HUMAN mRNA 1(LisH)+8WD40
A8K4K2_HUMA
17 N cDNA FLJ78025 1(LRR_1)+1wd
A8K806_HUMA
18 N cDNA FLJ77705 1wd40+1(BING4CT)
A8K9A1_HUMA
19 N cDNA FLJ77639 1wd40+1(BING4CT)

to Homo sapiens WD repeat and
HMG-box DNA binding protein
A8KAE0_HUMA 1 (WDHD1), transcript variant 1,
20 N mRNA 4WD40+(HMG domain)
A8MSP9_HUMA
21 N Uncharacterized protein TLE4 1(TLE_N)+6wd40
Echinoderm microtubule-
22 EMAL1_HUMAN associated protein-like 1 1(HELP)+1wd40
23 WDR46_HUMAN WD repeat-containing protein 46 1WD40+1(BING4CT)
U4/U6 small nuclear

24 PRP4_HUMAN ribonucleoprotein Prp4 1SFM+7wd40
F-box/WD repeat-containing
25 FBXW4_HUMAN protein 4 1(FBOX_+4wd40
Transducin-like enhancer protein

26 TLE1_HUMAN 1 1TLE_N+6wd40



Echinoderm microtubule-
30 EMAL5_HUMAN associated protein-like 5 12WD40+1HELP+4WD40
31 STRN3_HUMAN Striatin-3 1(Striatin)+7(wd40)
Ribosome biogenesis protein

32 BOP1_HUMAN BOP1 BOP1NT+7WD
NACHT and WD repeat domain-

33 NWD1_HUMAN containing protein 1 1NACHT+11wd40
Q14DD4_HUMA
34 N Syntaxin binding protein 5 5WD+LLGL+2WD
35 WDR43_HUMAN WD repeat-containing protein 43 5 WD40+1 NUC189
Periodic tryptophan protein 2

36 PWP2_HUMAN homolog 13 WD40+1 PWP2
Q2UVF1_HUMA Kinesin-like protein KIF21A

37 N variant 1KISC +7WD
EMAL3_HUMAN Echinoderm microtubule-

38 associated protein-like 3 HELP +8WD
Q4FD35_HUMA
39 N AHI1 6WD+1SH3
Q4VXZ0_HUMA
40 N WD repeat-containing protein 46 4WD+BING4CT
41 STXB5_HUMAN Syntaxin-binding protein 5 5WD+1LLGL+2WD
Q5TDG3_HUMA
42 N WD repeat domain 3 11WD+1UTP12
TAF5-like RNA polymerase II,

p300/CBP-associated factor
43 Q5TDI5_HUMAN (PCAF)-associated factor, 65kDa 1TFIID_90kDa+1WD
TAF5-like RNA polymerase II,
p300/CBP-associated factor
44 Q5TDI6_HUMAN (PCAF)-associated factor, 65kDa 1TFIID_90kDa+6WD
Q5W142_HUMA
45 N Beta-transducin repeat containing F-box+7WD
F-box/WD repeat-containing
46 FBXW9_HUMAN protein 9 F-box+6WD
47 A16L1_HUMAN Autophagy-related protein 16-1 ATG16+7WD
Q68D03_HUMA Putative uncharacterized protein

48 N DKFZp686K03100 Beach +5WD
Q68DS0_HUMA Putative uncharacterized protein

49 N DKFZp781N011 F-box+7WD
50 Q6IAP9_HUMAN PRPF4 protein SFM +7WD
51 Q6PI57_HUMAN TLE3 protein TLE_N +7WD
Q6UX91_HUMA
52 N SQFE253 1Beach +3WD
53 NBEAL_HUMAN Neurobeachin-like 1 1Beach +3WD
Q86YQ0_HUMA
54 N HZGJ 1EFh+4WD
Q8IVB7|
Q8IVB7_HUMAN
55 532 Transducin (Beta)-like 3 13WD+UTP13
Q8IWB7|
WDFY1_HUMA WD repeat and FYVE domain-
56 N 535 containing protein 1 6WD+FYVE+wd
Q8N157|
AHI1_HUMAN
57 545 Jouberin 6WD+1SH3
Q8N3Y1|
FBXW8_HUMAN F-box/WD repeat-containing
58 554 protein 8 F-BOX+6WD
Q8N5D0|
WDTC1_HUMA WD and tetratricopeptide repeats
59 N 556 protein 1 6WD+1TPR_1
Q8NAA4|
Q8NAA4_HUMA
60 N 566 Autophagy-related protein 16-2 ATG16+7WD
cDNA FLJ90436 fis, clone

NT2RP3000820, weakly similar
Q8NC76| to PUTATIVE
Q8NC76_HUMA SERINE/THREONINE-
61 N 570 PROTEIN KINASE PKWA 6WD+SOCS
>Q8TED0|
UTP15_HUMAN U3 small nucleolar RNA- 6WD+U3 small nucleolar
62 602 associated protein 15 homolog RNA C terminal
Q92828|
COR2A_HUMAN
63 620 Coronin-2A 4WD+DUF1900
Q969H0|
64 621 protein 7 8WD+FBOX
Q969U6|
Q96A78|
Q96A78_HUMA
66 N 625 TBL3 protein 13WD+UTP13
Q96BP3| Peptidylprolyl isomerase domain

PPWD1_HUMAN and WD repeat-containing
67 629 protein 1 4WD+PRO_ISOMERASE
Q96LK4|
Q96LK4_HUMA CDNA FLJ25420 fis, clone
68 N 642 TST03665 2WD+FYVE+1WD
Q96P52|
Q96P52_HUMAN WD40-and FYVE-domain
69 649 containing protein 3 4WD+FYVE
Q96P53|
70 N 650 containing protein 2 5WD+FYVE
Q99698|
LYST_HUMAN
71 658 Lysosomal-trafficking regulator 4WD+BEACH
Q9BQ87|
TBL1Y_HUMAN F-box-like/WD repeat-containing
72 661 protein TBL1Y 8WD+LiSH
Q9H803| cDNA FLJ14023 fis, clone

Q9H803_HUMA HEMBA1003645, weakly similar
73 N 695 to TIPD PROTEIN 5WD+SH3 1
Q9H8E2| cDNA FLJ13716 fis, clone

Q9H8E2_HUMA PLACE2000411, highly similar
74 N 697 to Homo sapiens epsin 2b mRNA 2WD+1TPR_1
Q9H8N9| cDNA FLJ13353 fis, clone

Q9H8N9_HUMA OVARC1002182, weakly similar
75 N 698 to BETA-TRCP 6WD+FYVE
Q9NRL3|
STRN4_HUMAN
76 717 Striatin-4 7WD+STRIATIN
Q9NV06|
SOF1_HUMAN WD repeat and SOF domain-
77 721 containing protein 1 5WD+SOF1
Q9NVX2|
NLE1_HUMAN
78 724 Notchless protein homolog 1 8WD+NLE
Q9NWG8|
Q9NWG8_HUMA cDNA FLJ10035 fis, clone
79 N 726 HEMBA1000919 2WD+ATG16
Q9NYS7|
WSB2_HUMAN WD repeat and SOCS box-
80 732 containing protein 2 6WD+SOCS
Q9P0U0|
Q9P0U0_HUMA
81 N 734 PC326 protein 2WD+IQ
Q9UKB1|
FBW1B_HUMAN F-box/WD repeat-containing
Q9UKT8|
Q9ULV4|
COR1C_HUMAN
84 751 Coronin-1C 3WD+DUF1900
Q9UNX4|
WDR3_HUMAN
85 754 WD repeat-containing protein 3 10WD+UTP12
FBW1A_HUMAN F-box/WD repeat-containing

86 758 protein 1A F-BOX+6WD
STB5L_HUMAN
87 760 Syntaxin-binding protein 5-like LLGL+6WD
WSB1_HUMAN WD repeat and SOCS box-

88 772 containing protein 1 6WD+SOCS
89 KI21B_HUMAN Kinesin-like protein KIF21B 1KISC+7WD
Q9C0J8|
WDR33_HUMAN
90 681 WD repeat-containing protein 33 6WD+COLLAGEN
Q9H2Y7|
ZF106_HUMAN
91 687 Zinc finger protein 106 homolog 6WD+1ZnF_C2H2
Q9UFC0|
LRWD1_HUMAN Leucine-rich repeat and WD
92 740 repeat-containing protein 1 1WD+1LRR
BRWD3_HUMA Bromodomain and WD repeat-

93 N 481 containing protein 3 8WD+1BROMO
94 Q8TBC3|SHKB1_HUMANSH3KBP1-binding
591 protein 1 1btb+1wd
WD repeat-containing protein
Q8NI36|WDR36_HUMAN 586 36 Utp21
wd+2
APAF1 protein 1CARD+1NB-ARC+12WD
A5YM44_HUMA
1 N
Apoptotic peptidase activating 1(CARD)+1NB-

factor 1 ARC+13wd40
A7E2A2_HUMA
2 N
3 A7J992_HUMAN PH-interacting protein 8WD+2BROMO

to Homo sapiens neutral
sphingomyelinase (N-SMase)
A8K9G4_HUMA activation associated factor
4 N (NSMAF), mRNA 1(GRAM)+1(Beach)+7wd40
Lipopolysaccharide-responsive
5 LRBA_HUMAN and beige-like anchor protein 1DUF1088+1Beach+5wd40
6 HIRA_HUMAN Protein HIRA 7WD+1HIRA_B+1HIRA

Transcription initiation factor 1 LisH+
7 TAF5_HUMAN TFIID subunit 5 1TFIID_90kDa+6wd40
WD40 repeat-containing protein

8 SMU1_HUMAN SMU1 1 LisH+1CTLH+7WD40
Q5T3M3_HUMA
9 N Tubby like protein 4 2WD+SOCS _BOX+TUB
7( WD40)+1(
Coatomer_WDAD)+1
10 COPA_HUMAN Coatomer subunit alpha COPI_C
Q17RK4_HUMA 4WD+1DUF1900+3WD+1D
11 N Coronin 7 UF1900
Q86TI4| 4WD+1PQQ+1WD+1PQQ+
12 Q86TI4_HUMAN WD repeat-containing protein 86 1WD
Q8IW26| Neutral sphingomyelinase (N-

Q8IW26_HUMA SMase) activation associated
13 N factor 1GRAM+1BEACH+7WD
Q8IZQ1|
14 N 540 containing protein 3 1BEACH+5WD+1FYVE
Q8N9V3|
WSDU1_HUMA WD repeat, SAM and U-box
15 N 563 domain-containing protein 1 7WD+SAM+UBOX
Q8WWQ0|
PHIP_HUMAN
16 614 PH-interacting protein 8WD+2BROMO
Q92636|
FAN_HUMAN
17 618 Protein FAN 1GRAM+1BEACH+7WD
Q9H7D7|
WDR26_HUMAN
18 692 WD repeat-containing protein 26 5WD+CTLH+LisH
Q9NRJ4|
TULP4_HUMAN
19 716 Tubby-related protein 4 1WD+SOCS+TUB
Q9NSI6|
BRWD1_HUMA Bromodomain and WD repeat-
20 N 718 containing protein 1 6WD+2BROMO
Tyrosine-protein kinase receptor 1HELP+1WD40+1Pkinase_T

yr
A6P4V4_HUMA
21 N

to H.sapiens HIRA mRNA
A8K194_HUMA 3(wd40)+1(HIRA_B)+1(Hira
22 N )
E3 ubiquitin-protein ligase
23 TRAF7_HUMAN TRAF7 1RING+1zf-TRAF+7WD
to Homo sapiens TAF5 RNA
polymerase II, TATA box
A8K5B4_HUMA binding protein (TBP)-associated 1LISH+1(TFIID_90kDa)+6w
24 N factor, 100kDa (TAF5), mRNA d40
Putative uncharacterized protein

25 Q587J1_HUMAN FLJ11294 7WD+1COLLAGEN+1RPT
Q5T3M2_HUMA
26 N Tubby like protein 4 2WD+1SOCS+2WD+TUB
A7MAP0_HUMA Coronin-1C_i2 protein DUF1899+3WD+1DUF1900

27 N
cDNA FLJ75486, highly similar DUF1899+4WD+DUF1900

to Homo sapiens coronin, actin
A8K0W3_HUMA binding protein, 2B (CORO2B),
28 N mRNA
29 COR1A_HUMAN Coronin-1A DUF1899+3WD+1DUF1900
Q5TBR5_HUMA Coronin, actin binding protein,

30 N 398 2A DUF1899+4WD+1DUF1900
CORO6_HUMAN
31 478 Coronin-6 DUF1899+3WD+1DUF1900
Q9UQ03|
COR2B_HUMAN
32 756 Coronin-2B DUF1899+4WD+1DUF1900
Q9BR76|
COR1B_HUMAN
33 663 Coronin-1B DUF1899+3WD+1DUF1900
4WD+1DUF1900+3WD+1D
34 CORO7_HUMAN Coronin-7 UF1900
Leucine-rich repeat
35 LRRK2_HUMAN serine/threonine-protein kinase 2 Miro+Pkinase+1WD
wd+3
Phosphoinositide-3-kinase,
1 A0JP11_HUMAN regulatory subunit 4, p150 1STYKc+2HEAT+6WD
Q99570|
PI3R4_HUMAN Phosphoinositide 3-kinase
2 656 regulatory subunit 4 6WD+S_TKC+2HEAT
Q8N122|
RPTOR_HUMAN Regulatory-associated protein of
3 543 mTOR 7WD+3HEAT
wd+6
A0AUV9_HUMA 4(TEP1_N)+1(TROVE)+1(N
1 N Telomerase-associated protein 1 ACHT)+18(wd)
Telomerase protein 4tep1+1trove+1

2 Q99973|TEP1_HUMAN
component
659 1 nacht+18wd
wd+7
HECT domain and RCC1-like 6( RCC1)+1 SPRY+1

1 Q15751_HUMAN domain-containing protein 1 HECT+6wd40
wd+10
Uncharacterized protein
1 K0329_HUMAN KIAA0329/KIAA0297 10(TECPR)+3wd40
wd+11
Q17RV3_HUMA 8(LRR)+1LRR_TYP+1small
1 N Leucine-rich repeat kinase 2 _GTPase +1STYKc+1WD40
positional analysis of positional analysis of WD domain in te

WD domain in tethered
proteins Nuber of proteins WD dom
WD domain present at C- at C-Ter
Termainal 67 WD dom
WD domain present at N- 51.54% at N-Ter
Termainal 23
WD domain dispersed throuh WD dom
out protein 12 10.00% persed t
WD domain lack at C- protein
Termainal 2 WD dom
WD domain lack at N- 17.69% C-Terma
Termainal 13 9.23% 1.54%10.00%
WD dom
WD domain lack at Middle 13 N-Terma
positional analysis tethered domain in W

positional analysis of WD
domain inwd+1 tethered Number of
population proteins
45.26%
tethered domain present in 14.74%

N terminal 43
40.00%
45.26%
14.74%
40.00%
tethered domain present in
middle 14
tethered domains present in

c terminal 38
positional analysis of tethered domain
40.00%
domain in wd+2 tethered Number of
population proteins
26.67%
tethered domain present in N
terminal 6
midle 4
tethered domain present in C
terminal 5
33.33%
domain in wd+2 tethered Number of positional analysis of tethered domain i
population proteins
tethered domain lack in N 25.00%
terminal 5
tethered domain lack in middle 13
tethered domain lack in C 10
terminal 2
65.00%
wd+3
tethered domains lack in C
terminal 2
tethered domains present only
in middle 1
wd+6
tethered domains lack in C
terminal 2
wd+7
tethered domains lack in
middle 1
wd+10
tethered domains lack in
Middle 1
wd+11
tethered domains lack in N
terminal 1
previous
Ubiquitin associated 19
Cell Cycle of
Regulation 3
transcription 24
autophagy 3
Cell organization 1
Apoptosis 3
Protein Transport 10
WNT signaling 12
Notch signalling 1
76
25
22.5
20
number of protein
17.5
15
12.5
10
7.5 Column B
5
2.5
0
Ubi- Cell Regu- auto- Cell Apop- Pro- WNT Notch
quitin Cycle lation phagy organ- tosis tein signal- sig-
asso- of ization Trans ing nalling
process involved
sir's
Ubiquitn Associated 11
Cell Cycle 2
Regulation of transcription 17
autophagy 3
Cell organization 1
Apoptosis 4
Protein Transport 9
WNT signaling 10
Notch signalling 1
gene id n-termini middle c-termini
STRN3 Striatin 1 0 0
wd 0 0 5
TBL1Y LisH 1 0 0
wd 0 1 7
WDR36 wd 2 0 1
utp 0 0 1
ATG16L1 ATG16 1 0 0
WD 0 0 6
ATG16L1 ATG16 1 0 0
WD 1 1 4
EML4 HELP 1 0 0
WD 0 0 1
TLE1 TLE_N 1 0 0
WD 0 0 6
NBEAL1 BEACH 0 0 1
WD 0 0 2
STRN3 Striatin 1 0 0
WD 0 0 5
EML5 HELP 0 0 1
WD 3 0 2
TLE4 TLE_N 1 0 0
WD 0 0 6
TBL1X LISH 1 0 0
WD 2 1 5
FBXW8 F-BOX 1 0 0
WD 0 0 1
BOP1 BOPOINT 1 0 0
WD 0 0 2
TLE1 TLE_N 1 0 0
WD 0 0 6
no terms found LISH 1 0 0

WD 1 1 6
no terms found LRR_1 1 0 0

WD 0 0 1
no terms found WD 0 0 1
BING4CT 0 0 1
BING4CT 0 0 1
HMG 0 0 1
TLE4 TLE_N 1 0 0
WD 0 0 6
EML1 HELP 1 0 0
WD 0 0 1
WDR46 WD 0 0 1
BING4CT 0 0 1
PRPF4 SFM 1 0 0
WD 1 0 6
FBXW4 FBOX 1 0 0
WD 1 1 2
TLE1 TLE_N 1 0 0
WD 0 1 5
TLE2 TLE_N 1 0 0
WD 0 0 6
TLE3 TLE_N 1 0 0
WD 0 0 6
TLE4 TLE_N 1 0 0
WD 0 0 6
EML5 WD 10 1 5
HELP 0 0 1
STRN3 striatin 0 1 0
wd 0 0 7
BOP1 BOP1NT 0 1 0
WD 0 0 7
NWD1 nacht 0 0 1
wd 0 0 11
STXBP5 LLGL 1 0 0
WD 7 0 0
WDR43 NUC189 0 0 1
WD 1 2 2
PWP2 PWP2 0 0 1
WD 0 3 10
KIF21A KISC 1 0 0
WD 0 0 7
EML3 HELP 1 0 0
WD 1 3 4
AHI1 SH3 0 0 1
WD 0 6 0
WDR46 BING4CT 0 0 1
WD 0 2 2
STXBP5 LLGL 1 0 0
WD 7 0 0
WDR3 UTP12 0 0 1
WD 4 3 4
TAF5L TFIID_90kDa 0 1 0
WD 0 0 1
TAF5L TFIID_90kDa 0 1 0
WD 0 0 6
BTRC F-BOX 0 1 0
WD 0 2 5
FBXW9 F-BOX 0 1 0
WD 0 3 3
ATG16L1 ATG16 1 0 0
WD 0 2 5
DKFZp686K03100 BEACH 0 1 0
WD 0 0 5
DKFZp781N011 F-BOX 0 1 0
WD 0 2 5
PRPF4 SFM 0 1 0
WD 0 2 5
TLE3 TLE_N 1 0 0
WD 0 0 7
NBEAL2 BEACH 0 1
WD 0 0 3
NBEAL1 BEACH 0 0 1
WD 0 0 3
HZGJ Efh 1 0 0
WD 0 0 4
TBL1Y WD 13 0 0
UTP13 0 0 1
WDFY1 WD 6 0 1
FYVE 0 0 1
AHI1 WD 0 0 6
SH3 0 0 1
FBXW8 F-BOX 1 0 0
WD 0 0 6
WDTC1 WD 4 0 2
TPR_1 0 1 0
ATG16L2 ATG16 1 0 0
WD 0 0 7
0
WD 0 0 6
SOCS 0 0 1
UTP15 WD 6 0 0
U3 small
nucleolar RNA
C terminal 0 0 1
CORO2A WD 4 0 0
DUF1900 0 1 0
FBXW7 WD 0 0 8
FBOX 1
FBXW5 WD 1 0 2
FBOX 1
TBL3 WD 4 5 4
UTP13 0 0 1
PPWD1 WD 2 2 0
PRO_ISOMER
ASE 0 0 1
WD 2 0 1
FYVE 0 0 1
WDFY3 WD 3 0 1
FYVE 0 0 1
WDFY2 WD 2 2 1
FYVE 0 0 1
LYST WD 0 0 4
BEACH 0 0 1
TBL1Y WD 0 0 8
LiSH 1 0 0
WD 3 2 0
SH3 1 1
WD 0 0 2
TPR_1 1 0 0
WD 5 0 1
FYVE 0 0 1
STRN4 WD 0 0 7
STRIATIN 1 0 0
WDSOF1 WD 2 1 2
SOF1 0 0 1
NLE1 WD 0 0 8
NLE 1 0 0
WD 0 0 2
ATG16 1 0 0
WSB2 WD 1 0 5
SOCS 0 0 1
IQWD1 WD 0 0 2
IQ 0 0 1
FBXW11 WD 0 0 7
FBOX 1 0 0
FBXW2 WD 0 0 5
FBOX 1 0 0
CORO1C WD 3 0 0
DUF1900 0 0 1
WDR3 WD 3 0 7
UTP12 0 0 1
BTRC WD 0 0 6
FBOX 0 1 0
STXBP5L WD 2 4 0
LLGL 1 0 0
WSB1 WD 0 0 6
SOCS 0 0 1
0
KIF21B KISC 1 0 0
WD 0 0 7
WDR33 WD 0 0 6
COLLAGEN 0 1 0
ZFP106 WD 0 0 6
ZnF_C2H2 0 0 1
LRWD1 LRR 1 0 0
WD 0 0 1
BRWD3 WD 8 0 0
BROMO 0 0 1
SHKBP1 BTB 1 0 0
wd 0 1 2
WDR36 Utp21 0 0 1
WD40 5 0 3
APAF1 CARD 1 0 0
NB-ARC 1 0 0
WD 0 6 6
APAF1 CARD 1 0 0
NB-ARC 1 0 0
WD 0 7 6
PHIP BROMO 0 0 2
WD 8 0 0
NSMAF GRAM 0 1 0
BEACH 0 1 0
WD 0 0 7
LRBA DUF1088 0 0 1
BEACH 0 0 1
WD 0 0 5
HIRA WD 7 0 0
HIRA_B 0 1 0
HIRA 0 0 1
TAF5 LISH 1 0 0
TFIID_90kDa 1 0 0
WD 0 0 6
SMU1 LISH 1 0 0
CTLH 1 0 0
WD 0 2 5
TULP4 WD 2 0 0
SOCS 1 0 0
TUB 0 0 1
WD 0 0 6
COPA WD 7 0 0
coatomer_WD
AD 0 1 0
COPI_C 0 0 1
CORO7 WD 4 0 3
DUF1900 1 0 1
WDR86 WD 1 3 2
PQQ 0 0 2
NSMAF GRAM 0 1 0
BEACH 0 1 0
WD 0 0 7
WDFY3 BEACH 0 0 1
WD 0 0 5
FYVE 0 0 1
WDSUB1 WD 4 3 0
SAM 0 0 1
UBOX 0 0 1
PHIP WD 8 0 0
BROMO 0 0 2
NSMAF GRAM 0 1 0
BEACH 0 1 0
WD 0 0 7
WDR26 WD 0 0 5
CTLH 0 1 0
LisH 1 0 0
TULP4 WD 1 0 0
SOCS 1 0 0
TUB 0 0 1
BRWD1 BROMO 0 1 1
WD 6 0 0
DDR1 HELP 1 0 0
WD 1 0 0
Pkinase_Tyr 0 0 1
HIRA wd 3 0 0
HIRA_B 0 1 0
hira 0 0 1
TRAF7 RING 1 0 0
zf-TRAF 0 1 0
WD 0 0 7
TAF5 LISH 1 0 0
TFIID_90kDa 1 0 0
WD 0 0 6
WDR33 COLLAGEN 0 1 0
RPT 0 1 0
WD 7 0 0
TULP4 SOCS 0 1 0
TUB 0 0 1
WD 2 2 0
CORO1C DUF1900 0 0 1
WD 3 0 0
DUF1899 1 0 0
DUF1900 0 0 1
WD 4 0 0
DUF1899 1 0 0
CORO1A WD 3 0 0
DUF1900 0 0 `1
DUF1899 1 0 0
CORO2A WD 4 0 0
DUF1900 0 0 1
DUF1899 1
CORO6 WD 3 0 0
DUF1900 0 0 1
DUF1899 1 0 0
CORO2B WD 4 0 0
DUF1900 0 0 1
DUF1899 1 0 0
CORO1B WD 3 0 0
DUF1900 0 0 1
DUF1899 1
CORO7 WD 4 0 3
DUF1900 1 0 1
LRRK2 miro 1 0 0
pkinase 0 0 1
WD 0 0 1
PIK3R4 STYKc 1 0 0
HAET 0 2 0
WD 0 0 6
PIK3R4 HEAT 0 2 0
S_TKC 1 0 0
wd 0 0 6
KIAA1303 wd 0 0 7
HEAT 0 3 0
TEP1 tep1 4 0 0
trove 1 0 0
nacht 0 1 0
wd 0 0 18
TEP1 tep1 4 0 0
trove 1 0 0
nacht 0 1 0
wd 0 0 12
HERC5 RCC1 2 0 4
SPRY 0 1 0
HECT 0 0 1
wd40 0 0 6
KIAA0329 TECPR 2 0 8
wd 3 0 0
LRRK2 LRR 0 8 0
LRR_TYP 0 1 0
small_GTPase 0 0 1
wd 0 0 1
STYKc 0 0 1
nalysis of WD domain in tethered proteins
WD domain present WD domain lack at

at C-Termainal Middle
WD domain present
at N-Termainal
WD domain dis-
10.00% persed throuh out
protein
WD domain lack at
C-Termainal
%10.00%
WD domain lack at
N-Termainal
al analysis tethered domain in WD+1 protein
45.26% tethered domain present in N

terminal
middle
c terminal
40.00%
45.26% tethered domain present in N
terminal
middle
c terminal
40.00%
alysis of tethered domain in WD+2 protein
40.00%
tethered domain
present in N terminal
tethered domain
present in midle
tethered domain
present in C terminal
33.33%
nal analysis of tethered domain in wd+2 protein
25.00%
tethered domain lack in

N terminal
10.00% tethered domain lack in
middle
tethered domain lack in
C terminal
Number of
Biological process proteins
Ubiquitn Associated 12
Cell Cycle 21
Regulation of transcription 22
Cell organization 13
Protein metabolism 1
cell communication 17
86
functional analysis in tethered population
24.42%
13.95%
25.58%
19.77%
15.12% 1.16%
Column B
functions tethering number
Cell cycle 1
Regulation of transcription, DNA-

dependent,Transcription,Ubiquitin cycle 1 1ERJ 7
rRNA processing,visual
perception,biological_processes,response to
stimulus 1 1ERJ 7
transport,autophagy,protein transport 1 1ERJ 7
transport,autophagy,protein transport 1 1ERJ 7
proteolysis 1
transcription,transduction,regulation of
transcription,DNA dependent signal
transduction,multicellular organismal
development,organ morphogenesis,wnt receptor
signalling pathway,negative regulation of
transcription,negative regulation of wnt receptor
signalling pathway,regulation of transcription 1 1GXR 7
not available 1
Cell cycle 1
not available 1
1
transcription,transduction,regulation of
transcription,DNA dependent signal
development,organ morphogenesis,wnt receptor
signalling pathway,negative regulation of
transcription,negative regulation of wnt receptor
signalling pathway,regulation of transcription 1 1GXR 7
regulation of transcription, DNA-dependent

biological_process,Wnt receptor signaling
pathway,regulation of transcription 1 1GXR 7
visual perception 1
translation,tRNA aminoacylation for protein
translation,biological_process,biosynthetic process 1
electron transport,mRNA processing,response to

oxidative stress,RNA splicing 1
ubiquitin-dependent protein catabolic

process,ubiquitin cycle,multicellular organismal
development,Wnt receptor signaling
pathway,embryonic limb morphogenesis 1
regulation of transcription, DNA-dependent,signal

development,organ morphogenesis,Wnt receptor
signaling pathway 1 1GXR 7

transduction,organ morphogenesis,Wnt receptor
signaling pathway,regulation of transcription 1 1GXR 7

transduction,organ morphogenesis,,Wnt receptor
regulation of transcription, DNA-

dependent,biological_process,Wnt receptor
not found 1
cell cycle 1
rRNA processing , ribosome biogenesis and

assembly 1
nucleotide binding , ATP binding(mol function) 1

transport 1
no function 1
proteolysis , signal transduction 1
microtubule-based movement 1
protein binding(mol function) 1
Gene Ontology is not available. 1
translation , tRNA aminoacylation for protein

translation , biological_process , biosynthetic
process 1

transport 1
rRNA processing 1

dependent , transcription from RNA polymerase
II promoter , regulation of transcription 1
dependent , transcription from RNA polymerase
II promoter , regulation of transcription 1 1ERJ 7

ubiquitin cycle , signal transduction , Wnt
receptor signaling pathway 1
ubiquitin cycle 1
transport , autophagy , protein transport 1
Biological process unknown 1
Biological process unknown 1
electron transport , RNA processing , mRNA

processing , response to oxidative stress , RNA
splicing , RNA splicing 1

dependent , signal transduction , organ
morphogenesis , Wnt receptor signaling pathway ,
regulation of transcription 1 1GXR 7
binding(mol function) 1
no results 1

dependent , ubiquitin cycle 1 1ERJ 7
phosphatidylinositol binding , zinc ion binding ,

metal ion binding
1

1
ubiquitin cycle
binding 1
rRNA processing
1
glutamine biosynthetic process , nitrogen
compound metabolic process , intracellular
signaling cascade
1
ubiquitin cycle , protein ubiquitination

1
ubiquitin cycle 1
rRNA processing , G-protein signaling, coupled

to cGMP nucleotide second messe 1
mRNA processing , protein folding , RNA

splicing
1
binding , zinc ion binding , metal ion binding
1
zinc ion binding , metal ion binding

1
electron transport , transport , cellular defense

response , signal transduction , endosome to
lysosome transport , protein transport 1

dependent , ubiquitin cycle 1 1ERJ 7
signal transduction , synaptic transmission 1
rRNA processing , ribosome biogenesis and

assembly 1
inner cell mass cell differentiation , Notch

signaling pathway 1
ubiquitin cycle , intracellular signaling cascade 1

receptor activity 1
ubiquitin cycle , Wnt receptor signaling pathway ,

protein ubiquitination 1
protein modification process , proteolysis ,

ubiquitin cycle 1
phagocytosis , signal transduction 1
rRNA processing
1
ubiquitin cycle , signal transduction , Wnt
receptor signaling pathway 1

transport 1
ubiquitin cycle , intracellular signaling cascade ,

biological_process 1
microtubule-based movement,actin cytoskeleton

organization and biogenesis 1
postreplication repair,transport,phosphate
transport,spermatogenesis 1
electron transport,insulin receptor signaling

pathway 1
protein binding 1
voltage-gated potassium channel activity , protein

binding,potassium ion transport
apoptosis , apoptosis , defense response ,
nervous system development , caspase activation
via cytochrome c , regulation of apoptosis ,
regulation of apoptosis 2
apoptosis , apoptosis , defense response ,

nervous system development , caspase activation
via cytochrome c , regulation of apoptosis ,
regulation of apoptosis 2
insulin receptor signaling pathway 2
ceramide metabolic process , signal transduction

2
regulation of DNA replication 2

promoter, gastrulation,anatomical structure
morphogenesis,chromatin modification,regulation
of transcription 2
dependent , transcription initiation from RNA
polymerase II promoter , chromatin modification ,
nucleus , cytoplasm 2
regulation of transcription, DNA-dependent ,

response to nutrient
2
protein folding,protein complex assembly,

intracellular protein transport,ER to Golgi vesicle-
mediated transport,vesicle-mediated transport
protein transport,intracellular protein transport

across a membrane 2
electron transport 2
signal transduction, ceramide metabolic

process,receptor signaling protein activity 2
metal ion binding, zinc ion binding,binding 2

protein ubiquitination 2
insulin receptor binding,insulin receptor signaling

pathway 2
signal transduction, ceramide metabolic

process,receptor signaling protein activity 2
homoiothermy,response to freezing 2H14 7

2
regulation of transcription, DNA-dependent,

ubiquitin cycle, intracellular signaling
cascade,response to nutrient
transcription,regulation of transcription, DNA-

dependent,regulation of transcription from RNA
polymerase II promoter 1ERJ. 6-Jan
2
regulation of transcription, DNA-dependent, protein

amino acid phosphorylation,cell
adhesion,transmembrane receptor protein tyrosine
kinase signaling pathway

promoter,gastrulation,anatomical structure
morphogenesis,chromatin modification,regulation
of transcription
activation of MAPKKK activity , transcription ,

ubiquitin cycle , apoptosis , protein
ubiquitination , regulation of exocytosis ,
exocrine system development , regulation of
apoptosis , positive regulation of MAPKKK
cascade 2 1ERJ 7
rregulation of transcription, DNA-dependent
transcription initiation from RNA polymerase II
promoter
regulation of transcription 2 1GXR 7
postreplication repair , phosphate transport ,

spermatogenesis 2

response to nutrient 2
phagocytosis , signal transduction 2
transport,cell motility, mitosis 2
glutamine biosynthetic process , nitrogen

compound metabolic process , intracellular
signaling cascade 2
actin binding,actin cytoskeleton organization and

biogenesis 2
protein binding, actin binding 2
2
MAPKKK cascade , protein amino acid
phosphorylation , small GTPase mediated signal
transduction , positive regulation of protein
ubiquitination , positive regulation of
programmed cell death , protein amino acid
autophosphorylation
protein amino acid phosphorylation,

Meiosis,Mitotic chromosome condensation
3
protein amino acid phosphorylation, nucleotide

binding,protein kinase activity,ATP binding
3
binding 1
telomere maintenance via

recombination,nucleoside-triphosphatase activity,
RNA binding,ATP binding
6
telomere maintenance via

recombination,nucleoside-triphosphatase activity,
RNA binding,ATP binding
regulation of cyclin-dependent protein kinase

activity, protein modification process,ubiquitin
cycle 7
UniProt/Swiss-Prot: HPS5_HUMAN, Q9UPZ3 10
Function: May regulate the synthesis and function
of lysosomes and of highly specialized
organelles, such as melanosomes and platelet dense
granules. Might be involved in the regulation
of general functions of integrins
protein amino acid phosphorylation,intracellular

protein transport,nucleocytoplasmic transport,
signal transduction,small GTPase mediated signal
transduction 11
onal analysis in tethered population
Ubiquitn Associated
24.42% Cell Cycle
13.95% Regulation of
transcription
19.77%
Cell organization
Protein metabolism
1.16% cell communication
process
cell cycle
regulation of transcription/Ubiquitin cycle
cell organization
cell cycle
cell cycle
protein metabolism
cell cycle
cell communication
cell organization
cell organization
ubiquitin cycle
cell organization
cell communication
cell organization
cell organization
cell organization
cell communication
ubiquitin cycle
cell cycle
cell organization
regulation of transcription/ubiquitin cycle

cell organization
cell communication
ubiquitin cycle
ubiquitin cycle
cell organization
cell communication
cell organization
cell comunication
ubiquitin cycle
cell communication
ubiquitin cycle
ubiquitin cycle
cell communication
cell organization
ubiquitin cycle
cell cycle
ubiquitin cycle
cell cycle
cell cycle
regulation of ranscription
cell cycle
cell cycle
cell communication
cell communication
cell organization
cell cycle
cell cycle
cell communication
ubiquitin cycle
cell communication
cell communication
cell communication
cell communication
cell cycle

cell communication
cell cycle
cell communication
cell cycle
cell cycle
ubiquitin cycle
cell cycle
cell cycle
cell cycle
cell cycle
Ubiquitin cycle
cell communication
description
transcriptional corepressor that binds to a number of transcription factors.

inhibits nf-kappa-b-regulated gene expression. inhibits the transcriptional
activation mediated by foxa2, and by ctnnb1 and tcf family members in wnt
signaling. the effects of full-length tle family members may be modulated by
association with dominant-negative aes. unusual function as coactivator for
esrrg.
may modify the assembly dynamics of microtubules, such that microtubules
are slightly longer, but more dynamic (by similarity).
involved in pre-mrna splicing.
binds calmodulin in a calcium dependent manner. may function as

scaffolding or signaling protein.
required for maturation of the 25s and 5.8s ribosomal rnas. required for
proper processing at four distinct sites located within the internal transcribed
spacers its1 and its2 and the 3' external spacer. may serve as an essential
factor in ribosome formation that coordinates processing of the spacer
regions in pre-rrna (by similarity).
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are
involved in docking and fusion of synaptic vesicles with the presynaptic
plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a
similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1
complex to form a 10S complex, an intermediate which can be converted to
the 7S SNARE complex. Thus this protein is thought to be involved in
neurotransmitter release by stimulating SNARE complex formation.
Alternatively spliced variants have been identified, but their biological
validity has not been determined.
microtubule-binding motor protein probably involved in neuronal axonal

transport. in vitro, has a plus-end directed motor activity (by similarity).
This gene encodes a nuclear protein containing 10 WD repeats. WD repeats

are approximately 30- to 40-amino acid domains containing several
conserved residues, which usually include a trp-asp at the C-terminal end.
Proteins belonging to the WD repeat family are involved in a variety of
cellular processes, including cell cycle progression, signal transduction,
apoptosis, and gene regulation.
plays an essential role in autophagy
involved in pre-mrna splicing.

This gene encodes a protein which contains WD repeats and an FYVE
domain. Multiple alternatively spliced transcript variants have been found
for this gene, but the full-length nature of some variants has not been
defined.
This gene encodes a protein that contains two WD domains and an FYVE
zinc finger region. The function of this gene is unknown. An alternatively
spliced transcript variant of this gene may exist.
may be required for sorting endosomal resident proteins into late

multivesicular endosomes by a mechanism involving microtubules.
may play a role in vesicle trafficking and exocytosis (potential).
cooperates with asf1a to promote replication-independent chromatin
assembly. required for the periodic repression of histone gene transcription
during the cell cycle. required for the formation of senescence-associated
heterochromatin foci (sahf) and efficient senescence-associated cell cycle
exit.
tafs are components of the transcription factor iid (tfiid) complex, pcaf
histone acetylase complex and tbp-free tafii complex (tftc). tafs components-
tiifd are essential for mediating regulation of rna polymerase transcription.
taf5/tafii100 interacts strongly with the histone h4-related taf6/tafii80 and
the histone h3-related taf9/tafii31, as well as a stable complex comprised of
both taf5/tafii80 and taf6/tafii31. apparently weaker interactions of
taf5/tafii100 with tbp, taf1/tafii250, taf11/tafii28, and taf12/tafii20, but not
taf7/tafii55, also have been observed.
the coatomer is a cytosolic protein complex that binds to dilysine motifs and
reversibly associates with golgi non- clathrin-coated vesicles, which further
mediate biosynthetic protein transport from the er, via the golgi up to the
trans golgi network. coatomer complex is required for budding from golgi
membranes, and is essential for the retrograde golgi-to-er transport of
dilysine-tagged proteins. in mammals, the coatomer can only be recruited by
membranes associated to adp-ribosylation factors (arfs), which are small gtp-
binding proteins; the complex also influences the golgi structural integrity,
as well as the processing, activity, and endocytic recycling of ldl receptors
(by similarity).
may be involved in cell-cell interactions and recognition.
cooperates with asf1a to promote replication-independent chromatin

assembly. required for the periodic repression of histone gene transcription
during the cell cycle. required for the formation of senescence-associated
heterochromatin foci (sahf) and efficient senescence-associated cell cycle
exit.
e3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation

by map3k3. potentiates mekk3-mediated activation of the nf-kappa-b,
jun/ap1 and ddit3 transcriptional regulators. induces apoptosis when
overexpressed.
tafs are components of the transcription factor iid (tfiid) complex, pcaf
histone acetylase complex and tbp-free tafii complex (tftc). tafs components-
tiifd are essential for mediating regulation of rna polymerase transcription.
taf5/tafii100 interacts strongly with the histone h4-related taf6/tafii80 and
the histone h3-related taf9/tafii31, as well as a stable complex comprised of
both taf5/tafii80 and taf6/tafii31. apparently weaker interactions of
taf5/tafii100 with tbp, taf1/tafii250, taf11/tafii28, and taf12/tafii20, but not
taf7/tafii55, also have been observed.
probable protein kinase whose role is not yet known. may play a role in the
phosphorylation of proteins central to parkinson disease. may also have
gtpase activity
regulatory subunit of the pi3k complex. may regulate membrane trafficking

late in the endocytic pathway.
regulatory subunit of the pi3k complex. may regulate membrane trafficking

late in the endocytic pathway.
component of the telomerase ribonucleoprotein complex that is essential for

the replication of chromosome termini. also component of the
ribonucleoprotein vaults particle, a multi- subunit structure involved in
nucleo-cytoplasmic transport. responsible for the localizing and stabilizing
vault rna (vrna) association in the vault ribonucleoprotein particle (by
similarity).
component of the telomerase ribonucleoprotein complex that is essential for

the replication of chromosome termini. also component of the
ribonucleoprotein vaults particle, a multi- subunit structure involved in
nucleo-cytoplasmic transport. responsible for the localizing and stabilizing
vault rna (vrna) association in the vault ribonucleoprotein particle (by
similarity).
probable protein kinase whose role is not yet known. may play a role in the
phosphorylation of proteins central to parkinson disease. may also have
gtpase activity
pathway
WNT signaling pathway. Part 1. Degradation of beta-catenin in

the absence WNT signaling
Putative FAK1 pathway






Estrogen receptor signaling pathway,Ligand-Dependent
Transcription of Retinoid-Target genes
Estrogen receptor signaling pathway,Ligand-Dependent
Transcription of Retinoid-Target genes
S-phase DNA damage response,WNT signaling pathway. Part

1. Degradation of beta-catenin in the absence WNT
signaling,Putative FAK1 pathway

Wnt receptor signaling pathway
insulin receptor signaling pathway

p53-dependent apoptosis,Cytoplasm/mitochondrial transport of
proapoptotic proteins Bid, Bmf and Bim,Regulation of
apoptosis by mitochondrial proteins,Caspases cascade
p53-dependent apoptosis,Cytoplasm/mitochondrial transport of

proapoptotic proteins Bid, Bmf and Bim,Regulation of
apoptosis by mitochondrial proteins,Caspases cascade
Insulin receptor signaling pathway

Assembly of RNA Polymerase II preinitiation complex on
TATA-less promoters,Ligand-Dependent Transcription of
Retinoid-Target genes
Putative integrins pathway in leukocytes. Part 1
Ceramide-dependent NO antiapoptotic action

Insulin receptor signaling pathway
Ceramide-dependent NO antiapoptotic action
may be involved in mapk pathways.

Assembly of RNA Polymerase II preinitiation complex on
TATA-less promoters,Ligand-Dependent Transcription of
desease
defects in ahi1 are the cause of joubert syndrome 3 (jbts3)
[mim:608629]. joubert syndrome is an autosomal recessive
brain congenital malformation of the cerebellar vermis and
brainstem with abnormalities of axonal decussation (crossing
in the brain) affecting the corticospinal tract and superior
cerebellar peduncles. individuals with joubert syndrome have
motor and behavioral abnormalities, including an inability to
walk due to severe clumsiness and 'mirror' movements, and
cognitive and behavioral disturbances.
defects in lyst are the cause of chediak-higashi syndrome
(chs) [mim:214500]. chs is a rare autosomal recessive
disorder characterized by hypopigmentation, severe
immunologic deficiency, a bleeding tendency, neurologic
abnormalities, abnormal intracellular transport to and from
the lysosome, and giant inclusion bodies in a variety of cell
types. most patients die at an early age unless they receive an
allogeneic hematopoietic stem cell transplant (sct).
Patients with Chediak-Higashi syndrome (CHS1; MIM
214500) suffer from a systemic immunodeficiency involving
defects in polarized trafficking of vesicles in a number of
immune system cell types. In mouse, this syndrome is
reproduced in strains with a mutation in the 'beige' gene that
results in proteins lacking the BEACH (beige and CHS1)
domain and C-terminal WD repeats. LRBA contains key
features of both beige/CHS1 and A kinase anchor proteins
(AKAPs; see MIM 602449).[supplied by OMIM]
Domains Occurrence
utp 1
BOPOINT 1
LRR_1 1
HMG 1
NUC189 1 Analysis of Doma
PWP2 1
35
FREQUENCY OF DOMAIN
32.5
RPT 1 APPEARANCE
zf-TRAF 1 30 1
PRO_ISOMERASE 1 2
SOF1 1 27.5 3
IQ 1 25 4
NLE 1 5
Number of domains
ZnF_C2H2 1 22.5 6
DUF1088 1 20 7
coatomer_WDAD 1 8
COPI_C 1 17.5 9
PQQ 1 15 10
SAM 1 11
UBOX 1 12.5
Pkinase_Tyr 1 10
S_TKC 1
tep1 1 7.5
trove 1
5
RCC1 1
HECT 1 2.5
SPRY 1
0
TECPR 1
1 2 3 4 5
LRR_TYP 1
DUF1899 1 Appeare
BTB 1
MIRO 1
UTP21 1
EFH 1
small_GTPase 1
SFM 2
KISC 2
COLLAGEN 2
STYKc 2
UTP12 2
RING 2
UTP13 2
TPR_1 2
CARD 2
HIRA_B 2
HIRA 2
CTLH 2
NB-ARC 2
nacht 3
LLGL 3
SH3 3
LRR 3 sl.no
TUB 3 1
GRAM 3 2
HEAT 3 3
striatin 4 4
TFIID_90kDa 4 5
BING4CT 4 6
BROMO 4 7
ATG16 5 8
HELP 6
SOCS 7
FYVE 6 tethered frequency o
Fbox 6
lish 8 350
TLE_N 9
300
BEACH 10
Number of proteins
DUF1900 11 250
total 171 200
150
100
50
0
Wd wd+1 wd+2 wd+3 wd+6
Domain tethered in Pr
WD sociality
Analysis of Domain occurence
No of TIMES OF DOMAIN
OCCURING IN THE
POPULATION
34
13
7
4
1
3
1
1
1
1
1
2 3 4 5 6 7 8 9 10 11
Appearence frequency
number of tethered domain number of proteins
Wd 303
wd+1 95
wd+2 35
wd+3 3
wd+6 2
wd+7 1
wd+10 1
wd+11 1
441
tethered frequency of WD Domain
Column G
wd+1 wd+2 wd+3 wd+6 wd+7 wd+10 wd+11

Domain tethered in Protein
WD sociality
Wd
wd+1
wd+2
wd+3
wd+6
wd+7
wd+10
wd+11
wd+7
wd+10
wd+11
Saccharomyces cerevisiae
Fungi
Caenorhabditis elegans
Nematoda (roundworms)
Metazoa
Drosophila melanogaster (Fruit fly)
Arthropoda
Chordata
Mus musculus (Mouse)
Homo sapiens (Human)
Eukaryota
Viruses
Archaea
Bacteria
Cyanobacteria
Synechocystis sp. (strain PCC 6803)
Oryza sativa (Rice)
Arabidopsis thaliana (Mouse-ear cress)
Viridiplantae(green plants)
plastid group
other eukaryotes
204
3972
171
477
4970
319
971
3108 species wide distribution of WD Proteins
670
718
15126
17
55 16000
909
261 15000
Saccharomyces
8 species wide distribution of wd proteins
14000 cerevisiae
811
443 13000 Fungi
2661 Caenorhabditis elegans
5225
12000 Nematoda (roundworms)
779 11000 Metazoa
10000 Drosophila melanogaster
(Fruit fly)
9000 Arthropoda
8000 Chordata
7000 Mus musculus (Mouse)
6000
Eukaryota
5000 Viruses
4000 Archaea
3000 Bacteria
Cyanobacteria
2000
Synechocystis sp. (strain
1000 PCC 6803)
0
Column H
6000
Eukaryota
5000 Viruses
4000 Archaea
3000 Bacteria
Cyanobacteria
2000
1000 PCC 6803)
0
Column H
species
WD Proteins
Saccharomyces Oryza sativa (Rice)

cerevisiae Arabidopsis thaliana
Fungi (Mouse-ear cress)
Caenorhabditis elegans Viridiplantae(green
Nematoda (roundworms) plants)
Metazoa plastid group
Drosophila melanogaster other eukaryotes
(Fruit fly)
Arthropoda
Chordata
Mus musculus (Mouse)
Eukaryota
Viruses
Archaea
Bacteria
Cyanobacteria
PCC 6803)
Eukaryota
Viruses
Archaea
Bacteria
Cyanobacteria
PCC 6803)
DOMAIN
SL. NO. ACCESSION ID PROTEIN NAME ARCHITECTURE GENE ID
Guanine nucleotide-
binding protein subunit
1 GBB5_HUMAN beta-5 5WD GNB5
Histone-binding protein
2 RBBP7_HUMAN RBBP7 6WD RBBP7
Q5JNZ9_HUMAN Retinoblastoma binding

3 354 protein 7 6WD RBBP7
Q6FHM2_HUMAN
4 447 GNB2 protein 5WD GNB2
APAF1 protein 1CARD+1NB-

ARC+12WD
5 A5YM44_HUMAN APAF1
FUNCTION process description
regulation of transcription from

RNA polymerase II
promoter,protein modification
process,proteolysis,ubiquitin-
dependent protein catabolic
process,ubiquitin cycle regulation of transcription 42 pathway
DNA replication , transcription ,
dependent , multicellular
organismal development , cell
proliferation , chromatin
modification regulation of transcription
DNA replication , transcription ,

dependent , multicellular
organismal development , cell
proliferation , chromatin
modification regulation of transcription
signal transduction , G-protein

coupled receptor protein signaling
pathway cell communication 44 pathway
apoptosis , apoptosis , defense

response , nervous system
development , caspase activation via
cytochrome c , regulation of
apoptosis , regulation of apoptosis cell cycle
PATHWAY
1.CREB pathway,Angiotensin activation of Akt,Angiotensin activation of ERK,Angiotensin signaling via PYK2,Angiotensin signaling via
STATs,Activation of PKC via G protein coupled receptor,G-Protein alpha-12 signaling pathway,G-protein families signaling pathway,Membrane
trafficking and signal transduction of G-alpha (i) heterotrimeric G-protein,Transcription factor Tubby signaling pathways,G-Proteins mediated
regulation MARK-ERK signaling,ChREBP regulation pathway,Rhodopsin phototransduction cascade in retina - the key role of Ca2+
transport,Putative erythropoietin signaling pathway (part 2),A2BR signaling via G-protein beta/gamma dimer. Activation of PI3K, PLCB and
PLA2,A2BR signaling via G-beta/gamma dimer. Activation of PH-domain proteins. (map 1),A2BR signaling via G-beta/gamma dimer. RGS and
CaM-related GIRK regulation,A2BR signaling via G-beta/gamma dimer. Activation of PH-domain proteins. (map 2),A2BR signaling via G-alpha-q:
Inhibition of TKR-specific PI3K activation (map 1a),A2BR signaling via G-alpha-q: Inhibition of TKR-specific PI3K activation (map 1b),A2BR
signaling via G-alpha-q: RSK and JNK specific pathways (map 2a),A2BR signaling via G-alpha-q: PRKCA - RSK & JNK specific pathways (map
2b),A2BR signaling via G-alpha-q: PRKCA - RSK & JNK specific pathways (map 2c),A2BR signaling via G-alpha-q: PRKCB/G/Q specific
pathways (map 3a),A2BR signaling via G-alpha-q: PRKCE - RASGRP specific pathways (map 3b),Regulation of fatty acid metabolic enzymes
FACL, ACADM, FASN and SCD via adenosin receptor activation, Angiotensin signaling via beta-arrestin,Calcium signaling,IP3 signaling,CXCR4
signaling pathway,ICOS-ICOSL pathway in T-helper cell,G-Protein alpha-i signaling cascades,G-Protein alpha-q signaling cascades,G-Protein
alpha-s signaling cascades,G-Protein beta/gamma signaling cascades,PDGF signaling via MAPK cascades, cAMP signaling,BAD
phosphorylation,Ceramide-dependent NO antiapoptotic action, PKA signaling,PIP3 signaling in cardiac myocytes,PIP3 signaling in B lymphocytes
Ligand-Dependent Transcription of Retinoid-Target genes,P53 signaling pathway,Estrogen receptor signaling pathway,ATM-H2AX-

NFBD1 DNA damage response,Role of heterochromatin protein 1 (HP1) family in transcriptional silencing,,Formation of Sin3A and
NuRD complexes and their role in transcription regulation
CREB pathway,Angiotensin activation of Akt,Angiotensin activation of ERK,Angiotensin signaling via PYK2,Angiotensin signaling via
STATs,Activation of PKC via G protein coupled receptor,G-Protein alpha-12 signaling pathway,G-protein families signaling
Ligand-Dependent
pathway,Membrane Transcription of Retinoid-Target
trafficking and genes,P53
signal transduction signaling
of G-alpha pathway,Estrogen
(i) heterotrimeric receptor signaling
G-protein,Transcription pathway,ATM-H2AX-
factor Tubby signaling
NFBD1 DNA damage
pathways,G-Proteins response,Role
mediated of heterochromatin
regulation protein 1 (HP1)regulation
MARK-ERK signaling,ChREBP family in transcriptional silencing,,Formation
pathway,Rhodopsin of Sin3A
phototransduction and in
cascade
NuRD complexes and their role in transcription regulation
retina - the key role of Ca2+ transport,Putative erythropoietin signaling pathway (part 2),A2B receptor: action via G-protein alpha s
(map 1),A2BR signaling via G-protein beta/gamma dimer. Activation of PI3K, PLCB and PLA2,A2BR signaling via G-beta/gamma
dimer. RGS and CaM-related GIRK regulation,A2BR signaling via G-beta/gamma dimer. Activation of PH-domain proteins. (map
2),A2B Receptor: Action via G-alpha s. (map 2),A2BR signaling via G-alpha-q: Inhibition of TKR-specific PI3K activation (map
1a),A2BR signaling via G-beta/gamma dimer. Activation of PH-domain proteins. (map 1),A2B Receptor: Action via G-alpha s. (map
2),A2BR signaling via G-alpha-q: Inhibition of TKR-specific PI3K activation (map 1a),A2BR signaling via G-alpha-q: Inhibition of TKR-
specific PI3K activation (map 1b),A2BR signaling via G-alpha-q: Inhibition of TKR-specific PI3K activation (map 1b),A2BR signaling via
G-alpha-q: PRKCA - RSK & JNK specific pathways (map 2c),A2BR signaling via G-alpha-q: PRKCB/G/Q specific pathways (map
3a),A2BR signaling via G-alpha-q: PRKCE - RASGRP specific pathways (map 3b),Regulation of fatty acid metabolic enzymes FACL,
ACADM, FASN and SCD via adenosin receptor activation,Angiotensin signaling via beta-arrestin,Calcium signaling,IP3
signaling,CXCR4 signaling pathway,ICOS-ICOSL pathway in T-helper cell,G-Protein alpha-i signaling cascades,G-Protein alpha-q
signaling cascades,G-Protein alpha-s signaling cascades,G-Protein beta/gamma signaling cascades,PDGF signaling via MAPK
cascades,cAMP signaling,cAMP signaling,Ceramide-dependent NO antiapoptotic action,PKA signaling,PIP3 signaling in cardiac
myocytes,PIP3 signaling in B lymphocytes
p53-dependent apoptosis,Cytoplasm/mitochondrial transport of proapoptotic proteins Bid, Bmf and Bim,Regulation of apoptosis by mitochondrial
proteins,Caspases cascade
G-protein adaptor/regulatory :beta/gamma
generic protein phosphatases,histone deacytalse class I
generic binding protein

domain
sl.no acc id protein name architecture gene id n-termini
WD+1
Uncharacterized protein 1TLE_N+6wd40
TLE1
A6NFH2_HUM
1 AN TLE1 TLE_N 1
WD 0
cDNA FLJ76330,
highly similar to Homo
sapiens F-box and WD-
40 domain protein 8
A8K0Q6_HUM (FBXW8), transcript
2 AN variant 2, mRNA 1(F-box)+1wd40 FBXW8 F-BOX 1
cDNA FLJ76273,
highly similar to Homo
sapiens transducin-like
enhancer of split 1
(E(sp1) homolog,
A8K495_HUM Drosophila) (TLE1),
3 AN mRNA 1(TLE_N)+6wd40 TLE1 TLE_N 1
A8MSP9_HUM Uncharacterized protein

4 AN TLE4 1(TLE_N)+6wd40 TLE4 TLE_N 1
FBXW4_HUM F-box/WD repeat-

5 AN containing protein 4 1(FBOX_+4wd40 FBXW4 FBOX 1
WD 1
Transducin-like
6 TLE1_HUMAN enhancer protein 1 1TLE_N+6wd40 TLE1 TLE_N 1
WD 0
Transducin-like
WD 0
Transducin-like
WD 0
Transducin-like
WD 0
TAF5-like RNA
polymerase II,
p300/CBP-associated
factor (PCAF)-
Q5TDI5_HUM associated factor, 1TFIID_90kDa+1W TFIID_90k
10 AN 65kDa D TAF5L Da 0
WD 0
Q5W142_HUM Beta-transducin repeat

11 AN containing F-box+7WD BTRC F-BOX 0
Q6PI57_HUM
12 AN TLE3 protein TLE_N +7WD TLE3 TLE_N 1
WD 0
Q96A78|
Q96A78_HUM
13 AN 625 TBL3 protein 13WD+UTP13 TBL3 WD 4
UTP13
Q9NVX2|
NLE1_HUMA Notchless protein
14 N 724 homolog 1 8WD+NLE NLE1 WD
NLE 1
Q9UKB1|
FBW1B_HUM F-box/WD repeat-
15 AN 648 containing protein 11 7WD+FBOX FBXW11 WD
FBOX 1
Q9H2Y7|
ZF106_HUMA Zinc finger protein 106
16 N 687 homolog 6WD+1ZnF_C2H2 ZFP106 WD 0
ZnF_C2H2 0
tethering
middle c-termini functions number
transcription,transduction,regulation of transcription,DNA
dependent signal transduction,multicellular organismal
development,organ morphogenesis,wnt receptor signalling
pathway,negative regulation of transcription,negative
regulation of wnt receptor signalling pathway,regulation of
0 0 transcription 1 1GXR
0 6
0 0 1
transcription,transduction,regulation of transcription,DNA
dependent signal transduction,multicellular organismal
development,organ morphogenesis,wnt receptor signalling
pathway,negative regulation of transcription,negative
regulation of wnt receptor signalling pathway,regulation of
regulation of transcription, DNA-dependent
biological_process,Wnt receptor signaling
0 0 pathway,regulation of transcription 1 1GXR
ubiquitin-dependent protein catabolic process,ubiquitin
cycle,multicellular organismal development,Wnt receptor
0 0 signaling pathway,embryonic limb morphogenesis 1
1 2
transduction,multicellular organismal development,organ
0 0 morphogenesis,Wnt receptor signaling pathway 1 1GXR
1 5

transduction,organ morphogenesis,Wnt receptor signaling
0 6

transduction,organ morphogenesis,,Wnt receptor signaling
0 6
dependent,biological_process,Wnt receptor signaling
0 6

dependent , transcription from RNA polymerase II
1 0 promoter , regulation of transcription 1
0 1
ubiquitin-dependent protein catabolic process , ubiquitin

cycle , signal transduction , Wnt receptor signaling
1 0 pathway 1

dependent , signal transduction , organ morphogenesis ,
Wnt receptor signaling pathway , regulation of
0 7
rRNA processing , G-protein signaling, coupled to cGMP

5 4 nucleotide second messe 1
1
inner cell mass cell differentiation , Notch signaling

8 pathway 1
ubiquitin cycle , Wnt receptor signaling pathway ,

7 protein ubiquitination 1
0 6 electron transport,insulin receptor signaling pathway 1

0 1
process description
transcriptional corepressor that binds to a number of

transcription factors. inhibits nf-kappa-b-regulated
gene expression. inhibits the transcriptional
activation mediated by foxa2, and by ctnnb1 and tcf
family members in wnt signaling. the effects of full-
length tle family members may be modulated by
association with dominant-negative aes. unusual
7 regulation of transcription function as coactivator for esrrg.
7 regulation of transcription
ubiquitin cycle
cell communication
cell comunication
ubiquitin cycle
regulation of ranscription
pathway desease
WNT signaling pathway. Part 1.

Degradation of beta-catenin in the absence it work in
WNT signaling coplex(oligomerization)
it work in
Putative FAK1 pathway coplex(oligomerization)

Degradation of beta-catenin in the absence
WNT signaling



Estrogen receptor signaling

pathway,Ligand-Dependent Transcription of
S-phase DNA damage response,WNT

signaling pathway. Part 1. Degradation of
beta-catenin in the absence WNT it work in
signaling,Putative FAK1 pathway coplex(oligomerization)

WNT signaling

WNT signaling
G-protein coupled receptor protein signaling

pathway
it work in
Wnt receptor signaling pathway coplex(oligomerization)
insulin receptor signaling pathway

wd is the interacting motif
F-box proteins, act as

protein-ubiquitin ligases. F-
box proteins interact with
SKP1 through the F box,
and they interact with
ubiquitination targets
through other protein
interaction domains

FBOX domain partcipate

interaction
FBOX domain partcipate

interaction

Final Sheet Win

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Final Sheet Win

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SL. NO.

ACCESSION ID PROTEIN NAME

3 Q3KQZ0_HUMAN 269 NUP214 protein

18 Q5JB47_HUMAN 352 Achalasia variant

21 DMWD_HUMAN Dystrophia myotonica WD repeat-containing protein

48 Q5SRN1_HUMAN 379 Cell division cycle 40 homolog

cDNA FLJ77024, highly similar to Homo sapiens

57 WDR44_HUMAN 359 WD repeat-containing protein 44

69 CDC20_HUMAN Cell division cycle protein 20 homolog

cDNA FLJ75002, highly similar to Homo sapiens,

Mediator of RNA polymerase II transcription subunit

cDNA FLJ77751, highly similar to Homo sapiens

9 O00149_HUMAN Embryonic ectoderm development protein homolog

11 WDR62_HUMAN WD repeat-containing protein 62

13 CSTF1_HUMAN Cleavage stimulation factor 50 kDa subunit

14 Q05DB2_HUMAN PREB protein

18 RBBP4_HUMAN Histone-binding protein RBBP4

20 Q14CB5_HUMAN MAPKBP1 protein

21 Q14CD8_HUMAN MAPKBP1 protein

22 Q15010_HUMAN KIAA0023 protein

27 Q6NTH2_HUMAN 456 EED protein

28 Q6NUQ0_HUMAN 457 WD repeat domain 33

33 RBBP7_HUMAN Histone-binding protein RBBP7

34 Q4G115_HUMAN 279 DNAI2 protein

36 Q5JNZ9_HUMAN 354 Retinoblastoma binding protein 7

37 Q5JPH5_HUMAN 358 Putative uncharacterized protein DKFZp686P0251

71 STRAP_HUMAN 763 Serine-threonine kinase receptor-associated protein

72 TBL2_HUMAN 767 Transducin beta-like 2 protein

76 RBBP5_HUMAN Retinoblastoma-binding protein 5

Q7LDA5|Q7LDA5_HUMAN Embryonic ectoderm development protein short

Serine/threonine-protein phosphatase 2A 55 kDa

107 SC31A_HUMAN Protein transport protein Sec31A

110 RAE1L_HUMAN mRNA export factor

111 Q5TFT1_HUMAN 405 OTTHUMP00000017265

117 Q5J8M4_HUMAN 350 Migration-inducing gene 14

119 Q06DW9_HUMAN WDR13

120 Q6NZ53_HUMAN 459 THOC3 protein

125 Q5J8M6_HUMAN 351 Proliferation-inducing gene 21

127 Q3B794_HUMAN 266 STXBP5 protein

132 CAF1B_HUMAN Chromatin assembly factor 1 subunit B

136 Q6FGN1_HUMAN 445 PEX7 protein

143 PEX7_HUMAN Peroxisomal targeting signal 2 receptor

Guanine nucleotide-binding protein G(I)/G(S)/G(T)

Guanine nucleotide-binding protein G(I)/G(S)/G(T)

169 Q49AJ8_HUMAN 275 MAPKBP1 protein

173 A8K8H8_HUMAN cDNA FLJ77821

175 SEC13_HUMAN Protein SEC13 homolog

cDNA FLJ78558, highly similar to Homo sapiens

182 BUB3_HUMAN Mitotic checkpoint protein BUB3

Actin related protein 2/3 complex, subunit 1B,

191 CIAO1_HUMAN Protein CIAO1

202 TBL3_HUMAN WD repeat-containing protein SAZD

biological process number of proteins

Positional analysis of WD domain

protein export from nucleus , transport , protein

protein export from nucleus , transport , protein

Gene Ontology is not available.

Gene Ontology is not available.

Gene Ontology is not available.

Gene Ontology is not available.

nucleocytoplasmic transport , regulation of

Gene Ontology is not available.

transcription , transcription, DNA-dependent , 5S

Gene Ontology is not available.