THE DANA REVIEW

http://www.g2conline.info/854 Title: Dissecting Genius: Einsteins Brain and the Search for the Neural Basis of Intellect Author: Frederick E. Lepore

Forty-ve years after Albert Einsteins death we still seek an explanation of his extraordinary gifts. Headlines have trumpeted that he was a parietal genius, or that his brain had more of a particular kind of cell, or that the key to his intellect lay in the unusual folds of his brain. But wait, says clinical neurologist Frederick E. Lepore (who lives three blocks from Einsteins house in Princeton), we may be indulging in a modern version of phrenology. He examines how far brain science has come in linking mental capabilities to specic brain areas, and how far it has to go. Our fascination with Einsteins brain, says Lepore, reveals more about usour assumptions about the brain and our reverence for geniusthan about Einstein. The death watch for Albert Einstein began with his collapse from a ruptured abdominal aortic aneurysm on April 13, 1955. Two days later he was moved from his house at 112 Mercer Street to Princeton Hospital. In the hospital he spoke with his son, Hans Albert, often declined morphine, called for writing materials, and announced, It is time to go. I will do it elegantly. On April 18, following a few words in German and two last breaths, Einstein died at age 76. Later that morning, Dr. Thomas Harvey (with Einsteins executor, Otto Nathan, in attendance) performed the autopsy, which revealed an abdomen full of blood from the fatal breach of Einsteins aorta.1 The brain and other internal organs were removed for gross inspection. The viscera were returned to the body, which was cremated in Trenton. To this day no one knows where Albert Einsteins ashes lie. What became of the brain of the man hailed as the embodiment of pure intellect and person of the century by Time magazine? Harvey, a Yale-trained pathologist who had worked with such neuroscientic luminaries as Harvey Cushing, John F. Fulton, and Harry Zimmerman, saw a unique opportunity in studying Einsteins brain. He lled the carotid arteries with a preservative solution and suspended the brain in the same chemical. The front page of the April 19, 1955, New York Times announced ...the removal, for scientic study, of...the brain that worked out the theory of relativity and made possible the development of nuclear ssion. Einsteins family questioned this decision, but Harvey persuaded them of the critical importance of further study. Harvey was not alone in his ambition to investigate Einsteins brain with scientic rigor. While the brain was being preserved, Harvey was summoned to a conference at the Armed Forces Institute of Pathology in Washington, DC, and was sorely importuned by Dr. Webb Haymaker and other eminences grises of American neuropathology to relinquish the brain. The 43-year-old Princeton pathologist rebuffed their overtures and began to prepare the brain for study. He made exact measurements directly from the brain and took calibrated photographs with his Exakta 35mm camera. Then he carried the brain across the Delaware River to the University of Pennsylvania, where he enlisted his former mentor, Fritz Lewy, to dissect it. Lewy, who was rst to describe the specic neurological changes that demarcate Parkinsons disease, and his Berlin-trained technician cut Einsteins hemispheres into 240 blocks, which were embedded in celloidin. Directing the dissection, Harvey relied on the neuroanatomical guidelines in Percival Bailey and Gerhardt von Bonins The Isocortex of Man. In addition to listing mid-20th century state-of-the-art techniques (tissue blocks permitting sections perpendicular to the cortical surface, Nissl staining of neuronal and glial cell bodies, and Weigert staining of myelinated axons connecting the neurons), Harveys dog-eared and underlined copy of this book included a healthy dose of skepticism about previous cerebral mapmakers... [whose] impossible to check [human studies] have been accepted by physiologists as a divine authority and a vast superstructure has been built on this shaky foundation.2 Twelve sets of microscope slides were painstakingly indexed to the tissue blocks, and Harvey gave the sets to the best and brightest in neuropathology at the time, including Bailey and von Bonin at the University of Illinois, Walle Nauta at MIT, and Harry Zimmerman at Monteore Hospital. But the potential Rosetta Stone of genius remained undecipherable to these savants, and Harvey received no report of neuropathological ndings beyond Zimmermans assurance that Einsteins brain was normal for his age.

The DANA Foundation. All rights reserved.

THE DANA REVIEW

http://www.g2conline.info/854 Title: Dissecting Genius: Einsteins Brain and the Search for the Neural Basis of Intellect Author: Frederick E. Lepore

At this point, we may well ask Harveys own professional opinion of Einsteins brain. Einsteins hospital record and autopsy report vanished without a trace, just as his last utterances in German were lost on his English-speaking night nurse. But 55 years after the autopsy, Harvey recalls nding a few plaques and neurobrillary tangles in Einsteins brain. (In great abundance these ndings indicate Alzheimers disease, but in lesser quantities are consistent with normal successful aging). Harveys examination did not nd signs of Parkinsons disease or dementia. Harvey concluded that Einsteins brain fell within normal limits for a man his age.3 THE BRAIN IN THE CIDER BOX Despite Harveys meticulous and systematic preservation of Einsteins brain, a long period of scientic silence ensued. In a 1978 interview published in Science, 23 years after Einsteins death, Harvey conceded that nothing has yet been published about the sections of brain distributed to various specialists. Emblematic of these scientic doldrums was storage of the brain fragments in a jar of formaldehyde that [is]...kept in a cider box, under a beer cooler, in Harveys ofce. Although he entrusted brain specimens to a dozen scientic investigators, not until collaborations with Marian Diamond in 19854 and Sandra Witelson in 19995 did Harvey think science was any closer to understanding whether the physical structure of Einsteins brain accounted for his genius. Both Diamond and Witelson concluded that the parietal lobes of Einsteins brain (parts of the cerebrum primarily concerned with processing sensory information and with spatial orientation) were anatomically unique. They used markedly different methodologies, however: Diamond counted the cells in the cerebral cortex; Witelson studied the brains gross anatomy. Diamond compared cell counts of parts of Einsteins cerebrum with those from former Veterans Administration hospital patients. The specimens were stained to distinguish two types of brain cell: neurons and glial cells. In Einsteins left parietal cortex, Diamond noted a signicant increase in glial cells but not neurons. She proposed that the differential cell counts constituted a potentially meaningful measure of the functional status of the brain in general, and, in particular, neuronal:glial ratios in selected regions of Einsteins brain might reect the enhanced use of this tissue in the expression of his unusual conceptual powers. On June 18, 1999, in a headline reminiscent of the heroic age of phrenology 200 years earlier, the New York Times proclaimed Key to intellect may lie in folds of Einsteins brain. Relying on visual inspection and meticulous measurement of a fifth of Einsteins brain, and on the photographs taken in 1955, Witelson found that Einsteins inferior parietal lobules were larger than those of normal-intellect controls from the brain bank at McMaster University. This suggested, according to Witelson, early extensive development of the posterior parietal lobes. That development, in turn, displaced to the front the posterior end of the Sylvian ssure, pushing it into the postcentral sulcus (a furrow on the cortical surface). As a consequence, the parietal opercula did not develop. Within the inferior parietal lobule, the supramarginal gyrus (a ridge on the cortical surface) was undivided by a major sulcus. Without that division, a more efcient axonal connectivity of this anomalous architecture may have given Einsteinand here is the payoff of the anatomy lessonan extraordinarily large expanse of highly integrated cortex within a functional network. Not surprisingly, the association of the inferior parietal lobule with visuospatial cognition, mathematical thought, and movement imagery readily lent itself to the hypothesis that Einsteins mastery of these conceptual areas may have related to his unusual parietal lobe structure. The wider implication was that this post-mortem case study suggested anatomical features of the parietal cortex may be related to visuospatial intelligence. Within days of publication of Witelsons article in The Lancet, Steven Pinker, one of neurosciences most articulate spokesmen, hailed the elegant study, consistent with the themes of modern cognitive neuroscience. He observed no one can claim to have explained Einsteins genius, but the study conrmed that the brain is a modular system composed of mostly nonverbal multiple capacities that serve diverse functions, such as vision, spatial sense, and movement. At the close of the 20th century, Einsteins brain was helping unify the last great dichotomy in the conceptual cosmos, matter and mind. Or was it?

The DANA Foundation. All rights reserved.

THE DANA REVIEW

http://www.g2conline.info/854 Title: Dissecting Genius: Einsteins Brain and the Search for the Neural Basis of Intellect Author: Frederick E. Lepore

CONNECTING BRAIN TO MIND Although it might be wise to heed John Lockes 1690 admonition in An Essay Concerning Human Understanding not to meddle with the physical consideration of the mind, over the ages investigators have thrown caution to the winds in speculating on the relationship of brain to mind. Our expectations of the study of Einsteins brain must be viewed in this context. Scholars of the Middle Ages, echoing the writers of Classical Antiquity, discounted the cerebral cortex as the fountainhead of intellect and proposed that the psyche resided in three brain ventricles, or cavities. Although in 1664 Thomas Willis presciently attributed brain function to gray matter made up primarily of neuron cell bodies the ventricular theory did not yield easily, and as late as 1798 Samuel Soemmering proposed that uid circulating in the ventricles was the seat of the soul. Even in 1858 the shape of cerebral ventricles was posited as a dening human characteristic by the Hunterian professor of the Royal College of Surgeons, Richard Owen. Franz Joseph Galls early 19th century theory of phrenology, which held that external skull conformation reected roughly 35 intellectual and emotional faculties, is regarded today as an example par excellence of pseudoscience. Unfortunately, Galls popular legacy is conned to phrenology; his perceptive emphasis on the cerebral cortex as a set of organs with different mental functions passed into oblivion with his death in 1828. Today we can scarcely imagine the revolutionary impact, in a world that had assigned brain function to the ventricles and depicted the cortex as a random arrangement of undifferentiated intestine-like convolutions, of the concept that great regions of mind correspond to great regions of the cerebral cortex. For once, the overused term paradigm shift applies. In 1861, Paul Brocas post-mortem examination of the brain of Monsieur Leborgne arguably did more than anything else to establish the validity of cortical localization. Leborgne had lost the power of speech 20 years earlier and very well-dened parts of his cerebral cortex were destroyed, including the second and third frontal convolutions, inferior Rolandic area, and rst temporosphenoidal convolution of the left hemisphere. No longer could the cortex be viewed as a homogeneous expanse of tissue dedicated to the vague global proposition of intellect; what is now called Brocas area for language had been identied. THE PROPOSED BASIS OF GENIUS The task of localizing functions in different parts of the cerebral cortex continues today, and primary motor and sensory areas have been charted. By contrast, parts of the cerebral cortex called the association cortex, where intermingling and higher processing of multiple sensory inputs occur and where the parietal lobes are, could not be so easily analyzed by correlating disordered functions with physical lesions. Sir William Gowers A Manual of Diseases of the Nervous System the Bible of 19th century neurologists listed no motor or sensory symptoms related to disease of the posterior parietal lobe. A half century later, in 1932, Johns Hopkins University neurosurgeon Walter Dandy wrote, right parietal lobe (excluding sensory function of the paracentral region) has no known functions, and deemed the left parietal lobe by far the most important part of the brain. The secrets of parietal lobe function eventually began to yield to specialized examination techniques, however, and the pendulum of scientific opinion swung toward assigning inordinate importance to the relationship between the parietal lobe and the mind. British neurologist Macdonald Critchley reminisced that a visitor to the prewar neurological centres in Europe might be tempted to remember the Psychiatric Clinic of Vienna as a posterior parietal lobe institute. Undoubtedly the psychiatrists intellectual curiosity was piqued by classic presentations of right parietal lobe lesions in which patients paid no attention to the left side of their environment or contended that their own paralyzed left arms belonged to other people. One of the mainstays of mapping the cortex, electrical stimulation, has evoked no specic characteristic motor or sensory response from the cortex of the superior and inferior parietal lobes. Instead, knowledge has been culled from meticulous observations of patients performing everyday acts that exploit this brain regions complex capabilities. Difculties with such mundane tasks as putting on a coat, drawing a clock face, or identifying a dime by touch have dened the distinctive differences between disordered right and left parietal lobe function.

The DANA Foundation. All rights reserved.

THE DANA REVIEW

http://www.g2conline.info/854 Title: Dissecting Genius: Einsteins Brain and the Search for the Neural Basis of Intellect Author: Frederick E. Lepore

A person with a disease or injury of the inferior parietal lobe in the dominant (usually left) hemisphere may not be able to perform skilled learned movements; name items; read, write, and calculate; identify his ngers; or distinguish between left and right. In the right (usually nondominant) inferior parietal lobe, however, lesions can cause a person to neglect the left side of extrapersonal space, and have faulty visuospatial integration and impaired drawing. These patients, for example, might put an arm in the wrong sleeve or strenuously deny being aficted in any way. Their performance of tasks involving mental rotation, route nding, and recognition of objects viewed from an unusual perspective is faulty, and they can experience a general state of confusion. The complex multiplicity of these symptoms arises from the parietal lobes location at the crossroads of visual, auditory, somatosensory, and vestibular pathways. Cognitive neuroscientist Marsel Mesulam sees the posterior parietal cortex not as a mere spatial map but as a critical gateway for accessing and integrating information necessary for motor strategies that exploit extrapersonal space.6 In just over a century, our view of the parietal lobe has evolved from terra incognita to a proposed basis of genius. What underlies this rapid acceptance of a supranormal inferior parietal lobe as the foundation of Einsteins epoch-defining scientific insight? It is no coincidence that the last 10 years of the 20th century were designated the Decade of the Brain; the success of the scientific method partially replaced older notions of the soul or mindbody dualism with the doctrine that mind and, by extension, intellectual creativity, is the brains exclusive output. The Zeitgeist of the computer-driven, late 20th century is firmly grounded in a materialistic basis for mind. The frontal and parietal lobes are the parts of the brain that changed most radically during evolutionary development and, not surprisingly, have kindled the greatest interest as possible wellsprings of intellect. What we call a paradigmatic neurologic patient is also very attractive to researchers. Here a single patient with an isolated brain lesion and clear-cut neurobehavioral abnormality can crystallize our understanding of an aspect of functional neuroanatomy. This is how Broca began to understand the neural basis of language when he held Leborgnes brain in his hands, and John Harlow found that the equilibrium or balance, so to speak, betweenintellectual faculty and animal propensities was destroyed by the 3.5-foot-long iron tamping rod that passed through the skull of his patient Phineas Gage in a blasting accident. Similarly, we focus great attention on celebrity illness, from Samuel Johnson reciting the Lords prayer in Latin to gauge his recovery from aphasia to former President Ronald Reagans Alzheimers disease. For better or worse, our culture readily accepts the lessons taught by afflictions of important brains. It is hardly surprising that critical scrutiny may be suspended when secular priests in the white raiment of science reveal that Einsteins brain is indeed different. WAS EINSTEIN A PARIETAL GENIUS? Is our n-de-siecle neuroscience sufciently mature to use Einsteins brain as a Rosetta Stone for translating neural architecture into the most sublime conceptual achievements? The Nobel Prize for discovering the basic building block of nervous systems, the neuron, was awarded to Ramon y Cajal and Camillo Golgi in 1906, within the memory of living people. If nearly a century later we still cannot precisely explain how patterns of action potentials of 1012 (trillion) neurons lead to a thought, can we presume to relate Einsteins life and thought to the purported unique structure of his brain? Witelson afrms that we can, citing Einsteins introspective description of his own scientic thinking, which relied on images of visual and muscular type rather than words. This way of thinking would be congruent with characterizing the parietal lobes as centers of visuospatial cognition. But before we unreservedly accept Einstein as a parietal genius, a few specimens of his intellectual legacy warrant examination. At the outset, it is treacherous to assume the absolute validity of Einsteins (or anyones) description of his own thought processes. Speaking of his scientic work, he observed, There is no logical way to the discovery of these elemental laws. There is only the way of intuition, which is helped by a feeling for the order lying behind appearance. Einstein clearly believed there was an impenetrable veil preventing an unambiguous view of the mechanics of mind. Terms such as intuition, ash of insight, and Eureka portray immediately recognizable aspects of human thought, demarcating the boundary beyond which cognitive processes are inaccessible to the searchlight of consciousness. Einsteins rebuttal to quantum theory, God does not play dice, was a declaration of faith consistent with the supposition that the moment of scientic discovery may not be purely logical, nor a The DANA Foundation. All rights reserved.

THE DANA REVIEW

http://www.g2conline.info/854 Title: Dissecting Genius: Einsteins Brain and the Search for the Neural Basis of Intellect Author: Frederick E. Lepore

proposition with rigorous proof. The daunting task of parsing Einsteins mind becomes innitely more difcult, given the limited accuracy of internal dialogue in reecting actual cognition. Where Einsteins inner voice is unrevealing, perhaps external events of his life may provide understanding. Einstein did not speak until he was three years old. It has been proposed that the expansion of his parietal lobes, especially in his speech-dominant left hemisphere, in effect intruded on his language areas; early language function was usurped by precocious mathematical and visuospatial capacities. Leaving behind the folklore gure of a genius who was slow to speak, Einsteins early academic path showed great promise; he received the highest or next-highest marks in mathematics and Latin. Following a short-lived and intensely religious phase in his eleventh year, he came to regard Euclid as his holy geometry book, and between 12 and 16 he taught himself integral and differential calculus. In 1896, as a prerequisite to enrollment at Eidgenossische Technische Hochschule in Zurich, he obtained the Matura (a high school diploma) with superior grades in mathematics and the sciences but less than excellent results in technical and artistic drawing and geography. These grades are difcult to reconcile with an idealized parietal-lobe prodigy armed with formidable visuospatial skills. If we agree with Mesulams analysis of the posterior parietal cortex as pivotal in integrating spatial information received via all our senses, it becomes difcult to envision Einsteins parietal lobe as the crucial element in his key theoretical constructs. Our senses cannot detect the curvature of space (as in the theory of general relativity) or the innitesimal changes in time and dimension that occur with the velocities encountered in daily existence (as in the theory of special relativity). Einsteins discoveries were not based on direct sensory experience but were pure thought experiments performed in his imagination. Such experiments are not easily reconciled with the current view of the parietal lobe as a provider of strategies to interact with and integrate direct sensory input from outside oneself. Einstein was undeniably a genius, but to qualify him as a parietal genius is premature, based on our current and relatively primitive understanding of cortical function. The hypothesis of genius driven by a supranormal parietal lobe does not satisfactorily explain how Einsteins intellectual productivity changed over time. Like most physicists and mathematicians, his greatest work was accomplished as a young man. In a magnicent creative outburst in 1905, 26-year-old Einstein completed six signicant papers, including those on special relativity, the e = mc2 equation, and a quantum explanation of the photoelectric effect that led to his Nobel Prize in physics. Ten years later, in his nal revision of the theory of general relativity, he proclaimed that space is curved and cannot be described by Euclidean geometry. An inclination to venerate his middle and later years must be tempered by C.P. Snows observation that he wasted the second half of his life in his quest for a unied eld theory that would show the forces of electromagnetism and gravity stemming from one grand overarching principle. This holy grail eluded the incessant mental effort of the man universally recognized at 37 as the greatest theoretical physicist of his age, the equal of Newton. As scientic incandescence dimmed in his later years, Einstein transformed into a complete internationalist and the voice of liberal sciencethe prophet of negotiation and peace for a generation. Fitting Einsteins multifaceted complexity and creativity into a Procrustean bed of cortical localization faces another challenge, the actual anatomy of the parietal lobes. In 1951, Critchley, who wrote the classic monograph, The Parietal Lobes, said, Strictly speaking there is no such structure as a parietal lobe; for it is only an anatomical convention; an empirical demarcation which has been pegged out on the surface of the brain. No natural boundary can be said to exist either behind or below. The traditional gyri and sulci are unhelpful landmarks and are often a matter of guesswork. Subtle distinctions and the variability of cortical topography led to a highly technical argument between neuroscientist Albert Galaburda and Witelson in The Lancet about just what could seen in Einsteins brain.7 To give readers the avor of this dispute: Galaburda contended that a parietal operculum is present and consequently the inferior parietal lobule is not enlarged as Witelson claimed. Witelson countered that Galaburda mistook the sulcus retrocentralis transversus for the post-central sulcus, and Einsteins brain must therefore lack a parietal operculum, allowing for an augmented inferior parietal lobule. Even when we make a leap of faith that the form of the cerebral cortex can tell us something about a persons higher The DANA Foundation. All rights reserved.

THE DANA REVIEW

http://www.g2conline.info/854 Title: Dissecting Genius: Einsteins Brain and the Search for the Neural Basis of Intellect Author: Frederick E. Lepore

faculties, we must temper the neuroanatomists interpretation with the knowledge that, as described in The Isocortex of Man, there is a bewildering variety of sulcal patterns in the parietal lobe reecting that the brain has a particularly high degree of developmental freedom. The brain is the most individualistic of all organs. Leaving aside the anatomical difculties in deciding whether a particular individual has enlarged parietal lobes, do others with bigger-than-normal parietal lobes also have extraordinary Einstein-like potential? One group with functionally enlarged parietal lobes are those who have been blind from an early age and who read Braille a formidable tactile sensory task in which a person extracts the meaning of 60 to 120 words from 2500 dots each minute. In normal individuals, tactile discrimination is performed by the parietal lobes, but visual processing occurs in the occipital lobes. Researchers have discovered, however, that people with early-onset blindness who receive pulses of magnetic stimulation to their occipital cortex show a signicant increase in Braille reading errors. The occipital lobes, rather than responding to visual stimuli, become extensions of the parietal lobes in processing sensory information; we might say that the functional boundaries of the parietal lobes have expanded. Despite the expansion, there is no widespread evidence of an association between early blindness and prowess in, for example, theoretical physics. Other difculties present themselves. As related by Harvey, Unfortunately we have [only] one brain of an Einstein. Scientic certainty tends to be conrmed by multiple subjects or experiments, so it is hard to draw denite conclusions from a single specimen, no matter how exceptional. Furthermore, in assuming that close observation of dead neural tissue can tell us about living thought, we may face the plight of Samuel Coleridges guide, who points with his nger to a heap of stones and tells the Traveler, That is Babylon, or Persepolis. There may be nite limits to what can be learned from static neuroanatomy divorced from neurophysiology. Before functional neuroimaging, most knowledge of the localization of brain functions came from meticulous clinical observations of patients with cerebral lesions. Although this approach may shed light on deciencies, it will not necessarily yield useful information about people with overabundant intellectual attributes. THE CULT OF GENIUS Given our inadequate knowledge of the relation between brain function and anatomy, and our inability to physically pinpoint the origins of ideas and opinions, why does Einsteins brain exert such irresistible attraction for neuroscientists and people from all walks of life? We seem to live in an age of the gifted, where the highest aspirations for our children include enrollment in school programs for the gifted to bring out the untapped genius of little Einsteins. The burgeoning cult of genius is reected in our evolving language. According to The Oxford English Dictionary, before the 18th century, genius referred to the pagan belief in a God or spirit allotted to every person at birth to determine the persons character and fortunes. By the 18th century, genius was no longer an external agent, but native intellectual power of an exalted type, such as is attributed to those who are esteemed greatest in any department of art, speculation, or practice. The transition of genius from an externally God-given quality to an innate endowment ts well in our era of the self-realizing individual. As we seek to understand what makes a genius tick, the better to emulate him, what most promising place to begin than with the 20th century icon of genius, Albert Einstein? Even the relationship between neurologic lesions and intellectual capacities is not straightforward. For example, in 1980 British neurologist John Lorber reported in Science that a patient with severe hydrocephalus had, instead of the normal 4.5 centimeter thickness of brain tissue between the ventricles and the cortical surface...just a thin layer of mantle measuring a millimeter or so. His cranium is lled mainly with cerebrospinal uid. Rather than showing devastating intellectual impairment, however, the patient was socially normal, had an IQ of 126, and gained a rst-class honors degree in mathematics. Similarly, according to V. S. Ramachandran, anthropologists assert that the great leap in technological sophistication, widespread cave art, clothes, and stereotyped dwellings occurred around 40 thousand years ago, even though the brain achieved its present size almost a million years earlier. We may follow a cultural mandate in studying the brain of a genius, but gaps in our knowledge of the physical and structural basis of cognition are humbling.

The DANA Foundation. All rights reserved.

THE DANA REVIEW

http://www.g2conline.info/854 Title: Dissecting Genius: Einsteins Brain and the Search for the Neural Basis of Intellect Author: Frederick E. Lepore

Would it have been better if Harvey had placed Einsteins brain back in the cranial cavity and let it blaze into ashes at the Ewing Crematorium on April 18, 1955? Most neuroscientists, rmly rooted in the prevalent philosophy that mind is dened by brain structure, would deeply regret the loss of a unique opportunity to investigate the neuroanatomy of arguably the 20th centurys most original thinker. In contrast, Wilder Peneld, whose neurosurgical explorations established the hallmark of localization, the cortical homunculus (the little man mapping body parts onto the cerebral hemispheres), was not sanguine about nding a solution to the mystery of the mind: Because it seems to me certain that it will always be quite impossible to explain the mind on the basis of neuronal action within the brain, and because it seems to me that the mind develops and matures independently throughout the individuals life as though it were a continuing element, and because a computer (which the brain is) must be programmed and operated by an agency capable of independent understanding, I am forced to choose the proposition that our being is to be explained on the basis of two fundamental elements.8 Penelds high standing in the pantheon of neuroscience makes it difcult to ignore his endorsement of mindbrain dualism. But before we consign Einsteins intellect to the realm of the unknowable or blindly revere his brain as a sacred talisman, we must recall that neuroscience is still a young discipline. Scientists may not have focused yet on the critical features that determine intellectual function. In the words of Ramon y Cajal, intellectual power and its most noble expressions, talent and genius, do not depend on the size or number of cerebral neurons, but on the richness of their connective processes, or in other words on the complexity of the association pathways to short and long distances. Deeper understanding of the staggering intricacy of the estimated 1015 (one thousand trillion) cerebral synapses may tell us a great deal more than would counting neurons or looking at the conguration of the brain. Roger Penrose, Oxford mathematician and author of The Emperors New Mind, and Stuart Hameroff, an anesthesiologist at the University of Arizona, have even questioned the assumption that the neuron is the building block of cognition. They say consciousness may not emerge from a critical mass and arrangement of neurons, but from quantum computations based on the changing shapes of tubulin proteins that are part of the neurons structural frame. Although recent work suggests the brain is a terrible environment for quantum computations, this innovative questioning of previous scientic assumptions may offer an escape from Penelds dilemma. Even if we ask the right questions, we must have adequate technology to provide the right answers. Examining the anatomy of Einsteins brain provides only indirect evidence of his physiology of thinking. Before the end of the 20th century, we had a few limited techniques, such as electroencephalography or evoked potentials, to study the physiology of the living brain. With positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), we are now able to obtain snapshots of activity that occurs in the brain while a person is engaged in cognitive tasks. For example, a PET scan shows increased cerebral blood ow to the primary visual cortex when the subject views a checkerboard target. It is now being used to link brain regions with more complex cognitive tasks. Recently, John Duncan at Cambridge used PET to delineate what he believes is a neural basis for general intelligence.9 Volunteers performing spatial, verbal, and perceptuomotor tasks had increased cerebral metabolism in the lateral frontal cortex in one or both hemispheres. PET scanning suggests that general intelligence (sometimes called g) needed to perform these diverse tasks arises from a specic frontal lobe system rather than from multiple brain areas. Further renements in neuroimaging of the functioning brain will help investigators tease out other neuronal circuits and patterns that underlie the human endowments of cognition, creativity, and emotioneven endowments as extraordinary as those of an Einstein. The intense interest in Einsteins brain is emblematic of our abiding curiosity about intellect in general and genius in particular. We may ask too much of this remarkable specimen when we expect 240 blocks of defunct neurons

The DANA Foundation. All rights reserved.

THE DANA REVIEW

http://www.g2conline.info/854 Title: Dissecting Genius: Einsteins Brain and the Search for the Neural Basis of Intellect Author: Frederick E. Lepore

to blaze a pathway to genius, but neuroscientists will persevere in the study of Einsteins brain as a potential key to understanding the brain for cultural and scientic reasons. Einsteins brain is now at the Department of Pathology at the Medical Center at Princeton. Elliot Krauss was entrusted with the brain because Thomas Harvey wanted to make sure that the brain was put in the right hands to keep the study alive.10 As Krauss deliberates over the best scientic use of this celebrated specimen, Einsteins brain oats in two glass jars, quietly waiting to assume its place in history as an avatar of genius or an anatomical curio.

References
1. Authors interview with Thomas Harvey, M.D., June 4, 2000. 2. Bailey, P, Von Bonin, G. The Isocortex of Man. Urbana: University of Illinois Press, 1951. 3. Editorial. Brain that rocked physics rests in cider box. Science 1978;201:696 4. Diamond MC, Scheibel AB, Murphy GM Jr, Harvey T. On the brain of a scientist: Albert Einstein. Experimental Neurology 1985;88(1):198-204 5. Witelson SF, Kigar DL, Harvey T. The exceptional brain of Albert Einstein. Lancet 1999;353:2149-53. 6. Mesulam M-M. Principles of Behavioral and Cognitive Neurology, 2nd ed. New York: Oxford University Press, 2000. 7. Galaburda AM. Albert Einsteins brain. Lancet 1999; 354: 1821. 8. Penfield W. The Mystery of the Mind. Princeton: Princeton University Press, 1975:80 9. Duncan J, Seitz RJ, Kolodny J, et al. A neural basis for general intelligence. Science 2000; 289:457460. 10. Paterniti M. Driving Mr. Albert: A Trip Across America with Einsteins Brain. New York: The Dial Press, 2000.

The DANA Foundation. All rights reserved.