Biocel

system
Designed for Life Science Applications
The Milli-Q Biocel water purification system provides water quality that is ideal for life science applications such as electrophoresis buffers or serum based cell and tissue culture media preparation for plant cells or bacteria development. In addition to the Milli-Q Academic purification and monitoring techniques, the Milli-Q Biocel system incorporates ultrafiltration technology for removal of pyrogens and other bacterial by-products. The Pyrogard 5000 UF cartridge guarantees very low nuclease and pyrogen levels (see page 6 for details). Water produced by the Milli-Q Biocel system conveniently replaces DEPC-treated water.

Milli-Q

9 12 6 5

8 10 11

1. Inlet Solenoid Valve 2. Pump 3. Q-Gard Pack 4. Quantum Cartridge 5. Sanitization Port 6. Pyrogard 5000 UF Cartridge 7. Automatic Flush Solenoid Valve 8. Resistivity Sensor 9. A10 TOC Monitor 10. Outlet Solenoid Valve 11. Millipak Final Filter 12. Check Valve

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Solution Technology Products Features

Accessible plug-in Q-Gard and Quantum packs make cartridge replacement a snap, literally taking seconds to replace.

Academic

Gradient

Biocel

Synthesis

Element

Standard Features Q-Gard Cartridge Quantum Cartridge Millipak Final Filter Optimizer Filter Resistivity Meter TOC Meter UV Lamp Pyrogard 5000 UF Cartridge Remote Water Dispenser Foot-pedal

Optional Features Remote Water Dispenser Remote Display Foot-pedal Pyrogard D Final Filter Explore Data Software Product water Specifications* Resistivity (M.cm) @ 25C TOC Level (typical values) Pyrogen Level (Eu/mL) Bacteria (cfu/mL) Particulates >0.22m (P/ml) Flow Rate (L/min)

18.2 5-10 NA <1 <1

1.5

18.2 1-5 NA <1 <1

1.5

18.2 5-10 <0.001 <1 <1

1.0

18.2 1-5 <0.001 <1 <1

1.0

18.2 <5 NA <1 <1

1.5

* Test conditions: Milli-Q system equipped with Q-Gard 1 pack, Quantum EX cartridge, feedwater produced by Elix system with resistivity > 1 megohm.cm @ 25 C, TOC < 50 ppb. Product water quality may vary due to local feedwater conditions.

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Milli-Q system specifications

feedwater requirements
Parameter Pressure Flow rate Temperature Connection Description / Specification Min 0.1 bar (1.5 psi) / Max 0.3 bar (4.5 psi) Min 100 L /hour Min 5C / Max 35C.
1/2 NPTM

information recording and transmission

High visibility, tilting backlit 2-line, 16-character display for easy view of system status from any angle, even in the dark or under direct sunlight. RS232 interface for data transmission to the printer or a computer of your choice

Millipore recommends the use of pure (Type 2 or type 3) water produced by Elix or RiOs systems to feed the Milli-Q system.

system installation information

Dimensions Size : H x W x D = 455 x 255 x 315 mm (18x10x12.4) Operating weight Milli-Q Academic A10: 16.6 kg (36.6 lb) Milli-Q Gradient A10: 17.4 kg (38.4 lb) Milli-Q Biocel A10: 16.9 kg (37.3 lb) Milli-Q Synthesis A10: 17.7 kg (38.9 lb) Milli-Q Element A10: 19.9 kg (39.8 lb) Connections Inlet water: 8 mm OD, 2.5 m long polyethylene tubing supplied with 1/2 NPTF connection with built-in screen UF cartridge reject tubing: 6 mm OD polyethylene tubing, 2.5 m long Electrical connection: 2.5 m long power cord with plug Electronic connection: RS232 interface Mounting : bench, wall (wall mounting device built-in) or underbench.

Clearances: right-hand side: 95 mm (3.7) top: 80 mm (3.1) front: door: 125 mm (4.9) or extended arm: 452 mm (17.8)

product water
Quality and Flow Rate: see page 9 Volumetric dispense: from 0.25 to 64.5L with 3% accuracy and 3% reproducibility

quality measurements
Milli-Q systems have 2 built-in monitors: Resistivity meter with a 0.01 cm-1 nominal cell constant and 0.1C accuracy thermistor for accurate monitoring of trace ionic contamination. The resistivity meter reports conductivity (S/cm) or resistivity (M.cm) compensated or not at 25C and meets USP 24 requirements. TOC monitor with a 1 to 999 ppb detection range for accurate analysis of organics. The TOC monitor passes the USP 24 suitability test.

Milli-Q system control, maintenance and warning messages on display control display
Product water resistivity (M.cm) compensated at 25C Product water resistivity (M.cm) non-compensated and temperature (C) Product water conductivity (S/cm) compensated at 25C Product water conductivity (S/cm) non-compensated and temperature (C) Product water temperature (C) Product water TOC (ppb) (A10 models) Product water resistivity < set point Product water conductivity > set point Product water TOC > set point

maintenance display
System depressurization Air purge activated Fast flush activated (Biocel and Synthesis models) Start sanitization (Biocel and Synthesis models) Exchange purification cartridges Exchange UV lamp (Gradient, Synthesis and Element models) Exchange A10 UV lamp (A10 models) A10 cell cleaning (A10 models)

Additional messages are displayed by the system or accessible to the user (for instance, days of operation of the different consumables) see the operation manual for a complete list.

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Optimal Pretreatment
and a Milli-Q Gradient system. parameter* Ions (ppb) Organic (ppb) Silica (ppb) tap water 250,000 1,000 10,000

To provide you with the best water quality at minimum global operating costs, Millipore has developed a complete range of water purification systems. The Elix system uses advanced pretreatment, reverse osmosis and electrodeionization technologies to produce pure (type 2) water from tap water. The results below show an example of some contaminant concentrations after treatment by an Elix

Elix system Milli-Q Gradient system <1 <50 <10 <0.05 <5 <0.5

Our application specialists can also help you choose the right design for your installation.
* Values above are typical and may vary depending on the nature and concentration of contaminants in the tap water.

When choosing a water purification system, you can rely on the expertise of our Application Specialists and Technical Service Representatives to provide you with accurate scientific and technical information adapted to your specific needs.

the complete solution Customer Care Service

As a user of our water purification systems you expect optimal performance from your equipment, but you may not have the time to ensure that regular maintenance is performed. Recognizing this need, Millipore offers preventive maintenance plans that

Validation

ensure you get the best performance from your system.

In 1998, we introduced the first complete Qualification Program for Water Purification Systems. This program, designed to facilitate laboratory validation procedures, includes Qualification Workbooks with Installation Qualification, Operational Qualification, Maintenance Procedures and examples of Performance Qualification files, and Calibration Certificates. Qualification Test Equipment is properly maintained and calibrated; validation support is provided by trained Certified Millipore Customer Care Engineers.

Solution Technology Products Features

Accessible plug-in Q-Gard and Quantum packs make cartridge replacement a snap, literally taking seconds to replace.

Academic

Gradient

Biocel

Synthesis

Element

Standard Features Q-Gard Cartridge Quantum Cartridge Millipak Final Filter Optimizer Filter Resistivity Meter TOC Meter UV Lamp Pyrogard 5000 UF Cartridge Remote Water Dispenser Foot-pedal

Optional Features Remote Water Dispenser Remote Display Foot-pedal Pyrogard D Final Filter Explore Data Software Product water Specifications* Resistivity (M.cm) @ 25C TOC Level (typical values) Pyrogen Level (Eu/mL) Bacteria (cfu/mL) Particulates >0.22m (P/ml) Flow Rate (L/min)

18.2 5-10 NA <1 <1

1.5

18.2 1-5 NA <1 <1

1.5

18.2 5-10 <0.001 <1 <1

1.0

18.2 1-5 <0.001 <1 <1

1.0

18.2 <5 NA <1 <1

1.5

* Test conditions: Milli-Q system equipped with Q-Gard 1 pack, Quantum EX cartridge, feedwater produced by Elix system with resistivity > 1 megohm.cm @ 25 C, TOC < 50 ppb. Product water quality may vary due to local feedwater conditions.

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p u r i f i c a t i o n

Milli-Q system specifications

feedwater requirements
Parameter Pressure Flow rate Temperature Connection Description / Specification Min 0.1 bar (1.5 psi) / Max 0.3 bar (4.5 psi) Min 100 L /hour Min 5C / Max 35C.
1/2 NPTM

information recording and transmission

High visibility, tilting backlit 2-line, 16-character display for easy view of system status from any angle, even in the dark or under direct sunlight. RS232 interface for data transmission to the printer or a computer of your choice

Millipore recommends the use of pure (Type 2 or type 3) water produced by Elix or RiOs systems to feed the Milli-Q system.

system installation information

Dimensions Size : H x W x D = 455 x 255 x 315 mm (18x10x12.4) Operating weight Milli-Q Academic A10: 16.6 kg (36.6 lb) Milli-Q Gradient A10: 17.4 kg (38.4 lb) Milli-Q Biocel A10: 16.9 kg (37.3 lb) Milli-Q Synthesis A10: 17.7 kg (38.9 lb) Milli-Q Element A10: 19.9 kg (39.8 lb) Connections Inlet water: 8 mm OD, 2.5 m long polyethylene tubing supplied with 1/2 NPTF connection with built-in screen UF cartridge reject tubing: 6 mm OD polyethylene tubing, 2.5 m long Electrical connection: 2.5 m long power cord with plug Electronic connection: RS232 interface Mounting : bench, wall (wall mounting device built-in) or underbench.

Clearances: right-hand side: 95 mm (3.7) top: 80 mm (3.1) front: door: 125 mm (4.9) or extended arm: 452 mm (17.8)

product water
Quality and Flow Rate: see page 9 Volumetric dispense: from 0.25 to 64.5L with 3% accuracy and 3% reproducibility

quality measurements
Milli-Q systems have 2 built-in monitors: Resistivity meter with a 0.01 cm-1 nominal cell constant and 0.1C accuracy thermistor for accurate monitoring of trace ionic contamination. The resistivity meter reports conductivity (S/cm) or resistivity (M.cm) compensated or not at 25C and meets USP 24 requirements. TOC monitor with a 1 to 999 ppb detection range for accurate analysis of organics. The TOC monitor passes the USP 24 suitability test.

Milli-Q system control, maintenance and warning messages on display control display
Product water resistivity (M.cm) compensated at 25C Product water resistivity (M.cm) non-compensated and temperature (C) Product water conductivity (S/cm) compensated at 25C Product water conductivity (S/cm) non-compensated and temperature (C) Product water temperature (C) Product water TOC (ppb) (A10 models) Product water resistivity < set point Product water conductivity > set point Product water TOC > set point

maintenance display
System depressurization Air purge activated Fast flush activated (Biocel and Synthesis models) Start sanitization (Biocel and Synthesis models) Exchange purification cartridges Exchange UV lamp (Gradient, Synthesis and Element models) Exchange A10 UV lamp (A10 models) A10 cell cleaning (A10 models)

Additional messages are displayed by the system or accessible to the user (for instance, days of operation of the different consumables) see the operation manual for a complete list.

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Optimal Pretreatment
and a Milli-Q Gradient system. parameter* Ions (ppb) Organic (ppb) Silica (ppb) tap water 250,000 1,000 10,000

To provide you with the best water quality at minimum global operating costs, Millipore has developed a complete range of water purification systems. The Elix system uses advanced pretreatment, reverse osmosis and electrodeionization technologies to produce pure (type 2) water from tap water. The results below show an example of some contaminant concentrations after treatment by an Elix

Elix system Milli-Q Gradient system <1 <50 <10 <0.05 <5 <0.5

Our application specialists can also help you choose the right design for your installation.
* Values above are typical and may vary depending on the nature and concentration of contaminants in the tap water.

When choosing a water purification system, you can rely on the expertise of our Application Specialists and Technical Service Representatives to provide you with accurate scientific and technical information adapted to your specific needs.

the complete solution Customer Care Service

As a user of our water purification systems you expect optimal performance from your equipment, but you may not have the time to ensure that regular maintenance is performed. Recognizing this need, Millipore offers preventive maintenance plans that

Validation

ensure you get the best performance from your system.

In 1998, we introduced the first complete Qualification Program for Water Purification Systems. This program, designed to facilitate laboratory validation procedures, includes Qualification Workbooks with Installation Qualification, Operational Qualification, Maintenance Procedures and examples of Performance Qualification files, and Calibration Certificates. Qualification Test Equipment is properly maintained and calibrated; validation support is provided by trained Certified Millipore Customer Care Engineers.