Course No.

BMTRY 701

COURSE DESCRIPTION COURSE TITLE

Biostatistical Methods II (Regression methods)

PRINICIPAL DEPARTMENT Biostatistics, Bioinformatics, INSTRUCTOR Biostatistics Faculty and Epidemiology APPROVED Department Chairman COURSE OFFERED Yearly x Alternate Years On Demand METHOD OF EVALUATION % of GRADE * 75 DATE

Written Assignment(s) Written Reports(s) Written Examination WHEN OFFERED Fall Semester (15 wks) Discussion/Presentation x Spring Semester (15 wks) Oral Examination(s) Summer Semester (14 wks) Attitude/Application Laboratory Projects/Reports * Written assignments include homework, laboratory projects LENGTH OF COURSE 15 WKS. Outside Prep. Est. Hrs./Week No. of Hrs./Week Semester Hrs. Credit

25*

TYPE OF SESSION Lecture Recitation or Discussion Laboratory Field Work Independent Study

No. Student Acc. Minimum 4 Maximum 20 Prerequisites 700

Total Credits

CATALOG DESCRIPTION (Include general objectives, content coverage, and student to whom it is directed).

The course is intended to focus on biostatistical applications by providing a broad coverage of critical biostatistical applications topics. The primary audience for the sequence is M.S. students (or first-year PhD students that do not have a prior M.S. degree) in biostatistics, but the course will be delivered at a level that it may be taken by graduate students in related scientific fields such as bioinformatics and epidemiology.

Class Topics:

Course No.

BMTRY 701

Simple linear regression (least squares estimation, partitioning sums of squares, hypothesis testing of slope and intercept, model fit, confidence intervals of mean response, prediction intervals) Correlation (the correlation coefficient, test of hypothesis and confidence intervals, testes of equality of correlation coefficients, multiple correlation coefficient, partial correlation) Analysis of variance (inference based on F-statistic, R-notation, sums of squares, one-way ANOVA) Multiple linear regression (general linear model, linear contrasts, testing of general linear hypotheses, confidence intervals, prediction intervals) Model Specification (biologic plausibility, interaction, confounding, indicator variables, iterative predictor selection routines) Model Diagnostics (diagnostic plots, multicollinearity, residual analysis, influence diagnostics) Nonstandard conditions (transformations, heterogeneous variance, weighted least squares) Maximum likelihood (principle of maximum likelihood, statistical inference via maximum likelihood, likelihood ratio tests) Logistic regression (ungrouped versus grouped data, interpretation, maximum likelihood estimation) Poisson regression (maximum likelihood estimation, interpretation, goodness of fit) Survival analysis (life tables, Kaplan Meier estimator, log-rank test, proportional-hazards (Cox) model, graphical examination of model assumptions)

TYPE AND AMOUNT OF WORK EXPECTED OF STUDENTS Weekly homework assignments, semester project, two midterm exams, and final exam.

ASSIGNED TEXT AND OTHER REFERENCE MATERIALS Applied Linear Statistical Models (5rd edition, 1998) Kutner et al.

SPECIAL FACILITIES REQUIRED (Including Library and other Learning Resources) (List and indicate whether presently available or must be obtained) Library and computers: Available.

Other Personnel Involved:

In What Capacity?

Course No.

BMTRY 701

Teaching Assistant (for large classes)

Grading homework assignments and assisting students

RELATION TO OTHER COURSES How does this course fit into the Department's Graduate Program? Core first year course. Is this course a prerequisite for any other course? If yes, what course(s)? Yes: Linear Models, Categorical Analysis, Survival Analysis, Multivariate Analysis, Experimental Design and Advanced Regression

Do other course(s) cover some of the same material? Which ones (explain extent)? This course is intended as a broad spectrum introduction to core methodology. While there is some review of 700 (simple linear regression), this course presents fundamental methods, in an applied sense, that will be reinforced more formally in advanced PhD-level courses.

PROJECTED SIZE AND SOURCE OF ENROLLMENT Graduate Students: Within Department Outside Department Per Year 8 2 Other Students: (Specify) 6 (Clin. M.S.) Per Year 0 2

DETAILED STATEMENT OF OBJECTIVES (i.e. what will the student gain from the course)? Students will be able to understand a considerable range of multiple predictor regression models including linear, logistic, survival, and Poisson. The SAS software will be used for computations, and students will be able to interpret results generated from SAS and other statistical packages. The modeling concepts will include interactions, covariates, dummy variables, remedies for assumptions not met, including transformations, multiple comparisons, and multicollinearity.

Course No.

BMTRY 701

Department of Biostatistics, Bioinformatics & Epidemiology Biostatistical Methods II (701) Class Meetin g 1 Chapter/Section* Topics

2-3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30

Concepts and Examples of Research Classification of Variables and the Choice of Analysis Basic Statistics: A Review Introduction to Regression Analysis Straight-Line Regression Analysis The Correlation Coefficient and Straight-Line Regression The Analysis-of-Variance Table Matrix Approach Multiple Regression Analysis: General Considerations Testing Hypotheses in Multiple Regression Correlations: Multiple Partial and Multiple-Partial Confounding and Interaction in Regression Review Exam Regression Diagnostics Regression Diagnostics (contd) Dummy Variables in Regression Analysis of Covariance and Other Methods for Adjusting Continuous Data Selecting the Best Regression Equation One-Way Analysis of Variance Randomized Blocks:Special Case of Two-Way ANOVA Overflow Review Exam Two-Way ANOVA With Equal Cell Numbers Two-Way ANOVA With Unequal Cell Numbers Analysis of Repeated Measures Data The Method of Maximum Likelihood Logistic Regression Analysis Poission Regression Analysis Review Final