Ranadheer gandrakota Student id:1474327 1) Which of the following histamine receptors present in cardic muscle a) Hi b) H2 c) H3 d) H4 e) All the above

H1 present in smooth muscles and vascular endothelium and brain H2 present in cardiac muscle,mast cells, brain H3 presemnt in CNS, and peripheral nervous system H4 present in hematopoietic cells and gastric mucosa Ans:b Ref: page 771, Golan 2) which of the following comes under anticancer drugs a) amantidine b) piperazine c) metronidazole d) cisplatin e) artemisnin ans:d (refer 634-691 golan) remaining all are anti bacterial agents 3) which of the following is used as a long acting insulin a) lispro b) regular insulin c) NPH d) Semi lente insulin e) Ultra lente And: e (refer 539 golan) Coz it is present in crystalline suspension form and lake of zinc 4) Which of the following harmones produced from hypothalamus a) Tsh b) Crh c) Adh d) Oxytocin e) All of the above Ans: e (refer 475 golan) 5) a) b) c) d) e) Which of the following receptors activate secondary messengers G protein Ligand gated Voltage gated Both a &b Both b&c

Ans: g protein Ref: page 10 golan 6) Unconsciousness comes under which stage of general anesthesia a) Stage 1 b) Stage 2 c) Stage 3 d) Stage 4 e) None Ans: c Coz stage 3 includes unconsciousness, decrease in eye movement and regular respiration Ref: page 241 golan 7) Which of the following is an Non steroidal analgesic a) Ametryptalline b) Precabalin c) Aspirin d) Alvimopan e) Propaxyphene Ans : c Ref page 281 golan 8) Which of the following drug causes vaso constriction a) Minoxidil b) Diltiazem c) Nitric oxide d) Endothelin e) ACE inhibitors Ans: d (refer 378,379 golan) Con remaining all causes vasodilation except endothelin 9) The mechanism action of 6-mercaptopurin used in anti cancer A) By inhibiting the thimidine synthesis B) By inhibiting the ribonucleotide reducatase C) By inhibiting the purine metabolism D) By inhibiting the pyridine metabolism E) All of the above Ans-C (refer-page number 686 golan) 10) Select the correct matching of the drug with its MOA i)niacin ii)fenofibrate iii)ezetimitide A) I only B) I and II C) I,II, and III D) II and III E) None

Ans- A(refer 438 golan) Exp- niacin reduces the free fatty acids released from adipose tissues Fenofibrate- decreases the cholesterol transport form micilide into the enterocyte Ezeimitide- against of proliferator-activated receptor

From Calcagnetti 11) Which of the following is bad cholesterol? A)VLDL B)HDL C) LDL D) Tri glyceridies E) All of the above. Ans- C (Refer Pg-78, Calcagnetti) Exp- because it carries the cholesterol from liver to peripheral tissues remaining all are carries cholesterol form peripheral to liver. 12) Which of the following is true regarding the haloperidol? A) It was the first therapeutic alternative to phenothiazines. B) It produces sedation C) Oral administration is effective. D) It occupies and blocks dopamine 2 receptors. E) All of the above. Ans- E (refer Pg.no 36- Calcagnetti) 13) Which if the following is a function of insulin? A) Decreases the blood glucose level. B) Increase the potassium uptake. C) Decrease the lipolysis D) Increase estrification of fatty acids. E) All of the above. Ans- E (refer Pg-96, Calcagnetti) 14) Which of the following is the high energy bond? A) Vander wall. B) Ionic. C) Covalent. D) Hydrogen. E) Both A and B. Ans- C (refer Pg-13, Calcagnetti) Exp- because covalent bond yield 100 kilo.cal/per mole of energy. Others are less than 100. 15) Which of the following is drug is good example for narcotic analgesics? A) Imipamine B) Oxy carbazipine C) Fentanyl D) Dexedrine

E) A and B Ans- C (refer Pg-11, Calcagnetti) Exp- A- used to treat pyschosis B-anti epilemitics C- used to treat acute and chronic pain. D- pyshcomotor stimulant. 16) Cardiac arrhythmia associated with which of the following symptoms? A) Angina B) Narrow angle glaucoma C) Shock during general anesthesia D) Organic brain damage E) All of the above. Ans- E(refer Pg-29, Calcagnetti) 17) Which of the following have both effinity and efficacy? A) Agonist B) Antagonist C) Partial agonist D) Partial antagonist E) A and B Ans- A(Refer Pg-8, Calcagnetti) 18) Which of the following substances are more soluble in water? A) Lipophilic B) Hydrophilic C) Hydrophobic D) Lipophobic E) B and D Ans-E(Refer Pg-7, Calcagnetti) Exp- both hydrophilic and lip phobic are water loving substances. Both lipophilic and hydrophobic are water hating substances. 19) Which of the following is use to treat cancer? A) acyclovir B) metrinidizole c) cisplatin D) chlorambucin E) Both C and D Ans- E( pg 130, Calcagnetti) Exp- cisplatin nd chlorambucin they are alkylating agents inhibit the protein synthesis. Acyclovir is anti viral drug, metrnidizole anti malarial drug. 20) A) B) C) Severity of dementia observed in which of the following disease? Parkinson disease Schizophrenia Alzheimers disease

D) Ischemia E) Cancer Ans-C(refer pg 25, Calcagnetti) Exp- in alzheimers disease neurofibrlaries tangles are made together form filaments. The density of this filaments within the neuron in the brain is direct related to severity of dementia which is not observed in remaining diseases .

PHARMACOKINETICS ASSIGNMENT

FromJITHENDER REDDY