miconazole nitrate

(mi kon' a zole)

Topical:
Absorbine Antifungal Foot Powder, Breeze Mist Antifungal,
Fungoid Tincture, Lotrimin AF, Maximum Strength Desenex Antifungal, Ony
Clear, Tetterine, Zeasorb-AF
Vaginal suppositories, topical:
Micatin, Micozole (CAN), Monazole 7 (CAN), Monistat 3, Monistat 7,
Monistat-Derm, Monistat Dual Pak

Pregnancy Category B

Drug class
Antifungal

Therapeutic actions
Fungicidal: Alters fungal cell membrane permeability, causing cell death; also may alter
fungal cell DNA and RNA metabolism or cause accumulation of toxic peroxides
intracellularly.

Indications
• Vaginal suppositories: Local treatment of vulvovaginal candidiasis (moniliasis)
• Topical administration: Tinea pedis, tinea cruris, tinea corporis caused by
Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum;
cutaneous candidiasis (moniliasis), tinea versicolor

Contraindications and cautions

• Contraindicated with allergy to miconazole or components used in preparation.
• Use cautiously with pregnancy, lactation.

Available forms
Vaginal suppositories—100, 200, 1,200 mg; topical cream—2%; vaginal cream—2%;
topical powder—2%; topical spray—2%; topical ointment—2%; spray powder or liquid
—2%; solution—2%

Dosages
ADULTS
Vaginal suppositories
Monistat 3: Insert 1 suppository intravaginally once daily hs for 3 days. Monistat 7: One
applicator cream or 1 suppository in the vagina daily hs for 7 days. Repeat course if
needed. Alternatively, one 1,200-mg suppository at hs for 1 dose.
Topical
Cream and lotion: Cover affected areas bid, morning and evening. Powder: Spray or
sprinkle powder liberally over affected area in the morning and evening.
PEDIATRIC PATIENTS
Topical
< 2 yr: Not recommended.
> 2 yr: Use adult dosage.

Pharmacokinetics
Route Onset Peak
Topical Rapid Unknown
Vaginal Unknown Unknown

Metabolism: Hepatic; T1/2: 21–24 hr

Distribution: Crosses placenta; may enter breast milk
Excretion: Urine and feces

Adverse effects
Vaginal suppositories
• Local: Irritation, sensitization or vulvovaginal burning, pelvic cramps
• Other: Rash, headache
Topical application
• Local: Irritation, burning, maceration, allergic contact dermatitis

Nursing considerations
Assessment
• History: Allergy to miconazole or components used in preparation; lactation,
pregnancy
• Physical: Skin color, lesions, area around lesions; T; orientation, affect; culture of
area involved

Interventions
• Culture fungus involved before therapy.
• Insert vaginal suppositories high into the vagina; have patient remain recumbent
for 10–15 min after insertion; provide sanitary napkin to protect clothing from
stains.
• Monitor response; if none is noted, arrange for further cultures to determine
causative organism.
• Apply lotion to intertriginous areas if topical application is required; if cream is
used, apply sparingly to avoid maceration of the area.
• Ensure patient receives the full course of therapy to eradicate the fungus and to
prevent recurrence.
• Discontinue topical or vaginal administration if rash or sensitivity occurs.

Teaching points
• Take the full course of drug therapy even if symptoms improve. Continue during
menstrual period even if vaginal route is being used. Long-term use will be
needed; beneficial effects may not be seen for several weeks.
• Insert vaginal suppositories high into the vagina.
• Use hygiene measures to prevent reinfection or spread of infection.
• This drug is for the fungus being treated; do not self-medicate other problems
with this drug.
 • Refrain from sexual intercourse, or advise partner to use a condom to avoid
reinfection; with vaginal form of drug, use a sanitary napkin to prevent staining of
clothing.
• These side effects may occur: Irritation, burning, stinging.
• Report local irritation, burning (topical application); rash, irritation, pelvic pain
(vaginal use).

Adverse effects in Italic are most common; those in Bold are life-threatening.