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Differential diagnosis
Common DD questions
Dry eye syndrome Pigmented conjunctival lesions Resistant corneal ulcer Interstitial keratitis Peripheral corneal thinning Corneal edema Management of chronic non-infectious uveitis Investigate a case of posterior uveitis Phakomatosis Iris nodules Leucocoria Subretinal neovascular membranes Cherry red spot Bulls eye maculopathy Macular edema Night blindness Pigmented fundus lesion Ocular manifestations of blunt trauma Ocular manifestations of blood diseases Ocular manifestations of renal diseases Anisocoria Optic cupping Optic disc swelling Diplopia Compressive neuropathy Restrictive myopathy Unilateral proptosis in children
Differential diagnosis
Differential diagnosis
III.
Obstructive epiphora 1. Punctual stenosis a. Primary 1. Idiopathic 2. Trachoma 3. HSV 4. Cicatrizing conjuctivitis 5. Irradiation b. Secondary 1. Punctual eversion (ectropion,) 2. Canalicular obstruction a. Idiopathic b. HSV c. Systemic 5-FU d. Chronic dacryocystitis e. Cicatrizing conjuctivitis 3. NLD-obstruction a. Congenital b. Acquired 1. Idiopathic 2. Trauma 3. Irradiation 4. Wegner granulomatosis 5. Nasopharyngeal tumors
Differential diagnosis
Orbital tumours
I. Vascular 1. Capillary haemangioma 2. Cavernous haemangioma 3. Lymphangioma II. Lacrimal gland 1. Pleomorphic adenoma 2. Carcinoma III. Neural 1. Op n glioma 2. Op n sheath meningioma 3. Neurofibroma IV. Miscellaneous 1. Lymphoma 2. Rhabdomyosarcoma V. Metastatic 1. Tumour invasion from adjacent sinuses
Differential diagnosis
Pediatric: proptosis
1. 2. 3. 4. 5. 6. 7. 8. 9. Rhabdomysarcoma Orbital cellulitis Inflammatory pseudotumour Optic nerve glioma Retrobulbar hge Thyroid ophthalmopathy Chloroma Neuroblastoma histocytosis
Differential diagnosis
Subconjunctival hge
I. Microvascular diseases II. Increased CVP III. Trauma IV. infection 1. Viral a. Entero virus 70 b. Coxsackie virus A24 c. Adenovirus d. A hgic conjitis 2. Bacterial a. Strept. pneumoniae b. H. aegyptius V. Amyloidosis
Differential diagnosis
Differential diagnosis
DD of conjunctival melanoma
1. 2. 3. 4. 5. Large naevus Ciliary body melanoma Melanocytoma Pyogenic granuloma Pigmented conj carcinoma
Differential diagnosis
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Differential diagnosis
Signs of previous ocular herpes infection Epith denderites Stromal keratitis / scarring Iris atrophy Irregular pupil Ant uveitis Inflammatory sterile keratitis
I. Stromal keratitis: Acute superficial and midstromal opacities with stroma oedema followed by vascularization and scarring II. Sclerosing keratitis:Perilimbal corneal thickening, opacification, lipid deposition and vascularization III. Furrowing:Peripheral corneal thinning +/- ulceration
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Differential diagnosis
IV. Keratolysis:Peripheral ulcerative keratitis with edema, infiltration and sromal melting may lead to perforation
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Differential diagnosis
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Differential diagnosis
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Differential diagnosis
Corneal pigmentation
Type Iron Cause Keratoconus Old age Ptrygium Filtering bleb Hyphema Siderosis Chrysiasis Argyrosis Wilsons dis. PDS Name Fleischer ring Hudson Stahli line Stockers line Ferrys line Blood staining Location Epithelium
Stroma
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Differential diagnosis
3. ++IOP
NB.Light scattering by edematous cornea does not occur until stroma swell>15%
DD of posterior scleritis
1. 2. 3. 4. 5. 6. Optic neuritis Rhegmatogenous retinal detachment Choroidal tumour Orbital inflammatory disease or mass Uveal effusion synd Harada disease
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Differential diagnosis
Mucopolysaccharidoses
Type MPS1-H MPS1-S MPS 2 MPS 3 MPS 4 MPS 6 Name Hurler Scheie Hunter Sanfilippo Morquio Marolteaux-Lamy + C.deposit R.deg +++ + Op A +
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Differential diagnosis
DD of heterochromia iridis
I. Hypochromia 1. Congenital 2. Horner synd especially congenital 3. Fuchs uveitis II. Hyperchromia 1. Naevus of Ota 2. Ocular siderosis 3. Diffuse iris naevus or melanoma 4. Sturge Weber synd 5. Unilateral use of latanoprost 6. Fuchs uveitis
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Differential diagnosis
HLA
Acute anterior uveitis: HLA-27B, B8. Ankylosing spondylitis: HLA-B27, B7 Rheumatoid A: HLA-DR4 Behcet disease: HLA-B51 Reiter syndrome: HLA-B27 Bird shot retinopathy: HLA-A29 Multiple sclerosis: HLA-DR2 Ocular pemphigoid: HLA-B12,DQw7
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Differential diagnosis
POHS: HLA-B7, DR2 Sympathetic ophthalmia: HLA-A11, DR4, Dw53. VKH: DR4, Dw53, DQw3 Causes of chronic non infective uveitis
I. With arthritis 1. Ankylosing spondylitis 2. Psoriatic arthritis 3. JCA II. With systemic diseases 1. Sarcoidosis 2. Behcet disease 3. VKH III. Idiopathic specific uveitis 1. Fuchs uveitis 2. Intermediate uveitis 3. Juvenile ch uveitis IV. Rare idiopathic specific uveitis 1. Sympathetic 2. Serpigenous choroidopathy 3. Bird shot retinochoroidopathy 4. Glaucomatocyclitic crises 5. Eales disease
II. Intermediate uveitis 1. Pars planitis III. Post uveitis 1. Toxoplasmosis 2. Toxocariasis 3. Sympathetic ophthalmia 4. Bacterial/ viral infections
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Differential diagnosis
Uveo-meningeal syndromes
I. Idiopathic 1. MS II. Infectious 1. Bacterial: syphilis, lyme, TB 2. Viral: CMV, HSV, HZV 3. Fungal: cryptococci, candida 4. Protozoal: toxoplasmosis III. Inflammatory 1. VKH 2. Behcet 3. Sarcoidosis 4. APMPPE 5. PAN IV. Neoplastic 1. Reticulum cell sarcoma 2. Lymphoma 3. Metastatic neoplasm
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Differential diagnosis
DD of Behcet disease
1. 2. 3. 4. 5. Sarcoidosis Rieter synd Viral whipple disease Crohns disease Collagen disease
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Differential diagnosis
Immunocompromised patients
1. 2. 3. 4. 5. 6. 7. Chemotherapy Long-term immunosuppressive therapy Long-term use of steroids AIDS Malnutrition DM Elderly
Multifocal chroidopathies
Multifocal infectious choroidopathies POHS Ocular coccidioidomycosis Cryptococcal choroiditis Pneumocystis carinii choroiditis Tuberculous choroiditis Syphilitic choroiditis Multifocal inflammatory choroidopathies Sarcoid choroidopathy VKH syndrome Sympathetic ophthalmia Bird shot PIC Multifocal choroiditis and panuveitis Multifocal Vascular choroidopathies AMPPPE SLE Pre-eclampsia and multifocal ischemic choroidopathy Multifocal neoplastic choroidopathies Choroidal metastasis Lymphomatous choroidopathy Leukaemic choroidopathy Bilateral diffuse uveal melanocytic proliferation Others MEWDS ARPE RMC Serpiginous choroiditis
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Differential diagnosis
vascultitis
DD of retinitis Focal
a. Associated with vitritis i. Arteritis 1. ARN 2. Behcet ii. Choroiditis 1. Toxoplasmosis 2. Toxocariasis 3. Fungal b. Macular i. Autoimmune: Behcet, SLE ii. Infection: DUSEN iii. Immunocompromised: CMV, toxoplasmosis, POHS iv. Masquerades: leukaemia, radiation retinopathy c. Peripheral v. Autoimmune: Behcet, sarcoidosis vi. Infection: ARN vii. Immunocompromised: CMV, toxoplasmosis, POHS viii. Masquerades: leukaemia, radiation retinopathy
Multifocal
Autoimmune: Behcet, sarcoidosis Infection: ARN, DUSN
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Differential diagnosis
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Differential diagnosis
Io tumors
Common tumors
Retina
1. 2. 3. 4. Retinoblastoma Astrocytoma (tuberous sclerosis) Haemangioma (capillary/ caverneous/ racemose) RPE tumors a. CHRPE (typical; solitary, grouped/ atypical multiple b. Combined hamartoma of RPE and retina
Choroid
1. 2. 3. 4. 5. 6. 7. Melanoma Naevus Haemangioma (circumscribed/ diffuse = Sturge Weber) Metastatic Osseous carcinoma Lymphoma melanocytoma
Causes of leukocoria
1. Retinoblastoma 2. Congenital cataract 3. Coats disease 4. ROP 5. Toxocariasis 6. PHPV 7. Retinal dysplasia 8. Inflammatory cyclitic membrane 9. Incontinenta pimenti 10.Retinal astrocytoma
DD of iris melanoma
1. 2. 3. 4. 5. 6. Iris naevus CB melanoma Metastases Primary iris cyst Adenoma of iris pigment epithelium leiomyoma
DD of CB melanoma
1. Medulloepithelioma (diktyoma)
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Differential diagnosis
2. Uveal effusion syndrome 3. Congenital epithlial iridociliary cysts 4. Other CB tumours a. Metastases b. Adenocarcinoma c. Cystic adenoma d. Leiomyoma e. Haemangioma
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Differential diagnosis
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Differential diagnosis
II. General 1. Vascular disease (arterial sclerosis, vascular retinopathy) 2. Blood disease 3. Severe straining
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Differential diagnosis
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Differential diagnosis
Causes of neovascularization
I. Central 1. PDR 2. Old RVO 3. Retinal vasculitis 4. RAO 5. Ocular ischaemic synd 6. Carotid-cavernous fistula 7. Radiation retinopathy II. Peripheral 1. ROP 2. Sickle cell retinopathy 3. Eals disease 4. Sarcoidosis 5. Intermediate uveitis 6. Ch myeloid leukaemia 7. Familial exudative vireoretinopathy 8. Incontinentia pigmenti
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Differential diagnosis
DD of peripheral retinal NV
I. Vascular disease + ischaemia 1. PDR 2. B-RVO 3. B-RAO 4. Carotid-Caverneous fistula 5. Sickling Hb pathies 6. Eales disease 7. Retinal embolization 8. ROP 9. FEVR 10.Hyperviscosity synd 11.Aortic arch synd/ OIS 12.IRVAN II. Inflammatory dis+ possible ischaemia 1. Sarcoidosis 2. Ret vasculitis eg SLE 3. Uveitis eg pplanitis 4. Bird shot CH-R pathy 5. Toxoplasmosis 6. M sclerosis III. Miscellaneous 1. Incontinentia pigmenti 2. Long standing RD 3. Ch melanoma 4. RP 5. Retinoschesis
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Differential diagnosis
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Differential diagnosis
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Differential diagnosis
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Differential diagnosis
Dystrophy of RPE
1. 2. 3. 4. 5. 6. Best bitelliform macular dystrophy Stargardt macular dystrophy, Fundus flavimaculatus Familial dominant drusen Sorsby pseudoinflammatory macular dystrophy North Carolina macular dystrophy Pattern dystrophy (Adult vitilliform, butterfly)
Choroidal dystrophy
1. Choroideremia 2. Gyrate atrophy 3. Central areolar choroidal dystrophy
Vitreoretinal degeneration
1. 2. 3. 4. Stickler syndrome Cong retinoschisis Favre-Goldmann syndrome Familial exudative VR
C.
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Differential diagnosis
1. 2. 3. 4. 5. 6.
Chloroquine maculopathy Cone dystrophy Advanced stargardt disease Inverse retinitis pigmentosa Bardet Biedle Benign concentric annular macular dystrophy 7. Fenestrated sheen dystrophy 8. Batten disease
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Differential diagnosis
7. Ocular hypotony
Causes of exudative RD
I. Choroidal tumours 1. Primary 2. Metastatic II. IO inflammation 1. Harada disease 2. Posterior scleritis 3. Necrosing retinitis III. Exudation of suretinal BV 1. CNV 2. Retinal telangiectasia IV. Systemic 1. HTN 2. Toxaemia of pregnancy 3. Hypoproteinaemia V. Iatrogenic 1. RD surgery 2. Extensive photocoagulation VI. Others 1. CSR 2. Derrame uveal syndrome
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Differential diagnosis
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Differential diagnosis
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Differential diagnosis
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Differential diagnosis
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Differential diagnosis
VII. Toxic and Metabolic 1. Lead poisoning 2. Ch hipervitaminosis A 3. Renal failure 4. Hypercapnia VIII. Developmental 1. Aqueduct stenois 2. Craniodysostoses 3. AV malformations IX. Iatrogenic 1. Radical neck surgery 2. tetracyclines
2. AION 3. ON drusen 4. Papillophlebitis 5. CRV-O 6. CRA-O 7. Hypotony after surgery, trauma 8. Ch ant uveitis, pars planitis 9. Leber heridiatary op neuropathy II. Orbital 1. ON tumors: glioma, meningioma, metastasis 2. ON trauma 3. Ophthalmic A aneurism 4. Orbital tumors, 5. Orbital cellulitis, abscess III. Intracranial 1. Post fossa tumor 2. Pseudotumor cerebri 3. Brain abscess 4. Subarachnoid hemorrhage 5. Early caverneous sinus thrombosis 6. Carotid caverneous fistula IV. True papilledema with controlateral 1. Op atrophy 2. Glaucoma 3. High myopia
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Differential diagnosis
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Differential diagnosis
1. Refractive errors 2. Amblyopia (check refraction, look for squint) 3. Non organic V loss 4. Delayed visual maturation 5. Incipient ret dystrophy a. Cone dystrophy b. Stargardt dystrophy 6. Cortical visual alterations II. With nomal eye movement In adults 1. Retrobulbar neuritis (check pupillary reaction, colour vision) 2. Nutritional amblyopia (check colour vision) 3. Cancer associtated retinopathy III. Without nomal eye movement In children 1. Leber congenital amaurosis (rotatory eye movements, high
hyperopia, eye poking) 2. Achromatopsia (nystagmus, photophobia) 3. X-linked recessive congenital stationary night blindness (nystagmus,nyctalopia, myopia)
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Differential diagnosis
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Differential diagnosis
Diminution of vision
I. Transient visual loss-Few seconds 1. Papilloedema II. Transient visual loss-Few minutes 1. Amaurosis fugax 2. Vertebrobasilar A insufficiency III. Transient visual loss-10 to 60 minutes 1. migrane 2. Impending CRV-O 3. ION 4. Ocular Ischaemic syndrome 5. Glaucoma 6. Sudden change in Bl Pr 7. CNS lesion 8. Optic disc drusen 9. GCA IV. Sudden Painless Visual Loss < 24 hrs 1. RAO / RVO 2. Commotio retinae 3. ION / Optic neuritis 4. RD / Vit hge 5. Other retinal dis 6. CNSstroke 7. Methanol poisoning V. Diminution of vision in few days 1. corneal ulcer 2. iritis and choroiditis 3. RD, retinopathy 4. op neuritis VI. Gradual Painless Visual Loss 1. Senile cataract 2. AMD 3. OAG 4. Refractive error especially progressive myopia 5. Op neuropathy, primary optic atrophy 6. retinitis pigmentosa 7. amblyopia ex anopsia 8. DR 9. Ch corneal dis dystrophy
Differential diagnosis
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Differential diagnosis
Causes of shallow AC
I. Small globe 1. Hyperopia 2. Nanophthalmos 3. Microphthalomos II. Small cornea 1. Microcornea 2. Cornea plana III. Lens 1. Inumescent cataract 2. Ant dislocation IV. Post traumatic 1. Ciclodialysis 2. Leaking wounds V. Post operative 1. Leaking wound 2. Pupillary block by AC-IOL 3. Expansile gas in vit 4. Choroidal detachement after PRP VI. Others 1. Inflammatory pupillary block with iris bombe 2. CB tumours, cysts 3. Peter anomaly 4. iridoschesis
Causes of hyphemia
I. Trauma II. Surgery III. Iritis 1. HSV, HZV IV. Blood dyscrayasis V. Ghost cells with vit hge VI. Anomalies of iris & angle 1. Rubeosis 2. Xanthogranuloma 3. Fuchs HU 4. Spontaneous
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Differential diagnosis
Ghost vessels
I. Bacterial disease 1. congenital syphilis 2. tuberculosis 3. leprosy II. Viral disease 1. herpes simple 2. herpes zoster 3. measles 4. mumps 5. rubella III. Parasitic disease 1. leishmaniasis 2. onchocerciasis 3. cysticerosis IV. Unknown aetiology V. Cogan's syndrome
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Differential diagnosis
Symblepharon
I. Congenital 1. isolated 2. associated with systemic: Goldenharg's syndrome II. Acquired 1. traumatic including chemical injury 2. post-surgical a. pterygium operation b. conjunctival incision for RD or squint surgery 3. inflammatory conditions a. ocular cicatricial pemphigoid b. Steven-Johnson's syndrome
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Differential diagnosis
Iris transillumination
I. Diffused 1. Fuch's heterochromic cyclitis 2. albinism 3. post-cataract surgery 4. diabetic mellitus 5. previous acute glaucoma causing iris ischaemia II. Sectorial 1. herpes zoster 2. iridoschisis 3. post-cataract surgery 4. previous acute glaucoma 5. iridocorneal-endothelial syndrome III. Peripupillary :pseudoexfoliation syndrome IV. Mid-periphery :pigment dispersion syndrome V. Localized 1. post-trabeculectomy 2. post-laser iridotomy (both iridectomy and iridotomy are usually
found superiorly) 3. post-vitrectomy with silicone implant (Ando's procedure and the iridectomy is performed inferiorly)
1. iris naevus 2. iris melanoma (both melanoma and naevus can cause corectopia ) 3. iris leiomyoma 4. tumour extended from the ciliary body 5. metastatic tumour 6. juvenile xanthogranuloma (in young children) 7. iris cyst (may result from surgery) 8. granuloma (typically in sarcoidosis, termed Koeppe nodules if at the
pupil margin and Busacca nodules if at the periphery) 9. Lisch nodules (usually multiple) 10. Brushfield's spots (seen in Down's syndrome and usually multiple) Corectopia (= diplacement of the pupils) 1. congenital (including coloboma)
2. iris naevus / iris melanoma 3. ectopia uvae 4. ciliary body tumours 5. anterior chamber cleavage syndrome (Axenfeld and Reiger's) 6. iridocorneal-endothelial syndrome 7. post-cataract surgery (+ vitreous loss or the haptic is displaced) 8. post-trabeculectomy
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Differential diagnosis
Retinal detachments
I. rhegamatogenous II. tractional 1. proliferative retinopathies
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Differential diagnosis
III.
2. penetrating ocular trauma 3. severe intraocular inflammation exudative 1. choroidal tumours a. melanoma b. other primary tumour c. metastatic tumour 2. intraocular inflammation a. Vogt-Koyanagi-Harada's disease b. posterior scleritis 3. leaking subretinal vessels a. choroidal neovascularisation b. retinal telangiectasia 4. systemic condition a. toxaemia of pregnancy b. malignant hypertension c. hypoproteinaemic states such as nephrotic syndrome 5. others a. retinal photocoagulation b. uveal effusion syndrome
Choroidal detachments
I. ocular hypotony 1. wound leak 2. glaucoma filter 3. cyclodialysis cleft 4. penetrating ocular trauma II. elevated veal venous pressure 1. arteriovenous fistula 2. Sturge-Weber syndrome 3. vortex vein compression by scleral buckle III. malignant hypertension IV. inflammatory factors 1. after photocoagulation or cryotherapy 2. scleritis 3. uveitis V. neoplastic conditions 1. metastatic carcinoma 2. malignant melanoma 3. lymphoid, leukemic or melanocytic choroidal infiltration VI. secondary to abnormal sclera 1. nanophthalmos 2. idiopathic uveal effusion syndrome
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Differential diagnosis
1. vascular lesions (ischaemic or haemorrhagic stroke) 2. tumours (1ry: meningioma and astrocytoma or 2ry)
Anisocoria
Abnormal small pupil congenital (essential) Horner's syndrome drug-induced Abnormal large pupil congenital (essential) Adie's pupil drug-induced (anticholinergic
blockage or adrenergic stimulation)
(parasympathomimetic)
I. Lesions of the afferent pathway 1. retina (when both eyes are blind as DR absent light response) 2. optic nerves (if both ON are damaged as in GCA) 3. midbrain (pretectal lesion: Parinaud's syndrome due to pinealoma) 4. Edinger-Westphal nucleus (Argyll-Robertson's pupil) II. Lesions of the efferent pathway (caused by aberrant regeneration of the
damaged nerve resulting in better near reaction)
1. third nerve 2. ciliary ganglion (Adie's pupil) 3. other peripheral neuropathies (Charcot-Marie-Tooth syndrome,
amyloidosis, alcoholism and diabetes can also cause light-near dissociation and are probably due to regeneration of damaged nerves) 4. Other cause of unknown aetiology
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Differential diagnosis
5. myotonic dystrophy
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Differential diagnosis