TM

fabriwerk
private limited
TM

boundaryless processing systems

CLEANING IN PLACE (CIP) MODULE

CIP is the process used to ensure that process reactors, vessels and lines are free of organic and inorganic contaminants

Applications
Pharmaceuticals Sterile Solutions Vials Ampoules I. V. fluids Aerosols LVP & SVP Solutions Biopharmaceuticals Vaccines Human Insulin Serums Plasma fractions Bacteria and cell cultures

CIP cycles can be subjected to the following process machinery

Fermentors Blending Vessels Media / Harvest / Storage / Filtration Vessels Transfer Lines Process Equipment

Technical Highlights
Completely Automated Process Cycles On line display of process parameters with P & I of Operating System Display of Fault messages Supervisory access code prevents unauthorized changes Detergent / Acid / Alkali dosing On Line pH,Conductivity, TOC Sensing CIP is designed in accordance with ASME BPE and EHEDG guidelines PLC-based, with Touch Screen MMI and SCADA Packages

Key Benefits
Validatable process for cleaning of process equipment Lower facility operating costs Minimal dismantling of equipment and piping Reduced turnaround time for cleaning WFI requirements for cleaning reduced significantly Exposure to hazardous activities or entry into tanks, is eliminated

Spray device characteristics

The cleaning liquid turns the spray head by means of a specially positioned nozzle Rapid repetition impact loosens the dirt and washes it off the tank surfaces The cleaning effect is optimum at low pressures in small to medium size tanks With increasing pressure, the rotation speed gets higher, while due to stronger atomization, the reach of the spray gets lower Operation at the optimum pressure ensures required cleaning results and avoids wear of the nozzle

Effective Cleaning Criteria Factors include

Cleaning Cycle Time Cleaning Agent and Temperature Concentration and Chemistry of the Cleaning Agent within the circuit Degree of Turbulence of the Cleaning Solution Characteristics of the surface being Cleaned Spray Device Selection ( Static or Dynamic )

Capacity
CIP Modules for Processing Vessels ranging from 50 litres to 30000 litres Adam Fabriwerk offers trial facilities to carry out cleaning in place recipe development, as well as scale up work and operator training

corporate office adam fabriwerk pvt. ltd. 103, rajguru, new nagardas road, andheri - east. mumbai - 400 069, India. tel : 91 - 22 - 2838 0548 / 2838 4173 | fax : 91 - 22 - 2839 0195 email : adamfab@vsnl.com | web : www.adamfabriwerk.com

TM

fabriwerk
private limited
TM

boundaryless processing systems

STERILIZATION IN PLACE (SIP) MODULE

Purpose
SIP Module is a fully automated Sterilization in Place System for Sterilization of Processing vessels in Sterile areas.

Applications
Pharmaceuticals Sterile Solutions Vials Ampoules I. V. fluids Aerosols LVP & SVP Solutions Biopharmaceuticals Vaccines Human Insulin Serums Plasma fractions Bacteria and cell cultures

Technical Highlights
Completely Automated Process Cycles On line display of process parameters with P & I of Operating System Display of Fault messages Supervisory access code prevents unauthorized changes Automated valves for pure steam and sterile air Vacuum Pulsing Cycles for validating Vessel Integrity SIP is designed in accordance with ASME BPE and EHEDG guidelines PLC-based, with Touch Screen MMI and SCADA Packages

Key Benefits
Validatable process for Sterilization of process equipment Lower Facility Operating Costs Minimal dismantling of equipment and piping Reduced turnaround time for Sterilization Process vessels need not be autoclaved, hence optimizing space and enhancing process vessel design using bottom mounted magnetic mixers

Capacity
SIP Modules for Processing Vessels ranging from 5 litres to 30000 litres Adam Fabriwerk offers trial facilities to carry out Sterilization In Place recipe development, as well as scale up work and operator training

corporate office adam fabriwerk pvt. ltd. 103, rajguru, new nagardas road, andheri - east. mumbai - 400 069, India. tel : 91 - 22 - 2838 0548 / 2838 4173 | fax : 91 - 22 - 2839 0195 email : adamfab@vsnl.com | web : www.adamfabriwerk.com